JP5943927B2 - アッセイデバイスにおける試薬貯蔵 - Google Patents

アッセイデバイスにおける試薬貯蔵 Download PDF

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JP5943927B2
JP5943927B2 JP2013533995A JP2013533995A JP5943927B2 JP 5943927 B2 JP5943927 B2 JP 5943927B2 JP 2013533995 A JP2013533995 A JP 2013533995A JP 2013533995 A JP2013533995 A JP 2013533995A JP 5943927 B2 JP5943927 B2 JP 5943927B2
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reagent
assay
binding
assay plate
analyte
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Japanese (ja)
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JP2013539867A5 (OSRAM
JP2013539867A (ja
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スディープ・クマー
ジョージ・シーガル
マイケル・ツィオンスキー
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メソ スケール テクノロジーズ エルエルシー
メソ スケール テクノロジーズ エルエルシー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
JP2013533995A 2010-10-14 2011-10-13 アッセイデバイスにおける試薬貯蔵 Active JP5943927B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45511210P 2010-10-14 2010-10-14
US61/455,112 2010-10-14
PCT/US2011/056095 WO2012051386A2 (en) 2010-10-14 2011-10-13 Reagent storage in an assay device

Publications (3)

Publication Number Publication Date
JP2013539867A JP2013539867A (ja) 2013-10-28
JP2013539867A5 JP2013539867A5 (OSRAM) 2014-11-27
JP5943927B2 true JP5943927B2 (ja) 2016-07-05

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JP2013533995A Active JP5943927B2 (ja) 2010-10-14 2011-10-13 アッセイデバイスにおける試薬貯蔵

Country Status (5)

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US (6) US20120157332A1 (OSRAM)
EP (3) EP4300100A3 (OSRAM)
JP (1) JP5943927B2 (OSRAM)
CA (3) CA3241642A1 (OSRAM)
WO (1) WO2012051386A2 (OSRAM)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120157332A1 (en) 2010-10-14 2012-06-21 Meso Scale Technologies, Llc Reagent Storage in an Assay Device
WO2014131046A1 (en) * 2013-02-25 2014-08-28 Wellstat Diagnostics, Llc Electrochemiluminescence (ecl) detection reagents and related methods for measuring enzyme activity
EP3027773B1 (en) 2013-07-30 2020-03-25 President and Fellows of Harvard College Quantitative dna-based imaging and super-resolution imaging
US20150185213A1 (en) * 2013-12-27 2015-07-02 Mag Array, Inc. Method of internal correction in one chip assay and method for measuring test substance using said method
CN110004208A (zh) * 2014-03-11 2019-07-12 哈佛学院院长及董事 利用可编程核酸探针的高通量且高度多路复用的成像
US10753940B2 (en) * 2015-08-03 2020-08-25 President And Fellows Of Harvard College Enhanced electrochemical detection using nanoparticles and precipitation
RU2018107453A (ru) 2015-08-10 2019-09-12 Эссенликс Корп. Устройства для анализов и способы в биологии/химии, предусматривающие упрощенные стадии, образцы небольшого объема, повышенную скорость и простоту применения
AU2016323072B2 (en) 2015-09-14 2019-09-19 Essenlix Corporation Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same
MY194887A (en) 2015-09-14 2022-12-21 Essenlix Corp Device and System for Analyzing a Sample, Particularly Blood, as Well as Methods of Using The Same
WO2017196917A1 (en) * 2016-05-11 2017-11-16 Mayo Foundation For Medical Education And Research Hpv screening platform
PL3523448T3 (pl) 2016-10-07 2021-10-18 Boehringer Ingelheim Vetmedica Gmbh Sposób i system analizy do badania próbki
CA3037217A1 (en) 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Analysis system and method for testing a sample
KR20190066619A (ko) 2016-10-07 2019-06-13 베링거잉겔하임베트메디카게엠베하 샘플을 테스트하기 위한 방법 및 분석 시스템
TW201832726A (zh) * 2016-11-01 2018-09-16 美商海科生醫有限責任公司 可基於輸入數據建議檢測之免疫檢測系統
US10628693B2 (en) 2016-12-21 2020-04-21 Essenlix Corporation Devices and methods for authenticating a sample and use of the same
US10324041B2 (en) * 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
WO2018148342A1 (en) 2017-02-07 2018-08-16 Essenlix Corporation Compressed open flow assay and use
CA3052809A1 (en) 2017-02-08 2018-08-23 Essenlix Corporation Qmax assays and applications
WO2018148764A1 (en) 2017-02-08 2018-08-16 Essenlix Corporation Molecular manipulation and assay with controlled temperature
CN111316096B (zh) 2017-02-08 2023-08-11 Essenlix公司 生物/化学材料提取和测定
WO2018148470A1 (en) 2017-02-08 2018-08-16 Essenlix Corporation Sample collection and handling for delayed analysis
CA3053120A1 (en) 2017-02-09 2018-08-16 Essenlix Corporation Colorimetric assays
CN110998325B (zh) 2017-02-09 2024-08-16 上海宜晟生物科技有限公司 扩增测定
CN111433606B (zh) 2017-02-09 2024-05-24 上海宜晟生物科技有限公司 采用不同间距高度的测定
JP2020508043A (ja) 2017-02-15 2020-03-19 エッセンリックス コーポレーション 急速な温度変化を伴うアッセイ
CN120195095A (zh) 2017-02-16 2025-06-24 上海宜晟生物科技有限公司 采用纹理化表面的测定方法及装置
BR112019026335A2 (pt) 2017-06-12 2020-07-21 Essenlix Corporation ensaio homogêneo
US11243201B2 (en) 2017-08-01 2022-02-08 Essenlix Corporation Sample collection, holding and assaying
US11280706B2 (en) 2017-08-01 2022-03-22 Essenlix Corporation Dilution calibration
CN120668916A (zh) 2017-08-01 2025-09-19 上海宜晟生物科技有限公司 检查药物对微生物影响的装置和方法
US12403465B2 (en) 2017-10-11 2025-09-02 Essenlix Corporation Containing a liquid sample
US11393561B2 (en) 2017-10-13 2022-07-19 Essenlix Corporation Devices and methods for authenticating a medical test and use of the same
US10807095B2 (en) 2017-10-26 2020-10-20 Essenlix Corporation Making and tracking assay card
US11609224B2 (en) 2017-10-26 2023-03-21 Essenlix Corporation Devices and methods for white blood cell analyses
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
US11648551B2 (en) 2017-12-12 2023-05-16 Essenlix Corporation Sample manipulation and assay with rapid temperature change
CN112534259A (zh) 2017-12-14 2021-03-19 Essenlix公司 监测毛发的装置，系统和方法
WO2019140334A1 (en) 2018-01-11 2019-07-18 Essenlix Corporation Homogeneous assay (ii)
US11885952B2 (en) 2018-07-30 2024-01-30 Essenlix Corporation Optics, device, and system for assaying and imaging
WO2021007844A1 (zh) * 2019-07-18 2021-01-21 京东方科技集团股份有限公司 微全分析系统及其工作方法、制作方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE388694B (sv) 1975-01-27 1976-10-11 Kabi Ab Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar
US4235601A (en) 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4442204A (en) 1981-04-10 1984-04-10 Miles Laboratories, Inc. Homogeneous specific binding assay device and preformed complex method
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5591581A (en) 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US6165729A (en) 1986-04-30 2000-12-26 Hyperion Catalysis International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US5236849A (en) 1987-08-11 1993-08-17 Eiji Ishikawa Method of high sensitivity immunoassay
JP2606722B2 (ja) * 1988-04-05 1997-05-07 栄治 石川 超高感度抗原物質の測定法
US5308754A (en) 1988-03-21 1994-05-03 Kankare Jouko J Electrogenerated luminescence in solution
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5705402A (en) 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5324457A (en) 1989-10-02 1994-06-28 Board Of Regents, The University Of Tx System Devices and methods for generating electrogenerated chemiluminescence
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
JPH04273065A (ja) * 1991-02-28 1992-09-29 Hitachi Ltd 免疫分析方法およびその分析装置
US5208535A (en) 1990-12-28 1993-05-04 Research Development Corporation Of Japan Mr position detecting device
JPH0534345A (ja) 1991-02-19 1993-02-09 Tdk Corp 化学発光を利用する抗原・抗体の測定方法
ZA929351B (en) 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
US5541623A (en) 1993-06-02 1996-07-30 Alps Electric (U.S.A.) Inc. Temperature compensated opto-electronic circuit and mouse using same
US5786141A (en) 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
US5707799A (en) 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
JPH08178926A (ja) * 1994-10-25 1996-07-12 Sumitomo Pharmaceut Co Ltd イムノアッセイプレートおよびその用途
US5866434A (en) 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US5643713A (en) 1995-06-07 1997-07-01 Liang; Pam Electrochemiluminescent monitoring of compounds
US5641623A (en) 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
EP0821726B1 (en) 1995-03-10 2014-05-07 Meso Scale Technologies, LLC. Multi-array, multi-specific electrochemiluminescence testing
US5679519A (en) 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
WO1997014028A2 (en) 1995-10-11 1997-04-17 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
GB9606850D0 (en) 1996-04-01 1996-06-05 Univ Liverpool An assay system and novel labelled compounds for use therwith
FR2764381A1 (fr) 1997-06-09 1998-12-11 Univ De Neuchatel Detecteur electrochimioluminescent
US6413783B1 (en) 1997-09-18 2002-07-02 Meso Scale Technologies, Llc Assay sonication apparatus and methodology
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
EP0962773A1 (en) 1998-06-03 1999-12-08 Mark Howard Jones Electrochemical based assay processes instrument and labels
GB9815042D0 (en) 1998-07-10 1998-09-09 Imperial College Detector
US6214552B1 (en) 1998-09-17 2001-04-10 Igen International, Inc. Assays for measuring nucleic acid damaging activities
US6136268A (en) 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
EP1259324A2 (en) * 2000-02-18 2002-11-27 Aclara BioSciences, Inc. Multiple-site reaction device and method
US20030003464A1 (en) * 2000-11-27 2003-01-02 Phan Brigitte C. Dual bead assays including optical biodiscs and methods relating thereto
WO2003031591A2 (en) * 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
JP2005530127A (ja) * 2001-11-27 2005-10-06 バースタイン テクノロジーズ，インコーポレイティド 光磁気バイオディスクおよび関連の方法を含むシステム
US20040009528A1 (en) * 2002-07-11 2004-01-15 Shyh-Yu Shaw Protein chips
US20060211055A1 (en) * 2002-11-12 2006-09-21 Caliper Life Sciences, Inc. Capture and release assay system and method
AU2003302263A1 (en) 2002-12-26 2004-07-29 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
ATE452208T1 (de) * 2004-10-08 2010-01-15 Sysmex Corp Verfahren zum nachweis einer zielsubstanz unter verwendung einer nukleinsäuresonde
JP2008541017A (ja) * 2005-04-29 2008-11-20 ベックマン コールター インコーポレイテッド 側方流動蛍光免疫測定法
CN101262948B (zh) * 2005-06-06 2011-07-06 决策生物标志股份有限公司 基于流过阵列的液体流的测定
US20070031283A1 (en) * 2005-06-23 2007-02-08 Davis Charles Q Assay cartridges and methods for point of care instruments
CA2616404A1 (en) * 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
WO2007076023A2 (en) * 2005-12-21 2007-07-05 Meso Scale Technologies, Llc Assay modules having assay reagents and methods of making and using same
AU2007225038B2 (en) * 2006-03-15 2013-08-29 Revvity Health Sciences, Inc. Integrated nucleic acid assays
WO2009126828A2 (en) * 2008-04-09 2009-10-15 California Institute Of Technology Capture agents and related methods and systems for detecting and/or sorting targets
CA2659745A1 (en) * 2006-08-02 2008-02-07 California Institute Of Technology Methods and systems for detecting and/or sorting targets
GB0618966D0 (en) * 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
CA3028780C (en) 2009-12-07 2022-05-31 Meso Scale Technologies, Llc Assay cartridges and methods of using the same
US20120157332A1 (en) 2010-10-14 2012-06-21 Meso Scale Technologies, Llc Reagent Storage in an Assay Device

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Publication number Publication date
US20160349253A1 (en) 2016-12-01
CA2814680A1 (en) 2012-04-19
CA3241642A1 (en) 2012-04-19
CA2814680C (en) 2021-11-16
EP2628004A4 (en) 2014-08-20
US11231417B2 (en) 2022-01-25
US10627399B2 (en) 2020-04-21
EP4300100A2 (en) 2024-01-03
US20250334571A1 (en) 2025-10-30
CA3139049A1 (en) 2012-04-19
EP3644058A1 (en) 2020-04-29
CA3139049C (en) 2024-10-15
EP4300100A3 (en) 2024-09-04
US20220252590A1 (en) 2022-08-11
US20120157332A1 (en) 2012-06-21
JP2013539867A (ja) 2013-10-28
WO2012051386A3 (en) 2012-07-19
US20130316928A1 (en) 2013-11-28
EP2628004A2 (en) 2013-08-21
US12216117B2 (en) 2025-02-04
US9797894B2 (en) 2017-10-24
WO2012051386A2 (en) 2012-04-19
US20200209234A1 (en) 2020-07-02

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