CN109589121A - A kind of electrochemical method and its device detecting in-vivo tissue liquid concentration of glucose information - Google Patents
A kind of electrochemical method and its device detecting in-vivo tissue liquid concentration of glucose information Download PDFInfo
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- CN109589121A CN109589121A CN201910102702.3A CN201910102702A CN109589121A CN 109589121 A CN109589121 A CN 109589121A CN 201910102702 A CN201910102702 A CN 201910102702A CN 109589121 A CN109589121 A CN 109589121A
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- glucose
- electrode
- conducting probe
- excitation
- needle
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 66
- 239000008103 glucose Substances 0.000 title claims abstract description 65
- 239000007788 liquid Substances 0.000 title claims abstract description 21
- 238000002848 electrochemical method Methods 0.000 title claims abstract description 13
- 238000001727 in vivo Methods 0.000 title claims abstract description 13
- 239000000523 sample Substances 0.000 claims abstract description 32
- 210000001519 tissue Anatomy 0.000 claims abstract description 26
- 108090000790 Enzymes Proteins 0.000 claims abstract description 13
- 102000004190 Enzymes Human genes 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 13
- 230000002500 effect on skin Effects 0.000 claims abstract description 7
- 210000003722 extracellular fluid Anatomy 0.000 claims abstract description 6
- 235000009754 Vitis X bourquina Nutrition 0.000 claims abstract description 4
- 235000012333 Vitis X labruscana Nutrition 0.000 claims abstract description 4
- 235000014787 Vitis vinifera Nutrition 0.000 claims abstract description 4
- 230000005284 excitation Effects 0.000 claims description 17
- 210000003491 skin Anatomy 0.000 claims description 13
- 229940088598 enzyme Drugs 0.000 claims description 12
- 108010015776 Glucose oxidase Proteins 0.000 claims description 7
- 239000004366 Glucose oxidase Substances 0.000 claims description 7
- 229940116332 glucose oxidase Drugs 0.000 claims description 7
- 235000019420 glucose oxidase Nutrition 0.000 claims description 7
- 210000004207 dermis Anatomy 0.000 claims description 4
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 3
- 241000219095 Vitis Species 0.000 claims description 3
- 102000030595 Glucokinase Human genes 0.000 claims description 2
- 108010021582 Glucokinase Proteins 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims description 2
- 239000012530 fluid Substances 0.000 abstract description 8
- 240000006365 Vitis vinifera Species 0.000 abstract 1
- 238000001514 detection method Methods 0.000 description 14
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 210000001124 body fluid Anatomy 0.000 description 6
- 239000010839 body fluid Substances 0.000 description 6
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 6
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 210000001742 aqueous humor Anatomy 0.000 description 3
- 206010033675 panniculitis Diseases 0.000 description 3
- -1 potassium ferricyanide Chemical compound 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 239000000276 potassium ferrocyanide Substances 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
Abstract
The invention discloses a kind of electrochemical methods and its device for detecting in-vivo tissue liquid concentration of glucose information, enzyme will be motivated to inject dermal layer of the skin using conducting probe, motivate glucose in tissue fluid, make the glycoxidative generation current signal of grape, and current signal is passed to by analytical equipment by the electrode sensor of conducting probe, analytical equipment obtains interstitial fluid glucose concentration information in detected part dermal layer of the skin by the size of analysis current signal.The present invention has many advantages, such as that method is simple to operation.
Description
Technical field
The present invention relates to a kind of electrochemical methods and its device for detecting in-vivo tissue liquid concentration of glucose information, belong to doctor
Treat detection technique field.
Background technique
The abnormal carbohydrate metabolisms person such as diabetes or hyperglycemia needs frequently detection concentration of glucose level to cooperate medication at present
And diet, this is the key link for the treatment of diabetes, and it is diabetes that whether internal glucose level, which obtains being monitored and controlled in time,
The deciding factor for the treatment of.
The glucose to be detected is present in internal liquid environment in the form of glucose solution, hereinafter referred to as body fluid.
Concentration of glucose is detected to need first then to establish glucose signals intensity with algorithm with the glucose signals in instrument detection body fluid
With the relationship of concentration of glucose.
Common detection method is external detection, i.e., first turns the body fluid such as blood or tissue fluid using the method for extracting or permeating
It moves on in vitro, then it is detected again.
In view of the frequent feeling of pain of external detecting glucose signal and not convenient operation, and it can not achieve continuous survey
, there is the method for internal detection glucose signals in amount.
The body fluid for being used to detect concentration of glucose at present has vessel inner blood, subcutaneous tissue liquid, aqueous humor (tissue fluid in eyes
One kind).There are body fluid circulatory between blood-tissue liquid, concentration of glucose substantially reaches unanimity, however after intake sugar not
Concentration of glucose variation with body fluid has differences, relative to the concentration of glucose in blood, in some cases in tissue fluid
Concentration of glucose contacted with treating diabetes it is even closer, increasingly by medical field pay attention to.
Therefore, it is necessary to a better methods to overcome a series of above-mentioned disadvantages, and this method requirement: internal detection replaces external
Detection；Detect interstitial fluid glucose signal rather than blood glucose Sugar signal.
For United States Patent (USP) US6181957 using the aqueous humor of optical means detection eyes, aqueous humor is interior to be free of blood vessel, can be to avoid blood
The influence of liquid signal, however proposed method have safety the problem of.
The existing method for even penetrating skin detection concentration of glucose using skin, such as use up across ear-lobe or hand
Refer to, or with being needled into subcutaneously, however the tissue at these positions contains a large amount of blood vessels, and these methods are not all mentioned and how to be avoided
The interference of blood signal, even without recognizing dividing tissue liquid and blood.
Current method all ignores the feasibility and necessity of interstitial fluid glucose signal in detection corium.Blood in corium
It manages and is mainly enriched in the intersection of upper surface and epidermis and the intersection of lower surface and subcutaneous tissue, by protein inside skin corium
Fiber forms space structure, wherein being filled with tissue fluid, if it is possible to only collect the signal inside skin corium, so that it may have
Effect reduces the signal for carrying out autoblood, and safe and convenient.
Summary of the invention
The present invention is intended to provide a kind of electrochemical method and its device for detecting in-vivo tissue liquid concentration of glucose information, leads to
It crosses and gives chemical pumping effect to interstitial fluid glucose in dermal layer of the skin, so that it is generated current signal, to obtain glucose
Concentration information.
The invention is realized by the following technical scheme:
A kind of electrochemical method detecting in-vivo tissue liquid concentration of glucose information, comprising:
Glucose excitation enzyme is loaded into conducting probe；
Conducting probe is pierced into detected part skin, the piercing depth of the conducting probe is 0.5 ~ 1.5mm；By glucokinase
Enzyme is encouraged to be trapped in dermal layer of the skin；
Make the glucose in glucose excitation enzyme excitation dermis layer tissue liquid, makes the glycoxidative generation current signal of grape, and pass through
Current signal is passed to analytical equipment by the electrode sensor of conducting probe, and analytical equipment passes through the size of analysis current signal,
Obtain interstitial fluid glucose concentration information in detected part dermal layer of the skin.
In above-mentioned technical proposal, the glucose excitation enzyme includes glucose dehydrogenase or glucose oxidase.
A kind of conducting probe can be used in the electrochemical method for implementing detection in-vivo tissue liquid concentration of glucose information, institute
Stating conducting probe includes at least one set of electrode, and the electrode includes at least working electrode and to electrode, and electric with the work
The glucose that pole connects motivates zymophore, and the glucose excitation zymophore is for carrying glucose excitation enzyme.
In above-mentioned technical proposal, the electrode further includes reference electrode.
In above-mentioned technical proposal, the conducting probe further includes puncture needle and the delay needle that is set in outside the puncture needle,
The delay needle is cylindrical, and the electrode is arranged on the delay needle outer wall.
A kind of electrochemical appliance can be used in the electrochemical method for implementing detection in-vivo tissue liquid concentration of glucose information,
Including conducting probe and analytical equipment, the conducting probe includes at least one set of electrode, and the electrode includes at least working electrode
With to electrode, and the glucose excitation zymophore to connect with the working electrode, glucose excitation zymophore is for taking
Band glucose motivates enzyme；The analytical equipment is connected with the electrode.
In above-mentioned technical proposal, the electrode further includes reference electrode.
In above-mentioned technical proposal, the conducting probe further includes puncture needle and the delay needle that is set in outside the puncture needle,
The delay needle is cylindrical, and the electrode is arranged on the outer wall for being detained needle.
The present invention has the following advantages and beneficial effects: injecting glucose by conducting probe and enzyme is motivated to make Portugal in tissue fluid
Grape sugar, which reacts, generates electric current, and analyzes to obtain concentration of glucose information by collected current, and method is simple, reliable.
Detailed description of the invention
Fig. 1 is human skin tissue according to the present invention and detection principle schematic diagram.
Fig. 2 is the conducting probe schematic diagram of one of embodiment according to the present invention.
Fig. 3 is the conducting probe schematic diagram of another embodiment according to the present invention.
Fig. 4 is the electrode current test schematic diagram of Fig. 3.
In figure: 1-analyzer；2-conducting probes；21-to electrode；22-working electrodes；23-glucose motivate zymophore；
24-reference electrodes；25-puncture needles；26-are detained needle；3-epidermis；4-skin coriums；5-subcutaneous tissues.
Specific embodiment
A specific embodiment of the invention and the course of work are further described with reference to the accompanying drawing.
The positional terms such as the upper, lower, left, right, front and rear in present specification be positional relationship based on the figure and
It establishes.Attached drawing is different, then corresponding positional relationship is also possible to change therewith, therefore cannot be interpreted as with this to protection model
The restriction enclosed.
The invention discloses a kind of electrochemical methods for detecting in-vivo tissue liquid concentration of glucose information, and this method is using such as
Electrochemical appliance shown in FIG. 1, electrochemical appliance include conducting probe 2 and analyzer 1, carry out excitation to detected part and obtain skin
Skin dermis layer tissue liquid concentration of glucose information.
As shown in Fig. 2, conducting probe 2 includes at least one group of bipolar electrode, i.e. working electrode 22 and to electrode 21, and setting
Glucose between bipolar electrode motivates zymophore 23.Glucose motivates enzyme to select glucose dehydrogenase or glucose oxidase.
As shown in figure 3, conducting probe 2 can also include puncture needle 25 and cover the delay needle 26 outside puncture needle 25.It is detained
Needle 26 is cylindrical, and electrode setting is on being detained 26 outer wall of needle.Electrode include three, i.e., working electrode 22, to electrode 21 and ginseng
Than electrode 24.
One of embodiment is to select conducting probe 2 as shown in Figure 3, including puncture needle 25 and cover in puncture needle 25
Outer delay needle 26.Wherein it is detained needle 26 to be made of polyester film, the length for being pierced into skin is 1.5mm, is less than this position of arm
Dermis thickness 2mm.Being detained printing on 26 outer wall of needle is working electrode 22(W respectively there are three electrode), to electrode 21(C) and
Reference electrode 24(R).Relative to dual-electrode sensor (working electrode with to electrode), three electrode sensors are introduced to stabilization
The reference electrode of working electrode.Wherein graphite is as working electrode and to electrode, silver/silver chloride as reference electrode,
Working electrode lower end loads glucose oxidase and the potassium ferricyanide, fixed with polyethylene oxide gel, and making it in retardation, let the acupuncture needle remain at a certain point
The distribution in direction is less than 1mm, to ensure that it acts only on intradermal.Puncture needle 25 and delay needle 26 are pierced into vivo, pulls out and wears
Pricker 25, the glucose oxidase being detained on needle 26 start to motivate the glucose in tissue fluid, glucose oxidase (GOD) catalysis
Grape in tissue fluid is glycoxidative, and the cooperation potassium ferricyanide generates gluconic acid and potassium ferrocyanide, later as electron mediator
Potassium ferrocyanide can also lose electronics and revert to the potassium ferricyanide, which is accompanied by the gain and loss of electronics, form current signal.Electricity
Stream flows through working electrode and to electrode, and reference electrode is used to keep the stability of current potential.As shown in figure 4, working electrode 22 and ginseng
Than 24 no power of electrode, the electrode potential of fixed voltage, working electrode 22 and the system that an energization is constituted to electrode 21 are constituted,
The electric current that working electrode passes through can be measured.By analyzing the size of the electric current, the information of concentration of glucose can be obtained.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of electrochemical method for detecting in-vivo tissue liquid concentration of glucose information, which is characterized in that the described method includes:
Glucose excitation enzyme is loaded into conducting probe；
Conducting probe is pierced into detected part skin, the piercing depth of the conducting probe is 0.5 ~ 1.5mm；By glucokinase
Enzyme is encouraged to be trapped in dermal layer of the skin；
Make the glucose in glucose excitation enzyme excitation dermis layer tissue liquid, makes the glycoxidative generation current signal of grape, and pass through
Current signal is passed to analytical equipment by the electrode sensor of conducting probe, and analytical equipment passes through the size of analysis current signal,
Obtain interstitial fluid glucose concentration information in detected part dermal layer of the skin.
2. a kind of electrochemical method for detecting in-vivo tissue liquid concentration of glucose information according to claim 1, feature
It is, the glucose excitation enzyme includes glucose dehydrogenase or glucose oxidase.
3. a kind of conducting probe, it can be used to implement to detect in-vivo tissue liquid concentration of glucose letter as described in claim 1
The electrochemical method of breath, which is characterized in that the conducting probe includes at least one set of electrode, and the electrode includes at least work electricity
Pole (22) and to electrode (21), and glucose excitation zymophore (23) to connect with the working electrode (22), the grape
Sugar excitation zymophore (23) is for carrying glucose excitation enzyme.
4. a kind of conducting probe according to claim 3, which is characterized in that the electrode further includes reference electrode (24).
5. a kind of conducting probe according to claim 3 or 4, which is characterized in that the conducting probe further includes puncture needle
(25) and it is set in the delay needle (26) of the puncture needle (25) outside, the electrode setting is in the outer wall for being detained needle (26).
6. a kind of electrochemical appliance, it can be used to implement to detect in-vivo tissue liquid concentration of glucose as described in claim 1
The electrochemical method of information, which is characterized in that the electrochemical appliance includes conducting probe (2) and analytical equipment (1), described to lead
Electric probe (2) includes at least one set of electrode, and the electrode includes at least working electrode (22) and to electrode (21), and with it is described
The glucose that working electrode (22) connects motivates zymophore (23), and glucose excitation zymophore (23) is for carrying glucose
Motivate enzyme；The analytical equipment (1) is connected with the electrode.
7. a kind of electrochemical appliance according to claim 6, which is characterized in that the electrode further includes reference electrode
(24).
8. a kind of electrochemical appliance according to claim 6, which is characterized in that the conducting probe (2) further includes puncturing
Needle (25) and it is set in the delay needle (26) of the puncture needle (25) outside, the electrode setting is detained the outer of needle (26) described
Wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910102702.3A CN109589121A (en) | 2019-02-01 | 2019-02-01 | A kind of electrochemical method and its device detecting in-vivo tissue liquid concentration of glucose information |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910102702.3A CN109589121A (en) | 2019-02-01 | 2019-02-01 | A kind of electrochemical method and its device detecting in-vivo tissue liquid concentration of glucose information |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109589121A true CN109589121A (en) | 2019-04-09 |
Family
ID=65967299
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|---|---|---|---|
| CN201910102702.3A Pending CN109589121A (en) | 2019-02-01 | 2019-02-01 | A kind of electrochemical method and its device detecting in-vivo tissue liquid concentration of glucose information |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1606423A (en) * | 2001-12-21 | 2005-04-13 | 贝克顿迪肯森公司 | A minimally-invasive system and method for monitoring analyte levels |
| US20090259118A1 (en) * | 2008-03-31 | 2009-10-15 | Abbott Diabetes Care Inc. | Shallow Implantable Analyte Sensor with Rapid Physiological Response |
| CN101970030A (en) * | 2007-12-17 | 2011-02-09 | 新世界药品有限公司 | Integrated intra-dermal delivery, diagnostic and communication system |
| US20140275907A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Diabetes Care Inc. | In vivo glucose sensing in an increased perfusion dermal layer |
| US20170196487A1 (en) * | 2012-12-18 | 2017-07-13 | Abbott Diabetes Care Inc. | Dermal layer analyte sensing devices and methods |
| CN107249459A (en) * | 2015-02-16 | 2017-10-13 | 威里利生命科学有限责任公司 | Electrochemical sensor for the continuous glucose monitoring system of bandage type |
| WO2018065954A1 (en) * | 2016-10-07 | 2018-04-12 | Debiotech S.A. | Micro sensor |
-
2019
- 2019-02-01 CN CN201910102702.3A patent/CN109589121A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1606423A (en) * | 2001-12-21 | 2005-04-13 | 贝克顿迪肯森公司 | A minimally-invasive system and method for monitoring analyte levels |
| CN101970030A (en) * | 2007-12-17 | 2011-02-09 | 新世界药品有限公司 | Integrated intra-dermal delivery, diagnostic and communication system |
| US20090259118A1 (en) * | 2008-03-31 | 2009-10-15 | Abbott Diabetes Care Inc. | Shallow Implantable Analyte Sensor with Rapid Physiological Response |
| US20170196487A1 (en) * | 2012-12-18 | 2017-07-13 | Abbott Diabetes Care Inc. | Dermal layer analyte sensing devices and methods |
| US20140275907A1 (en) * | 2013-03-15 | 2014-09-18 | Abbott Diabetes Care Inc. | In vivo glucose sensing in an increased perfusion dermal layer |
| CN107249459A (en) * | 2015-02-16 | 2017-10-13 | 威里利生命科学有限责任公司 | Electrochemical sensor for the continuous glucose monitoring system of bandage type |
| WO2018065954A1 (en) * | 2016-10-07 | 2018-04-12 | Debiotech S.A. | Micro sensor |
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Application publication date: 20190409 |