JP6146990B2 - 重水素化されたｃｆｔｒ増強物質 - Google Patents

重水素化されたｃｆｔｒ増強物質 Download PDF

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JP6146990B2
JP6146990B2 JP2012251831A JP2012251831A JP6146990B2 JP 6146990 B2 JP6146990 B2 JP 6146990B2 JP 2012251831 A JP2012251831 A JP 2012251831A JP 2012251831 A JP2012251831 A JP 2012251831A JP 6146990 B2 JP6146990 B2 JP 6146990B2
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compound
deuterium
pharmaceutically acceptable
mmol
acid
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JP2014097964A (ja
JP2014097964A5 (enExample
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アダム ジェイ． モーガン
アダム ジェイ． モーガン
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コンサート ファーマシューティカルズ インコーポレイテッド
コンサート ファーマシューティカルズ インコーポレイテッド
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JP2012251831A 2012-11-16 2012-11-16 重水素化されたｃｆｔｒ増強物質 Active JP6146990B2 (ja)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017105824A (ja) * 2017-02-10 2017-06-15 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
JP2018188474A (ja) * 2018-08-13 2018-11-29 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質

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US20110064811A1 (en) 2005-12-28 2011-03-17 Patricia Hurter Solid forms of N-[2,4-BIS(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
WO2011133751A2 (en) 2010-04-22 2011-10-27 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
SI3424534T1 (sl) 2014-04-15 2021-08-31 Vertex Pharmaceutical Incorporated Farmacevtski sestavki za zdravljenje bolezni, ki jih povzroča regulator transmembranske prevodnosti pri cistični fibrozi
AU2015330923B2 (en) 2014-10-07 2020-03-12 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
JP7068827B2 (ja) 2015-06-30 2022-05-17 アイガー グループ インターナショナル インコーポレイテッド 炎症性状態および癌性状態を治療するための、クロロキン化合物およびクレミゾール化合物の使用
US10206915B2 (en) 2016-04-25 2019-02-19 Druggability Technologies Ip Holdco Limited Complexes of Ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HUP1600270A2 (hu) 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Ivacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadott készítményei
HUP1600271A2 (hu) 2016-04-25 2017-10-30 Druggability Tech Ip Holdco Ltd Ivacaftor és Lumacaftor sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadható készítményei
US10383865B2 (en) 2016-04-25 2019-08-20 Druggability Technologies Ip Holdco Limited Pharmaceutical combination composition comprising complex formulations of Ivacaftor and Lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them
CN108368134B (zh) 2016-07-25 2019-06-14 深圳市塔吉瑞生物医药有限公司 一种取代的硼酸化合物及包含该化合物的药物组合物及其用途
SG11202004264VA (en) * 2017-12-01 2020-06-29 Vertex Pharma Processes for making modulators of cystic fibrosis transmembrane conductance regulator
AU2021206286A1 (en) * 2020-01-10 2024-08-08 Consynance Therapeutics, Inc. Therapeutic combinations of drugs and methods of using them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100477070B1 (ko) * 1994-03-25 2006-04-21 이소테크니카 인코포레이티드 중수소화작용에의한의약품의효능강화법
ATE328882T1 (de) * 2002-04-08 2006-06-15 Pfizer Tropanderivative als ccr5-modulatoren
CA2490121C (en) * 2002-06-20 2013-01-08 Ic Vec Limited Modified phospholipids
RS53895B1 (sr) * 2004-06-24 2015-08-31 Vertex Pharmaceuticals Incorporated Modulatori atp-vezujućih kasetnih transportera
EA028378B1 (ru) * 2011-05-18 2017-11-30 Консерт Фармасъютиклс Инк. Дейтерированные производные ивакафтора

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017105824A (ja) * 2017-02-10 2017-06-15 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
JP2018188474A (ja) * 2018-08-13 2018-11-29 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質

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