JP5968784B2 - 原核細胞における免疫原性多糖体生成の生合成システム - Google Patents

原核細胞における免疫原性多糖体生成の生合成システム Download PDF

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JP5968784B2
JP5968784B2 JP2012539870A JP2012539870A JP5968784B2 JP 5968784 B2 JP5968784 B2 JP 5968784B2 JP 2012539870 A JP2012539870 A JP 2012539870A JP 2012539870 A JP2012539870 A JP 2012539870A JP 5968784 B2 JP5968784 B2 JP 5968784B2
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galnac
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polysaccharide
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glcnac
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JP2013511520A (ja
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ワッカー マイケル
ワッカー マイケル
ワエクター チャールズ
ワエクター チャールズ
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グリコヴァキシン アーゲー
グリコヴァキシン アーゲー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0283—Shigella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2012539870A 2009-11-19 2010-11-16 原核細胞における免疫原性多糖体生成の生合成システム Active JP5968784B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27293109P 2009-11-19 2009-11-19
US61/272,931 2009-11-19
PCT/US2010/002980 WO2011062615A1 (en) 2009-11-19 2010-11-16 Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells

Related Child Applications (1)

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JP2016133786A Division JP2017018098A (ja) 2009-11-19 2016-07-06 原核細胞における免疫原性多糖体生成の生合成システム

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JP5968784B2 true JP5968784B2 (ja) 2016-08-10

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JP2012539870A Active JP5968784B2 (ja) 2009-11-19 2010-11-16 原核細胞における免疫原性多糖体生成の生合成システム
JP2016133786A Pending JP2017018098A (ja) 2009-11-19 2016-07-06 原核細胞における免疫原性多糖体生成の生合成システム

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US (2) US8846342B2 (https=)
EP (1) EP2501406B8 (https=)
JP (2) JP5968784B2 (https=)
KR (1) KR101855380B1 (https=)
CN (1) CN102724997B (https=)
AU (1) AU2010322454B2 (https=)
CA (1) CA2780487C (https=)
CY (1) CY1119995T1 (https=)
DK (1) DK2501406T3 (https=)
ES (1) ES2660227T3 (https=)
HR (1) HRP20180338T1 (https=)
HU (1) HUE038456T2 (https=)
IL (1) IL219733A (https=)
LT (1) LT2501406T (https=)
NO (1) NO2501406T3 (https=)
PL (1) PL2501406T3 (https=)
PT (1) PT2501406T (https=)
SI (1) SI2501406T1 (https=)
TR (1) TR201803015T4 (https=)
WO (1) WO2011062615A1 (https=)

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JP2017018098A (ja) 2017-01-26
KR101855380B1 (ko) 2018-05-08
PL2501406T3 (pl) 2018-05-30
CN102724997A (zh) 2012-10-10
EP2501406B1 (en) 2017-12-20
IL219733A (en) 2017-08-31
HUE038456T2 (hu) 2018-10-29
EP2501406A1 (en) 2012-09-26
PT2501406T (pt) 2018-02-21
EP2501406B8 (en) 2018-01-24
KR20120102086A (ko) 2012-09-17
ES2660227T3 (es) 2018-03-21
CN102724997B (zh) 2016-09-21
EP2501406A4 (en) 2013-04-24
DK2501406T3 (en) 2018-02-26
CY1119995T1 (el) 2018-12-12
IL219733A0 (en) 2012-07-31
US8846342B2 (en) 2014-09-30
US20150190492A1 (en) 2015-07-09
AU2010322454A1 (en) 2012-06-07
AU2010322454B2 (en) 2016-05-19
NO2501406T3 (https=) 2018-05-19
CA2780487C (en) 2019-05-21
CA2780487A1 (en) 2011-05-26
HRP20180338T1 (hr) 2018-04-06
TR201803015T4 (tr) 2018-03-21
SI2501406T1 (en) 2018-03-30
WO2011062615A1 (en) 2011-05-26
US20130028926A1 (en) 2013-01-31
JP2013511520A (ja) 2013-04-04
US9764018B2 (en) 2017-09-19
LT2501406T (lt) 2018-03-26

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