JP6054379B2 - キナーゼをモジュレートするための組成物および方法 - Google Patents

キナーゼをモジュレートするための組成物および方法 Download PDF

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JP6054379B2
JP6054379B2 JP2014514164A JP2014514164A JP6054379B2 JP 6054379 B2 JP6054379 B2 JP 6054379B2 JP 2014514164 A JP2014514164 A JP 2014514164A JP 2014514164 A JP2014514164 A JP 2014514164A JP 6054379 B2 JP6054379 B2 JP 6054379B2
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cancer
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JP2014520108A5 (enExample
JP2014520108A (ja
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ベッカー、オーレン・エム．
ブロッチ、イタイ
ベン—ゼーブ・エフラット
ベン―ゼーブ・エフラット
シトリット、アリーナ
ヤコバン、アビハイ
ガザル、シャロン
ベハル、ベレド
コンソン、アレクサンダー
シュッズ、ニリ
ミリラシュビリ、シマ
ゴラン、ガリ
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Clevexel Pharma
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
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  • Transplantation (AREA)
  • Diabetes (AREA)
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  • Neurology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014514164A 2011-06-07 2012-06-07 キナーゼをモジュレートするための組成物および方法 Active JP6054379B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161520256P 2011-06-07 2011-06-07
US61/520,256 2011-06-07
US201161562700P 2011-11-22 2011-11-22
US61/562,700 2011-11-22
US201261640139P 2012-04-30 2012-04-30
US61/640,139 2012-04-30
PCT/IB2012/001987 WO2012172438A2 (en) 2011-06-07 2012-06-07 Compositions and methods for modulating a kinase

Publications (3)

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JP2014520108A JP2014520108A (ja) 2014-08-21
JP2014520108A5 JP2014520108A5 (enExample) 2015-06-11
JP6054379B2 true JP6054379B2 (ja) 2016-12-27

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CN (1) CN103717593B (enExample)
AU (1) AU2012270029B2 (enExample)
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KR20180088926A (ko) 2012-07-24 2018-08-07 파마싸이클릭스 엘엘씨 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
WO2017097215A1 (zh) * 2015-12-07 2017-06-15 杭州雷索药业有限公司 内嵌脲类结构的wnt通路抑制剂
KR102214225B1 (ko) * 2015-12-07 2021-02-10 쑤저우 시노벤트 파마슈티칼즈 씨오., 엘티디. 5원 헤테로시클릭 아미드계 wnt 경로 억제제
MY209468A (en) * 2018-05-29 2025-07-10 Omeros Corp Masp-2 inhibitors and methods of use
AU2020356575A1 (en) 2019-09-27 2022-04-14 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
KR20220110530A (ko) * 2019-12-04 2022-08-08 오메로스 코포레이션 Masp-2 억제자 및 사용 방법
WO2021146903A1 (zh) * 2020-01-21 2021-07-29 苏州信诺维医药科技股份有限公司 一种含氮化合物的晶型
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
WO2022251434A1 (en) * 2021-05-26 2022-12-01 Emory University Jak inhibitors for managing conditions in patients with down's syndrome or other trisomy
MX2024003795A (es) * 2021-09-29 2024-06-03 Repare Therapeutics Inc Compuestos de n-(5-sustituido-[(1,3,4-tiadiazolil) o (tiazolil)])(sustituido)carboxamida y uso de estos para inhibir la polimerasa theta humana.
KR20250108598A (ko) * 2022-09-29 2025-07-15 리페어 세라퓨틱스 인크. N-(5-치환된-[(1,3,4-티아다이아졸릴) 또는 (1,3-티아졸릴)](치환된)카복스아마이드 화합물, 약제학적 조성물, 그리고 아마이드 화합물의 제조 방법 및 이의 용도
EP4620949A1 (en) * 2024-03-18 2025-09-24 Eberhard Karls Universität Tübingen (Medizinische Fakultät) Ackr3 modulators for cardiovascular or antiplatelet therapy

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AU2012270029B2 (en) 2017-08-10
MX355415B (es) 2018-04-18
HUE028097T2 (en) 2016-11-28
MX2013014433A (es) 2014-02-27
WO2012172438A2 (en) 2012-12-20
AU2012270029A1 (en) 2012-12-20
US8937065B2 (en) 2015-01-20
PL2718290T3 (pl) 2016-11-30
PT2718290T (pt) 2016-07-14
ES2585244T3 (es) 2016-10-04
IL229692A0 (en) 2014-01-30
WO2012172438A9 (en) 2013-02-07
BR112013031121B1 (pt) 2022-03-29
HRP20160879T1 (hr) 2016-09-23
US20120316148A1 (en) 2012-12-13
BR112013031121A2 (pt) 2019-04-09
CA2837268C (en) 2020-05-12
AU2012270029A8 (en) 2014-01-30
WO2012172438A3 (en) 2013-03-28
HK1191324A1 (zh) 2014-07-25
EP2718290A2 (en) 2014-04-16
IL229692A (en) 2017-04-30
CA2837268A1 (en) 2012-12-20
CN103717593B (zh) 2016-07-06
JP2014520108A (ja) 2014-08-21
DK2718290T3 (en) 2016-08-15
CN103717593A (zh) 2014-04-09

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