JP6239635B2 - 血管石灰化の誘導因子であるソルチリン1 - Google Patents
血管石灰化の誘導因子であるソルチリン1 Download PDFInfo
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- JP6239635B2 JP6239635B2 JP2015540800A JP2015540800A JP6239635B2 JP 6239635 B2 JP6239635 B2 JP 6239635B2 JP 2015540800 A JP2015540800 A JP 2015540800A JP 2015540800 A JP2015540800 A JP 2015540800A JP 6239635 B2 JP6239635 B2 JP 6239635B2
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C12Q2600/00—Oligonucleotides characterized by their use
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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- G—PHYSICS
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- G01N2800/00—Detection or diagnosis of diseases
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- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Physics & Mathematics (AREA)
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- Microbiology (AREA)
- Wood Science & Technology (AREA)
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- Pathology (AREA)
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- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721727P | 2012-11-02 | 2012-11-02 | |
| US61/721,727 | 2012-11-02 | ||
| PCT/US2013/067969 WO2014071131A1 (en) | 2012-11-02 | 2013-11-01 | Sortilin 1 is a novel inducer of vascular calcification |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016502517A JP2016502517A (ja) | 2016-01-28 |
| JP2016502517A5 JP2016502517A5 (https=) | 2016-08-25 |
| JP6239635B2 true JP6239635B2 (ja) | 2017-11-29 |
Family
ID=50628077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540800A Active JP6239635B2 (ja) | 2012-11-02 | 2013-11-01 | 血管石灰化の誘導因子であるソルチリン1 |
Country Status (3)
| Country | Link |
|---|---|
| US (3) | US9822366B2 (https=) |
| JP (1) | JP6239635B2 (https=) |
| WO (1) | WO2014071131A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011053822A2 (en) | 2009-11-01 | 2011-05-05 | The Brigham And Women's Hospital, Inc. | Notch inhibition in the treatment and prevention of obesity and metabolic syndrome |
| CN106538029B (zh) | 2014-06-27 | 2020-10-16 | 泰科弗勒克斯公司 | 用于发送数据单元的方法和装置 |
| WO2016164608A1 (en) | 2015-04-07 | 2016-10-13 | Alector Llc | Methods of screening for sortilin binding antagonists |
| SI3280441T1 (sl) | 2015-04-07 | 2022-01-31 | Alector Llc | Protitelesa anti-sortilin in metoda njihove uporabe |
| GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| JP6632116B2 (ja) * | 2015-08-20 | 2020-01-15 | 国立大学法人広島大学 | 破骨細胞形成および/または機能抑制剤、破骨細胞形成および/または機能促進剤並びに破骨細胞形成および/または機能を抑制または促進する薬剤のスクリーニング法 |
| US10894833B2 (en) | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
| LT3618928T (lt) | 2018-07-13 | 2023-04-11 | Alector Llc | Anti-sortilino antikūnai ir jų panaudojimo būdai |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551990B2 (en) | 1998-12-07 | 2003-04-22 | University Of Washington | Methods of inhibiting ectopic calcification |
| IL142707A0 (en) * | 2000-04-27 | 2002-03-10 | Pfizer Prod Inc | Methods of treating obesity using a neurotensin receptor ligand |
| JP2007530029A (ja) | 2004-03-26 | 2007-11-01 | クアーク・ファーマスーティカルス、インコーポレイテッド | アネキシンii及びその使用 |
| WO2006047820A1 (en) | 2004-11-01 | 2006-05-11 | Newsouth Innovations Pty Limited | Use of calgranulin a and b in the promotion and inhibition of mineralized tissue formation |
| JP2008239488A (ja) | 2005-07-07 | 2008-10-09 | Saitama Medical Univ | 動脈硬化の治療剤 |
| DK2851084T3 (en) * | 2008-05-22 | 2018-07-30 | H Lundbeck As | Modulation of Vps10p domain receptors for the treatment of cardiovascular disease |
| WO2009143519A2 (en) * | 2008-05-23 | 2009-11-26 | The Johns Hopkins University | Biomarkers for myocardial ischemia |
| US8168390B2 (en) * | 2009-05-27 | 2012-05-01 | University Of Regensburg | Method and apparatus for diagnosing age-related macular degeneration |
| US20130115222A1 (en) * | 2010-06-15 | 2013-05-09 | Cornell University | Methods of limiting microvascular damage following acute myocardial ischemia |
| JP5852433B2 (ja) * | 2010-12-20 | 2016-02-03 | 株式会社ビー・エム・エル | ソルチリンによる動脈硬化の判定方法 |
-
2013
- 2013-11-01 JP JP2015540800A patent/JP6239635B2/ja active Active
- 2013-11-01 US US14/439,951 patent/US9822366B2/en active Active
- 2013-11-01 WO PCT/US2013/067969 patent/WO2014071131A1/en not_active Ceased
-
2017
- 2017-10-13 US US15/783,947 patent/US10508278B2/en active Active
-
2019
- 2019-10-24 US US16/662,776 patent/US11274306B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9822366B2 (en) | 2017-11-21 |
| US20150291963A1 (en) | 2015-10-15 |
| US10508278B2 (en) | 2019-12-17 |
| US11274306B2 (en) | 2022-03-15 |
| US20200095588A1 (en) | 2020-03-26 |
| WO2014071131A1 (en) | 2014-05-08 |
| JP2016502517A (ja) | 2016-01-28 |
| US20180163211A1 (en) | 2018-06-14 |
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