JP6130387B2 - 強直性脊椎炎の患者間で共有されるｔ細胞受容体クロノタイプ - Google Patents

強直性脊椎炎の患者間で共有されるｔ細胞受容体クロノタイプ Download PDF

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JP6130387B2
JP6130387B2 JP2014539995A JP2014539995A JP6130387B2 JP 6130387 B2 JP6130387 B2 JP 6130387B2 JP 2014539995 A JP2014539995 A JP 2014539995A JP 2014539995 A JP2014539995 A JP 2014539995A JP 6130387 B2 JP6130387 B2 JP 6130387B2
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sample
pcr
amplification
nucleic acid
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マレク ファハム
マレク ファハム
ビクトリア カールトン
ビクトリア カールトン
マーティン ムーアヘッド
マーティン ムーアヘッド
チャンビャオ チェン
チャンビャオ チェン
トーマス アズベリー
トーマス アズベリー
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アダプティヴ バイオテクノロジーズ コーポレーション
アダプティヴ バイオテクノロジーズ コーポレーション
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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JP2014539995A 2011-11-04 2012-10-25 強直性脊椎炎の患者間で共有されるｔ細胞受容体クロノタイプ Active JP6130387B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161556125P 2011-11-04 2011-11-04
US61/556,125 2011-11-04
US201161561234P 2011-11-17 2011-11-17
US61/561,234 2011-11-17
PCT/US2012/061977 WO2013066726A1 (en) 2011-11-04 2012-10-25 T-cell receptor clonotypes shared among ankylosing spondylitis patients

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JP2014533102A JP2014533102A (ja) 2014-12-11
JP2014533102A5 JP2014533102A5 (https=) 2015-12-10
JP6130387B2 true JP6130387B2 (ja) 2017-05-17

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JP2014539995A Active JP6130387B2 (ja) 2011-11-04 2012-10-25 強直性脊椎炎の患者間で共有されるｔ細胞受容体クロノタイプ

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US (2) US20150252422A1 (https=)
EP (1) EP2773773B1 (https=)
JP (1) JP6130387B2 (https=)
ES (1) ES2619713T3 (https=)
WO (1) WO2013066726A1 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
CN104195227B (zh) 2008-11-07 2017-04-12 适应生物技术公司 通过序列分析监测状况的方法
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
EP2387627B1 (en) 2009-01-15 2016-03-30 Adaptive Biotechnologies Corporation Adaptive immunity profiling and methods for generation of monoclonal antibodies
CN102459643B (zh) 2009-06-25 2016-06-01 弗雷德哈钦森癌症研究中心 检测获得性免疫的方法
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
EP2768982A4 (en) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS
US9824179B2 (en) 2011-12-09 2017-11-21 Adaptive Biotechnologies Corp. Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
CA2872468C (en) 2012-05-08 2020-10-27 Adaptive Biotechnologies Corporation Compositions and methods for measuring and calibrating amplification bias in multiplexed pcr reactions
JP6449160B2 (ja) 2012-10-01 2019-01-09 アダプティブ バイオテクノロジーズ コーポレイション 適応免疫受容体多様性およびクローン性特性決定による免疫能力評価関連出願の相互参照
US10150996B2 (en) 2012-10-19 2018-12-11 Adaptive Biotechnologies Corp. Quantification of adaptive immune cell genomes in a complex mixture of cells
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
WO2016086029A1 (en) 2014-11-25 2016-06-02 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
CA2976580A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
AU2016242967B2 (en) 2015-04-01 2021-07-01 Adaptive Biotechnologies Corp. Method of identifying human compatible T cell receptors specific for an antigenic target
CN107345240A (zh) * 2016-05-12 2017-11-14 眭维国 T细胞抗原受体β链CDR3的处理方法
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5667967A (en) * 1990-05-01 1997-09-16 The Board Of Trustees Of The Leland Stanford Junior University T-cell receptor varible transcripts as disease related markers
EP0910668A4 (en) * 1996-06-03 2003-02-19 Univ Alberta METHOD FOR DETECTING REASSEMBLED DNA
NZ567286A (en) * 2005-11-01 2012-03-30 Abbott Biotechnolgy Ltd Methods and compositions for diagnosing ankylosing spondylitis using biomarkers
ES2261104B1 (es) * 2006-06-19 2007-06-16 Grifols, S.A. "tapon para frascos de productos esteriles y utilizacion de dicho tapon en la dosificacion esteril".
US8748103B2 (en) * 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
MX2011007030A (es) * 2008-12-30 2011-07-20 Centocor Ortho Biotech Inc Marcadores sericos que predicen la respuesta clinica a los anticuerpos anti-factor de necrosis tumoral alfa en pacientes con espondilitis anquilosante.
KR101323827B1 (ko) * 2010-01-08 2013-10-31 키스트 유럽 에프게엠베하 강직성척추염 진단용 프라이머 및 이를 이용한 강직성 척추염 진단 방법

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JP2014533102A (ja) 2014-12-11
US20170191132A1 (en) 2017-07-06
ES2619713T3 (es) 2017-06-26
EP2773773B1 (en) 2017-01-11
US20150252422A1 (en) 2015-09-10
WO2013066726A1 (en) 2013-05-10
EP2773773A4 (en) 2015-07-22
EP2773773A1 (en) 2014-09-10

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