JP6200501B2 - 栄養医薬品および医薬品のための細胞ベース品質管理バイオアッセイ - Google Patents

栄養医薬品および医薬品のための細胞ベース品質管理バイオアッセイ Download PDF

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Publication number
JP6200501B2
JP6200501B2 JP2015523300A JP2015523300A JP6200501B2 JP 6200501 B2 JP6200501 B2 JP 6200501B2 JP 2015523300 A JP2015523300 A JP 2015523300A JP 2015523300 A JP2015523300 A JP 2015523300A JP 6200501 B2 JP6200501 B2 JP 6200501B2
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cells
composition
sample
level
activity
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Japanese (ja)
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JP2015524269A (ja
Inventor
ハルペリン，ジョセ・エイ
チョレブ，マイケル
アクタス，フセイン
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Harvard University
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Harvard University
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2015523300A 2012-07-20 2013-07-22 栄養医薬品および医薬品のための細胞ベース品質管理バイオアッセイ Expired - Fee Related JP6200501B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261674180P 2012-07-20 2012-07-20
US61/674,180 2012-07-20
PCT/US2013/051433 WO2014015328A1 (en) 2012-07-20 2013-07-22 Cell based quality control bioassays for nutriceutical and medicinal products

Publications (2)

Publication Number Publication Date
JP2015524269A JP2015524269A (ja) 2015-08-24
JP6200501B2 true JP6200501B2 (ja) 2017-09-20

Family

ID=48916225

Family Applications (1)

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JP2015523300A Expired - Fee Related JP6200501B2 (ja) 2012-07-20 2013-07-22 栄養医薬品および医薬品のための細胞ベース品質管理バイオアッセイ

Country Status (22)

Country Link
US (1) US9952200B2 (enExample)
EP (1) EP2820418B1 (enExample)
JP (1) JP6200501B2 (enExample)
KR (1) KR102136763B1 (enExample)
CN (1) CN104641231B (enExample)
AU (1) AU2013292266B2 (enExample)
CA (1) CA2866175C (enExample)
CL (1) CL2014002530A1 (enExample)
CO (1) CO7151536A2 (enExample)
DK (1) DK2820418T3 (enExample)
ES (1) ES2656941T3 (enExample)
HU (1) HUE036166T2 (enExample)
IN (1) IN2014DN07866A (enExample)
MA (1) MA35924B1 (enExample)
MX (1) MX356147B (enExample)
NO (1) NO2912013T3 (enExample)
PE (1) PE20142297A1 (enExample)
PL (1) PL2820418T3 (enExample)
PT (1) PT2820418T (enExample)
RU (1) RU2662358C2 (enExample)
WO (1) WO2014015328A1 (enExample)
ZA (1) ZA201406653B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107217087B (zh) * 2016-03-22 2019-12-10 中国石油化工股份有限公司 迅速测量油田污水和成品油中细菌含量的方法
CN115785247B (zh) * 2022-12-22 2025-06-24 中国农业大学 一种猪流行性腹泻病毒抗性相关蛋白质eif2a及其相关生物材料和应用

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US4318846A (en) 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US5091519A (en) 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
US5151507A (en) 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5066580A (en) 1988-08-31 1991-11-19 Becton Dickinson And Company Xanthene dyes that emit to the red of fluorescein
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6426513B1 (en) 1998-09-18 2002-07-30 Massachusetts Institute Of Technology Water-soluble thiol-capped nanocrystals
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US6576291B2 (en) 2000-12-08 2003-06-10 Massachusetts Institute Of Technology Preparation of nanocrystallites
ATE556845T1 (de) 2001-07-20 2012-05-15 Life Technologies Corp Lumineszierende nanopartikel und ihre herstellung
WO2007008221A2 (en) * 2004-08-10 2007-01-18 President And Fellows Of Harvard College DETECTION OF PHOSPHORYLATED eIF2α AS A DIAGNOSTIC TEST FOR EFFICIENCY AND SENSITVITY OF TRANSLATION INITIATION INHIBITORS IN THE TREATMENT OF CANCER AND OTHE R PROLIFERATIVE DISEASES
WO2008008333A2 (en) * 2006-07-11 2008-01-17 President And Fellows Of Harvard College Bioassays for quality control of nutriceuticals that inhibit, upregulate or otherwise modulate translation initiation
JP2012523837A (ja) * 2009-04-17 2012-10-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 栄養医薬品および医薬品のための品質管理バイオアッセイ
CA2763589A1 (en) * 2009-05-28 2010-12-02 President And Fellows Of Harvard College N,n'-diarylurea compounds and n,n'-diarylthiourea compounds as inhibitors of translation initiation
CN101671669B (zh) * 2009-08-27 2012-05-02 浙江大学 一种肝癌靶向性基因表达元件ae及其应用

Also Published As

Publication number Publication date
CL2014002530A1 (es) 2015-01-09
KR20150035496A (ko) 2015-04-06
EP2820418A1 (en) 2015-01-07
ES2656941T3 (es) 2018-03-01
MX2014012542A (es) 2014-11-21
US20150301023A1 (en) 2015-10-22
NO2912013T3 (enExample) 2018-03-10
AU2013292266B2 (en) 2019-01-03
KR102136763B1 (ko) 2020-08-13
US9952200B2 (en) 2018-04-24
CA2866175A1 (en) 2014-01-23
RU2662358C2 (ru) 2018-07-25
CA2866175C (en) 2021-04-20
PE20142297A1 (es) 2014-12-19
PL2820418T3 (pl) 2018-05-30
EP2820418B1 (en) 2017-12-06
JP2015524269A (ja) 2015-08-24
ZA201406653B (en) 2022-05-25
MA35924B1 (fr) 2014-12-01
AU2013292266A1 (en) 2014-09-25
RU2014136408A (ru) 2016-09-10
CN104641231B (zh) 2016-09-07
DK2820418T3 (en) 2018-02-12
CN104641231A (zh) 2015-05-20
IN2014DN07866A (enExample) 2015-04-24
MX356147B (es) 2018-05-15
PT2820418T (pt) 2018-02-12
CO7151536A2 (es) 2014-12-29
HUE036166T2 (hu) 2018-06-28
WO2014015328A1 (en) 2014-01-23

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