JP6059735B2 - 脳卒中診断のためのNT−proANP及びNT−proBNP - Google Patents

脳卒中診断のためのNT−proANP及びNT−proBNP Download PDF

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JP6059735B2
JP6059735B2 JP2014543882A JP2014543882A JP6059735B2 JP 6059735 B2 JP6059735 B2 JP 6059735B2 JP 2014543882 A JP2014543882 A JP 2014543882A JP 2014543882 A JP2014543882 A JP 2014543882A JP 6059735 B2 JP6059735 B2 JP 6059735B2
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proanp
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JP2015504519A5 (https=
JP2015504519A (ja
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ヘス,ゲオルク
ホルシュ,アンドレア
ズドゥネック,ディートマー
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F Hoffmann La Roche AG
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/58Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2014543882A 2011-12-01 2012-11-29 脳卒中診断のためのNT−proANP及びNT−proBNP Active JP6059735B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11191579 2011-12-01
EP11191579.9 2011-12-01
PCT/EP2012/073897 WO2013079567A2 (en) 2011-12-01 2012-11-29 Nt-proanp and nt-probnp for the diagnosis of stroke

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016239317A Division JP6441885B2 (ja) 2011-12-01 2016-12-09 脳卒中診断のためのNT−proANP及びNT−proBNP

Publications (3)

Publication Number Publication Date
JP2015504519A JP2015504519A (ja) 2015-02-12
JP2015504519A5 JP2015504519A5 (https=) 2016-10-20
JP6059735B2 true JP6059735B2 (ja) 2017-01-11

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JP2014543882A Active JP6059735B2 (ja) 2011-12-01 2012-11-29 脳卒中診断のためのNT−proANP及びNT−proBNP
JP2016239317A Active JP6441885B2 (ja) 2011-12-01 2016-12-09 脳卒中診断のためのNT−proANP及びNT−proBNP

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US (2) US10732188B2 (https=)
EP (2) EP3290924B1 (https=)
JP (2) JP6059735B2 (https=)
CN (2) CN107064516B (https=)
CA (2) CA3081979C (https=)
ES (2) ES2899923T3 (https=)
WO (1) WO2013079567A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3206032B1 (en) * 2014-10-10 2019-02-27 Akira Matsumori Method for detecting cardiac failure patient, method for discrimination of cardiac disease, test reagent for cardiac failure, test kit for cardiac failure, device for detecting cardiac failure, and program for detecting cardiac failure
KR20210038893A (ko) * 2018-07-31 2021-04-08 에프. 호프만-라 로슈 아게 심방 세동의 평가에서 순환하는 dkk3(딕오프 관련 단백질 3)
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US20220381794A1 (en) * 2019-05-16 2022-12-01 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Method for selecting a patient for a reperfusion therapy
JP2021173559A (ja) 2020-04-21 2021-11-01 株式会社デンソー 物理量計測装置

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
EP1322957B1 (en) 2001-05-04 2009-08-12 Biosite Incorporated Diagnostic markers of acute coronary syndromes and methods of use thereof
DE60233949D1 (de) 2001-08-20 2009-11-19 Biosite Inc Diagnostische marker für schlaganfall und hirntrauma sowie verfahren zur verwendung davon
ATE462001T1 (de) * 2002-12-24 2010-04-15 Nitto Boseki Co Ltd Markerproteine zur diagnose einer lebererkrankung und verfahren zur diagnose einer lebererkrankung damit
JP2006526140A (ja) * 2002-12-24 2006-11-16 バイオサイト インコーポレイテッド 鑑別診断のためのマーカーおよびその使用方法
US20050181386A1 (en) * 2003-09-23 2005-08-18 Cornelius Diamond Diagnostic markers of cardiovascular illness and methods of use thereof
EP1582597A1 (en) 2004-03-29 2005-10-05 Aventis Pharma Deutschland GmbH Method of diagnosis of a predisposition to develop thrombotic disease and its uses
US20060166303A1 (en) * 2005-01-24 2006-07-27 Eberhard Spanuth Use of cardiac hormones for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs
DK1849009T3 (da) 2005-01-24 2009-01-12 Hoffann La Roche Ag F Anvendelse af cardiachormoner til diagnose af cardiovaskulære risici som fölge af en administration af antiinflammatoriske lægemidler
JP4828550B2 (ja) * 2005-02-17 2011-11-30 エフ.ホフマン−ラ ロシュ アーゲー 心機能障害を診断するためのNT−proANP/NT−proBNP比の使用
EP1731910A1 (en) * 2005-06-07 2006-12-13 F. Hoffmann-La Roche Ag Use of NT-proANP and NT-proBNP for diagnosing cardiac diseases
DE102005048899A1 (de) * 2005-10-12 2007-04-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Diagnose thromboembolischer Erkrankungen und koronarer Herzerkrankungen
ES2344993T3 (es) * 2006-03-24 2010-09-13 F. Hoffmann-La Roche Ag Medios y metodos para la diferenciacion de la necrosis de miocardio aguda y cronica en pacientes sintomaticos.
EP1882945A1 (en) 2006-07-28 2008-01-30 F.Hoffmann-La Roche Ag Means and methods for the differentiation of cardiac and pulmonary causes of acute shortness of breath
ATE449966T1 (de) * 2006-09-15 2009-12-15 Hoffmann La Roche Biochemische marker für akute lungenembolie
JP2011501113A (ja) 2007-10-10 2011-01-06 エフ.ホフマン−ラ ロシュ アーゲー 急性冠症候群を有する患者での既存の心筋機能不全の評価のためのナトリウム利尿ペプチド/トロポニン比
CN102257386B (zh) * 2008-10-24 2014-12-31 B.R.A.H.M.S有限公司 通过测定标志肽的水平在已患过中风或短暂性缺血性发作的患者中进行预后和风险评估
CA2751090A1 (en) * 2009-01-30 2010-08-05 Electrophoretics Limited Method for the in vitro diagnosis of stroke
EP2466311A1 (en) 2010-12-17 2012-06-20 Roche Diagnostics GmbH sFlt1 in patients with ischemic stroke

Also Published As

Publication number Publication date
US10732188B2 (en) 2020-08-04
CN104094121A (zh) 2014-10-08
EP2786154B1 (en) 2017-11-01
CA2856461C (en) 2020-08-18
WO2013079567A2 (en) 2013-06-06
CN104094121B (zh) 2016-10-26
HK1201327A1 (en) 2015-08-28
JP2017075959A (ja) 2017-04-20
CA2856461A1 (en) 2013-06-06
EP3290924B1 (en) 2021-10-13
CN107064516A (zh) 2017-08-18
WO2013079567A3 (en) 2013-08-29
ES2656082T3 (es) 2018-02-23
EP3290924A1 (en) 2018-03-07
US20200333360A1 (en) 2020-10-22
JP2015504519A (ja) 2015-02-12
US20140274793A1 (en) 2014-09-18
CA3081979C (en) 2023-07-11
EP2786154A2 (en) 2014-10-08
ES2899923T3 (es) 2022-03-15
CN107064516B (zh) 2019-08-02
JP6441885B2 (ja) 2018-12-19
CA3081979A1 (en) 2013-06-06

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