JP6124986B2 - 拡張期心不全を処置するための増殖分化因子（ｇｄｆ） - Google Patents

拡張期心不全を処置するための増殖分化因子（ｇｄｆ） Download PDF

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JP6124986B2
JP6124986B2 JP2015501721A JP2015501721A JP6124986B2 JP 6124986 B2 JP6124986 B2 JP 6124986B2 JP 2015501721 A JP2015501721 A JP 2015501721A JP 2015501721 A JP2015501721 A JP 2015501721A JP 6124986 B2 JP6124986 B2 JP 6124986B2
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gdf11
mice
polypeptide
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JP2015512387A5 (https=
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リチャード ティー． リー
リチャード ティー． リー
フランチェスコ ロフレド
フランチェスコ ロフレド
ジェイムズ パンコースト
ジェイムズ パンコースト
マシュー スタインハウザー
マシュー スタインハウザー
エイミー ウエイジャーズ
エイミー ウエイジャーズ
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Brigham and Womens Hospital Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2015501721A 2012-03-19 2013-03-11 拡張期心不全を処置するための増殖分化因子（ｇｄｆ） Active JP6124986B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261612550P 2012-03-19 2012-03-19
US61/612,550 2012-03-19
US201261649962P 2012-05-22 2012-05-22
US61/649,962 2012-05-22
PCT/US2013/030140 WO2013142114A1 (en) 2012-03-19 2013-03-11 Growth differentiation factor (gdf) for treatment of diastolic heart failure

Publications (3)

Publication Number Publication Date
JP2015512387A JP2015512387A (ja) 2015-04-27
JP2015512387A5 JP2015512387A5 (https=) 2016-04-07
JP6124986B2 true JP6124986B2 (ja) 2017-05-10

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JP2015501721A Active JP6124986B2 (ja) 2012-03-19 2013-03-11 拡張期心不全を処置するための増殖分化因子（ｇｄｆ）

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US (1) US9434779B2 (https=)
EP (1) EP2828289B1 (https=)
JP (1) JP6124986B2 (https=)
CA (1) CA2901394A1 (https=)
ES (1) ES2779698T3 (https=)
WO (1) WO2013142114A1 (https=)

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MX373248B (es) * 2011-09-30 2020-05-11 Somalogic Operating Co Inc Prediccion de riesgo de evento cardiovascular y usos del mismo.
EP2983694B1 (en) * 2013-04-08 2022-06-22 President and Fellows of Harvard College Compositions for rejuvenating skeletal muscle stem cells
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US10017566B2 (en) 2013-11-12 2018-07-10 The Brigham And Women's Hospital, Inc. Growth differentiation factor (GDF) for treatment of diastolic heart failure
JP2017518514A (ja) * 2014-05-16 2017-07-06 インターミューン， インコーポレイテッド Ｌｐａ関連タンパク質及びｒｎａ発現
WO2016049662A1 (en) * 2014-09-23 2016-03-31 President And Fellows Of Harvard College Methods and compositions for treating age-related disorders
TWI695068B (zh) 2014-11-24 2020-06-01 美商身體邏輯股份有限公司 用於結合生長分化因子１１的核酸化合物
US11041006B2 (en) 2015-12-28 2021-06-22 Riken Compositions for use in recovering or ameliorating deterioration of physiological functions due to aging
CA3010799A1 (en) * 2016-01-06 2017-07-13 President And Fellows Of Harvard College Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis
WO2019144053A1 (en) * 2018-01-19 2019-07-25 President And Fellows Of Harward College Gdf11 variants and uses thereof
US20200222459A1 (en) * 2019-01-16 2020-07-16 Melvin Barnes System, Method and Compositions for Treating Age-Related Illnesses and Conditions
JP2022001603A (ja) * 2021-10-14 2022-01-06 功 加治佐 自分由来ｉＰＳ若い血液応用ＧＤＦ１１分子コーティング若返り経口不老不死薬９
CN114989310B (zh) * 2022-06-20 2024-11-19 深圳先进技术研究院 一种嵌合抗原受体、表达嵌合抗原受体的巨噬细胞及应用
CN115212299B (zh) * 2022-06-21 2026-02-24 深圳先进技术研究院 Car-t和car-m联用在制备抗肿瘤药物中的应用

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EP2828289A4 (en) 2016-01-06
US9434779B2 (en) 2016-09-06
EP2828289B1 (en) 2020-02-26
WO2013142114A1 (en) 2013-09-26
ES2779698T3 (es) 2020-08-18
EP2828289A1 (en) 2015-01-28
CA2901394A1 (en) 2013-09-26
US20150045297A1 (en) 2015-02-12
JP2015512387A (ja) 2015-04-27

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