JP6117212B2 - 改変されたグラム陽性菌及びその使用 - Google Patents

改変されたグラム陽性菌及びその使用 Download PDF

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JP6117212B2
JP6117212B2 JP2014531242A JP2014531242A JP6117212B2 JP 6117212 B2 JP6117212 B2 JP 6117212B2 JP 2014531242 A JP2014531242 A JP 2014531242A JP 2014531242 A JP2014531242 A JP 2014531242A JP 6117212 B2 JP6117212 B2 JP 6117212B2
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trehalose
gram
lab
lactic acid
bifidobacteria
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JP2014526266A (ja
JP2014526266A5 (enExample
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ステイドラー,ローター
ヒュイネヘム,カロリアン ファン
ヒュイネヘム,カロリアン ファン
ファンデンブルック,クラース
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Intrexon Actobiotics NV
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/74Bacteria
    • A61K35/741Probiotics
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04Preserving or maintaining viable microorganisms
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/12Disaccharides
    • CCHEMISTRY; METALLURGY
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    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01216Trehalose 6-phosphate phosphorylase (2.4.1.216)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
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  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014531242A 2011-09-23 2012-09-21 改変されたグラム陽性菌及びその使用 Active JP6117212B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11182642 2011-09-23
EP11182642.6 2011-09-23
PCT/EP2012/068633 WO2013041672A1 (en) 2011-09-23 2012-09-21 Modified gram positive bacteria and uses thereof

Publications (3)

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JP2014526266A JP2014526266A (ja) 2014-10-06
JP2014526266A5 JP2014526266A5 (enExample) 2016-06-30
JP6117212B2 true JP6117212B2 (ja) 2017-04-19

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JP2014531242A Active JP6117212B2 (ja) 2011-09-23 2012-09-21 改変されたグラム陽性菌及びその使用

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US (2) US9458467B2 (enExample)
EP (1) EP2758512B1 (enExample)
JP (1) JP6117212B2 (enExample)
DK (1) DK2758512T3 (enExample)
ES (1) ES2676707T3 (enExample)
HU (1) HUE038830T2 (enExample)
WO (1) WO2013041672A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014006883A8 (pt) * 2011-09-23 2018-06-26 Actogenix Nv bactéria gram-positiva não patogênica carecendo de atividade do componente llc do sistema pts celobiose específico (ptcc), medicamento, aditivo alimentar, composição probiótica, ou cultura iniciadora, produto alimentar e métodos
CA2971520C (en) 2014-12-23 2024-04-09 Ilya Pharma Ab Methods for wound healing
CN109843320A (zh) * 2016-09-02 2019-06-04 英特瑞克斯顿阿克图比奥帝克斯有限公司 稳定表达il-10和胰岛素的遗传修饰的细菌
RU2762940C2 (ru) 2016-09-13 2021-12-24 Интрексон Актобиотикс Н.В. Мукоадгезивный микроорганизм
CN108410763B (zh) * 2018-03-14 2020-10-09 绍兴同创生物科技有限公司 长双歧杆菌tc01及其应用和应用其的产品
CN113481207B (zh) * 2021-07-15 2023-04-07 西南大学 家蚕卵滞育的必需基因Bmtret1及其应用

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GB9006400D0 (en) 1990-03-22 1990-05-23 Ciba Geigy Ag Bacterial vectors
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
IT1270123B (it) 1994-10-05 1997-04-28 Dompe Spa Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia
GB9521568D0 (en) 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
DE69914932T2 (de) 1998-10-20 2004-12-09 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis
AU781679B2 (en) 1999-07-05 2005-06-09 Intrexon Actobiotics Nv Delivery of trefoil peptides
AT407730B (de) 2000-01-14 2001-05-25 Hoerbiger Hydraulik Betätigungsanordnung für schwenkbare teile an fahrzeugen
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
JP4347575B2 (ja) 2001-05-03 2009-10-21 アクトジェニックス・エヌブイ 自己自制ラクトコッカス(Loctococcus)株
WO2004046346A2 (en) 2002-11-15 2004-06-03 Vib Vzw Self-containing lactobacillus strain
AU2005215858B2 (en) 2004-02-24 2010-07-15 Chr. Hansen A/S Frozen lactic acid bacteria culture of individual pellets
CA2567106A1 (en) 2004-05-18 2005-11-24 Vib Vzw Self-containing lactobacillus strain
WO2006018446A2 (en) * 2004-08-20 2006-02-23 Actogenix Nv Method to improve lactococcus preservation
ES2626610T3 (es) 2005-08-30 2017-07-25 Intrexon Actobiotics Nv Bacterias de ácido láctico productoras del anti-TNF alfa para el tratamiento de la enfermedad inflamatoria intestinal
ES2405552T3 (es) 2005-11-29 2013-05-31 Actogenix N.V. Inducción de tolerancia mucosa a antiantígenos de células beta de islotes pancreáticos
RU2008147398A (ru) 2006-05-02 2010-06-10 Актогеникс Н.В. (Be) Доставка пептидов, связанных с ожирением, через кишечник посредством микроорганизмов
CA2672229A1 (en) 2006-12-14 2008-06-19 Actogenix N.V. Delivery of binding molecules to induce immunomodulation
EP3124614B1 (en) 2007-01-12 2022-06-08 Intrexon Actobiotics NV Lactococcus promoters and uses thereof
EP2774621B1 (en) * 2007-01-25 2018-01-24 Intrexon Actobiotics NV Treatment of immune disease by mucosal delivery of antigens
EP2344626B1 (en) 2008-09-29 2017-03-29 Intrexon Actobiotics NV Reduced colonization of microbes at the mucosa
WO2010124855A1 (en) 2009-04-30 2010-11-04 Actogenix Nv Cryoprotectants for freeze drying of lactic acid bacteria
BR112014006883A8 (pt) 2011-09-23 2018-06-26 Actogenix Nv bactéria gram-positiva não patogênica carecendo de atividade do componente llc do sistema pts celobiose específico (ptcc), medicamento, aditivo alimentar, composição probiótica, ou cultura iniciadora, produto alimentar e métodos

Also Published As

Publication number Publication date
WO2013041672A1 (en) 2013-03-28
HUE038830T2 (hu) 2018-11-28
JP2014526266A (ja) 2014-10-06
US20140234371A1 (en) 2014-08-21
EP2758512B1 (en) 2018-05-09
US9458467B2 (en) 2016-10-04
DK2758512T3 (en) 2018-07-23
US20160376574A1 (en) 2016-12-29
ES2676707T3 (es) 2018-07-24
US10030234B2 (en) 2018-07-24
EP2758512A1 (en) 2014-07-30

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