JP6039553B2 - エンドモルフィンのμオピオイド受容体アゴニスト類似体 - Google Patents

エンドモルフィンのμオピオイド受容体アゴニスト類似体 Download PDF

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Publication number
JP6039553B2
JP6039553B2 JP2013519718A JP2013519718A JP6039553B2 JP 6039553 B2 JP6039553 B2 JP 6039553B2 JP 2013519718 A JP2013519718 A JP 2013519718A JP 2013519718 A JP2013519718 A JP 2013519718A JP 6039553 B2 JP6039553 B2 JP 6039553B2
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peptide
phe
amino acid
peptide according
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JP2013533890A5 (enExample
JP2013533890A (ja
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ジェームズ イー ザディナ
ジェームズ イー ザディナ
ラズロ ハックラー
ラズロ ハックラー
Original Assignee
ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド
ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド
ユナイテッド ステイツ デパートメント オブ ヴェテランズ アフェアーズ
ユナイテッド ステイツ デパートメント オブ ヴェテランズ アフェアーズ
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Application filed by ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド, ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド, ユナイテッド ステイツ デパートメント オブ ヴェテランズ アフェアーズ, ユナイテッド ステイツ デパートメント オブ ヴェテランズ アフェアーズ filed Critical ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9486—Analgesics, e.g. opiates, aspirine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
JP2013519718A 2010-07-09 2011-07-08 エンドモルフィンのμオピオイド受容体アゴニスト類似体 Expired - Fee Related JP6039553B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36303910P 2010-07-09 2010-07-09
US61/363,039 2010-07-09
PCT/US2011/043306 WO2012006497A2 (en) 2010-07-09 2011-07-08 Mu opioid receptor agonist analogs of the endomorphins

Related Child Applications (1)

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JP2016010055A Division JP6279626B2 (ja) 2010-07-09 2016-01-21 エンドモルフィンのμオピオイド受容体アゴニスト類似体

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JP2013533890A JP2013533890A (ja) 2013-08-29
JP2013533890A5 JP2013533890A5 (enExample) 2014-08-28
JP6039553B2 true JP6039553B2 (ja) 2016-12-07

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JP2013519718A Expired - Fee Related JP6039553B2 (ja) 2010-07-09 2011-07-08 エンドモルフィンのμオピオイド受容体アゴニスト類似体
JP2016010055A Expired - Fee Related JP6279626B2 (ja) 2010-07-09 2016-01-21 エンドモルフィンのμオピオイド受容体アゴニスト類似体

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JP2016010055A Expired - Fee Related JP6279626B2 (ja) 2010-07-09 2016-01-21 エンドモルフィンのμオピオイド受容体アゴニスト類似体

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US (3) US8716436B2 (enExample)
EP (2) EP2590992B1 (enExample)
JP (2) JP6039553B2 (enExample)
CA (1) CA2810170C (enExample)
CY (1) CY1120618T1 (enExample)
ES (1) ES2632787T3 (enExample)
HR (1) HRP20171119T1 (enExample)
HU (1) HUE033875T2 (enExample)
PL (1) PL2590992T3 (enExample)
PT (1) PT2590992T (enExample)
RS (1) RS56129B1 (enExample)
SI (1) SI2590992T1 (enExample)
WO (1) WO2012006497A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110065648A1 (en) * 2009-09-15 2011-03-17 Maione Theodore E Advantageous mu-opiate receptor peptide compounds
US20160176930A1 (en) 2010-07-09 2016-06-23 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
WO2014137496A1 (en) * 2013-03-08 2014-09-12 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
US20130178427A1 (en) * 2010-07-09 2013-07-11 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
US10975121B2 (en) 2017-06-24 2021-04-13 Cytogel Pharma, Llc Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
EP3681900A4 (en) 2017-09-11 2021-09-08 Protagonist Therapeutics, Inc. OPIOID AGONIST PEPTIDES AND THEIR USES
CN111511757A (zh) 2017-11-17 2020-08-07 细胞凝胶制药有限责任公司 μ阿片受体的聚合物激动剂
CN111683654A (zh) * 2017-11-30 2020-09-18 细胞凝胶制药有限责任公司 新型镇痛药物制剂及其用途
US11578100B2 (en) 2018-03-28 2023-02-14 Florida Atlantic University Research Corporation Cyclic peptides, cyclic peptide conjugates and methods of use thereof
RU2687740C1 (ru) * 2018-11-26 2019-05-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации Применение пептида Gly-His-Lys-Pro-Gly-Pro для достижения анальгетического эффекта при боли, вызванной температурным раздражением
EP3962928A4 (en) * 2019-05-03 2023-05-17 The Administrators of The Tulane Educational Fund METHODS OF TREATMENT OF OPIOID USE DISEASE
WO2023235232A2 (en) * 2022-05-31 2023-12-07 The Administrators Of The Tulane Educational Fund Glycosylated cyclic endomorphin analogs
CN116120402B (zh) * 2022-11-04 2024-03-15 深圳市维琪科技股份有限公司 一种环肽及其组合物和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9203496D0 (sv) * 1992-11-20 1992-11-20 Kabi Pharmacia Ab New oligopeptides
US5885958A (en) 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US6759520B1 (en) * 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
JP2006525942A (ja) 2002-12-23 2006-11-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ トロンビン受容体アンタゴニストとしての新規なヘテロアリールペプチド模倣物
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
US8809278B2 (en) * 2008-07-11 2014-08-19 University Of Kansas Cyclic tetrapeptides

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Publication number Publication date
ES2632787T3 (es) 2017-09-15
EP2590992B1 (en) 2017-04-26
US20180222940A1 (en) 2018-08-09
HK1246811A1 (en) 2018-09-14
CY1120618T1 (el) 2019-12-11
CA2810170C (en) 2022-01-25
EP3246333B1 (en) 2020-10-07
AU2011274522A1 (en) 2013-02-07
US8716436B2 (en) 2014-05-06
PL2590992T3 (pl) 2017-09-29
HUE033875T2 (en) 2018-01-29
EP2590992A4 (en) 2013-12-18
JP2016084357A (ja) 2016-05-19
JP2013533890A (ja) 2013-08-29
AU2011274522B2 (en) 2016-03-31
WO2012006497A3 (en) 2012-05-24
US20150315238A1 (en) 2015-11-05
HRP20171119T1 (hr) 2017-10-06
PT2590992T (pt) 2017-07-26
RS56129B1 (sr) 2017-10-31
EP3246333A1 (en) 2017-11-22
JP6279626B2 (ja) 2018-02-14
SI2590992T1 (sl) 2017-11-30
CA2810170A1 (en) 2012-01-12
AU2011274522A8 (en) 2016-04-14
EP2590992A2 (en) 2013-05-15
US20120322740A1 (en) 2012-12-20
WO2012006497A2 (en) 2012-01-12

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