JP6006473B2 - 高密度集束超音波ビームを追尾し、誘導するシステム及び方法 - Google Patents
高密度集束超音波ビームを追尾し、誘導するシステム及び方法 Download PDFInfo
- Publication number
- JP6006473B2 JP6006473B2 JP2010539022A JP2010539022A JP6006473B2 JP 6006473 B2 JP6006473 B2 JP 6006473B2 JP 2010539022 A JP2010539022 A JP 2010539022A JP 2010539022 A JP2010539022 A JP 2010539022A JP 6006473 B2 JP6006473 B2 JP 6006473B2
- Authority
- JP
- Japan
- Prior art keywords
- transducer
- hifu
- focus
- target area
- processor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/485—Diagnostic techniques involving measuring strain or elastic properties
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Surgical Instruments (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1594707P | 2007-12-21 | 2007-12-21 | |
| US61/015,947 | 2007-12-21 | ||
| PCT/IB2008/055391 WO2009081339A1 (en) | 2007-12-21 | 2008-12-17 | Systems and methods for tracking and guiding high intensity focused ultrasound beams |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507585A JP2011507585A (ja) | 2011-03-10 |
| JP2011507585A5 JP2011507585A5 (enExample) | 2012-02-09 |
| JP6006473B2 true JP6006473B2 (ja) | 2016-10-12 |
Family
ID=40475083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539022A Expired - Fee Related JP6006473B2 (ja) | 2007-12-21 | 2008-12-17 | 高密度集束超音波ビームを追尾し、誘導するシステム及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9420988B2 (enExample) |
| EP (1) | EP2240081A1 (enExample) |
| JP (1) | JP6006473B2 (enExample) |
| CN (1) | CN101902971B (enExample) |
| WO (1) | WO2009081339A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8409099B2 (en) | 2004-08-26 | 2013-04-02 | Insightec Ltd. | Focused ultrasound system for surrounding a body tissue mass and treatment method |
| CN101313354B (zh) | 2005-11-23 | 2012-02-15 | 因赛泰克有限公司 | 超高密度超声阵列中的分级切换 |
| JP5255964B2 (ja) * | 2008-09-18 | 2013-08-07 | 株式会社日立メディコ | 手術支援装置 |
| US8425424B2 (en) | 2008-11-19 | 2013-04-23 | Inightee Ltd. | Closed-loop clot lysis |
| JP5679988B2 (ja) * | 2008-12-22 | 2015-03-04 | コーニンクレッカ フィリップス エヌ ヴェ | 印加された力に対する組織変位のリアルタイムの監視のためのアブレーション制御装置 |
| US8448499B2 (en) | 2008-12-23 | 2013-05-28 | C A Casyso Ag | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method |
| US8343050B2 (en) * | 2009-05-04 | 2013-01-01 | Siemens Medical Solutions Usa, Inc. | Feedback in medical ultrasound imaging for high intensity focused ultrasound |
| WO2011024074A2 (en) | 2009-08-26 | 2011-03-03 | Insightec Ltd. | Asymmetric phased-array ultrasound transducer |
| US8469904B2 (en) | 2009-10-12 | 2013-06-25 | Kona Medical, Inc. | Energetic modulation of nerves |
| US8986231B2 (en) | 2009-10-12 | 2015-03-24 | Kona Medical, Inc. | Energetic modulation of nerves |
| US8986211B2 (en) | 2009-10-12 | 2015-03-24 | Kona Medical, Inc. | Energetic modulation of nerves |
| US20160059044A1 (en) | 2009-10-12 | 2016-03-03 | Kona Medical, Inc. | Energy delivery to intraparenchymal regions of the kidney to treat hypertension |
| US9174065B2 (en) | 2009-10-12 | 2015-11-03 | Kona Medical, Inc. | Energetic modulation of nerves |
| US20110118600A1 (en) | 2009-11-16 | 2011-05-19 | Michael Gertner | External Autonomic Modulation |
| US11998266B2 (en) | 2009-10-12 | 2024-06-04 | Otsuka Medical Devices Co., Ltd | Intravascular energy delivery |
| US9119951B2 (en) | 2009-10-12 | 2015-09-01 | Kona Medical, Inc. | Energetic modulation of nerves |
| US8295912B2 (en) | 2009-10-12 | 2012-10-23 | Kona Medical, Inc. | Method and system to inhibit a function of a nerve traveling with an artery |
| WO2011045669A2 (en) | 2009-10-14 | 2011-04-21 | Insightec Ltd. | Mapping ultrasound transducers |
| DE102009049403A1 (de) * | 2009-10-14 | 2011-04-28 | Siemens Aktiengesellschaft | Positioniervorrichtung |
| JP5681727B2 (ja) | 2009-12-28 | 2015-03-11 | コーニンクレッカ フィリップス エヌ ヴェ | 高密度焦点式超音波トランスデューサ最適化 |
| DK2555704T3 (da) | 2010-04-08 | 2019-08-05 | Hemosonics Llc | Visning af hæmostatiske parametre |
| US9852727B2 (en) | 2010-04-28 | 2017-12-26 | Insightec, Ltd. | Multi-segment ultrasound transducers |
| US8932237B2 (en) * | 2010-04-28 | 2015-01-13 | Insightec, Ltd. | Efficient ultrasound focusing |
| JP2012045198A (ja) * | 2010-08-27 | 2012-03-08 | Hitachi Medical Corp | 治療支援装置及び治療支援システム |
| WO2012080909A1 (en) * | 2010-12-14 | 2012-06-21 | Koninklijke Philips Electronics N.V. | Monitoring for postpartum hemorrhage |
| BR112013018044A2 (pt) * | 2011-01-18 | 2019-09-03 | Koninl Philips Electronics Nv | aparelho terapêutico, produto de programa de computador e método de renderização de uma região alvo atingível |
| US8968205B2 (en) * | 2011-02-10 | 2015-03-03 | Siemens Medical Solutions Usa, Inc. | Sub-aperture control in high intensity focused ultrasound |
| BR112013020675B1 (pt) | 2011-02-15 | 2022-01-25 | Hemosonics, Llc | Dispositivos e método para avaliação de hemostasia |
| WO2013105987A2 (en) | 2011-02-15 | 2013-07-18 | Hemosonics, Llc | Characterization of blood hemostasis and oxygen transport parameters |
| CN102670264B (zh) * | 2011-03-15 | 2015-05-13 | 迈克尔·格特纳 | 神经的能量调节 |
| US20120294767A1 (en) | 2011-05-19 | 2012-11-22 | Hemosonics Llc | Portable hemostasis analyzer |
| CN102871645A (zh) * | 2011-07-11 | 2013-01-16 | 浙江大学 | 近红外成像超声血管治疗仪 |
| AU2012326218B2 (en) | 2011-10-17 | 2017-03-09 | Butterfly Network, Inc. | Transmissive imaging and related apparatus and methods |
| CN103931007A (zh) * | 2011-11-15 | 2014-07-16 | 皇家飞利浦有限公司 | 包括压电供能的x射线源的电子短距治疗辐射施加装置 |
| US20130296743A1 (en) * | 2012-05-02 | 2013-11-07 | Siemens Medical Solutions Usa, Inc. | Ultrasound for Therapy Control or Monitoring |
| BR112014030634A2 (pt) | 2012-06-11 | 2017-06-27 | Koninklijke Philips Nv | aparelho médico e produto de programa de computador |
| KR20130143434A (ko) * | 2012-06-21 | 2013-12-31 | 삼성전자주식회사 | 고강도 집속 초음파의 초점을 결정하는 방법 및 장치 |
| CN103537016B (zh) * | 2012-07-13 | 2016-09-21 | 重庆融海超声医学工程研究中心有限公司 | 超声换能器焦点的校正方法、装置及超声治疗设备 |
| WO2014013285A1 (en) | 2012-07-16 | 2014-01-23 | Super Sonic Imagine | Apparatus and method for determining optimal positions of a hifu probe |
| JP5590493B1 (ja) * | 2013-05-30 | 2014-09-17 | 国立大学法人 東京大学 | 超音波医用装置 |
| EP3013242B1 (en) * | 2013-06-28 | 2018-11-07 | Koninklijke Philips N.V. | Ultrasound acquisition feedback guidance to a target view |
| WO2015048767A1 (en) | 2013-09-30 | 2015-04-02 | Grisell Ronald | Automatic focused assessment with sonography for trauma exams |
| US10539579B2 (en) | 2014-09-29 | 2020-01-21 | C A Casyso Gmbh | Blood testing system and method |
| US10175225B2 (en) | 2014-09-29 | 2019-01-08 | C A Casyso Ag | Blood testing system and method |
| US10925579B2 (en) | 2014-11-05 | 2021-02-23 | Otsuka Medical Devices Co., Ltd. | Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery |
| US9726647B2 (en) | 2015-03-17 | 2017-08-08 | Hemosonics, Llc | Determining mechanical properties via ultrasound-induced resonance |
| EP3277378B1 (en) * | 2015-04-02 | 2025-05-21 | Cardiawave | Apparatus for treating valvular disease |
| CN104815399B (zh) * | 2015-04-03 | 2018-04-17 | 西安交通大学 | 基于六轴机械臂的高强度聚焦超声治疗引导和控制系统及方法 |
| CN105054972A (zh) * | 2015-07-20 | 2015-11-18 | 东南大学 | 一种超声诊疗系统及利用该系统治疗肿瘤的方法 |
| CN105193452B (zh) * | 2015-10-10 | 2018-11-23 | 北京长江源科技发展有限公司 | 基于超声影像监控体位移动的hifu治疗设备 |
| WO2017101288A1 (zh) * | 2015-12-17 | 2017-06-22 | 南京广慈医疗科技有限公司 | 高强度聚焦超声系统在预防原发性高血压方面的用途 |
| US12350526B2 (en) | 2016-07-17 | 2025-07-08 | Nina Medical Ltd | Doppler guided ultrasound therapy |
| WO2018031754A1 (en) | 2016-08-10 | 2018-02-15 | U.S. Government As Represented By The Secretary Of The Army | Automated three and four-dimensional ultrasound quantification and surveillance of free fluid in body cavities and intravascular volume |
| PT3612838T (pt) | 2017-04-20 | 2024-10-15 | Hemosonics Llc | Sistema descartável para a análise da função hemostática |
| WO2018227088A1 (en) | 2017-06-08 | 2018-12-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and methods for generating an elastogram of brain tissue using mesoscopic wavelength ultrasound |
| CN110831665B (zh) * | 2017-06-29 | 2022-03-04 | 医视特有限公司 | 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统 |
| US11806496B2 (en) * | 2017-12-11 | 2023-11-07 | Insightec Ltd. | Adaptive, closed-loop ultrasound therapy |
| WO2020068306A1 (en) | 2018-08-21 | 2020-04-02 | The Government Of The United States, As Represented By The Secretary Of The Army | Systems and methods for ultrasound imaging |
| CN109259822B (zh) * | 2018-11-07 | 2019-12-24 | 西安交通大学 | 基于被动空化检测成像的聚焦超声治疗三维引导与动态实时监控系统及方法 |
| CN110200657B (zh) * | 2019-05-27 | 2020-09-08 | 重庆海扶医疗科技股份有限公司 | B超影像焦点及聚焦超声焦点校准装置以及方法 |
| EP3986548A1 (en) * | 2019-06-19 | 2022-04-27 | Theraclion SA | Device and method for treatment of a patient by high-intensity focused ultrasound (hifu) |
| US20210236858A1 (en) * | 2020-02-04 | 2021-08-05 | General Electric Company | Automated ultrasound bleeding detection and treatment |
| CN111863227A (zh) * | 2020-06-16 | 2020-10-30 | 中国科学院深圳先进技术研究院 | 超声聚焦控制方法、装置、电子设备及存储介质 |
| CN112023284A (zh) * | 2020-09-01 | 2020-12-04 | 中国科学院声学研究所 | 一种用于聚焦声动力疗法的焦点位置实时监测方法 |
| DE102022200740B3 (de) * | 2022-01-24 | 2023-01-26 | Siemens Healthcare Gmbh | Therapievorrichtung zur Ultraschallbehandlung |
| CN119633277A (zh) * | 2025-01-21 | 2025-03-18 | 四川大学 | 关节滑膜消融柔性聚焦超声换能器及其动态补偿方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5993389A (en) * | 1995-05-22 | 1999-11-30 | Ths International, Inc. | Devices for providing acoustic hemostasis |
| JP2002516586A (ja) * | 1997-06-23 | 2002-06-04 | ティーエイチエス インターナショナル,インコーポレイテッド | 音響止血を提供する方法及びその装置 |
| US6036643A (en) | 1998-05-14 | 2000-03-14 | Advanced Technology Laboratories, Inc. | Ultrasonic harmonic doppler imaging |
| US6425867B1 (en) * | 1998-09-18 | 2002-07-30 | University Of Washington | Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy |
| US6488626B1 (en) * | 1999-04-07 | 2002-12-03 | Riverside Research Institute | Ultrasonic sensing by induced tissue motion |
| US7520856B2 (en) | 1999-09-17 | 2009-04-21 | University Of Washington | Image guided high intensity focused ultrasound device for therapy in obstetrics and gynecology |
| US6846290B2 (en) * | 2002-05-14 | 2005-01-25 | Riverside Research Institute | Ultrasound method and system |
| US7311701B2 (en) * | 2003-06-10 | 2007-12-25 | Cierra, Inc. | Methods and apparatus for non-invasively treating atrial fibrillation using high intensity focused ultrasound |
| US20050215899A1 (en) * | 2004-01-15 | 2005-09-29 | Trahey Gregg E | Methods, systems, and computer program products for acoustic radiation force impulse (ARFI) imaging of ablated tissue |
| CN100542635C (zh) * | 2005-01-10 | 2009-09-23 | 重庆海扶(Hifu)技术有限公司 | 高强度聚焦超声治疗装置和方法 |
| TW200732011A (en) * | 2006-02-20 | 2007-09-01 | Chiung-Nien Chen | Orientation system for focal point position of non-invasive therapeutical ultrasonic |
| JP4489048B2 (ja) | 2006-04-27 | 2010-06-23 | 株式会社日立メディコ | 超音波治療装置 |
| US20080097207A1 (en) * | 2006-09-12 | 2008-04-24 | Siemens Medical Solutions Usa, Inc. | Ultrasound therapy monitoring with diagnostic ultrasound |
| JP4160622B2 (ja) | 2007-01-31 | 2008-10-01 | 株式会社東芝 | 超音波治療装置 |
-
2008
- 2008-12-17 EP EP08864857A patent/EP2240081A1/en not_active Withdrawn
- 2008-12-17 CN CN2008801222948A patent/CN101902971B/zh not_active Expired - Fee Related
- 2008-12-17 US US12/809,617 patent/US9420988B2/en active Active
- 2008-12-17 JP JP2010539022A patent/JP6006473B2/ja not_active Expired - Fee Related
- 2008-12-17 WO PCT/IB2008/055391 patent/WO2009081339A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN101902971B (zh) | 2013-03-13 |
| US9420988B2 (en) | 2016-08-23 |
| EP2240081A1 (en) | 2010-10-20 |
| WO2009081339A1 (en) | 2009-07-02 |
| JP2011507585A (ja) | 2011-03-10 |
| CN101902971A (zh) | 2010-12-01 |
| US20100274130A1 (en) | 2010-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6006473B2 (ja) | 高密度集束超音波ビームを追尾し、誘導するシステム及び方法 | |
| RU2707037C2 (ru) | Система и способ адаптивной абляции и терапии на основании эластографического мониторинга | |
| JP4833997B2 (ja) | 高強度集束超音波療法のための方法および装置 | |
| CN113710163B (zh) | 用于调节超声手术中的微泡的系统和方法 | |
| US9198635B2 (en) | Method and apparatus for preparing organs and tissues for laparoscopic surgery | |
| EP2352558B1 (en) | System for ultrasound therapy | |
| JP3373602B2 (ja) | 超音波治療装置 | |
| KR20140113172A (ko) | 초음파 조사 계획 수립 방법 및 장치, 초음파 조사 방법 | |
| JP2013022450A (ja) | 集束超音波治療装置及びその焦点制御方法 | |
| JPH0747079A (ja) | 超音波治療装置 | |
| KR20120131552A (ko) | 초음파를 이용한 치료 및 진단 방법 및 시스템 | |
| JP2020518385A5 (enExample) | ||
| RU2608433C2 (ru) | Устройство, выполняющее тестовые обработки ультразвуком с использованием высокоинтенсивного фокусированного ультразвука | |
| KR20140008103A (ko) | 집속 초음파 치료 장치에 제공되는 치료 계획을 생성하는 방법 및 장치. | |
| JP6599885B2 (ja) | 正規化された変位差に基づく熱的破壊痕サイズ制御のための手法 | |
| US20160082293A1 (en) | Hifu treatment optimization in vicinity of sensitive zones | |
| JP2000210300A (ja) | 超音波治療装置 | |
| Kisting et al. | Imaging for targeting, monitoring, and assessment after histotripsy: a non-invasive, non-thermal therapy for cancer | |
| JP2012529962A (ja) | 粘弾性媒質を撮像するための結像系 | |
| EP2698183A2 (en) | Apparatus for ultrasonic therapeutic treatment, and method for driving the apparatus | |
| Zhu et al. | Quantitative assessment of damage during MCET: a parametric study in a rodent model | |
| KR20140094955A (ko) | 온도 영상 생성 방법 및 장치, 이를 포함한 초음파 시스템 | |
| US20240122570A1 (en) | Device and method for characterizing the evolution of the fluid flow rate profile at a treatment area by energy emission | |
| TAHIR et al. | SIMULATION AND OPTIMIZATION OF HIFU TRANSDUCER FOR LIVER TUMOR ABLATION | |
| Mast et al. | Acoustic propagation effects in therapeutic ultrasound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111214 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20111214 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20130225 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130228 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130530 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130606 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130828 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131001 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20131224 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140107 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20140828 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141222 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20150106 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20150320 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160224 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160531 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160715 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160909 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6006473 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |