JP5997257B2 - 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法 - Google Patents

単一サイクルでコンディショニングおよび化学選択を組み合わせる方法 Download PDF

Info

Publication number
JP5997257B2
JP5997257B2 JP2014506605A JP2014506605A JP5997257B2 JP 5997257 B2 JP5997257 B2 JP 5997257B2 JP 2014506605 A JP2014506605 A JP 2014506605A JP 2014506605 A JP2014506605 A JP 2014506605A JP 5997257 B2 JP5997257 B2 JP 5997257B2
Authority
JP
Japan
Prior art keywords
hprt
deficient
hsc
subject
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014506605A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014512391A (ja
JP2014512391A5 (enrdf_load_stackoverflow
Inventor
典之 笠原
典之 笠原
ロバート エイチ． シストル
ロバート エイチ． シストル
カトリーン ハッケ
カトリーン ハッケ
アコス シャークメアリ
アコス シャークメアリ
ガイ エム． クルックス
ガイ エム． クルックス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of JP2014512391A publication Critical patent/JP2014512391A/ja
Publication of JP2014512391A5 publication Critical patent/JP2014512391A5/ja
Application granted granted Critical
Publication of JP5997257B2 publication Critical patent/JP5997257B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014506605A 2011-04-20 2012-04-20 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法 Expired - Fee Related JP5997257B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477440P 2011-04-20 2011-04-20
US61/477,440 2011-04-20
PCT/US2012/034586 WO2012145723A1 (en) 2011-04-20 2012-04-20 Method for combined conditioning and chemoselection in a single cycle

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016164295A Division JP6266716B2 (ja) 2011-04-20 2016-08-25 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法

Publications (3)

Publication Number Publication Date
JP2014512391A JP2014512391A (ja) 2014-05-22
JP2014512391A5 JP2014512391A5 (enrdf_load_stackoverflow) 2015-06-11
JP5997257B2 true JP5997257B2 (ja) 2016-09-28

Family

ID=47041955

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2014506605A Expired - Fee Related JP5997257B2 (ja) 2011-04-20 2012-04-20 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法
JP2016164295A Expired - Fee Related JP6266716B2 (ja) 2011-04-20 2016-08-25 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法
JP2017243476A Expired - Fee Related JP6560332B2 (ja) 2011-04-20 2017-12-20 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法
JP2019132856A Expired - Fee Related JP6799117B2 (ja) 2011-04-20 2019-07-18 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2016164295A Expired - Fee Related JP6266716B2 (ja) 2011-04-20 2016-08-25 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法
JP2017243476A Expired - Fee Related JP6560332B2 (ja) 2011-04-20 2017-12-20 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法
JP2019132856A Expired - Fee Related JP6799117B2 (ja) 2011-04-20 2019-07-18 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法

Country Status (11)

Country Link
US (1) US9439928B2 (enrdf_load_stackoverflow)
EP (3) EP3384912B1 (enrdf_load_stackoverflow)
JP (4) JP5997257B2 (enrdf_load_stackoverflow)
AU (3) AU2012245269B2 (enrdf_load_stackoverflow)
CA (1) CA2861440C (enrdf_load_stackoverflow)
DK (1) DK2699247T3 (enrdf_load_stackoverflow)
ES (1) ES2672693T3 (enrdf_load_stackoverflow)
PL (1) PL2699247T3 (enrdf_load_stackoverflow)
RU (2) RU2728867C2 (enrdf_load_stackoverflow)
TR (1) TR201808037T4 (enrdf_load_stackoverflow)
WO (1) WO2012145723A1 (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017008090A (ja) * 2011-04-20 2017-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9682106B2 (en) * 2011-04-20 2017-06-20 The Regents Of The University Of California Method for combined conditioning and chemoselection in a single cycle
EP3177294B1 (en) * 2014-08-07 2022-03-23 Laevoroc Immunology AG Compositions comprising a pnp inhibitor for use in the treatment of the relapse of malignancy following hematopoietic stem cell transplant
US20180140606A1 (en) * 2016-11-18 2018-05-24 Calimmune, Inc. In Vivo Chemoselection with Low Dose Thioguanine
JP6783674B2 (ja) 2017-01-20 2020-11-11 株式会社日立ハイテク 自動分析装置、自動分析装置における廃液方法、及び、三方電磁弁
MX2020000676A (es) * 2017-07-18 2021-05-14 Csl Behring Gene Therapy Inc Composiciones y metodos para tratar beta-hemoglobinopatias.
US10426798B2 (en) * 2017-07-18 2019-10-01 Calimmune, Inc. Modulatable switch for selection of donor modified cells
KR102733714B1 (ko) 2017-10-09 2024-11-26 스토워스 인스티튜트 포 메디컬 리서치 세포 집단의 증대를 위한 방법 및 조성물
EP3897831A1 (en) * 2018-12-23 2021-10-27 CSL Behring LLC Donor t-cells with kill switch
KR20210118402A (ko) * 2018-12-23 2021-09-30 씨에스엘 베링 엘엘씨 위스콧-알드리치(Wiskott-Aldrich) 증후군에 대한 조혈 줄기 세포-유전자 치료요법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965126A (en) 1996-03-25 1999-10-12 The Penn State Research Foundation use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents
WO1997043900A1 (en) * 1996-05-24 1997-11-27 The President And Fellows Of Harvard College In vivo selection
WO1998019540A1 (en) 1996-11-04 1998-05-14 Saint Jude Children's Research Hospital In vivo selection of primitive hematopoietic cells
JP2001523645A (ja) * 1997-11-14 2001-11-27 ザ・ゼネラル・ホスピタル・コーポレイション 血液学的疾患の処置
GB9904281D0 (en) * 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US20030032003A1 (en) 2000-02-02 2003-02-13 Schiestl Robert H. In vivo selection
CA2428721A1 (en) 2000-11-14 2002-05-23 The General Hospital Corporation Blockade of t cell migration into epithelial gvhd target tissues
US7037900B2 (en) * 2001-10-12 2006-05-02 Supergen, Inc. Composition and method for treating graft-versus-host disease
ES2672693T3 (es) * 2011-04-20 2018-06-15 The Regents Of The University Of California Método para el acondicionamiento y quimioselección combinadas en un único ciclo

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017008090A (ja) * 2011-04-20 2017-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法
JP2018044007A (ja) * 2011-04-20 2018-03-22 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法

Also Published As

Publication number Publication date
AU2012245269B2 (en) 2016-09-29
RU2017104621A (ru) 2018-08-15
EP3799876A1 (en) 2021-04-07
WO2012145723A1 (en) 2012-10-26
AU2016259368A1 (en) 2016-12-08
US9439928B2 (en) 2016-09-13
JP6799117B2 (ja) 2020-12-09
JP2017008090A (ja) 2017-01-12
EP3384912B1 (en) 2020-11-11
JP6266716B2 (ja) 2018-01-24
AU2018200967B2 (en) 2019-08-15
JP2019199476A (ja) 2019-11-21
CA2861440A1 (en) 2012-10-26
JP2014512391A (ja) 2014-05-22
EP3384912A1 (en) 2018-10-10
RU2728867C2 (ru) 2020-07-31
HK1256048A1 (en) 2019-09-13
AU2012245269A1 (en) 2013-12-05
ES2672693T3 (es) 2018-06-15
RU2017104621A3 (enrdf_load_stackoverflow) 2020-06-04
RU2611396C2 (ru) 2017-02-21
RU2013151632A (ru) 2015-05-27
DK2699247T3 (en) 2018-06-14
EP2699247A4 (en) 2014-11-19
PL2699247T3 (pl) 2018-09-28
AU2018200967A1 (en) 2018-03-01
AU2016259368B2 (en) 2017-12-14
EP2699247B1 (en) 2018-03-07
JP2018044007A (ja) 2018-03-22
CA2861440C (en) 2022-11-15
JP6560332B2 (ja) 2019-08-14
US20140154225A1 (en) 2014-06-05
TR201808037T4 (tr) 2018-06-21
EP2699247A1 (en) 2014-02-26

Similar Documents

Publication Publication Date Title
JP6560332B2 (ja) 単一サイクルでコンディショニングおよび化学選択を組み合わせる方法
ES2940681T3 (es) Un interruptor modulable para la selección de células modificadas donantes
JP2021529184A (ja) 遺伝子治療
Kirby et al. Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene.
US11607427B2 (en) Method for chemoselection
US20090035318A1 (en) Method and composition for increasing the engraftment efficiency of stem cells
HK1256048B (en) Method for combined conditioning and chemoselection in a single cycle
Fielding Cholinergic signals promote the quiescence of normal or leukaemic stem cells through the activation of the α7-nicotinic receptor in bone marrow mesenchymal stromal cells
Burgos Espadinha Exploring combined treatment strategies to target quiescent chronic myeloid leukemia (CML) stem cells
DE69434159T2 (de) Allogene und xenogene Transplantation
Carbonaro Cell and gene therapy in the murine model of adenosine deaminase deficiency
Larochelle et al. Mobilization for Gene Therapy
Huo Mouse model of Cooley's anemia

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131121

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150416

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150416

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150526

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160309

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160608

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160801

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160825

R150 Certificate of patent or registration of utility model

Ref document number: 5997257

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees