JP6022311B2 - Multi-layer sheet for PTP - Google Patents

Description

  The present invention relates to a multilayer sheet for PTP having excellent moisture resistance and impact resistance.

  In the field of packaging pharmaceuticals and foods, PTP (press-through package) is widely used for packaging solid agents such as capsules and tablets, and granular foods.

  PTP, for example, after heating a transparent sheet, forming a pocket portion for storing solids such as capsules and tablets by performing pressure forming, vacuum forming, etc., after storing the capsule in the pocket portion, For example, it is a package in a form in which a foil or film of a material that can be easily torn or opened by hand, such as aluminum foil, is bonded and integrated as a lid. According to PTP, the solid agent or food stored in the pocket of the transparent sheet can be confirmed directly with the naked eye before opening, and when opening, push the solid agent etc. in the pocket with your finger to break the lid material Thus, the contents can be easily taken out.

  As a raw material for sheets used in PTP, polyvinyl chloride resin (hereinafter sometimes referred to as “PVC”) has good thermoformability, rigidity at room temperature, impact resistance, and transparency, so it has been used conventionally. It has been. However, since the moisture resistance of PVC may not be sufficient, when packaging contents that require more moisture resistance, a polypropylene resin (hereinafter sometimes referred to as “PP”) is used as an alternative to PVC. Yes.

  However, although PP is superior in moisture resistance compared to PVC, in recent years, further improvement in moisture resistance has been demanded. As a material having excellent transparency and moisture resistance, a cyclic olefin polymer (hereinafter referred to as “COP”) is also known. And cyclic olefin copolymers (hereinafter sometimes referred to as “COC”) are attracting attention as alternative materials for PVC and PP. On the other hand, while COP and COC are excellent in transparency, moisture resistance, mechanical strength, moldability and the like, problems have been pointed out that they are insufficient in impact resistance or have poor ability to take out capsules and tablets.

  Further, as PTP having excellent moisture resistance like COP and COC, a sheet made of PVC or PP and coated with latex of polyvinylidene chloride copolymer resin (hereinafter sometimes referred to as “PVDC copolymer resin”). However, when the proportion of PVDC in the PVDC copolymer resin is increased in order to improve moisture resistance, the impact resistance may be insufficient as in COP and COC. Therefore, in order to improve such problems, a sheet in which layers made of PVC are provided on both sides of a layer made of a PVDC copolymer resin has been proposed.

  For example, Patent Document 1 mainly includes a non-plasticizer soft polyvinyl chloride layer mainly composed of a vinyl chloride resin and ethylene / carbon monoxide / (meth) acrylic acid alkyl ester copolymer, and a vinylidene chloride resin. A composite film in which layers as components are laminated has been proposed. Patent Document 2 discloses a polyvinylidene chloride resin copolymerized from 91 to 99% by mass of vinylidene chloride monomer and 9 to 1% by mass of one or more monomers copolymerizable with vinylidene chloride. There has been proposed a multilayer sheet including a layer, and both outer layers of the multilayer sheet are composed of hard vinyl chloride resin layers.

Japanese Patent Laid-Open No. 02-209239 Japanese Patent Laying-Open No. 2005-112426

  However, the techniques disclosed in Patent Document 1 and Patent Document 2 are excellent in barrier properties but are not particularly referred to in terms of impact resistance. It is difficult to relate impact resistance during use.

  Accordingly, an object of the present invention is to provide a multilayer sheet for PTP which is excellent in moisture resistance and impact resistance in view of such problems of the conventional technology.

In the present invention, a layer (i) composed of a polyvinyl chloride resin (A) and a layer (ii) composed of a polyvinylidene chloride resin (B) are combined into layer (i) / layer (ii) / layer (i ), And the layer (ii) is a layer (ii) ^-1 comprising a polyvinylidene chloride resin having an absorbance ratio of 1046 cm ⁻¹ and 1070 cm ⁻¹ of 1.05 to 1.40, And a multilayer for PTP in which one or more layers (ii) -2 made of polyvinylidene chloride resin having an absorbance ratio of 1046 cm ⁻¹ and 1070 cm ⁻¹ are 0.80 to 1.05 are alternately laminated. A sheet is proposed.

  Since the multilayer sheet for PTP proposed by the present invention is excellent in moisture resistance and impact resistance, it can be suitably used for applications requiring moisture resistance among PTPs.

  Hereinafter, a multilayer sheet for PTP (hereinafter also referred to as “this sheet”) as an example of an embodiment of the present invention will be described. However, the scope of the present invention is not limited to the embodiments described below.

<Polyvinyl chloride resin (A)>
As the polyvinyl chloride resin (A) used in the present invention, a vinyl chloride resin having an arbitrary average degree of polymerization can be used, preferably 600 to 1,300. If the average degree of polymerization is 600 or more, sufficient mechanical strength can be obtained. On the other hand, if the average degree of polymerization is 1,300 or less, heat generation due to an increase in melt viscosity does not occur, and the occurrence of coloring due to decomposition is rare.
From such a viewpoint, the average degree of polymerization of the polyvinyl chloride resin (A) is more preferably 600 or more or 1,100 or less, particularly 650 or more or 900 or less. Is more preferable.

  As the polyvinyl chloride resin (A), in addition to a homopolymer of vinyl chloride (referred to as “vinyl chloride homopolymer”), a copolymer with a monomer copolymerizable with vinyl chloride (hereinafter referred to as “vinyl chloride homopolymer”). , A “vinyl chloride copolymer”), a graft copolymer obtained by graft copolymerization of vinyl chloride with a polymer other than this vinyl chloride copolymer (hereinafter referred to as a vinyl chloride graft copolymer), etc. Can be mentioned.

The vinyl chloride copolymer has a mechanical property that decreases as the content of constituent units other than vinyl chloride in the copolymer increases. Therefore, the proportion of vinyl chloride in the vinyl chloride copolymer is 60 to 60%. It is preferable that it is 99 mass%.
The vinyl chloride homopolymer and the vinyl chloride copolymer can be polymerized by an arbitrary method such as an emulsion polymerization method, a suspension polymerization method, a solution polymerization method or a bulk polymerization method.

  Here, the monomer copolymerizable with vinyl chloride may be any monomer having a reactive double bond in the molecule. For example, α-olefins such as ethylene, propylene and butylene, vinyl esters such as vinyl acetate and vinyl propionate, vinyl ethers such as butyl vinyl ether and cetyl vinyl ether, unsaturated carboxylic acids such as acrylic acid and methacrylic acid, methyl acrylate , Esters of acrylic acid or methacrylic acid such as ethyl methacrylate and phenyl methacrylate, aromatic vinyls such as styrene and α-methylstyrene, vinyl halides such as vinylidene chloride and vinyl fluoride, N-phenylmaleimide, N-substituted maleimides such as N-cyclohexylmaleimide can be used, and these can be used alone or in combination of two or more.

  As the polymer other than the vinyl chloride copolymer, any polymer that can graft-polymerize vinyl chloride may be used. For example, ethylene / vinyl acetate copolymer, ethylene / vinyl acetate / carbon monoxide copolymer, ethylene / ethyl acrylate copolymer, ethylene / ethyl acrylate / carbon monoxide copolymer, ethylene / methyl methacrylate copolymer, ethylene -A propylene copolymer, an acrylonitrile butadiene copolymer, a polyurethane, a chlorinated polyethylene, a chlorinated polypropylene etc. can be mentioned, These can be used individually or in combination of 2 or more types.

Various additives can be added to the polyvinyl chloride resin (A) within a range not impairing the effects of the present invention.
For example, in order to improve the thermal stability of the polyvinyl chloride resin (A), a Ca—Zn stabilizer can be blended. The Ca—Zn stabilizer is a mixture of a calcium fatty acid salt and a zinc fatty acid salt. Specific examples of the fatty acid include behenic acid, stearic acid, lauric acid, oleic acid, palmitic acid, ricinoleic acid, benzoic acid and the like, and can be used in combination of two or more according to the purpose. In addition, other stabilizers such as alkyltin maleate, alkyltin laurate, alkyltin mercapto and tin mercapto ester can also be used.

  Also, impact absorbers such as MBS resin, ABS resin, acrylic rubber mainly composed of butyl acrylate, lubricants such as aliphatic alcohol, fatty acid ester, fatty acid metal salt, or ultraviolet absorption of salicylic acid ester, benzophenone, benzotriazole, etc. An agent, a plasticizer, an antistatic agent, a pigment, and a resin other than PVC can be added.

<Polyvinylidene chloride resin (B)>
In the present invention, it is important to use two types of polyvinylidene chloride resins in order to achieve both impact resistance and moisture resistance. And 1046cm ^-1 / absorbance ratio of 1070 cm ^-1 is made of polyvinylidene chloride-based resin is 1.05 to 1.40 the layer (ii) ^-1, the absorbance ratio 1046cm ^-1 / 1070cm -1 is 0.80 By alternately laminating one or more layers (ii) -2 made of polyvinylidene chloride resin of 1.05, each layer (ii) -1 gives moisture resistance, and layer (ii) -2 Thus, impact resistance can be imparted. In view of impact resistance, layer (ii) -2 is preferably adjacent to layer (i).

A more preferable range of the absorbance ratio of the layer (ii) -1 at 1046 cm ⁻¹ / 1070 cm ⁻¹ is 1.06 to 1.38, and a more preferable range is 1.07 to 1.35. When the layer (ii) the absorbance ratio -1 ^{1046cm -1} / ^1070cm -1 is below this range, it is impossible to impart sufficient moisture resistance, whereas ^the absorbance ratio 1046cm ^-1 / 1070cm -1 is applied When it exceeds the range, the crystallinity becomes too high, and the transparency may be lowered. Furthermore, more preferable range of the absorbance ratio of the layer (ii) -2 of ^{1046cm -1} / ^1070cm -1 is 0.82 to 1.04, furthermore preferably from 0.85 to 1.03. If below the range the layer (ii) absorbance ratio of -2 ^{1046cm -1} / ^1070cm -1 is applied, it may significantly impair the moisture resistance, ^whereas, over the range of absorbance ratio of 1046cm ^-1 / 1070cm -1 is applied In some cases, sufficient impact resistance may not be obtained.

The absorbance ratio of 1046 cm ⁻¹ / 1070 cm ⁻¹ was calculated by the following method.
The latex of the polyvinylidene chloride resin (B) is applied to a biaxially stretched polypropylene film (hereinafter referred to as OPP film) so that the coating amount after drying is about 8 g / m ² . Next, after drying at 80 ° C. for 15 seconds, heat treatment is performed at 40 ° C. for 16 hours. Next, the spectrum of 1200 to 800 cm ⁻¹ of the OPP film coated with the polyvinylidene chloride resin (B) is measured using a Fourier transform infrared spectrophotometer. In the obtained spectrum, connected by lines to 1100 cm ^-1 and 850 cm ^-1, this line as the base peak intensity of 1046Cm ^-1 and 1070 cm ^-1 were measured, the absorbance ratio (the 1046Cm ^-1 absorbance / 1070 cm ^-1 Absorbance) was calculated. A larger absorbance ratio indicates a higher crystallinity.

  As the polyvinylidene chloride resin (B), a vinylidene chloride monomer or a copolymer with various monomers can be used. Specific examples of copolymer monomers include vinyl chloride, unsaturated carboxylic acids such as acrylic acid, methacrylic acid, fumaric acid and maleic acid, aromatic vinyl compounds such as α-methylstyrene and vinyltoluene, and (meth) acrylic. (Meth) acrylates such as methyl acrylate, ethyl (meth) acrylate, hydroxylethyl (meth) acrylate, glycidyl acrylate acrylate, (meth) acrylamide, N-methylol (meth) acrylamide ( (Meth) acrylamide, and these can be used alone or in combination of two or more. Although it does not specifically limit as a manufacturing method of the said polyvinylidene chloride type-resin (B), A well-known method, for example, an emulsion polymerization method etc., are employable. Specific examples of the polyvinylidene chloride-based resin (B) include “Saran Latex” series trade names of Asahi Kasei Chemicals Corporation.

<Method for producing this sheet>
Although the manufacturing method of this sheet | seat is not specifically limited, For example, it can manufacture with the following method.
First, the layer (i) made of the polyvinyl chloride resin (A) can be produced by a rolling method. Specifically, a blend of the polyvinyl chloride resin (A) and various additives is rolled and formed into a sheet by a rolling device such as a four-calender roll. Thereafter, the sheet is taken up by a take-up roll and gradually cooled by a plurality of cooling rolls to obtain a sheet having a predetermined thickness.

Next, the layer (ii) made of the vinylidene chloride resin (B) is applied to the layer (i) made of the polyvinyl chloride resin (A) by a known method, for example, an air knife coater, a roll coater, or a reverse gravure coater. Alternatively, layer (ii) can be applied using a doctor blade coater. Next, after preheating treatment with an infrared heater or the like, the moisture of the PVDC latex is removed by hot air drying or drum drying to form a film. At this time, although the layer (ii) can be directly applied to the layer (i), the alkyl titanate compound, the polyisocyanate compound, the polyalkyleneimine compound, and the polyurethane resin are used to improve the adhesion. An anchor coating agent such as can be used.
The layer (ii) in this sheet is preferably composed of at least two layers, more preferably at least five layers, respectively, of the layer (ii) -1 and the layer (ii) -2.

  Next, after repeatedly applying the layer (ii) so as to have a predetermined thickness on the layer (i), the method for producing the multilayer sheet of the present invention by laminating the layer (i) (layer (i) / (Anchor coating agent) / layer (ii) -1 / layer (ii) -2... / (Anchor coating agent) / layer (i)) or a predetermined thickness on layer (i) A method for producing a multilayer body by laminating the two layers (ii) of the same sheet repeatedly coated with the layer (ii) using a general adhesive (layer (i) / (anchor coating agent) / Layer (ii) -1 / layer (ii) -2.. ./Adhesive/layer (ii) -2 / layer (ii) -1 / (anchor coating agent) / layer (i)) .

  Known adhesives can be used as the adhesive, for example, solvent-soluble or water-soluble polyester resins, isocyanate resins, urethane resins, acrylic resins, vinyl alcohol resins, ethylene vinyl alcohol. Resin, vinyl-based modified resin, epoxy-based resin, oxazoline group-containing resin, modified styrene-based resin, modified silicone-based resin and the like can be used alone or in admixture of two or more. Among these, urethane resin, acrylic resin, and epoxy resin are preferably used from the viewpoint of adhesion to the polyvinylidene chloride resin (B), and among them, an epoxy resin having a small volatile component at the time of curing is used. It is particularly preferable to use it. The thickness of the adhesive is not particularly limited, but is preferably 0.004 to 0.014 mm, more preferably 0.005 to 0.013 mm, and 0.006 to 0.012 mm. More preferably it is. If the thickness of the adhesive is within the range, sufficient adhesive strength can be obtained.

<Sheet thickness>
The thickness of the sheet is not particularly limited, but for example, in consideration of workability and practicality, it is preferably 0.1 mm or more and 0.4 mm or less, and is 0.15 mm or more and 0.35 mm or less. More preferably, it is 0.2 mm or more and 0.3 mm or less. If the thickness of this multilayer sheet is 0.1 mm or more, suitable rigidity and moisture resistance of the sheet can be obtained. On the other hand, when the thickness of the sheet is 0.4 mm or less, there is no problem in taking out the medicine when used as PTP.

Moreover, it is preferable that the ratio of the thickness of the said layer (ii) to all the layers exists in the range of 5 to 50%. If the thickness of the layer (ii) is within such a range, both excellent secondary processability and moisture resistance can be achieved. In addition, the more preferable range of the ratio of the thickness of layer (ii) is 7 to 48%, and a more preferable range is 10 to 45%.
The ratio of the thickness of the layer (ii) -2 in the layer (ii) is preferably in the range of 30 to 70%. If the ratio of the thickness of the layer (ii) -2 in the layer (ii) is within such a range, sufficient moisture resistance and impact resistance can be obtained. In addition, the more preferable range of the ratio of the thickness of layer (ii) -2 which occupies in layer (ii) is 35 to 65%, and a more preferable range is 40 to 60%.

  Moreover, it is preferable that the thickness per one layer of said layer (ii) -1 and layer (ii) -2 is 0.002-0.040 mm. If the thickness per layer of layer (ii) -1 and layer (ii) -2 is within such a range, both impact resistance and moisture resistance can be achieved. A more preferable range of the thickness per layer of the layer (ii) -1 and the layer (ii) -2 is 0.003 to 0.038 mm, and a more preferable range is 0.004 to 0.035 mm.

  Further, in order to further improve the impact resistance, heat resistance, rigidity, etc. within a range not impairing the effects of the present invention, it is possible to provide a layer other than the layer (i) and the layer (ii). . Examples of the layers other than the layer (i) and the layer (ii) include a layer made of a resin such as a polyolefin resin, a polystyrene resin, a polyester resin, a polyolefin resin, or a polystyrene thermoplastic elastomer. Can be given.

<Physical properties of this sheet>
When this sheet is used for PTP applications, the water vapor transmission rate at a thickness of 0.26 mm measured at a temperature of 40 ° C. and a relative humidity of 90% based on the JIS K7129B method is 0.30 g from the viewpoint of preventing deterioration of the contents due to moisture. / is preferably ^(m 2 · 24 hr) or less, among others 0.29 g / more preferably ^(m 2 · 24 hr) or less, particularly 0.28g / ^(m 2 · 24 hours) among them below Is more preferable. If the water vapor transmission rate at a thickness of 0.26 mm is 0.30 g / (m ² · 24 hours) or less, a product having sufficient moisture resistance as PTP can be obtained.

  Furthermore, from the viewpoint of content protection, the tensile elongation at break measured in accordance with JIS K6734 is preferably 160% or more in both the longitudinal direction and the transverse direction, more preferably 180% or more, and particularly preferably 200 % Or more is even more preferable. In addition, the hydroshot fracture energy at 23 ° C. is preferably 10 kgf · mm or more, more preferably 12 kgf · mm or more, and particularly preferably 15 kgf · mm or more. In addition, the hydroshot fracture energy at 0 ° C. is preferably 4 kgf · mm or more, more preferably 4.5 kgf · mm or more, and even more preferably 5 kgf · mm or more. Sufficient impact resistance can be obtained as long as the tensile elongation at break and hydroshot fracture energy are within the range, and damage to the contents during transportation and storage can be prevented.

<Use of this sheet>
This sheet can be formed into various shaped molded bodies by vacuum forming, compressed air forming, compressed air vacuum forming, press forming, and other thermoforming, and suitable for producing and using a molded body for PTP packaging. Can do.

  As a method of producing a molded sheet for PTP packaging, the multilayer sheet of the present invention is heated and softened with a heating plate before molding, the sheet is sandwiched with a molding die, and compressed air is injected to conform to the concave mold of the molding die. Then, a large number of pockets may be formed in the sheet surface. In addition, the moldability can be assisted by raising and lowering the plug at an appropriate timing when pressurized air is injected as required.

  In addition to performing the thermoforming, an aluminum foil, an aluminum vapor deposition film, a plastic film (for example, a biaxially stretched polypropylene film, a nylon film, an ethylene-vinyl alcohol copolymer film) or the like is laminated on the sheet surface, the back surface or both surfaces. It is also possible. In addition, after forming a composite sheet | seat by laminating | stacking aluminum foil, the said various film, etc. on the sheet | seat surface or the back surface or both surfaces, this can also be thermoformed.

  Further, for the purpose of improving the designability and secondary processability of the product, the sheet surface may be subjected to processing such as embossing or matting. In this case, even if a mirror-like sheet is once created and then processed with an embossing roll or a matte roll, the cast roll is changed to an embossing roll or a matte roll during extrusion molding. May be. As long as the gist of the present invention is not impaired, the surface of the sheet may be coated with an antistatic agent, silicone, wax, etc., a film may be formed using a surface protective sheet for the purpose of preventing fouling adhesion, etc. It is also possible. Any currently known means can be adopted as the means for forming the printed layer.

  Since this multilayer sheet is excellent in all of moisture resistance, impact resistance and secondary processability, it is particularly moisture-proof as PTP packaging for packaging solid drugs such as capsules and tablets, granular foods, etc. in the field of pharmaceutical packaging. Can be suitably used for applications that require.

  Examples are shown below, but the present invention is not limited by these. In addition, the various measured value and evaluation about the raw material and test piece which are displayed in this specification were performed as follows. Here, the flow direction in manufacturing the sheet is referred to as the vertical direction, and the orthogonal direction is referred to as the horizontal direction.

(1) Water vapor transmission rate Based on JIS K7129B, using a PERMATRAN W 3/31 manufactured by MOCON, water vapor transmission rate was measured for a sample having a thickness of 0.3 mm in an atmosphere of 40 ° C. and 90% RH. A water vapor transmission rate of 0.30 g / (m ² · 24 hours) or less was accepted.

(2) Tensile breaking elongation The tensile breaking elongation was measured based on JIS K6734 using a sample for evaluation of length 200 mm x width 10 mm x thickness 0.26 mm. The elongation at break was measured at an ambient temperature of 23 ° C., a relative humidity of 50%, a pulling speed of 50 mm / min, and a grip interval of 80 mm, and the average value at n = 6 was determined. The tensile elongation at break was determined to be 160% or more in both the vertical and horizontal directions.

(3) Hydro-shot fracture energy Using a hydro-shot high-speed impact tester (“HTM-1 type” manufactured by Shimadzu Corporation), a sheet cut into a size of 100 mm in the vertical direction and 100 mm in the horizontal direction is used as a sample and fixed with a clamp. The impact energy (kgf · mm) at the time of breaking the sample was measured by applying an impact by dropping a striker having a diameter of ½ inch in the center of the sheet at a dropping speed of 3 m / sec at a temperature of 23 ° C. A fracture energy of 10 kgf · mm or more at 23 ° C. and 4 kgf · mm or more at 0 ° C. was regarded as acceptable.

<Materials used>
[Polyvinyl chloride resin (A)]
(A) -1: Rigid PVC sheet (Vinyl foil C-0459, thickness = 0.09 mm)

[Polyvinylidene chloride resin (B)]
(B) -1: Saran latex L574A (absorbance ratio = 1.10)
(B) -2: Saran latex L580C (absorbance ratio = 0.96)

Example 1
Using (A) as the layer (i), (B) -1 as the layer (ii) -1 and (B) -2 as the layer (ii) -2, the anchor coating agent (Mitsui Chemical: Takelac A-616 and Takenate A-65 (16: 1 mixed dilution) were coated using a gravure coater and dried, then (B) -1 and (B) -2 were air knife coaters A two-layer sheet of layer (i) / layer (ii) was obtained by coating and drying using Next, the two-layer sheet of layer (i) / layer (ii) is bonded to one layer (ii) surface with an adhesive (Toyo Morton Co., Ltd .: TM-569 and CAT-RT37 100: 8.9 mixed dilution) Is coated and dried using a gravure coater and then laminated so that layer (ii) is on the inside, layer (i) / layer (ii) -1 / layer (ii) -2 / layer (ii)- 1 / layer (ii) -2 / layer (ii) -1 / layer (ii) -2 / layer (ii) -1 / layer (ii) -2 / adhesive / layer (ii) -2 / layer (ii ) -1 / layer (ii) -2 / layer (ii) -1 / layer (ii) -2 / layer (ii) -1 / layer (ii) -2 / layer (ii) -1 / layer (i) The thickness is 0.09 / 0.0045 / 0.0045 / 0.0045 / 0.0045 / 0.0045 / 0.0045 / 0.0045 / 0.0045 / 0.008 / 0.0045 / 0. .0045 / 0.0045 / 0.0045 / .0045 / 0.0045 / 0.0045 / 0.0045 / 0.09mm was formed a multilayer sheet so that the (total thickness = 0.26 mm). The obtained sheet was evaluated for moisture resistance and impact resistance. The results are shown in Table 1.

(Example 2)
Using (A) as layer (i), (B) -1 as layer (ii) -1 and (B) -2 as layer (ii) -2, layer (i) / Layer (ii) -2 / layer (ii) -1 / adhesive / layer (ii) -1 / layer (ii) -2 / layer (i) has a thickness of 0.09 / 0.024 / 0. A multilayer sheet was formed so as to be 012 / 0.008 / 0.012 / 0.024 / 0.09 mm (total thickness = 0.26 mm). The obtained sheet was evaluated for moisture resistance and impact resistance. The results are shown in Table 1.

(Example 3)
Using (A) as layer (i), (B) -1 as layer (ii) -1 and (B) -2 as layer (ii) -2, layer (i) / The thickness of the layer (ii) -1 / adhesive / layer (ii) -2 / layer (i) is 0.09 / 0.036 / 0.008 / 0.036 / 0.09 mm (total thickness = The multilayer sheet was formed so as to be 0.26 mm). The obtained sheet was evaluated for moisture resistance and impact resistance. The results are shown in Table 1.

(Comparative Example 1)
Layer (i) / layer (ii) / adhesive / layer (ii) / layer in the same manner as in Example 1, using only (A) as layer (i) and (B) -1 as layer (ii) A multilayer sheet was formed so that the thickness in the configuration (i) was 0.09 / 0.036 / 0.008 / 0.036 / 0.09 mm (total thickness = 0.26 mm). The obtained sheet was evaluated for moisture resistance and impact resistance. The results are shown in Table 1.

(Comparative Example 2)
Layer (i) / layer (ii) / adhesive / layer (ii) / layer in the same manner as in Example 1, using only (A) as layer (i) and (B) -2 as layer (ii) A multilayer sheet was formed so that the thickness in the configuration (i) was 0.09 / 0.036 / 0.008 / 0.036 / 0.09 mm (total thickness = 0.26 mm). The obtained sheet was evaluated for moisture resistance and impact resistance. The results are shown in Table 1.

  The multilayer sheet for PTP of the present invention can be suitably used for applications that require high moisture resistance and impact resistance, such as solid agents such as capsules and tablets, and packages such as granular foods.

Claims (3)

Layer (i) made of polyvinyl chloride resin (A) and layer (ii) made of polyvinylidene chloride resin (B) are laminated in the order of layer (i) / layer (ii) / layer (i). And the layer (ii) is a layer (ii) ^-1 made of a polyvinylidene chloride resin having an absorbance ratio of 1046 cm ⁻¹ and 1070 cm ⁻¹ of 1.05 to 1.40, and 1046 cm ^{−. A} multilayer sheet for PTP obtained by alternately laminating one or more layers (ii) -2 made of polyvinylidene chloride resin having an absorbance ratio of ¹ and 1070 cm ⁻¹ of 0.80 to 1.05.   The ratio of the thickness of the layer (ii) in all layers is 5 to 50%, and the ratio of the thickness of the layer (ii) -2 in the layer (ii) is 30 to 70%. The multilayer sheet for PTP according to claim 1, wherein the multilayer sheet is for PTP.   3. The PTP multilayer sheet according to claim 1, wherein the layer (ii) -1 and the layer (ii) -2 have a thickness of 0.002 to 0.040 mm per layer.