JP6174809B2 - 低温度係数を有するセンサ膜 - Google Patents
低温度係数を有するセンサ膜 Download PDFInfo
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- JP6174809B2 JP6174809B2 JP2016536573A JP2016536573A JP6174809B2 JP 6174809 B2 JP6174809 B2 JP 6174809B2 JP 2016536573 A JP2016536573 A JP 2016536573A JP 2016536573 A JP2016536573 A JP 2016536573A JP 6174809 B2 JP6174809 B2 JP 6174809B2
- Authority
- JP
- Japan
- Prior art keywords
- analyte
- sensor
- methacrylic acid
- glucose
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000012528 membrane Substances 0.000 title description 26
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 58
- 239000008103 glucose Substances 0.000 claims description 58
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- 230000035699 permeability Effects 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 18
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- DWHJJLTXBKSHJG-UHFFFAOYSA-N 5-hydroxy-2-methylpent-2-enoic acid Chemical compound OC(=O)C(C)=CCCO DWHJJLTXBKSHJG-UHFFFAOYSA-N 0.000 claims description 4
- 239000003990 capacitor Substances 0.000 claims description 2
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- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 1
- 239000011768 flavin mononucleotide Substances 0.000 description 1
- 229940013640 flavin mononucleotide Drugs 0.000 description 1
- FVTCRASFADXXNN-UHFFFAOYSA-N flavin mononucleotide Natural products OP(=O)(O)OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-UHFFFAOYSA-N 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
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- 229920001477 hydrophilic polymer Polymers 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
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- 210000004561 lacrimal apparatus Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- RXRHXOLQBOFMDI-UHFFFAOYSA-N methoxymethane;2-methylprop-2-enoic acid Chemical compound COC.CC(=C)C(O)=O RXRHXOLQBOFMDI-UHFFFAOYSA-N 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6821—Eye
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- Optics & Photonics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
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- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/098,806 | 2013-12-06 | ||
| US14/098,806 US9617578B2 (en) | 2013-12-06 | 2013-12-06 | Sensor membrane with low temperature coefficient |
| PCT/US2014/065905 WO2015084570A1 (en) | 2013-12-06 | 2014-11-17 | Sensor membrane with low temperature coefficient |
Publications (3)
| Publication Number | Publication Date |
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| JP2016539337A JP2016539337A (ja) | 2016-12-15 |
| JP2016539337A5 JP2016539337A5 (enExample) | 2017-06-15 |
| JP6174809B2 true JP6174809B2 (ja) | 2017-08-02 |
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| JP2016536573A Expired - Fee Related JP6174809B2 (ja) | 2013-12-06 | 2014-11-17 | 低温度係数を有するセンサ膜 |
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| Country | Link |
|---|---|
| US (1) | US9617578B2 (enExample) |
| EP (1) | EP3077805A4 (enExample) |
| JP (1) | JP6174809B2 (enExample) |
| CN (1) | CN105960591A (enExample) |
| RU (1) | RU2641966C2 (enExample) |
| WO (1) | WO2015084570A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103037755A (zh) | 2010-07-28 | 2013-04-10 | 雅培糖尿病护理股份有限公司 | 具有温度不敏感膜的分析物传感器 |
| US9696564B1 (en) | 2012-08-21 | 2017-07-04 | Verily Life Sciences Llc | Contact lens with metal portion and polymer layer having indentations |
| US9834805B2 (en) | 2013-12-23 | 2017-12-05 | Verily Life Sciences Llc | Two-layer analyte sensor |
| US9690118B2 (en) * | 2014-06-13 | 2017-06-27 | Verily Life Sciences Llc | Eye-mountable device to provide automatic accommodation and method of making same |
| WO2022106502A1 (en) | 2020-11-20 | 2022-05-27 | F. Hoffmann-La Roche Ag | Flux-limiting polymer membrane |
| CN114609213A (zh) * | 2022-03-17 | 2022-06-10 | 苏州中星医疗技术有限公司 | 葡萄糖传感器及其制备方法、应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5102552A (en) | 1987-12-16 | 1992-04-07 | Hoechst Celanese Corporation | Membranes from UV-curable resins |
| US5985129A (en) | 1989-12-14 | 1999-11-16 | The Regents Of The University Of California | Method for increasing the service life of an implantable sensor |
| US5209849A (en) | 1992-04-24 | 1993-05-11 | Gelman Sciences Inc. | Hydrophilic microporous polyolefin membrane |
| AT401653B (de) | 1994-10-05 | 1996-11-25 | Avl Verbrennungskraft Messtech | Verfahren zur immobilisierung biologischer komponenten in einer polymermatrix sowie biosensoren unter verwendung derartiger immobilisate |
| WO2000031183A1 (en) | 1998-11-24 | 2000-06-02 | The Dow Chemical Company | A composition containing a cross-linkable matrix precursor and a poragen, and a porous matrix prepared therefrom |
| US7045054B1 (en) | 1999-09-20 | 2006-05-16 | Roche Diagnostics Corporation | Small volume biosensor for continuous analyte monitoring |
| WO2002066986A2 (en) | 2001-02-15 | 2002-08-29 | Medtronic Minimed, Inc. | Polymers functionalized with fluorescent boronate motifs |
| US6932894B2 (en) | 2001-05-15 | 2005-08-23 | Therasense, Inc. | Biosensor membranes composed of polymers containing heterocyclic nitrogens |
| US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
| US7162289B2 (en) * | 2002-09-27 | 2007-01-09 | Medtronic Minimed, Inc. | Method and apparatus for enhancing the integrity of an implantable sensor device |
| AU2003900285A0 (en) | 2003-01-20 | 2003-02-06 | Universal Biosensors Pty Limited | Electrochemical detection method |
| JP2004233302A (ja) | 2003-01-31 | 2004-08-19 | Tanita Corp | センサ保存液、センサ較正液およびセンサ |
| US20050118204A1 (en) * | 2003-09-25 | 2005-06-02 | Kazutami Sakamoto | Methods for controlling membrane permeability of a membrane permeable substance and screening methods for a membrane permeable substance |
| JP2005315871A (ja) | 2004-03-31 | 2005-11-10 | Terumo Corp | 体内物質測定用構成物、体内物質測定用構成物の製造方法、および埋込型物質センサー |
| US7450980B2 (en) | 2004-03-31 | 2008-11-11 | Terumo Kabushiki Kaisha | Intracorporeal substance measuring assembly |
| US7326649B2 (en) | 2004-05-14 | 2008-02-05 | University Of Southern California | Parylene-based flexible multi-electrode arrays for neuronal stimulation and recording and methods for manufacturing the same |
| US20060094944A1 (en) | 2004-10-28 | 2006-05-04 | Sontra Medical Corporation | System and method for analyte sampling and analysis with error correction |
| CN102608176B (zh) * | 2005-05-17 | 2016-08-10 | 雷迪奥米特医学公司 | 用二价锰离子溶液稳定或再活化肌酸酐传感器的方法 |
| KR101433550B1 (ko) * | 2007-03-07 | 2014-08-27 | 에코 테라퓨틱스, 인크. | 경피 피분석물 모니터링 시스템 및 피분석물 검출 방법 |
| MY173855A (en) | 2007-03-21 | 2020-02-25 | Univ Putra Malaysia | Amperometric biosensor for histamine determination |
| WO2008121375A2 (en) | 2007-03-29 | 2008-10-09 | Pacific Biosciences Of California, Inc. | Modified surfaces for immobilization of active molecules |
| US8608310B2 (en) | 2007-11-07 | 2013-12-17 | University Of Washington Through Its Center For Commercialization | Wireless powered contact lens with biosensor |
| US8268637B2 (en) | 2008-01-11 | 2012-09-18 | The Board Of Trustees Of The University Of Illinois | Label-free biosensors based upon distributed feedback laser |
| US8364218B2 (en) * | 2008-02-11 | 2013-01-29 | Glucovista, Inc. | Apparatus and method for non-invasive measurement of the concentration of a substance in subjects blood |
| US8274021B2 (en) | 2008-03-07 | 2012-09-25 | California Institute Of Technology | Fully integrated temperature regulator for biochemical applications |
| US20110136929A1 (en) | 2008-07-09 | 2011-06-09 | Pei Yong Edwin Chow | Trapping glucose probe in pores of polymer |
| CA2683467C (en) | 2008-10-24 | 2016-01-26 | Jin Zhang | Contact lens integrated with a biosensor for detection of glucose and other components in tears |
| WO2010057095A2 (en) | 2008-11-14 | 2010-05-20 | The Regents Of The University Of Michigan | Method for manufacturing an implantable electronic device |
| CN102308204B (zh) | 2009-02-09 | 2014-07-09 | 爱科来株式会社 | 电化学传感器及其制备方法 |
| US20110082356A1 (en) * | 2009-10-01 | 2011-04-07 | Medtronic Minimed, Inc. | Analyte sensor apparatuses having interference rejection membranes and methods for making and using them |
| US8467843B2 (en) | 2009-11-04 | 2013-06-18 | Glumetrics, Inc. | Optical sensor configuration for ratiometric correction of blood glucose measurement |
| US8660628B2 (en) | 2009-12-21 | 2014-02-25 | Medtronic Minimed, Inc. | Analyte sensors comprising blended membrane compositions and methods for making and using them |
| WO2011101627A2 (en) | 2010-02-19 | 2011-08-25 | Glysure Ltd | Fluorescence measurement |
| WO2011113020A1 (en) | 2010-03-11 | 2011-09-15 | Glumetrics, Inc. | Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction |
| CN103037755A (zh) | 2010-07-28 | 2013-04-10 | 雅培糖尿病护理股份有限公司 | 具有温度不敏感膜的分析物传感器 |
| US20120088997A1 (en) | 2010-10-12 | 2012-04-12 | Anthony Guiseppi-Elie | Implantable biochip for managing trauma--induced hemorrhage |
| US8542024B2 (en) | 2010-12-23 | 2013-09-24 | General Electric Company | Temperature-independent chemical and biological sensors |
| US8608921B2 (en) * | 2011-01-20 | 2013-12-17 | Medtronic Minimed, Inc. | Layered enzyme compositions for use with analyte sensors |
| MY159008A (en) | 2011-02-22 | 2016-11-30 | Mimos Berhad | Protective coating for biosensor membrane and method of forming said coating |
| TW201302244A (zh) | 2011-07-08 | 2013-01-16 | Univ Nat Chiao Tung | 載藥型隱形眼鏡及其製備方法 |
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2013
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2014
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- 2014-11-17 EP EP14867505.1A patent/EP3077805A4/en not_active Withdrawn
- 2014-11-17 RU RU2016126203A patent/RU2641966C2/ru not_active IP Right Cessation
- 2014-11-17 CN CN201480065950.0A patent/CN105960591A/zh active Pending
- 2014-11-17 WO PCT/US2014/065905 patent/WO2015084570A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2641966C2 (ru) | 2018-01-23 |
| EP3077805A4 (en) | 2017-08-02 |
| WO2015084570A1 (en) | 2015-06-11 |
| JP2016539337A (ja) | 2016-12-15 |
| US9617578B2 (en) | 2017-04-11 |
| EP3077805A1 (en) | 2016-10-12 |
| US20150159190A1 (en) | 2015-06-11 |
| CN105960591A (zh) | 2016-09-21 |
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