JP6083928B2 - 身体組織にエネルギーに印加する方法および装置 - Google Patents
身体組織にエネルギーに印加する方法および装置 Download PDFInfo
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Description
本願は、米国仮特許出願第61/107,252号(2008年10月21日出願)、同第61/162,241号(2009年3月20日出願)、同第61/180,133号(2009年5月21日出願)および、同第61/222,409号(2009年7月1日出願)の非仮特許出願であり、これらの出願の各々の開示は、その全体が本明細書に参考として援用される。
本発明は、患者の身体の上または内側で診断および/または治療手技を実施するために使用可能な医療要素(例えば、マイクロ波アブレーションアンテナ)に関する。
本発明は、例えば、以下の項目も提供する。
(項目1)
マイクロ波エネルギーを組織に印加するためのマイクロ波エネルギー源に連結されるように適合される医療デバイスであって、該医療デバイスは、
遮蔽要素を有する伝送線と、
マイクロ波エネルギーを組織に印加するように構成されるマイクロ波アンテナであって、該アンテナは、該伝送線を介して該マイクロ波エネルギー源に動作可能に連結される放射部材と、アンテナ誘電体と、該遮蔽要素に電気的に連結される成形部材であって、導電性である成形部材とを備えるアンテナと
を備え、該放射部材は、該放射部材単独によるマイクロ波エネルギーの印加が第1の成形されていないマイクロ波エネルギー場をもたらすように第1のプロファイルを備え、成形要素は、該成形要素が該第1の成形されていないマイクロ波エネルギー場を該アンテナの周囲に容量的に延在する第2の成形されたマイクロ波エネルギー場に改変するように第2のプロファイルを備える、デバイス。
(項目2)
前記アンテナは、臨床使用中に前記伝送線の遠位端に対して屈曲するほど十分に可撓性である、項目1に記載のデバイス。
(項目3)
前記アンテナは、前記伝送線のサイズと実質的に同様の圧縮された配備前サイズを有するほど十分に可撓性である、項目2に記載のデバイス。
(項目4)
前記アンテナは、実質的に直線状の配備前構成から実質的に非直線状の配備構成に変化するほど十分に可撓性である、項目2に記載のデバイス。
(項目5)
前記放射要素の前記第1のプロファイルは、直線状のプロファイル、実質的に平面のプロファイル、または3次元のプロファイルから成る群より選択されるプロファイルを備える、項目1に記載のデバイス。
(項目6)
前記アンテナは、前記伝送線の遠位端に接続され、前記放射部材および前記成形部材は、該伝送線の遠位端の遠位に位置する、項目1に記載のデバイス。
(項目7)
前記放射部材は、非直線状の導体を備える、項目1に記載のデバイス。
(項目8)
前記放射部材は、螺旋状の導体を備える、項目1に記載のデバイス。
(項目9)
前記放射部材は、組織または前記成形部材から絶縁されたままでいるために電気的に絶縁されたカバーを備える、項目1に記載のデバイス。
(項目10)
前記伝送線は、内側導体および外側導体を有する同軸ケーブルを備え、前記遮蔽要素は、該外側導体に電気的に連結され、前記放射部材は、該内側導体に電気的に連結される、項目1に記載のデバイス。
(項目11)
前記放射部材は、433MHz ISM帯域、915MHz ISM帯域、2.45GHz ISM帯域、および5.8GHz ISM帯域のうちの少なくとも1つにおける有効波長の4分の1の奇数倍数の長さを備える、項目1に記載のデバイス。
(項目12)
前記放射部材は、前記伝送線の導体の継続を備える、項目1に記載のデバイス。
(項目13)
少なくとも1つの付加的な放射部材をさらに備える、項目1に記載のデバイス。
(項目14)
少なくとも1つの付加的な成形部材をさらに備える、項目1に記載のデバイス。
(項目15)
前記成形部材は、前記アンテナの長さに沿って前記第1の成形されていないマイクロ波エネルギー場よりも均一になるよう前記第2の成形されたマイクロ波エネルギー場を成形するように構成される、項目1に記載のデバイス。
(項目16)
前記成形部材は、前記伝送線の前記遠位端から前記第1の成形されていないマイクロ波エネルギー場よりもさらに遠位に、前記第2の成形されたマイクロ波エネルギー場を成形するように構成される、項目1に記載のデバイス。
(項目17)
前記成形部材は、実質的に直線状である、項目1に記載のデバイス。
(項目18)
前記放射部材と成形部材とは、実質的に平行である、項目1に記載のデバイス。
(項目19)
前記放射部材は、実質的に平面であり、前記成形部材は、実質的に平面であり、該放射部材の平面は、該成形部材の平面と実質的に平行である、項目1に記載のデバイス。
(項目20)
前記放射部材は、前記成形部材を実質的に取り囲んでいる、項目1に記載のデバイス。
(項目21)
前記成形部材は、マイクロ波エネルギーを送達するときに前記アンテナの反射減衰量を低減する、項目1に記載のデバイス。
(項目22)
前記成形部材は、前記アンテナが許容性能を達成する周波数範囲を増加させる、項目1に記載のデバイス。
(項目23)
前記放射部材は、誘電材料内に封入される、項目1に記載のデバイス。
(項目24)
前記成形部材は、誘電材料内に封入される、項目1に記載のデバイス。
(項目25)
前記アンテナ誘電体は、EPTFE、PTFE、FEP、および他のフッ素重合体、シリコーン、空気、PEEK、ポリイミド、天然ゴム、人造ゴム、およびそれらの組み合わせから成る群から選択される、項目1に記載のデバイス。
(項目26)
前記第2の成形されたマイクロ波エネルギー場は、実質的に細長い、項目1に記載のデバイス。
(項目27)
前記第2の成形されたマイクロ波エネルギー場は、前記アンテナの周囲において実質的に放射方向に対称である、項目1に記載のデバイス。
(項目28)
前記第2の成形されたマイクロ波エネルギー場は、実質的に左右対称である、項目1に記載のデバイス。
(項目29)
前記第2の成形されたマイクロ波エネルギー場は、前記アンテナの遠位端においてより広く、該アンテナの近位端においてより狭い、項目1に記載のデバイス。
(項目30)
前記第2の成形されたマイクロ波エネルギー場は、前記成形部材を包む、項目1に記載のデバイス。
(項目31)
前記第2の成形されたマイクロ波エネルギー場は、前記放射部材を包む、項目30に記載のデバイス。
(項目32)
身体領域内で組織を切除する方法であって、該方法は、
該身体領域内にアンテナを挿入することであって、該アンテナは、放射部材と、成形部材と、誘電材料とを備え、該成形部材は、該アンテナの周囲に延在する容量的な成形されたマイクロ波エネルギー場を形成するように、該放射部材によって生成されたマイクロ波エネルギー場を改変し、該放射部材および成形部材は、各々、それぞれのプロファイルを備え、該放射部材の該プロファイルおよび該成形部材の該プロファイルは、該身体領域の容量に近似するように該容量的な成形されたマイクロ波エネルギー場を形成するように選択される、ことと、
該アンテナの周囲に延在する容量的な成形されたマイクロ波エネルギー場を生成するために該アンテナを使用することと
を含む、方法。
(項目33)
前記身体領域における体腔内で前記アンテナを前進させることをさらに含み、前記容量的な成形されたマイクロ波エネルギー場は、該体腔の少なくとも一部分を切除する、項目32に記載の方法。
(項目34)
マイクロ波エネルギーの1回の印加において、前記体腔を画定する壁の表面を切除することをさらに含む、項目32に記載の方法。
(項目35)
身体組織を切除する方法であって、該方法は、
該身体組織に近接してアンテナを設置することであって、該アンテナは、成形部材が伝送線の一部分に電気的に接続されるように、放射部材および該成形部材を備える、ことと、
マイクロ波場を生成することによって標的組織を切除するために、第1の損傷を作成することであって、該マイクロ波場は、該アンテナの外周を包囲し、該伝送線の遠位端の遠位に実質的に画定される、ことと
を含む、方法。
(項目36)
成形されたマイクロ波場を産生することによってマイクロ波エネルギーを送達する方法であって、該方法は、
伝送線と、アンテナとを備えるマイクロ波デバイスを配備することであって、該アンテナは、放射要素と、成形要素とを備える、ことと、
第1の成形されていないマイクロ波場を生成することと、
該放射要素に近接して成形部材を配備することであって、該成形部材は、該伝送線の遮蔽要素に電気的に接続される、ことと、
漏洩電流が該成形部材上に誘発されるように、該放射要素の十分近くに該成形部材を設置することであって、該成形部材は、第2の成形されたマイクロ波場を作成するように、該第1の成形されていないマイクロ波場を成形する、ことと
を含む、方法。
Claims (34)
- マイクロ波エネルギーを組織に印加するためのマイクロ波エネルギー源に連結されるように適合される医療デバイスであって、該医療デバイスは、
遮蔽要素を有する伝送線と、
マイクロ波エネルギーを組織に印加するように構成されるマイクロ波アンテナであって、該アンテナは、マイクロ波エネルギー場を放射するように該伝送線を介して該マイクロ波エネルギー源に動作可能に連結される放射部材と、アンテナ誘電体と、該遮蔽要素に電気的に連結される成形部材であって、該成形部材は、導電性であり、かつ、該放射部材により放射された該マイクロ波場に最も近い伝導性経路を提供するように該放射部材に隣接して位置する、成形部材とを備える、アンテナと
を備え、該放射部材は、該成形部材と相互作用して該成形部材上に漏洩電流を誘発する第1の成形されていないマイクロ波エネルギー場を生成し、該成形部材は、該アンテナの長さに沿って均一な第2の成形されたマイクロ波エネルギー場を該漏洩電流が作成するような形状を有する、デバイス。 - 前記アンテナは、臨床使用中に前記伝送線の遠位端に対して屈曲するほど十分に可撓性である、請求項1に記載のデバイス。
- 前記アンテナは、前記伝送線のサイズと実質的に同様の圧縮された配備前サイズを有するほど十分に可撓性である、請求項2に記載のデバイス。
- 前記アンテナは、実質的に直線状の配備前構成から実質的に非直線状の配備構成に変化するほど十分に可撓性である、請求項2に記載のデバイス。
- 前記放射部材は、直線状の形状、実質的に平面の形状、または3次元の形状から成る群より選択される形状を備える、請求項1に記載のデバイス。
- 前記アンテナは、前記伝送線の遠位端に接続され、前記放射部材および前記成形部材は、該伝送線の遠位端の遠位に位置する、請求項1に記載のデバイス。
- 前記放射部材は、非直線状の導体を備える、請求項1に記載のデバイス。
- 前記放射部材は、螺旋状の導体を備える、請求項1に記載のデバイス。
- 前記放射部材は、組織または前記成形部材から絶縁されたままでいるために電気的に絶縁されたカバーを備える、請求項1に記載のデバイス。
- 前記伝送線は、内側導体および外側導体を有する同軸ケーブルを備え、前記成形部材は、該外側導体に電気的に連結され、前記放射部材は、該内側導体に電気的に連結される、請求項1に記載のデバイス。
- 前記放射部材は、433MHz ISM帯域、915MHz ISM帯域、2.45GHz ISM帯域、および5.8GHz ISM帯域のうちの1つにおける有効波長の4分の1の奇数倍数である長さを備える、請求項1に記載のデバイス。
- 前記放射部材は、前記伝送線の内側導体の一部分である、請求項1に記載のデバイス。
- 少なくとも1つの付加的な放射部材をさらに備える、請求項1に記載のデバイス。
- 少なくとも1つの付加的な成形部材をさらに備える、請求項1に記載のデバイス。
- 前記成形部材は、前記伝送線の遠位端から前記第1の成形されていないマイクロ波エネルギー場よりもさらに遠位に、前記第2の成形されたマイクロ波エネルギー場を成形するように構成される、請求項1に記載のデバイス。
- 前記成形部材は、実質的に直線状である、請求項1に記載のデバイス。
- 前記放射部材と前記成形部材とは、実質的に平行である、請求項1に記載のデバイス。
- 前記放射部材は、実質的に平面であり、前記成形部材は、実質的に平面であり、該放射部材の平面は、該成形部材の平面と実質的に平行である、請求項1に記載のデバイス。
- 前記放射部材は、前記成形部材を実質的に取り囲んでいる、請求項1に記載のデバイス。
- 前記成形部材は、マイクロ波エネルギーを送達するときに前記アンテナの反射減衰量を低減する、請求項1に記載のデバイス。
- 前記成形部材は、前記アンテナが許容性能を達成する周波数範囲を増加させる、請求項1に記載のデバイス。
- 前記放射部材は、誘電材料内に封入される、請求項1に記載のデバイス。
- 前記成形部材は、誘電材料内に封入される、請求項1に記載のデバイス。
- 前記アンテナ誘電体は、EPTFE、PTFE、FEP、および他のフッ素重合体、シリコーン、空気、PEEK、ポリイミド、天然ゴム、人造ゴム、およびそれらの組み合わせから成る群から選択される、請求項1に記載のデバイス。
- 前記第2の成形されたマイクロ波エネルギー場は、実質的に細長い、請求項1に記載のデバイス。
- 前記第2の成形されたマイクロ波エネルギー場は、前記アンテナの周囲において実質的に放射方向に対称である、請求項1に記載のデバイス。
- 前記第2の成形されたマイクロ波エネルギー場は、実質的に左右対称である、請求項1に記載のデバイス。
- 前記第2の成形されたマイクロ波エネルギー場は、前記アンテナの遠位端においてより広く、該アンテナの近位端においてより狭い、請求項1に記載のデバイス。
- 前記第2の成形されたマイクロ波エネルギー場は、前記成形部材を包む、請求項1に記載のデバイス。
- 前記第2の成形されたマイクロ波エネルギー場は、前記放射部材を包む、請求項29に記載のデバイス。
- 身体領域内で組織を切除するためのシステムであって、該システムは、
該身体領域内に挿入されるように構成されたアンテナを備え、該アンテナは、放射部材と、成形部材と、誘電材料とを備え、該成形部材は、該アンテナの長さに沿って均一な成形されたマイクロ波エネルギー場を形成するように、該放射部材によって生成されたマイクロ波エネルギー場を改変するように構成され、該成形部材は、該放射部材によって生成されたマイクロ波エネルギー場に最も近い伝導性経路であるように配置され、該放射部材および成形部材は、各々、それぞれの形状を有し、該放射部材の該形状および該成形部材の該形状は、該成形されたマイクロ波エネルギー場が該身体領域の形状に近似するように該成形されたマイクロ波エネルギー場を形成するように選択され、
該アンテナは、該アンテナの長さに沿った成形されたマイクロ波エネルギー場を生成するように構成され、
該放射部材によって生成されたマイクロ波エネルギー場は、該成形部材と相互作用して該成形部材上に漏洩電流を誘発する、システム。 - 前記成形されたマイクロ波エネルギー場は、身体領域における体腔の少なくとも一部分を切除するように構成される、請求項31に記載のシステム。
- 身体組織を切除するためのシステムであって、該システムは、
該身体組織に近接して配置されるように構成されたアンテナを備え、該アンテナは、成形部材が伝送線の外側導体または遮蔽要素に電気的に接続されるように、放射部材および該成形部材を備え、該放射部材は、該アンテナの長さに沿って均一なマイクロ波場を生成することによって標的組織を切除するために第1の損傷を作成するように構成され、
該成形部材は、該マイクロ波場が該成形部材と相互作用して該成形部材上に漏洩電流を誘発するように、該放射部材の十分近くに設置されるように構成される、システム。 - 成形されたマイクロ波場を生成することによってマイクロ波エネルギーを送達するためのシステムであって、該システムは、
伝送線とアンテナとを備えるマイクロ波デバイスを含み、該アンテナは、放射要素と、成形部材とを備え、該放射要素は、該成形部材と相互作用して該成形部材上に漏洩電流を誘発する第1の成形されていないマイクロ波場を生成するように構成され、
該成形部材は、該放射要素に近接し、該成形部材は、該伝送線の遮蔽要素に電気的に接続され、該成形部材は、漏洩電流が該成形部材上に誘発されるように、該放射要素の十分近くに設置されるように構成され、該成形部材は、該アンテナの長さに沿って均一な第2の成形されたマイクロ波場を該漏洩電流が作成するような形状を有する、システム。
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