JP6063628B2 - ５−アザシチジンを用いる、非小細胞肺癌の治療方法 - Google Patents

５−アザシチジンを用いる、非小細胞肺癌の治療方法 Download PDF

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JP6063628B2
JP6063628B2 JP2011549167A JP2011549167A JP6063628B2 JP 6063628 B2 JP6063628 B2 JP 6063628B2 JP 2011549167 A JP2011549167 A JP 2011549167A JP 2011549167 A JP2011549167 A JP 2011549167A JP 6063628 B2 JP6063628 B2 JP 6063628B2
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azacytidine
cells
nsclc
cell
aza
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JP2012517427A (ja
JP2012517427A5 (enExample
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エヌ． ングエン アアロン
エヌ． ングエン アアロン
ジェイ． マクベトフ クイルエ
ジェイ． マクベトフ クイルエ
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セルジーン インターナショナル サルル
セルジーン インターナショナル サルル
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011549167A 2009-02-10 2010-02-09 ５−アザシチジンを用いる、非小細胞肺癌の治療方法 Active JP6063628B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15147909P 2009-02-10 2009-02-10
US61/151,479 2009-02-10
PCT/US2010/000361 WO2010093435A1 (en) 2009-02-10 2010-02-09 Methods for treating non-small cell lung cancer using 5-azacytidine

Related Child Applications (1)

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JP2015032530A Division JP2015131822A (ja) 2009-02-10 2015-02-23 ５−アザシチジンを用いる、非小細胞肺癌の治療方法

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JP2012517427A JP2012517427A (ja) 2012-08-02
JP2012517427A5 JP2012517427A5 (enExample) 2013-03-21
JP6063628B2 true JP6063628B2 (ja) 2017-01-18

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JP2011549167A Active JP6063628B2 (ja) 2009-02-10 2010-02-09 ５−アザシチジンを用いる、非小細胞肺癌の治療方法
JP2015032530A Pending JP2015131822A (ja) 2009-02-10 2015-02-23 ５−アザシチジンを用いる、非小細胞肺癌の治療方法

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US (2) US8492361B2 (enExample)
EP (1) EP2396007A1 (enExample)
JP (2) JP6063628B2 (enExample)
CA (1) CA2789365A1 (enExample)
WO (1) WO2010093435A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6063628B2 (ja) 2009-02-10 2017-01-18 セルジーン インターナショナル サルル ５−アザシチジンを用いる、非小細胞肺癌の治療方法
WO2013022872A1 (en) 2011-08-10 2013-02-14 Celgene Corporation Gene methylation biomarkers and methods of use thereof
CN104039330A (zh) 2011-09-26 2014-09-10 细胞基因公司 化疗耐药性的癌症的联合治疗
TW201700103A (zh) 2011-11-01 2017-01-01 西建公司 利用胞嘧啶核苷類似物之口服配方治療癌症的方法
JP6114317B2 (ja) * 2012-02-24 2017-04-12 シグナル ファーマシューティカルズ，エルエルシー Ｔｏｒキナーゼ阻害剤の組合せ療法を用いて、非小細胞肺がんを処置する方法
AU2014254059B2 (en) * 2013-04-17 2019-06-06 Signal Pharmaceuticals, Llc Combination therapy comprising a TOR kinase inhibitor and a cytidine analog for treating cancer
WO2014180996A1 (en) * 2013-05-10 2014-11-13 Embl Use of 5-azacytidine to inhibit nonsense-mediated rna decay (nmd)
JP6783224B2 (ja) 2014-04-04 2020-11-11 デル マー ファーマシューティカルズ 肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用
EP3131552B1 (en) 2014-04-16 2020-07-15 Signal Pharmaceuticals, LLC Methods for treating cancer using tor kinase inhibitor combination therapy
US9718824B2 (en) 2014-04-16 2017-08-01 Signal Pharmaceuticals, Llc Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof
WO2015195786A2 (en) * 2014-06-17 2015-12-23 Celgene Corporation Methods for treating cancers using oral formulations of cytidine analogs
AU2015315435A1 (en) * 2014-09-08 2017-03-23 Celgene Corporation Methods for treating a disease or disorder using oral formulations of cytidine analogs in combination with an anti-PD1 or anti-PDL1 monoclonal antibody
US9801983B2 (en) 2014-12-18 2017-10-31 Cook Medical Technologies Llc Medical devices for delivering a bioactive to a point of treatment and methods of making medical devices
WO2016201337A1 (en) * 2015-06-12 2016-12-15 Immungene, Inc. Engineered antibody-interferon fusion molecules for the treatment of glucose-regulated protein 94 (grp94) expressing cancers
CA3007357C (en) 2015-12-03 2023-12-05 Epidestiny, Inc. Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof
ES2959860T3 (es) 2017-06-22 2024-02-28 Celgene Corp Tratamiento del carcinoma hepatocelular caracterizado por la infección por el virus de la hepatitis B
JP7017638B2 (ja) 2018-02-07 2022-02-08 ラブレス バイオメディカル リサーチ インスティテュート 吸入可能な乾燥粉末シチジン類似体組成物及び癌への治療として使用する方法
US10632211B2 (en) 2018-06-11 2020-04-28 The Regents Of The University Of California Demethylation to treat eye disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063735A1 (en) * 2004-09-17 2006-03-23 Supergen, Inc. Salts of 5-azacytidine
CA2742252A1 (en) 2007-11-01 2009-05-07 Celgene Corporation Cytidine analogs for treatment of myelodysplastic syndromes
HUE055911T2 (hu) 2008-05-15 2021-12-28 Celgene Corp Citidin-analógokat tartalmazó orális készítmények, és eljárások azok alkalmazására
JP6063628B2 (ja) 2009-02-10 2017-01-18 セルジーン インターナショナル サルル ５−アザシチジンを用いる、非小細胞肺癌の治療方法
WO2013022872A1 (en) 2011-08-10 2013-02-14 Celgene Corporation Gene methylation biomarkers and methods of use thereof

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Publication number Publication date
WO2010093435A1 (en) 2010-08-19
US8841277B2 (en) 2014-09-23
JP2012517427A (ja) 2012-08-02
JP2015131822A (ja) 2015-07-23
US8492361B2 (en) 2013-07-23
EP2396007A1 (en) 2011-12-21
CA2789365A1 (en) 2010-08-19
US20110319355A1 (en) 2011-12-29
US20130274219A1 (en) 2013-10-17

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