JP6120257B2 - Needle-like device for skin puncture, device for collecting biological components, and biological component measuring system - Google Patents

Description

The present invention relates to a skin puncture needle-like device, a biological component recovery device, and a biological component measurement system that are used for measuring biological components.

  The biological component is an important index for knowing the health condition of the body, and in general, various health tests are performed using blood, urine, saliva, and the like. As a conventional apparatus for measuring biological components such as lactic acid and glucose, there is one that collects a small amount of blood and performs measurement (see, for example, Patent Document 1 or 2).

  Conventionally, a microdialysis method has been used as a method of collecting biological components in the brain and abdominal subcutaneous fat. In this method, a probe equipped with a fine flow path and a dialysis membrane is inserted into a tissue, and necessary biological components are continuously collected using osmotic pressure (for example, see Patent Document 3). As a probe, a shape such as a flat needle or a hollow needle has been developed (see, for example, Non-Patent Document 1 or 2).

  It should be noted that biological components are exchanged through the blood vessel wall between the blood and the subcutaneous tissue fluid filled in the subcutaneous skin of about 0.2 to 2 mm and the subcutaneous tissue of 2 to 4 mm. For this reason, it has been reported that the concentrations of low-molecular weight biological components such as lactic acid and glucose in the blood are almost in equilibrium with the concentrations in the subcutaneous tissue fluid (for example, there is a non-correlation). (See Patent Document 3).

Japanese Patent No. 3978489 Japanese Patent No. 3498105 JP-T-2006-501912

Jeffrey D. Zahn, et al, “Microdialysis Microneedles for Continuous Medical Monitoring”, Biomedical Microdevices, 2005, Vol. 7, No. 1, p59-69 M. Ellmerer, et al, “Continuous measurement of subcutaneous lactate concentration during exercise by combining open-flowmicroperfusion and thin-film lactate sensors”, Biosensors & Bioelectronics, 1998, Vol.13, p1007-1013 Narumi Ito, “Measurement of transdermal lactic acid concentration using microbiosensor”, M & BE, 1995, Vol.6, No.4, p275-283

  The thing which collect | recovers the blood of patent document 1 and 2 and measures a biological component had the subject that it accompanied some pain in the case of puncture. Moreover, since it is necessary to puncture and collect blood for each measurement, there is also a problem that it is difficult to continuously measure biological components. The probe conventionally used in the microdialysis method as described in Non-Patent Document 1 or 2 must be operated at the time of installation, or a dedicated insertion device must be used. There was a problem of taking time and effort.

The present invention has been made in view of such problems, stinging in easily installed only small pain during puncture, continuous needle for skin-piercing capable of measuring biological components It is an object to provide a device, a biological component recovery device, and a biological component measurement system.

A needle-like device for skin puncture according to the present invention includes a needle body composed of a needle having a circular cross section having a circular cross section, and a side surface of at least the circular cross section of the needle body along the length direction of the needle body. And a conduction hole provided in the surface layer so as to extend in the longitudinal direction of the needle body, and the conduction hole reaches the subcutaneous tissue when the needle body is pierced into the skin. The biological component in the subcutaneous tissue fluid is provided so as to be collected or measured.

The needle-like device for skin puncture according to the present invention can reach the dermis and subcutaneous tissue through the epidermis having a thickness of about 0.2 mm by piercing the skin from its tip. At this time, the biological component in the subcutaneous tissue fluid can be collected or measured by using a conduction hole provided so as to extend in the longitudinal direction of the needle body. For biological components of low molecular weight such as lactic acid and glucose, the concentration in blood and the concentration in subcutaneous tissue fluid are almost in equilibrium, and there is a correlation between them, so measure biological components in subcutaneous tissue fluid Thus, the same result as that obtained by measuring a biological component in blood can be obtained. In this way, the needle-like device for skin puncture according to the present invention can be easily installed simply by pricking, and can stab anywhere and measure biological components.

Moreover, the pain at the time of puncture can be reduced by using a needle | hook with small diameters, such as an acupuncture needle about 0.2 mm in thickness, for a needle body. In addition, by using a needle with a small diameter , the needle-like device for skin puncture does not break or bleed even if daily activities and actions are performed while being stabbed, and the wearing feeling and discomfort are extremely small . For this reason, it is possible to continuously measure biological components during daily activities and actions.

Since the conduction hole is provided so as to be covered with the surface layer film, it is not necessary to directly process the needle body, so that the manufacturing is easy and the conduction hole is easily processed into a desired structure. The surface layer film is preferably made of a material such as polyimide that can be micro-processed by laser ablation or the like so that the conduction hole can be arbitrarily processed.
The needle-like device for skin puncture according to the present invention can be used in various ways to measure biological components as will be described below.

The biological component recovery device according to the present invention is a biological component recovery device for recovering a biological component using dialysis, and has the skin puncture needle device according to the present invention, wherein the conduction hole is When the needle body is stabbed into the skin, it has an inlet and an outlet at a position outside the epidermis, and extends from the inlet to a position reaching the subcutaneous tissue when the needle body is stabbed into the skin. It is provided so as to circulate back to the discharge port, and the surface layer film communicates with the conduction hole so as to allow the biological component to pass to a position reaching the dermis or subcutaneous tissue when the needle body is inserted into the skin. It has one or a plurality of dialysis holes provided.

The biological component collection device according to the present invention is used by piercing the skin with the tip so that the dialysis hole is located in the dermis or subcutaneous tissue. When the needle body is stabbed into the skin from the inlet with the skin stabbed , the dialysate is circulated through a conduction hole provided so as to extend to a position reaching the subcutaneous tissue and circulate back to the outlet. Thereby, the biological component in a subcutaneous tissue fluid can be collect | recovered in the dialysate in a conduction hole through a dialysis hole using an osmotic pressure.

  In the biological component collecting device according to the present invention, it is preferable that the dialysis hole is provided as close to the tip of the needle body as possible in order to suppress the depth of penetration into the skin. The dialysis hole is preferably formed in a size corresponding to the size of the biological component to be measured so that proteins having a large molecular weight do not enter the conduction hole. The biological component collection device according to the present invention has a through-hole provided through the surface layer film on the distal end side of the needle body of the conduction hole, and a semipermeable membrane provided so as to cover the through-hole. You may do it. In this case, the hole formed in the semipermeable membrane forms a dialysis hole.

  The biological component measurement system according to the present invention stores the biological component recovery device according to the present invention, a dialysate stored in the dialysate, and the dialysate tank connected to the inflow port, and the dialysate in the dialysate tank. A liquid feed pump for flowing from the inlet to the conduction hole, a measurement means provided so as to be able to measure the biological component contained in the dialysate discharged from the discharge port through the conduction hole, and the measurement means And a drainage tank for storing the dialysate after measurement in (1).

  The biological component measurement system according to the present invention can circulate dialysate through the conduction hole by flowing the dialysate stored in the dialysate tank from the inflow port to the conduction hole by the liquid feed pump. Since the biological components are collected in the dialysate by this circulation, the biological components that are considered to be contained in the subcutaneous tissue fluid are measured by measuring the biological components contained in the dialysate discharged from the discharge port with the measuring means. can do. Further, by continuously feeding the dialysate with the liquid feed pump, the biological component can be measured continuously or intermittently by the measuring means, and the change of the biological component over time can be measured. The dialysate after the measurement can be stored and recovered in a drainage tank and discarded.

  The dialysate may be composed of any component as long as it can be dialyzed against the subcutaneous tissue fluid and the collected biological component can be analyzed. The dialysate is made of, for example, physiological saline. The measuring means only needs to be able to measure a biological component to be measured. For example, when measuring lactic acid or glucose, the measuring means may be composed of an enzyme sensor capable of measuring each. The measuring means may have a storage unit for storing the measurement results so that the measurement results can be collected and analyzed later. The biological component measuring system according to the present invention can measure various types of biological components by exchanging the measuring means. Also, by providing a plurality of measuring means, it is possible to measure a plurality of types of biological components at a time. You may have a display means to display the result measured by the measurement means.

  In the biological component measurement system and the biological component recovery device according to the present invention, the biological component is a biological component that can be recovered by dialysis, such as lactic acid, glucose, alcohol, moisture, ions such as sodium ions and potassium ions, and hormone components. Anything is acceptable. For example, when the biological component to be measured is made of lactic acid, it is possible to measure exercise intensity that has a strong correlation with the lactic acid concentration.

In the needle puncture device for skin puncture according to the present invention, the conduction holes are composed of a pair, each configured to allow light to pass through , and when the needle body is pierced into the skin, an opening is formed at a position reaching the dermis or subcutaneous tissue. You may have. Further, in this case, the biological component measurement system according to the present invention provides a needle-like device for skin puncture according to the present invention and light from one position outside the epidermis to one conduction hole when the needle body is stabbed into the skin. You may have the light emission means to let pass, and the light measurement means to measure the light which passes the other conduction hole in the position outside the epidermis when the needle body is stabbed in the skin . In these cases, light emitted from the light emitting means and passing through the dermis or subcutaneous tissue can be measured by the light measuring means. By utilizing this measurement result, it is possible to analyze biological components in the dermis and subcutaneous tissue.

The biological component measurement system according to the present invention has an adhesive sheet having an adhesive layer on one side, and the skin puncture needle-like device is attached to the adhesive sheet so that a tip portion protrudes from the adhesive layer. In addition, the parts other than the needle puncture device for skin puncture may be attached to the other surface side of the adhesive sheet. In this case, all the components can be integrated into the sticking sheet. By sticking the patch sheet to the skin, the needle-like device for skin puncture can be fixed in a state of being stabbed into the skin. Moreover, a biological component can be measured and analyzed in a state where an adhesive sheet is attached. Thereby, even during daily activities and actions, it is possible to continuously measure the biological components without losing. By downsizing the constituent elements, it is possible to easily measure the biological components without feeling bothered even when the sticking sheet is pasted, with extremely little wearing feeling and uncomfortable feeling. When the skin puncture needle-like device is composed of a biological component recovery device, the dialysate tank, the liquid feed pump, the measuring means, and the drainage tank are attached to the other side of the adhesive sheet. When light passing through the conduction hole and passing through the dermis or subcutaneous tissue is measured, the light emitting means and the light measuring means are attached to the other surface side of the adhesive sheet.

According to the present invention, the needle-like device for skin puncture, which can be easily installed just by puncturing, has little pain during puncture, and can continuously measure a biological component, a biological component recovery device, and a biological component measurement A system can be provided.

It is the (a) block diagram which shows the use condition of the biological component measuring system of embodiment of this invention, (b) A partial expanded sectional view of the front-end | tip part of the biological component collection | recovery device. BRIEF DESCRIPTION OF THE DRAWINGS (a) The perspective view of a use condition which shows the biological component measuring system of embodiment of this invention, (b) A perspective view, (c) A-A 'sectional view taken on the line. It is a cross-sectional view which shows the manufacturing process of the biological component collection | recovery device of the biological component measuring system shown in FIG. It is a perspective view which shows the modification of the device for biological component collection | recovery of the biological component measuring system of embodiment of this invention. It is a schematic side view which shows the experiment aspect which confirms the collection | recovery function of the biological component collection | recovery device of the biological component measurement system of embodiment of this invention. 6 is a graph showing the relationship between the lactic acid concentration (recovered solution lactic acid concentration) of the collected dialysate and the standard solution lactic acid concentration obtained by the experiment shown in FIG.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
FIG. 1 to FIG. 6 show a skin puncture needle device, a biological component collection device, and a biological component measurement system according to an embodiment of the present invention.
As shown in FIGS. 1 and 2, the biological component measurement system 10 includes a patch sheet 11, a biological component recovery device 12, a dialysate tank 13, a water supply tube 14, a liquid supply pump 15, a drainage tube 16, and measurement means (measurement). Part, sensor) 17 and a drainage tank (waste liquid tank) 18.

  As shown in FIG. 2, the sticking sheet 11 has an elongated shape in which both ends of a rectangular shape are formed in an arc shape, and has the same size as a commercially available adhesive bandage. The adhesive sheet 11 has an adhesive layer 11a on one surface, and can be applied to the surface of the skin with the adhesive layer 11a.

As shown in FIG. 1B, the biological component recovery device 12 is composed of a skin puncture needle-like device, and has an elongated needle body 21, a surface layer film 22, a conduction hole 23, and a plurality of dialysis holes 24. ing. The needle body 21 is composed of a commercially available scissors for scissors with a short tip and a small diameter. In a specific example, the needle body 21 has a tip portion with a thickness of about 0.2 to 0.26 mm and a length of about 0.3 to 1.8 mm.

  The surface layer film 22 is made of polyimide and is provided so as to cover the side surface of the needle body 21 along the length direction of the needle body 21 from the distal end portion to the distal end portion of the needle body 21. Note that the surface layer film 22 may cover the needle tip of the needle body 21 as long as the penetration of the needle body 21 is maintained. The conduction hole 23 is provided in the surface layer film 22 so as to extend from the distal end side to the distal end side of the needle body 21. The conduction hole 23 is formed on the surface of the surface layer film 22 on the needle body 21 side. The conduction hole 23 has an inflow port 23a and a discharge port 23b on the end side of the needle body 21, and extends from the inflow port 23a to the tip side of the needle body 21 so as to circulate back to the discharge port 23b. . Each dialysis hole 24 is provided on the distal end side of the needle body 21 of the surface layer film 22 so as to communicate the outside with the conduction hole 23. Each dialysis hole 24 is formed in a size capable of passing the biological component to be measured.

  As shown in FIG. 3, the surface layer film 22, the conduction hole 23, and each dialysis hole 24 of the biological component recovery device 12 are formed as follows, for example. First, as shown in FIG. 3A, a polyimide film having a thickness of about 20 μm is electrodeposited on the needle body 21 as the surface layer film 22. Next, as shown in FIG. 3B, a flow path portion (width 50 μm) to be the conduction hole 23 is formed in the polyimide film by laser ablation (wavelength 355 nm). As shown in FIG. 3 (c), copper (Cu) is electroplated as a sacrificial layer on the flow path portion, and as shown in FIG. To wear. As shown in FIG. 3E, a dialysis hole 24 having a diameter of about 10 μm is formed on the dialysis membrane by laser ablation, and the copper sacrificial layer is removed by etching as shown in FIG. Holes 23 are created.

  As shown in FIGS. 2 (b) and 2 (c), the biological component recovery device 12 has an annular portion opposite to the adhesive layer 11a of the adhesive sheet 11 so that the tip portion protrudes from the adhesive layer 11a. Is attached to the adhesive sheet 11.

  As shown in FIGS. 1 (a), 2 (b) and 2 (c), the dialysate tank 13 is configured to be able to store dialysate and is provided on the surface of the adhesive sheet 11 opposite to the adhesive layer 11a. It is attached to one end. The water supply tube 14 is made of a polyethylene tube, and is provided so as to connect the inlet 23 a of the conduction hole 23 and the dialysate tank 13. The liquid feed pump 15 is built in the dialysate tank 13 and is configured to flow the dialysate in the dialysate tank 13 from the inlet 23 a to the conduction hole 23 through the water feed tube 14.

  The drainage tube 16 is made of a polyethylene tube, and is provided so as to connect the discharge port 23 b of the conduction hole 23 and the drainage tank 18. The measuring means 17 is composed of an enzyme sensor capable of measuring a biological component to be measured. The measuring means 17 is attached to the center of the surface of the adhesive sheet 11 opposite to the pressure-sensitive adhesive layer 11a. The measuring means 17 is provided so as to be able to measure a biological component contained in the dialysate flowing through the drainage tube 16. The drainage tank 18 is configured to receive and store the dialysate after being measured by the measuring means 17 from the drainage tube 16. The drainage tank 18 is attached to the other end of the surface of the adhesive sheet 11 opposite to the adhesive layer 11a.

Next, the operation will be described.
The biological component measurement system 10 can perform measurement by collecting biological components using dialysis. As shown in FIGS. 1 and 2, the biological component measurement system 10 pierces the skin with the tip of the biological component recovery device 12 so that the dialysis hole 24 is located in the dermis 2 or subcutaneous tissue through the epidermis 1. Used. By sticking the patch sheet 11 on the skin, the biological component collecting device 12 can be fixed in a state of being stabbed into the skin. When the dialysate stored in the dialysate tank 13 is pierced into the skin, the dialysate can be circulated through the conduction hole 23 by flowing the dialysate from the inlet 23a to the conduction hole 23 by the liquid feeding pump 15. By this circulation, the biological component in the subcutaneous tissue fluid can be collected into the dialysate inside the conduction hole 23 through the dialysis hole 24 by utilizing the osmotic pressure. Thereby, the biological component contained in the dialysate discharged | emitted from the discharge port 23b is measured by the measurement means 17, and the biological component considered to be contained in a subcutaneous tissue fluid is measurable.

  As described above, the biological component measurement system 10 can be easily installed simply by pricking the biological component recovery device 12, and can measure the biological component by pricking anywhere. Further, by continuously feeding the dialysate with the liquid feed pump 15, the biological component can be measured continuously or intermittently by the measuring means 17, and the change with time of the biological component can be measured. . The dialysate after the measurement can be stored and recovered in the drainage tank 18 and discarded.

  In the biological component measurement system 10, all components are integrated with the adhesive sheet 11, and the biological component can be measured with the adhesive sheet 11 attached. Thereby, even during daily activities and actions, it is possible to continuously measure the biological components without losing. Since all the constituent elements are miniaturized so as to fit within the size of the adhesive bandage, even when the adhesive sheet 11 is applied, there is little concern about wearing and discomfort, and biological components can be measured easily. it can.

  The biological component measuring system 10 can measure various types of biological components by exchanging the measuring means 17 with a different measuring target biological component. Further, by providing a plurality of measuring means 17, a plurality of types of biological components can be measured at a time. The biological component to be measured may be any biological component that can be recovered by dialysis, such as lactic acid, glucose, alcohol, water, ions such as sodium ions and potassium ions, and hormone components. For example, when the biological component to be measured is made of lactic acid, it is possible to measure exercise intensity that has a strong correlation with the lactic acid concentration.

  Since the biological component measurement system 10 uses a needle for acupuncture as the needle body 21, it can reduce pain during puncture. In addition, since a needle with a small diameter is used, the biological component recovery device 12 does not break or bleed even if daily activities and actions are carried out while being stabbed, and the wearing feeling and discomfort are extremely high. small. Since the conduction hole 23 is provided in the surface layer film 22 and it is not necessary to directly process the needle body 21, manufacturing is easy and the conduction hole 23 is easily processed into a desired structure.

  The dialysate may be composed of any component as long as it can be dialyzed against the subcutaneous tissue fluid and the collected biological component can be analyzed. When proteins having a large molecular weight enter the conduction hole 23, the conduction hole 23 is clogged, metabolism of biological components such as lactic acid occurs, or protein or the like adheres to the enzyme electrode of the measuring means 17 and continuous measurement cannot be performed. Therefore, it is preferable that the dialysis hole 24 has a diameter of about several tens of nanometers through which a low molecular weight biological component to be measured passes and proteins do not pass.

  As shown in FIG. 4, in the biological component collecting device 12, the needle body 21 may be formed of an elongated needle having a diameter of 0.2 mm (for example, a needle made by Seirin Co., Ltd.). Also in this case, pain during puncture is small and bleeding is difficult. For example, the biological component measurement system 10 may include a display unit that changes the color or displays a measurement value according to a result measured by the measurement unit 17.

  Further, the biological component measurement system 10 may not be integrated using the adhesive sheet 11, and the dialysate tank 13, the liquid feed pump 15, and the drainage tank (waste liquid tank) 18 use a syringe or the like. It may be configured. Even in such a case, the biological component can be collected and measured by using the biological component collecting device 12. In the biological component measurement system 10, an electrode pattern for measuring a potential may be formed on the needle body 21 or the surface layer film 22. In this case, nerve potential or myoelectric potential can be combined with biological component measurement.

Further, in the biological component measurement system 10, the skin puncture needle-like device is not the biological component collection device 12, but a device for measuring light, and the conduction holes 23 are made of a pair so that light can pass through each device. A light emitting means configured to pass light from the distal end side of the needle body 21 to the one conduction hole 23; and the other conduction hole 23 on the distal end side of the needle body 21. You may have the light measurement means which measures the light which passes. In these cases, light emitted from the light emitting means and passed through the dermis 2 or the subcutaneous tissue can be measured by the light measuring means. By using this measurement result and performing spectral analysis, it is possible to analyze biological components in the dermis 2 and subcutaneous tissue. Each conduction hole 23 may be made of, for example, a SiO ₂ optical waveguide filled with SiO ₂ so as to efficiently transmit light.

  As shown in FIG. 5, in order to confirm the recovery function of the biological component recovery device 12, a standard solution (lactic acid standard solution) in which lactic acid is mixed with a phosphate buffer solution is prepared, and lactic acid can be recovered using the standard solution. A confirmation experiment was conducted. The biological component recovery device 12 shown in FIG. 4 was used, and the biological component to be measured was lactic acid, and the measurement means 17 was an enzyme sensor capable of measuring lactic acid. Moreover, physiological saline was used as the dialysate.

  In the experiment, first, the tip of the biological component collection device 12 was immersed in the standard solution so that the dialysis hole 24 was disposed inside the standard solution. Next, the dialysate was supplied from the syringe pump to the conduction hole 23 through the inlet 23a, the dialysate was circulated through the conduction hole 23, and the dialysate circulated through the conduction hole 23 was collected from the discharge port 23b to the collection syringe. At this time, the side of the discharge port 23b of the conduction hole 23 was set to a negative pressure with a recovery syringe, thereby making it easier to collect the dialysate.

  After flowing the dialysate for 10 minutes, the lactic acid concentration of the collected dialysate was measured using a commercially available blood lactic acid concentration sensor (product name “Lactate Pro”, manufactured by ARKRAY, Inc.). Three standard lactate concentrations are available: 0 mmol / liter of phosphate buffer only, 1 mmol / liter, which is a measure of resting blood lactate concentration, and 6 mmol / liter, a measure of blood lactate concentration during exercise. It was.

  FIG. 6 shows the relationship between the measured value of the lactic acid concentration of each collected dialysate and the lactic acid concentration when each standard solution was measured with a commercially available blood lactic acid concentration sensor. As shown in FIG. 6, the lactic acid concentration of each collected dialysis solution and the lactic acid concentration of each standard solution show almost the same value, and it was confirmed that lactic acid could be collected by the biological component collection device 12. It was.

  In order to confirm whether or not exercise is possible with the biological component collection device 12 inserted subcutaneously, an experiment was performed using a mouse. As the biological component recovery device 12, the device shown in FIG. 4 was used. The hair on the back of the mouse was partially shaved, and the biological component collection device 12 was inserted there. Thereafter, the biological component collection device 12 was fixed to the mouse with a tape, and the mouse was allowed to exercise for 15 minutes with a treadmill (15 m / min). After the exercise, it was confirmed whether the surface layer film 22 and the like of the biological component collection device 12 were not damaged and whether the mouse skin was affected.

  As a result, even after the movement of the mouse, no damage or the like of the surface layer film 22 was observed, and no bleeding or the like was observed in the skin of the inserted portion of the mouse. From this, it was confirmed that even if exercise or the like is performed with the living body component collecting device 12 stabbed, the needle body 21 and the surface layer film 22 are not easily damaged or bleeding.

DESCRIPTION OF SYMBOLS 1 Epidermis 2 Dermis 10 Biological component measurement system 11 Adhesive sheet 11a Adhesive layer 12 Biological component collection device 21 Needle body 22 Surface layer 23 Conductive hole 23a Inflow port 23b Outlet port 24 Dialysis hole 13 Dialysate tank 14 Water supply tube 15 Liquid supply Pump 16 Drain tube 17 Measuring means 18 Drain tank

Claims (8)

A needle body comprising a needle having a circular cross section with a circular cross section ;
A surface layer film provided on a side surface of at least the circular cross section of the needle body along the length direction of the needle body,
A conduction hole provided in the surface layer film to extend in the longitudinal direction of the needle body ,
The conduction hole is provided so as to reach the dermis or subcutaneous tissue when the needle is stabbed into the skin and collect or measure a biological component in the subcutaneous tissue fluid.
A needle-like device for skin puncture. The needle-like device for skin puncture according to claim 1, wherein a plurality of the conductive holes are provided on a side surface of the needle body . A needle-like device for skin puncture for collecting biological components using dialysis,
The conduction hole is capable of passing dialysate and biological components,
The surface layer film has one or a plurality of dialysis holes provided to communicate with the conduction hole so that the biological component can pass through at a position reaching the dermis or subcutaneous tissue when the needle body is pierced into the skin. The
The needle-like device for skin puncture according to claim 1 or 2. A biological component recovery device for recovering biological components using dialysis,
A needle-like device for skin puncture according to any one of claims 1 to 3 ,
The conduction hole has an inlet and an outlet at a position outside the epidermis when the needle is stabbed into the skin, and when the needle is stabbed into the skin from the inlet , the dermis or subcutaneous tissue It is provided to extend to a position reaching up to and circulate back to the outlet,
The surface layer film has one or a plurality of dialysis holes provided to communicate with the conduction hole so that the biological component can pass through at a position reaching the dermis or subcutaneous tissue when the needle body is pierced into the skin. A biological component recovery device characterized by the following. The biological component recovery device according to claim 4 ,
A dialysate tank for storing dialysate and connected to the inlet;
A liquid feed pump for flowing the dialysate in the dialysate tank from the inlet to the conduction hole;
Measuring means provided so as to be able to measure the biological component contained in the dialysate discharged from the outlet through the conduction hole;
A drainage tank for storing the dialysate after being measured by the measuring means;
A biological component measurement system comprising: The through hole consists of a pair, is passed configured to enable light respectively, when stabbed the needle body to the skin, claim 1, characterized in that has an opening at a position reaching the dermis or subcutaneous tissue Or a needle-like device for skin puncture according to 2 . A needle-like device for skin puncture according to claim 6 ,
When the needle body is stabbed into the skin, a light emitting means for passing light from one position outside the epidermis to one conduction hole;
A light measuring means for measuring light passing through the other conduction hole at a position outside the epidermis when the needle is stabbed into the skin ;
A biological component measurement system comprising: Having a patch sheet with an adhesive layer on one side,
The needle-like device for skin puncture is attached to the adhesive sheet so that the tip protrudes from the adhesive layer,
The biological component measurement system according to claim 5 or 7 , wherein parts other than the needle- puncture device for skin puncture are attached to the other surface side of the adhesive sheet.