JP5939158B2 - 治療的有用性を有する受容体調節物質としての新規化合物 - Google Patents
治療的有用性を有する受容体調節物質としての新規化合物 Download PDFInfo
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- JP5939158B2 JP5939158B2 JP2012541125A JP2012541125A JP5939158B2 JP 5939158 B2 JP5939158 B2 JP 5939158B2 JP 2012541125 A JP2012541125 A JP 2012541125A JP 2012541125 A JP2012541125 A JP 2012541125A JP 5939158 B2 JP5939158 B2 JP 5939158B2
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- alkyl
- amino
- phenylpentyl
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- aromatic heterocycle
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| SG194184A1 (en) * | 2011-04-14 | 2013-11-29 | Allergan Inc | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators |
| CA2865215A1 (en) | 2012-02-21 | 2013-08-29 | Allergan, Inc. | Phenoxy-azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators |
| US20140171393A1 (en) * | 2012-12-13 | 2014-06-19 | Allergan, Inc. | Novel aromatic thio compounds as receptor modulators |
| HUE039931T2 (hu) | 2013-02-20 | 2019-02-28 | Lg Chemical Ltd | Szfingozin-1-foszfát receptor agonisták, azok elkészítési eljárásai, és azokat aktív ágensként tartalmazó gyógyszerészeti készítmények |
| US20140256945A1 (en) * | 2013-03-07 | 2014-09-11 | Allergan, Inc. | Phosphonic acid compounds as sphingosine-1-phosphate receptor modulators |
| WO2015021112A1 (en) * | 2013-08-08 | 2015-02-12 | Allergan, Inc. | Disubstituted aryl oxy derivatives as sphingosine-1- phosphate receptors modulators |
| WO2015021109A1 (en) * | 2013-08-08 | 2015-02-12 | Allergan, Inc. | Disubstituted aryl azetidine derivatives as sphingosine-1-phosphate receptors modulators |
| WO2015073547A1 (en) * | 2013-11-13 | 2015-05-21 | Allergan, Inc. | Disubstituted phenoxy azetidine derivatives as sphingosine-1-phosphate (s1p) receptor modulators |
| KR20200116953A (ko) | 2018-02-02 | 2020-10-13 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 안내 혈관 신생 및/또는 안내 혈관 투과성 항진을 수반하는 안과 질환의 예방 또는 치료를 위한 의약 |
| US20240228461A1 (en) * | 2021-04-14 | 2024-07-11 | Lg Chem, Ltd. | Novel method for preparing sphingosine-1-phosphate receptor agonist |
| WO2022220611A1 (ko) * | 2021-04-14 | 2022-10-20 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제의 신규한 제조방법 |
| US20240217935A1 (en) * | 2021-04-14 | 2024-07-04 | Lg Chem, Ltd. | Method for preparing intermediate for synthesis of sphingosine-1-phosphate receptor agonist |
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| EP0146810A3 (de) | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| US5110987A (en) | 1988-06-17 | 1992-05-05 | Emory University | Method of preparing sphingosine derivatives |
| ZA902794B (en) * | 1989-04-18 | 1991-04-24 | Duphar Int Res | New 3-n substituted carbamoyl-indole derivatives |
| US5294722A (en) | 1992-04-16 | 1994-03-15 | E. R. Squibb & Sons, Inc. | Process for the preparation of imidazoles useful in angiotensin II antagonism |
| US5403851A (en) * | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| WO1998040349A1 (en) | 1997-03-12 | 1998-09-17 | Takara Shuzo Co., Ltd. | Sphingosine analogues |
| JP4091250B2 (ja) * | 1997-09-11 | 2008-05-28 | タカラバイオ株式会社 | スフィンゴシン類誘導体及び医薬組成物 |
| DE10010067A1 (de) * | 2000-03-02 | 2001-09-06 | Bayer Ag | Neue Imidazotriazinone und ihre Verwendung |
| US7074817B2 (en) * | 2001-06-20 | 2006-07-11 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| EP1575964B1 (en) * | 2002-01-18 | 2009-11-11 | Merck & Co., Inc. | N-(benzyl)aminoalkyl carboxylate, phosphinates, phosphonates and tetrazoles as edg receptor agonists |
| WO2003061567A2 (en) * | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Selective s1p1/edg1 receptor agonists |
| JP4430941B2 (ja) * | 2002-01-18 | 2010-03-10 | メルク エンド カムパニー インコーポレーテッド | Edg受容体作動薬 |
| MXPA05012459A (es) * | 2003-05-19 | 2006-02-22 | Irm Llc | Compuestos y composiciones inmunosupresoras. |
| CN101407471A (zh) * | 2003-08-29 | 2009-04-15 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
| RU2007109778A (ru) * | 2004-08-17 | 2008-09-27 | Галдерма Ресерч Энд Девелопмент, С.Н.С. (Fr) | Новые биароматические соединения, которые активируют рецепторы типа ppar, и их применение в косметических и фармацевтических композициях |
| GB0612721D0 (en) * | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| WO2008030843A1 (en) * | 2006-09-07 | 2008-03-13 | Allergan, Inc. | Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity |
| EP2064183A2 (en) * | 2006-09-07 | 2009-06-03 | Allergan, Inc. | Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist biological activity |
| US8614103B2 (en) * | 2006-10-27 | 2013-12-24 | Lpath, Inc. | Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions |
| TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| US8633245B2 (en) | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
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