JP5935696B2 - ポータブルな液体クロマトグラフ及び液体クロマトグラフィー - Google Patents
ポータブルな液体クロマトグラフ及び液体クロマトグラフィー Download PDFInfo
- Publication number
- JP5935696B2 JP5935696B2 JP2012545690A JP2012545690A JP5935696B2 JP 5935696 B2 JP5935696 B2 JP 5935696B2 JP 2012545690 A JP2012545690 A JP 2012545690A JP 2012545690 A JP2012545690 A JP 2012545690A JP 5935696 B2 JP5935696 B2 JP 5935696B2
- Authority
- JP
- Japan
- Prior art keywords
- pump
- electroosmotic
- reservoir
- separation column
- mobile phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 title claims description 93
- 238000004811 liquid chromatography Methods 0.000 title claims description 10
- 239000002904 solvent Substances 0.000 claims description 59
- 238000000926 separation method Methods 0.000 claims description 51
- 230000007246 mechanism Effects 0.000 claims description 41
- 238000005370 electroosmosis Methods 0.000 claims description 35
- 239000013076 target substance Substances 0.000 claims description 35
- 239000012530 fluid Substances 0.000 claims description 30
- 239000000758 substrate Substances 0.000 claims description 16
- 239000000945 filler Substances 0.000 claims description 12
- 239000000523 sample Substances 0.000 claims description 11
- 229910001410 inorganic ion Inorganic materials 0.000 claims description 7
- 150000002894 organic compounds Chemical class 0.000 claims description 7
- 230000004913 activation Effects 0.000 claims description 6
- 239000012488 sample solution Substances 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000004458 analytical method Methods 0.000 description 14
- 238000003780 insertion Methods 0.000 description 11
- 230000037431 insertion Effects 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 238000010586 diagram Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 8
- 230000003287 optical effect Effects 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 6
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 6
- 235000005487 catechin Nutrition 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 150000001765 catechin Chemical class 0.000 description 5
- 150000003943 catecholamines Chemical class 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 150000002989 phenols Chemical class 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000007726 management method Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000013307 optical fiber Substances 0.000 description 3
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 2
- IXQGCWUGDFDQMF-UHFFFAOYSA-N 2-Ethylphenol Chemical compound CCC1=CC=CC=C1O IXQGCWUGDFDQMF-UHFFFAOYSA-N 0.000 description 2
- LCHYEKKJCUJAKN-UHFFFAOYSA-N 2-propylphenol Chemical compound CCCC1=CC=CC=C1O LCHYEKKJCUJAKN-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 1
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 1
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 description 1
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- WDEFWOPTRFWZLM-LEQGEALCSA-N (2,5-dioxopyrrolidin-1-yl) (2r)-2,5,7,8-tetramethyl-6-(oxan-2-yloxy)-3,4-dihydrochromene-2-carboxylate Chemical compound C([C@@](C)(OC=1C(C)=C2C)C(=O)ON3C(CCC3=O)=O)CC=1C(C)=C2OC1CCCCO1 WDEFWOPTRFWZLM-LEQGEALCSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 1
- 235000012734 epicatechin Nutrition 0.000 description 1
- 229940030275 epigallocatechin gallate Drugs 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000011491 glass wool Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- WLGDAKIJYPIYLR-UHFFFAOYSA-N octane-1-sulfonic acid Chemical compound CCCCCCCCS(O)(=O)=O WLGDAKIJYPIYLR-UHFFFAOYSA-N 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 description 1
- 229910001488 sodium perchlorate Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N2030/162—Injection electromigration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010260192 | 2010-11-22 | ||
JP2010260192 | 2010-11-22 | ||
PCT/JP2011/076297 WO2012070431A1 (fr) | 2010-11-22 | 2011-11-15 | Chromatographe en phase liquide portable et chromatographie en phase liquide |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2012070431A1 JPWO2012070431A1 (ja) | 2014-05-19 |
JP5935696B2 true JP5935696B2 (ja) | 2016-06-15 |
Family
ID=46145777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012545690A Active JP5935696B2 (ja) | 2010-11-22 | 2011-11-15 | ポータブルな液体クロマトグラフ及び液体クロマトグラフィー |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP5935696B2 (fr) |
WO (1) | WO2012070431A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103698428B (zh) * | 2013-12-18 | 2015-07-01 | 中国科学院过程工程研究所 | 一种车载便携式液相色谱仪 |
CN105417482B (zh) * | 2015-12-04 | 2017-09-29 | 上海蓝科石化环保科技股份有限公司 | 一种密闭连续的环氧乙烷输送系统及方法 |
US11143639B2 (en) * | 2018-02-26 | 2021-10-12 | Brigham Young University | Integrated column and detector in a module for liquid chromatography |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003517591A (ja) * | 1999-12-09 | 2003-05-27 | モトローラ・インコーポレイテッド | 分析試料の反応を行うための多層微量流体デバイス |
US20060147344A1 (en) * | 2004-09-30 | 2006-07-06 | The University Of Cincinnati | Fully packed capillary electrophoretic separation microchips with self-assembled silica colloidal particles in microchannels and their preparation methods |
JP2006311796A (ja) * | 2005-03-30 | 2006-11-09 | Science Solutions International Laboratory Inc | 電気浸透流ポンプ及び液体供給装置 |
JP2010085146A (ja) * | 2008-09-30 | 2010-04-15 | Hitachi High-Technologies Corp | グラジエント送液装置,グラジエント送液システム、および液体クロマトグラフ |
JP2010094019A (ja) * | 2001-06-13 | 2010-04-22 | Eksigent Technologies Llc | 流量制御システム |
JP2010242764A (ja) * | 2003-06-17 | 2010-10-28 | Seiko Epson Corp | ポンプ |
-
2011
- 2011-11-15 JP JP2012545690A patent/JP5935696B2/ja active Active
- 2011-11-15 WO PCT/JP2011/076297 patent/WO2012070431A1/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003517591A (ja) * | 1999-12-09 | 2003-05-27 | モトローラ・インコーポレイテッド | 分析試料の反応を行うための多層微量流体デバイス |
JP2010094019A (ja) * | 2001-06-13 | 2010-04-22 | Eksigent Technologies Llc | 流量制御システム |
JP2010242764A (ja) * | 2003-06-17 | 2010-10-28 | Seiko Epson Corp | ポンプ |
US20060147344A1 (en) * | 2004-09-30 | 2006-07-06 | The University Of Cincinnati | Fully packed capillary electrophoretic separation microchips with self-assembled silica colloidal particles in microchannels and their preparation methods |
JP2006311796A (ja) * | 2005-03-30 | 2006-11-09 | Science Solutions International Laboratory Inc | 電気浸透流ポンプ及び液体供給装置 |
JP2010085146A (ja) * | 2008-09-30 | 2010-04-15 | Hitachi High-Technologies Corp | グラジエント送液装置,グラジエント送液システム、および液体クロマトグラフ |
Also Published As
Publication number | Publication date |
---|---|
JPWO2012070431A1 (ja) | 2014-05-19 |
WO2012070431A1 (fr) | 2012-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2963416B1 (fr) | Procédé et système permettant de surveiller des séparations biomoléculaires par spectrométrie de masse | |
JP5935696B2 (ja) | ポータブルな液体クロマトグラフ及び液体クロマトグラフィー | |
US8881580B2 (en) | Process analysis unit | |
EP1664725B1 (fr) | Pompe d'injection electro-osmotique et dispositif de microanalyse | |
AU2018204839B2 (en) | Bottle pressurization delivery system | |
Ishida et al. | A portable liquid chromatograph with a battery-operated compact electroosmotic pump and a microfluidic chip device with a reversed phase packed column | |
Guan et al. | The use of a micropump based on capillary and evaporation effects in a microfluidic flow injection chemiluminescence system | |
JP6827452B2 (ja) | 高速起動イオンクロマトグラフィシステム及び方法 | |
WO2012159040A3 (fr) | Prise en charge de fluide et système de surveillance de patients | |
CN103543192A (zh) | 一种用于诊断装置的试剂包 | |
US11219867B2 (en) | Single-use filtering module and single-use cleaning module, each insertable in a modular filtering system | |
EP2040064A1 (fr) | Dispositif de mesure du carbone organique total | |
US7462280B2 (en) | Liquid chromatography chip with flexible interface | |
US20080152509A1 (en) | Integrated micro-pump and electro-spray | |
JP2009250961A (ja) | マイクロ検査チップおよび送液システム | |
JP6789889B2 (ja) | 試料処理装置 | |
WO2006091743A2 (fr) | Micro-pompe et pulverisation electrique integrees | |
JP2007024840A (ja) | シリンジポンプ及びそれを用いたtoc測定装置 | |
US6793462B2 (en) | Fluidic pump | |
JP2006267038A (ja) | マイクロ総合分析システム | |
JP2019128237A (ja) | 試料処理装置 | |
US20200147605A1 (en) | Test sample devices and methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141020 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150915 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151112 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160329 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160425 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5935696 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |