JP6129864B2 - 被照射物に入射する線量の決定装置 - Google Patents
被照射物に入射する線量の決定装置 Download PDFInfo
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- JP6129864B2 JP6129864B2 JP2014545197A JP2014545197A JP6129864B2 JP 6129864 B2 JP6129864 B2 JP 6129864B2 JP 2014545197 A JP2014545197 A JP 2014545197A JP 2014545197 A JP2014545197 A JP 2014545197A JP 6129864 B2 JP6129864 B2 JP 6129864B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1031—Treatment planning systems using a specific method of dose optimization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
- A61N5/1065—Beam adjustment
- A61N5/1067—Beam adjustment in real time, i.e. during treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1087—Ions; Protons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1089—Electrons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1043—Scanning the radiation beam, e.g. spot scanning or raster scanning
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Radiation-Therapy Devices (AREA)
Description
は関数d(Ebeam,z)に使用可能であり、例えば科学刊行物「Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization」、M. Kramer, O Jaeckel, T. Haberer, G. Kraft, D. Schardt and U. Weber in Phys. Med. Biol. 45 (2000) 3299-3317において導かれた関係である。これに関連して、dN/dEは、個別の微分等エネルギーディスクの微分エネルギースペクトルである。Tは特定の粒子種類の測定値であり、原子番号Z及び原子質量Aにより定義される。ρは浸透材料の密度を意味する。
そこでDnorm(Ei,rk m,zk m)には以下が成り立つ:
2 オブジェクト
3 粒子ビーム
4 運動代替測定センサ
5 ビーム位置
6 位置
7 シンクロトロン
8 一対の水平偏向コイル
9 一対の垂直偏向コイル
10 ウェッジ吸収体
11 電子コンピュータ
12 データライン
13 オブジェクトの詳細
14 弱い付与
15 中付与
16 中点
17 粒子ビーム直径
18 ガウスカーブ
19 フロー図
20 運動フェーズを決定
21 線量入力を決定
22 差を決定
23 補正ステップ
24 ジャンプバック
25 停止
Claims (15)
- 放射線の適用中に、エネルギー粒子ビーム(3)での照射対象オブジェクト(2)への線量入力を決定する装置であって、
前記エネルギー粒子ビーム(3)により照射された目標体積領域(5)の外に位置する体積領域(6,14,15)への前記線量入力を、放射線の適用中に決定するための線量入力決定手段を含み、
前記線量入力を決定するために、前記エネルギー粒子ビーム(3)の物理的モデルに基づく計算関数を使用することを特徴とする装置。 - 前記線量入力決定手段は、前記エネルギー粒子ビーム(3)により照射される前記目標体積領域(5)への前記線量入力をさらに、かつ別に決定することを特徴とする、請求項1に記載の装置。
- 前記粒子ビーム(3)の前記物理的モデルは、粒子ビームプロファイル(17)の実質的にガウス状の分布(18)に基づくことを特徴とする、請求項1又は2のいずれかに記載の装置。
- 前記物理的モデルは、材料を透過する際のエネルギー損失モデル(図3a)に基づくことを特徴とする、請求項1から3のいずれかに記載の装置。
- 前記放射線の適用中に、前記照射対象オブジェクト(2)が運動することを特徴とする、請求項1から4のいずれかに記載の装置。
- 少なくとも前記照射対象オブジェクトの部分領域が並進運動及び/又は回転運動及び/又は膨張若しくは圧縮運動をすることを特徴とする、請求項5に記載の装置。
- 前記照射対象オブジェクト(2)の少なくとも一部の運動を検出することを特徴とする、請求項1から6、特に請求項5から6のいずれかに記載の装置。
- 前記エネルギー粒子ビーム(3)は、前記照射対象オブジェクト(2)の運動による前記目標体積領域の位置変化を補償するように制御されることを特徴とする、請求項1から7、特に請求項5から7のいずれかに記載の装置。
- 前記放射線の適用中に決定する前記線量入力は、後続の照射に影響することを特徴とする、請求項1から8のいずれかに記載の装置。
- 前記放射線の適用中に決定する前記線量入力を、記憶及び/又は出力することを特徴とする、請求項1から9のいずれかに記載の装置。
- 前記物理的モデルは、解析関数及び/又は数値テーブルの形式であることを特徴とする、請求項1から10のいずれかに記載の装置。
- 前記エネルギー粒子ビーム(3)は、前記放射線の適用中に移動し、特に走査方式で移動し、好ましくはラスタ走査方式、スポット走査方式、及び/又は連続走査方式で移動することを特徴とする、請求項1から11のいずれかに記載の装置。
- 目標線量と実際に適用される線量との間の差を決定することを特徴とする、請求項1から12のいずれかに記載の装置。
- 請求項1から13のいずれかに記載の装置を少なくとも一つ含む治療監視システム(11)。
- 照射システム(1)であって、少なくとも一つの請求項14に記載の治療監視システム(11)を含むことを特徴とするシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011056882.4A DE102011056882B4 (de) | 2011-12-22 | 2011-12-22 | Ermittlung eines Dosiseintrags in ein zu bestrahlendes Objekt |
DE102011056882.4 | 2011-12-22 | ||
PCT/EP2012/074223 WO2013092181A1 (de) | 2011-12-22 | 2012-12-03 | Verfahren zur ermittlung eines dosiseintrags in ein zu bestrahlendes objekt |
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JP2015500069A JP2015500069A (ja) | 2015-01-05 |
JP6129864B2 true JP6129864B2 (ja) | 2017-05-17 |
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JP2014545197A Expired - Fee Related JP6129864B2 (ja) | 2011-12-22 | 2012-12-03 | 被照射物に入射する線量の決定装置 |
Country Status (6)
Country | Link |
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US (1) | US9861835B2 (ja) |
EP (1) | EP2794006B1 (ja) |
JP (1) | JP6129864B2 (ja) |
CN (1) | CN103998097B (ja) |
DE (1) | DE102011056882B4 (ja) |
WO (1) | WO2013092181A1 (ja) |
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EP2853292B1 (en) * | 2013-09-30 | 2019-07-31 | Ion Beam Applications S.A. | Charged hadron beam delivery |
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JP3932667B2 (ja) * | 1998-04-16 | 2007-06-20 | 株式会社日立製作所 | 陽子線治療計画システム |
US6661871B2 (en) * | 2001-09-28 | 2003-12-09 | Siemens Medical Solutions Usa, Inc. | System and method for optimizing radiation treatment with an intensity modulating multi-leaf collimator by minimizing junctions |
DE102004028035A1 (de) * | 2004-06-09 | 2005-12-29 | Gesellschaft für Schwerionenforschung mbH | Vorrichtung und Verfahren zur Kompensation von Bewegungen eines Zielvolumens während einer Ionenstrahl-Bestrahlung |
JP4414370B2 (ja) * | 2005-06-06 | 2010-02-10 | 富士フイルム株式会社 | 照射野変化動作判定方法および装置 |
US7460640B2 (en) * | 2005-10-14 | 2008-12-02 | Norihiko Kamikonya | Radiotherapy monitoring apparatus |
DE102005063220A1 (de) * | 2005-12-22 | 2007-06-28 | GSI Gesellschaft für Schwerionenforschung mbH | Vorrichtung zum Bestrahlen von Tumorgewebe eines Patienten mit einem Teilchenstrahl |
DE102006044139B4 (de) * | 2006-09-15 | 2008-10-02 | Siemens Ag | Strahlentherapieanlage und Verfahren zur Anpassung eines Bestrahlungsfeldes für einen Bestrahlungsvorgang eines zu bestrahlenden Zielvolumens eines Patienten |
JP5071849B2 (ja) * | 2007-08-20 | 2012-11-14 | 独立行政法人放射線医学総合研究所 | スキャニング照射装置 |
DE102007045879B4 (de) | 2007-09-25 | 2014-07-10 | Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh | Bestrahlung eines bewegten Zielvolumens |
US8107589B2 (en) * | 2007-12-21 | 2012-01-31 | Kabushiki Kaisha Toshiba | Radiotherapeutic system and radiotherapeutic dose distribution measuring method |
JP5197026B2 (ja) * | 2008-01-09 | 2013-05-15 | 株式会社東芝 | 放射線治療システム、放射線治療支援装置及び放射線治療支援プログラム |
DE102008053611A1 (de) * | 2008-10-27 | 2010-05-06 | Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh | Bestrahlung eines Zielvolumens unter Berücksichtigung eines zu schützenden Volumens |
DE102009055902B4 (de) | 2009-11-26 | 2013-02-21 | Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh | Verfahren und Vorrichtung zur Steuerung der Dosisapplikation bei der Bestrahlung |
DE102009058294A1 (de) * | 2009-12-05 | 2011-06-09 | Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh | Bestrahlungsverfahren und Vorrichtung zur Durchführung des Verfahrens |
CA2796159A1 (en) * | 2010-06-07 | 2011-12-15 | The University Of Manitoba | Multi-objective radiation therapy optimization method |
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2011
- 2011-12-22 DE DE102011056882.4A patent/DE102011056882B4/de not_active Expired - Fee Related
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2012
- 2012-12-03 WO PCT/EP2012/074223 patent/WO2013092181A1/de active Application Filing
- 2012-12-03 JP JP2014545197A patent/JP6129864B2/ja not_active Expired - Fee Related
- 2012-12-03 CN CN201280062359.0A patent/CN103998097B/zh active Active
- 2012-12-03 EP EP12815651.0A patent/EP2794006B1/de not_active Not-in-force
- 2012-12-03 US US14/357,577 patent/US9861835B2/en active Active
Also Published As
Publication number | Publication date |
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WO2013092181A1 (de) | 2013-06-27 |
US20140324402A1 (en) | 2014-10-30 |
CN103998097B (zh) | 2017-06-23 |
DE102011056882B4 (de) | 2015-07-02 |
JP2015500069A (ja) | 2015-01-05 |
EP2794006B1 (de) | 2017-03-29 |
US9861835B2 (en) | 2018-01-09 |
CN103998097A (zh) | 2014-08-20 |
DE102011056882A1 (de) | 2013-06-27 |
EP2794006A1 (de) | 2014-10-29 |
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