JP6128133B2 - Ｉｇｆ−１ｒ／ｉｒ阻害剤としての５，８−ジヒドロ−６ｈ−ピラゾロ［３，４−ｈ］キナゾリン - Google Patents
Ｉｇｆ−１ｒ／ｉｒ阻害剤としての５，８−ジヒドロ−６ｈ−ピラゾロ［３，４−ｈ］キナゾリン Download PDFInfo
- Publication number
- JP6128133B2 JP6128133B2 JP2014552655A JP2014552655A JP6128133B2 JP 6128133 B2 JP6128133 B2 JP 6128133B2 JP 2014552655 A JP2014552655 A JP 2014552655A JP 2014552655 A JP2014552655 A JP 2014552655A JP 6128133 B2 JP6128133 B2 JP 6128133B2
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- JP
- Japan
- Prior art keywords
- alkyl
- independently
- hydrogen
- phenyl
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- CLXCUJAIQNKPCW-UHFFFAOYSA-N C[n]1ncc(-c(cc2)ccc2-c2c3-c4nc(Nc(ccc(C(N5CCN(C)CC5)=O)c5)c5OC)ncc4CCc3n[n]2C)c1 Chemical compound C[n]1ncc(-c(cc2)ccc2-c2c3-c4nc(Nc(ccc(C(N5CCN(C)CC5)=O)c5)c5OC)ncc4CCc3n[n]2C)c1 CLXCUJAIQNKPCW-UHFFFAOYSA-N 0.000 description 1
- KCZLTVJTTQQVRB-UHFFFAOYSA-N C[n]1ncc(-c(cc2)ccc2-c2c3-c4nc(Nc(ccc(C(O)=O)c5)c5OC)ncc4CCc3n[n]2C)c1 Chemical compound C[n]1ncc(-c(cc2)ccc2-c2c3-c4nc(Nc(ccc(C(O)=O)c5)c5OC)ncc4CCc3n[n]2C)c1 KCZLTVJTTQQVRB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12152193 | 2012-01-23 | ||
| EP12152193.4 | 2012-01-23 | ||
| PCT/EP2013/051097 WO2013110585A1 (en) | 2012-01-23 | 2013-01-22 | 5, 8 -dihydro- 6h- pyrazolo [3, 4 -h] quinazolines as igf-lr/lr inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504081A JP2015504081A (ja) | 2015-02-05 |
| JP2015504081A5 JP2015504081A5 (https=) | 2016-03-10 |
| JP6128133B2 true JP6128133B2 (ja) | 2017-05-17 |
Family
ID=47605520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014552655A Active JP6128133B2 (ja) | 2012-01-23 | 2013-01-22 | Ｉｇｆ−１ｒ／ｉｒ阻害剤としての５，８−ジヒドロ−６ｈ−ピラゾロ［３，４−ｈ］キナゾリン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9150578B2 (https=) |
| EP (1) | EP2807166B1 (https=) |
| JP (1) | JP6128133B2 (https=) |
| AR (1) | AR089776A1 (https=) |
| TW (1) | TW201343648A (https=) |
| UY (1) | UY34586A (https=) |
| WO (1) | WO2013110585A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3189051A1 (en) * | 2014-09-02 | 2017-07-12 | Pierre Fabre Médicament | Isoquinolinone derivatives useful in the treatment of cancer |
| JP6664414B2 (ja) * | 2015-05-13 | 2020-03-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ＩＧＦ−１Ｒ／ＩＲ阻害薬としての新規５，８−ジメチル−９−フェニル−５，８−ジヒドロ−６Ｈ−ピラゾロ［３，４−ｈ］キナゾリン−２−イル）−（１Ｈ−ピラゾール−３−イル）−アミン及び誘導体 |
| CN111094291B (zh) * | 2017-08-11 | 2022-06-21 | 晟科药业（江苏）有限公司 | 1h-吡唑并[4,3-h]喹唑啉类化合物作为蛋白激酶抑制剂 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| CA3150681A1 (en) | 2019-08-14 | 2021-02-18 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| AU2020337958A1 (en) | 2019-08-28 | 2022-03-17 | Horizon Therapeutics Ireland Dac | Methods for the treatment of thyroid eye disease |
| US11851426B2 (en) | 2019-10-11 | 2023-12-26 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| WO2023150663A1 (en) * | 2022-02-04 | 2023-08-10 | Retune Pharma Inc. | Certain chemical entities, compositions, and methods |
| CN120569391A (zh) * | 2023-01-19 | 2025-08-29 | 北京普祺医药科技股份有限公司 | 一种吡唑并环类化合物、药物组合物及其用途 |
| WO2024153237A1 (zh) * | 2023-01-19 | 2024-07-25 | 北京普祺医药科技股份有限公司 | 一种igf-1r酪氨酸激酶抑制剂、药物组合物及其用途 |
| CN116473073A (zh) * | 2023-05-08 | 2023-07-25 | 广东方中高新材料有限公司 | 一种含镓配合物的吡唑醚菌酯增效悬浮制剂及其制备方法 |
| CN116473077B (zh) * | 2023-05-08 | 2025-04-11 | 广东方中高新材料有限公司 | 一种n,n配位的镓配合物抗菌剂的合成和应用 |
| CN116458513A (zh) * | 2023-05-08 | 2023-07-21 | 广东方中高新材料有限公司 | 一种含镓配合物的咪鲜胺增效水乳制剂及其制备方法 |
| AU2024287547A1 (en) | 2023-07-07 | 2026-01-22 | Viridian Therapeutics, Inc. | Methods of treating chronic thyroid eye disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2450769A1 (en) | 2001-06-15 | 2002-12-27 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors |
| EP1560824A1 (en) | 2002-11-05 | 2005-08-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of jak and other protein kinases |
| BR122019010200B8 (pt) * | 2003-05-22 | 2021-07-27 | Nerviano Medical Science S R L | compostos de pirazol-quinazolina, seus sais, produtos ou kits e composições farmacêuticas |
| US20050075358A1 (en) | 2003-10-06 | 2005-04-07 | Carboni Joan M. | Methods for treating IGF1R-inhibitor induced hyperglycemia |
| CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| PL2027123T3 (pl) * | 2006-05-11 | 2011-09-30 | Irm Llc | Związki i kompozycje jako inhibitory kinaz białkowych |
| US8735386B2 (en) * | 2010-07-23 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Aminopyrazoloquinazolines |
-
2013
- 2013-01-22 WO PCT/EP2013/051097 patent/WO2013110585A1/en not_active Ceased
- 2013-01-22 JP JP2014552655A patent/JP6128133B2/ja active Active
- 2013-01-22 TW TW102102378A patent/TW201343648A/zh unknown
- 2013-01-22 AR ARP130100189A patent/AR089776A1/es unknown
- 2013-01-22 US US13/746,411 patent/US9150578B2/en active Active
- 2013-01-22 EP EP13701426.2A patent/EP2807166B1/en active Active
- 2013-01-23 UY UY0001034586A patent/UY34586A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015504081A (ja) | 2015-02-05 |
| TW201343648A (zh) | 2013-11-01 |
| UY34586A (es) | 2013-09-02 |
| EP2807166B1 (en) | 2016-04-06 |
| WO2013110585A1 (en) | 2013-08-01 |
| US9150578B2 (en) | 2015-10-06 |
| US20130190305A1 (en) | 2013-07-25 |
| EP2807166A1 (en) | 2014-12-03 |
| AR089776A1 (es) | 2014-09-17 |
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