JP6073778B2 - 炎症を治療する方法 - Google Patents

炎症を治療する方法 Download PDF

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JP6073778B2
JP6073778B2 JP2013502886A JP2013502886A JP6073778B2 JP 6073778 B2 JP6073778 B2 JP 6073778B2 JP 2013502886 A JP2013502886 A JP 2013502886A JP 2013502886 A JP2013502886 A JP 2013502886A JP 6073778 B2 JP6073778 B2 JP 6073778B2
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fluid
poly
polymer
biocompatible polymer
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JP2013523772A (ja
JP2013523772A5 (enExample
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チャン,フィリップ・ピー
ヤング,ウェイ−タイ
カポニ,ヴィンセント・ジェイ
ゴロビシュ,トーマス・ディー
バートレット,ロバート・エイチ
ハマリャ,ベーガム・アリ
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サイトソーベンツ・コーポレーション
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  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
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JP2013502886A 2010-04-01 2011-04-01 炎症を治療する方法 Active JP6073778B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31999310P 2010-04-01 2010-04-01
US61/319,993 2010-04-01
PCT/US2011/030919 WO2011123767A1 (en) 2010-04-01 2011-04-01 Method of treating inflammation

Related Child Applications (1)

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JP2016079100A Division JP2016175914A (ja) 2010-04-01 2016-04-11 炎症を治療する方法

Publications (3)

Publication Number Publication Date
JP2013523772A JP2013523772A (ja) 2013-06-17
JP2013523772A5 JP2013523772A5 (enExample) 2014-05-01
JP6073778B2 true JP6073778B2 (ja) 2017-02-01

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JP2013502886A Active JP6073778B2 (ja) 2010-04-01 2011-04-01 炎症を治療する方法
JP2016079100A Pending JP2016175914A (ja) 2010-04-01 2016-04-11 炎症を治療する方法

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US (6) US9717755B2 (enExample)
EP (2) EP3384916A1 (enExample)
JP (2) JP6073778B2 (enExample)
CN (2) CN107260755A (enExample)
AU (1) AU2011234978B2 (enExample)
CA (1) CA2795177C (enExample)
ES (1) ES2686545T3 (enExample)
MX (1) MX342421B (enExample)
WO (1) WO2011123767A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107260755A (zh) * 2010-04-01 2017-10-20 西托索尔本茨公司 治疗炎症的方法
JP6049685B2 (ja) 2011-03-23 2016-12-21 ネクステージ メディカル インコーポレイテッド 腹膜透析使い捨てユニット、コントローラ、腹膜透析システム
US9861733B2 (en) 2012-03-23 2018-01-09 Nxstage Medical Inc. Peritoneal dialysis systems, devices, and methods
EP2679302A1 (de) 2012-06-28 2014-01-01 Zentrum für biomedizinische Technologie der Donau- Universität Krems Selektives Sorptionsmittel für die extrakorporale Blutreinigung
US20150335576A1 (en) * 2012-06-29 2015-11-26 Cytosorbents Corporation Methods of using polymers
US10639405B2 (en) 2014-07-22 2020-05-05 Asahi Kasei Medical Co., Ltd. Adsorbent for removing histone and purification device for liquid derived from living organism
CN114306208A (zh) * 2014-10-02 2022-04-12 西托索尔本茨公司 经胃肠施用的多孔消化道吸着剂聚合物用于预防或治疗的用途
US20190060545A1 (en) * 2016-03-08 2019-02-28 Cytosorbents Corporation The use of a hemocompatible porous polymer bead sorbent for removal of pamps and damps
RU2018146119A (ru) 2016-05-26 2020-06-26 Сайтосорбентс Корпорейшн Использование гемосовместимого сорбента из пористых полимерных шариков для удаления вызывающих эндотоксикоз молекул
EP3630325A4 (en) 2017-05-23 2021-02-17 Cytosorbents Corporation METHODS FOR TREATMENT OF TRAUMATIC BRAIN INJURY
WO2018237375A1 (en) 2017-06-24 2018-12-27 Nxstage Medical, Inc. Peritoneal dialysis fluid preparation and/or treatment devices methods and systems
MX2020002048A (es) * 2017-08-31 2020-09-21 Cytosorbents Corp Reduccion de productos finales de glicacion avanzada a partir de fluidos corporales.
CA3092575A1 (en) 2018-02-28 2019-09-06 Nxstage Medical, Inc. Fluid preparation and treatment devices, methods, and systems
CA3118792A1 (en) 2018-11-16 2020-05-22 Hemanext Inc. Methods for managing adverse events in patients with inflammation
WO2021034773A1 (en) * 2019-08-16 2021-02-25 Cytosorbents Corporation Methods for improving bone fracture healing
JP7614656B2 (ja) 2019-09-30 2025-01-16 ヘモチューン アーゲー 体液の体外処理のためのアセンブリ
EP4135749A4 (en) * 2020-04-14 2024-04-17 Cytosorbents Corporation IMPROVED IMMUNE RESPONSE AND REDUCED IMMUNOPARALYSIS WITH IMMUNOMODULATOR TREATMENT
JP2023539106A (ja) * 2020-08-19 2023-09-13 サイトソーベンツ・コーポレーション 治療的および美容的な創傷処置法
CN118613294A (zh) * 2021-11-29 2024-09-06 西托索尔本茨公司 经改善的癌症免疫疗法治疗

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU213165B (en) * 1993-05-11 1997-02-28 Bot Process to prepare biopolymers with detoxicating activity
US20020197250A1 (en) 2001-04-10 2002-12-26 Renal Tech International Biocompatible devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood
US6416487B1 (en) 1997-07-30 2002-07-09 Renal Tech International Llc Method of removing beta-2 microglobulin from blood
US5904663A (en) 1997-07-30 1999-05-18 Braverman; Andrew Method of removing beta-2 microglobulin from blood
US20020159995A1 (en) * 1997-07-30 2002-10-31 Renal Tech International Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood, generated as a result of extracorporeal blood processing
CN1136042C (zh) * 1998-01-06 2004-01-28 塞鲁斯公司 降低生物组合物中化合物的流动式设备和使用方法
US20020197252A1 (en) 2001-04-10 2002-12-26 Renal Tech International Selective adsorption devices and systems
US7651974B2 (en) 2002-11-01 2010-01-26 Kureha Chemical Industry Co., Ltd. Adsorbent for oral administration
JP3672200B2 (ja) 2002-11-01 2005-07-13 呉羽化学工業株式会社 経口投与用吸着剤
TWI370012B (en) * 2004-04-02 2012-08-11 Kureha Corp Adsorbent for oral administration, and agent for treating or preventing renal or liver disease
WO2005115336A2 (en) * 2004-05-15 2005-12-08 Collegium Pharmaceutical, Inc. Sprayable formulations for the treatment of acute inflammatory skin conditions
WO2006044577A1 (en) 2004-10-13 2006-04-27 Ilypsa, Inc. Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle
US20060078534A1 (en) * 2004-10-13 2006-04-13 Dominique Charmot Toxin binding compositions
US20060228416A1 (en) 2005-04-06 2006-10-12 Marie-Pierre Faure Methods for modulating topical inflammatory response
EP1842545A1 (en) * 2006-04-04 2007-10-10 Marinomed Biotechnologie GmbH Anti-inflammatory polymer
US8048413B2 (en) 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
US7875182B2 (en) * 2006-11-20 2011-01-25 Cytosorbents, Inc. Size-selective hemoperfusion polymeric adsorbents
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
CN101307149B (zh) 2008-05-30 2011-06-01 珠海健帆生物科技股份有限公司 一种医用吸附剂载体的制备方法
EP2352568B1 (en) * 2008-10-02 2017-11-29 University of Pittsburgh - Of the Commonwealth System of Higher Education Administration of an adsorbent polymer for treatment of systemic inflammation
US8923172B2 (en) * 2009-08-24 2014-12-30 Qualcomm Incorporated Deterministic backoff channel access
CN107260755A (zh) * 2010-04-01 2017-10-20 西托索尔本茨公司 治疗炎症的方法
US10064406B2 (en) 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products

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US20160279163A1 (en) 2016-09-29
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CA2795177A1 (en) 2011-10-06
US20170296574A1 (en) 2017-10-19
US20210330697A1 (en) 2021-10-28
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US9717755B2 (en) 2017-08-01
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US11058715B2 (en) 2021-07-13
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CA2795177C (en) 2018-07-03
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