JP6094578B2 - 代謝性障害の治療のためのｇｐｒ１１９モジュレーターとしての置換ピペリジン - Google Patents

代謝性障害の治療のためのｇｐｒ１１９モジュレーターとしての置換ピペリジン Download PDF

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JP6094578B2
JP6094578B2 JP2014514056A JP2014514056A JP6094578B2 JP 6094578 B2 JP6094578 B2 JP 6094578B2 JP 2014514056 A JP2014514056 A JP 2014514056A JP 2014514056 A JP2014514056 A JP 2014514056A JP 6094578 B2 JP6094578 B2 JP 6094578B2
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alkyl
substituted
phenyl
cyclopropyl
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JP2014516070A (ja
JP2014516070A5 (OSRAM
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アルミン ヘケル
アルミン ヘケル
ヒンメルスバッハ　フランク
フランク ヒンメルスバッハ
エルケ ランクコープフ
エルケ ランクコープフ
ベルント ノゼ
ベルント ノゼ
ニール ジェイ アシュウィーク
ニール ジェイ アシュウィーク
ニコル ハリオット
ニコル ハリオット
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014514056A 2011-06-09 2012-06-06 代謝性障害の治療のためのｇｐｒ１１９モジュレーターとしての置換ピペリジン Active JP6094578B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11169297.6 2011-06-09
EP11169297 2011-06-09
PCT/EP2012/060729 WO2012168315A1 (en) 2011-06-09 2012-06-06 Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders

Publications (3)

Publication Number Publication Date
JP2014516070A JP2014516070A (ja) 2014-07-07
JP2014516070A5 JP2014516070A5 (OSRAM) 2015-07-23
JP6094578B2 true JP6094578B2 (ja) 2017-03-15

Family

ID=46245574

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JP2014514056A Active JP6094578B2 (ja) 2011-06-09 2012-06-06 代謝性障害の治療のためのｇｐｒ１１９モジュレーターとしての置換ピペリジン

Country Status (5)

Country Link
US (1) US8921398B2 (OSRAM)
EP (1) EP2718288B1 (OSRAM)
JP (1) JP6094578B2 (OSRAM)
AR (1) AR086895A1 (OSRAM)
WO (1) WO2012168315A1 (OSRAM)

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* Cited by examiner, † Cited by third party
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WO2014011926A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
EP2686312B1 (en) 2011-03-14 2016-08-31 Boehringer Ingelheim International GmbH N-cyclopropyl-n-piperidinylbenzamides as gpr119 modulators
EP2718288B1 (en) 2011-06-09 2015-03-11 Boehringer Ingelheim International GmbH Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders
WO2014019967A1 (en) * 2012-08-02 2014-02-06 Boehringer Ingelheim International Gmbh N-cyclopropyl-n-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof
AU2013322855B2 (en) * 2012-09-25 2017-06-22 Bayer Cropscience Ag Herbicidal and fungicidal 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides
LT3490986T (lt) 2016-07-28 2022-02-10 Idorsia Pharmaceuticals Ltd Piperidino cxcr7 receptoriaus moduliatoriai
JP7076010B2 (ja) 2018-01-26 2022-05-26 イドーシア ファーマシューティカルズ リミテッド （３ｓ，４ｓ）－１－シクロプロピルメチル－４－｛［５－（２，４－ジフルオロ－フェニル）－イソオキサゾール－３－カルボニル］－アミノ｝－ピペリジン－３－カルボン酸 （１－ピリミジン－２－イル－シクロプロピル）－アミドの結晶形
CN112955448B (zh) * 2019-01-31 2023-02-03 中国医药研究开发中心有限公司 芳环或芳杂环类化合物及其制备方法和医药用途
WO2025128834A1 (en) * 2023-12-15 2025-06-19 Alterome Therapeutics, Inc. Akt1 modulators
WO2025207620A1 (en) * 2024-03-27 2025-10-02 Alterome Therapeutics, Inc. Akt1 modulators

Family Cites Families (18)

* Cited by examiner, † Cited by third party
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TWI326214B (en) 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
CA2504805A1 (en) 2002-11-06 2004-05-21 Takeda Pharmaceutical Company Limited Receptor regulator
EP1877401A2 (en) 2005-04-15 2008-01-16 Elan Pharmaceuticals Inc. Novel compounds useful for bradykinin b1 receptor antagonism
AU2006297089B2 (en) * 2005-09-27 2012-05-03 Irm Llc Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
US8039458B2 (en) 2005-11-17 2011-10-18 Bristol-Myers Squibb Company HIV integrase inhibitors
EP2029540B1 (en) * 2006-06-08 2010-08-04 Amgen Inc. Benzamide derivatives and uses related thereto
AU2007291252A1 (en) 2006-08-30 2008-03-06 Inovacia Ab Pyridine compounds for treating GPR119 related disorders
US20100120807A1 (en) 2007-03-08 2010-05-13 Irm Llc Compounds and compositions as modulators of gpr119 activity
GB0812649D0 (en) 2008-07-10 2008-08-20 Prosidion Ltd Compounds
GB0812648D0 (en) 2008-07-10 2008-08-20 Prosidion Ltd Compounds
TWI469979B (zh) * 2008-12-24 2015-01-21 Bial Portela & Ca Sa 脂肪酸醯胺水解酶(faah)抑制劑、以及其藥學組成物與用途
TW201111361A (en) 2009-06-24 2011-04-01 Boehringer Ingelheim Int New compounds, pharmaceutical composition and methods relating thereto
US8481731B2 (en) 2009-06-24 2013-07-09 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical composition and methods relating thereto
WO2011138427A2 (en) 2010-05-07 2011-11-10 Boehringer Ingelheim International Gmbh Pyridazinones as gpr119 agonists
UY33805A (es) 2010-12-17 2012-07-31 Boehringer Ingelheim Int ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?.
EA201300846A1 (ru) 2011-01-21 2013-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Конденсированные дигидрофураны в качестве модуляторов gpr119, предназначенные для лечения диабета, ожирения и родственных нарушений
EP2686312B1 (en) 2011-03-14 2016-08-31 Boehringer Ingelheim International GmbH N-cyclopropyl-n-piperidinylbenzamides as gpr119 modulators
EP2718288B1 (en) 2011-06-09 2015-03-11 Boehringer Ingelheim International GmbH Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders

Also Published As

Publication number Publication date
JP2014516070A (ja) 2014-07-07
AR086895A1 (es) 2014-01-29
EP2718288B1 (en) 2015-03-11
EP2718288A1 (en) 2014-04-16
WO2012168315A1 (en) 2012-12-13
US8921398B2 (en) 2014-12-30
US20130143892A1 (en) 2013-06-06

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