JP5986095B2 - コンジュゲートおよび分子イメージングにおけるそれらの用途 - Google Patents

コンジュゲートおよび分子イメージングにおけるそれらの用途 Download PDF

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JP5986095B2
JP5986095B2 JP2013538264A JP2013538264A JP5986095B2 JP 5986095 B2 JP5986095 B2 JP 5986095B2 JP 2013538264 A JP2013538264 A JP 2013538264A JP 2013538264 A JP2013538264 A JP 2013538264A JP 5986095 B2 JP5986095 B2 JP 5986095B2
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composition
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radionuclide
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JP2014501714A (ja
JP2014501714A5 (enExample
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ラッセル バリンガー ジェイムズ
ラッセル バリンガー ジェイムズ
ベリー デイビッド
ベリー デイビッド
ジョン ブロワー フィリップ
ジョン ブロワー フィリップ
ヨンミン マ
ヨンミン マ
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キングス・カレッジ・ロンドン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A61K51/1033—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against receptors for cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013538264A 2010-11-11 2011-11-11 コンジュゲートおよび分子イメージングにおけるそれらの用途 Active JP5986095B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1019118.7 2010-11-11
GB201019118A GB201019118D0 (en) 2010-11-11 2010-11-11 Conjugates and their uses in molecular imaging
PCT/GB2011/001599 WO2012063028A1 (en) 2010-11-11 2011-11-11 Conjugates and their uses in molecular imaging

Publications (3)

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JP2014501714A JP2014501714A (ja) 2014-01-23
JP2014501714A5 JP2014501714A5 (enExample) 2014-12-25
JP5986095B2 true JP5986095B2 (ja) 2016-09-06

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JP2013538264A Active JP5986095B2 (ja) 2010-11-11 2011-11-11 コンジュゲートおよび分子イメージングにおけるそれらの用途

Country Status (7)

Country Link
US (1) US9138495B2 (enExample)
EP (1) EP2637705B1 (enExample)
JP (1) JP5986095B2 (enExample)
AU (1) AU2011327931B2 (enExample)
ES (1) ES2625829T3 (enExample)
GB (1) GB201019118D0 (enExample)
WO (1) WO2012063028A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098442B2 (en) 2003-03-05 2006-08-29 Raytheon Company Thin micropolarizing filter, and a method for making it
CA2830349C (en) 2011-03-17 2019-07-16 The University Of Birmingham Re-directed immunotherapy
EP4147724A1 (en) 2013-10-31 2023-03-15 Beth Israel Deaconess Medical Center Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
GB201417067D0 (en) 2014-09-26 2014-11-12 South African Nuclear Energy Radiopharmaceutical conjugate
GB201504064D0 (en) * 2015-03-10 2015-04-22 Accretion Biotechnology Ltd Method and kits for preparing radionuclide complexes
JP7253762B2 (ja) * 2017-12-27 2023-04-07 慈濟大學 タンパク質を表面に発現させた小胞によるオートファジー細胞およびアポトーシス細胞への薬剤送達
US20250082795A1 (en) 2023-09-12 2025-03-13 Curadel Surgical Innovations, Inc. Combinations of imaging agent conjugates and application thereof
CN120590625A (zh) * 2024-11-06 2025-09-05 江苏申命医疗科技有限公司 一种放射性核素标记的聚合物、其制备方法及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
EP0672142B1 (en) 1992-12-04 2001-02-28 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
AU2865995A (en) 1995-06-14 1997-01-15 Regents Of The University Of California, The 3-hydroxy-2(1h)-pyridinone chelating agents
WO2007042504A2 (fr) * 2005-10-07 2007-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
US8158804B2 (en) 2007-01-11 2012-04-17 Ge Healthcare As Chelating agents
US8475768B2 (en) 2007-08-13 2013-07-02 Ge Healthcare As Paramagnetic chelates thereof and their use as contrast agents in magnetic resonance imaging (MRI)
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Also Published As

Publication number Publication date
WO2012063028A1 (en) 2012-05-18
GB201019118D0 (en) 2010-12-29
AU2011327931A1 (en) 2013-07-04
US9138495B2 (en) 2015-09-22
AU2011327931A2 (en) 2013-07-11
US20140056810A1 (en) 2014-02-27
EP2637705B1 (en) 2017-03-29
ES2625829T3 (es) 2017-07-20
AU2011327931B2 (en) 2017-02-23
EP2637705A1 (en) 2013-09-18
JP2014501714A (ja) 2014-01-23

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