JP5927803B2 - Surfactant composition - Google Patents

Description

  The present invention relates to a surfactant composition, particularly a composition comprising an anionic surfactant.

  In medical institutions, food factories, pharmaceutical factories, etc., in order to maintain the hygiene of the hands of workers engaged and the like, as well as various instruments and devices, it is necessary to remove sterilization and sterilize during washing. For this reason, the development of a cleaning agent having bactericidal properties is underway.

  As a cleaning agent having bactericidal properties, Patent Document 1 describes an antibacterial liquid cleaning composition containing a surfactant, a buffering agent and an antibacterial agent which are less irritating than soap. However, the antibacterial agent used here is expensive such as 2-hydroxy-4,2 ′, 4′-trichlorodiphenyl ether, 2,6-dimethyl-4-hydroxychlorobenzene, etc. Will increase. In addition, since such antibacterial agents are difficult to obtain in large quantities, the composition is difficult to mass produce.

Japanese translation of PCT publication No. 10-500962 (claims, page 3, lines 4-13 and page 12, lines 11-13, line 18 etc.)

  An object of the present invention is to realize an inexpensive and mass-produced surfactant composition having bactericidal properties.

The surfactant composition of the present invention contains monododecyl sodium phosphate and an alkali metal salt different from the ionic surfactant.

Rua alkali metal salt used herein is a formic acid salt.

  The surfactant composition of the present invention is usually a solution containing an anionic surfactant and an alkali metal salt. In this case, the surfactant composition of the present invention may further contain a pH buffer.

  The surfactant composition of the present invention is a combination of an anionic surfactant other than a higher fatty acid salt having 10 to 20 carbon atoms and an alkali metal salt different from an ionic surfactant. It can be mass-produced at low cost.

The figure which shows the logarithm decreasing value of the number of bacteria about Experimental example A1-A7. The figure which shows the logarithm reduction value of the number of bacteria about Experimental example B1-B5. The figure which shows the logarithm decreasing value of the number of bacteria about Experimental example C1-C7. The figure which shows the logarithm decreasing value of the number of bacteria about Experimental example D1-D5. The figure which shows the logarithm reduction value of the number of bacteria about Experimental example E1-E9.

  The surfactant composition of the present invention contains an anionic surfactant and an alkali metal salt. The anionic surfactant used here is not particularly limited as long as it is other than a higher fatty acid salt having 10 to 20 carbon atoms, but usually carboxylate, sulfonate, sulfate ester salt or It is in the form of a phosphate ester salt. Each of such anionic surfactants may be used alone or in combination of two or more.

  Examples of carboxylic acid type anionic surfactants include polyoxyethylene alkyl ether carboxylates and N-acyl sarcosine salts.

  Examples of the sulfonate type anionic surfactant include dialkyl sulfosuccinate, alkane sulfonate, alpha olefin sulfonate, linear alkyl benzene sulfonate, branched alkyl benzene sulfonate, naphthalene sulfonate-formaldehyde Mention may be made of condensates, alkyl naphthalene sulfonates and N-methyl-N-acyl taurine salts.

  Examples of sulfate ester type anionic surfactants include alkyl sulfate ester salts, polyoxyethylene alkyl ether sulfates, and oil sulfate ester salts.

  Examples of phosphoric acid ester salt type anionic surfactants include alkyl phosphates, polyoxyethylene alkyl ether phosphates, and polyoxyethylene alkyl phenyl ether phosphates.

  The carboxylate salt, sulfonate salt, sulfate ester salt and phosphate ester salt as described above are usually preferably alkali metal salts such as potassium salt and sodium salt.

  On the other hand, the alkali metal salt used in the present invention can generate a cation as a counter ion with respect to the anionic surfactant by dissociation in water or the like, that is, an alkali metal ion such as potassium ion or sodium ion. And are not ionic surfactants, ie, cationic surfactants and anionic surfactants. Preferred alkali metal salts include, for example, chloride salts such as potassium chloride and sodium chloride, carbonates such as potassium carbonate and sodium carbonate, because practical bactericidal properties are easily achieved in the surfactant composition of the present invention. , Hydrogen carbonates such as potassium hydrogen carbonate and sodium hydrogen carbonate, hydroxide salts such as potassium hydroxide and sodium hydroxide, nitrates such as potassium nitrate and sodium nitrate, sulfates such as potassium sulfate and sodium sulfate, potassium hydrogen phosphate And hydrogen phosphates such as sodium hydrogen phosphate, dihydrogen phosphates such as potassium dihydrogen phosphate and sodium dihydrogen phosphate, formate salts such as potassium formate and sodium formate, and potassium acetate and sodium acetate Mention may be made of acetate.

  Each alkali metal salt may be used alone or in combination of two or more.

  In the surfactant composition of the present invention, the content ratio of the alkali metal salt to the anionic surfactant is usually preferably set to 0.05 to 100 times by weight, and preferably 0.1 to 60 times by weight. It is more preferable to set so that. When the content ratio of the alkali metal salt is less than 0.05 times by weight, the bactericidal effect of the surfactant composition may be difficult to increase. On the other hand, when it exceeds 100 weight times, there exists a possibility of inhibiting the effect | action of the anionic surfactant according to the use of the surfactant composition mentioned later.

  The surfactant composition of the present invention is a combination of a general-purpose and easily available alkali metal salt with an anionic surfactant, so that it can be provided at low cost and mass production is also easy. . The surfactant composition of the present invention is a component other than the above-described anionic surfactant and alkali metal salt, for example, a fragrance, a coloring material, a moisturizing agent, an antioxidizing agent, and an antioxidant, depending on the use described later. An additive such as an agent and a sequestering agent may further be included.

  Since the surfactant composition of the present invention contains an anionic surfactant, the body of human fingers and the like, the body and hair of animals such as dogs and horses, clothing, bedding, tableware and cooking utensils, etc. Used as a cleaning agent for cleaning kitchen utensils and various medical instruments, or as a cleaning agent for cleaning living spaces such as living rooms, bathrooms, toilets and washrooms, and walls and floors of operating rooms. It can also be used as an antistatic agent for easily charged products such as emulsifiers and resin molded products for preparing emulsions of various synthetic resins.

  In these applications, the surfactant composition of the present invention can exhibit a practical bactericidal power against bacteria since the bactericidal power of the anionic surfactant itself is enhanced by the action of the alkali metal salt, Growth of fungi such as fungi and yeast can also be effectively suppressed. For this reason, when the surfactant composition of the present invention is used as a cleaning agent, it can be sterilized at the same time as cleaning the object to be cleaned. Moreover, when used as an emulsifier, the antibacterial action which suppresses propagation and proliferation of various germs and fungi can be imparted to the prepared emulsion. Furthermore, when used as an antistatic agent, an antibacterial action that suppresses the propagation and proliferation of various germs and fungi can be simultaneously imparted to an object to be treated such as a resin molded product.

  In the above-mentioned use, the surfactant composition of the present invention can be used as a solution in which a mixture of an anionic surfactant, an alkali metal salt and other components is dissolved in a solvent. Examples of the solvent used here include water such as tap water and purified water such as pure water, distilled water and ion exchange water, alcohols such as ethanol, ethylene glycol and glycerin, acetone, hexane and xylene. And organic solvents such as Two or more solvents may be used in combination. A solvent can be selected according to the use of a surfactant composition. For example, when the surfactant composition is used as a cleaning agent, particularly a body or hair cleaning agent, water or a mixture of water and a safe organic solvent (for example, safe alcohols) for a living body is used as a solvent. Is particularly preferred. On the other hand, when using as an emulsifier or an antistatic agent, water and an organic solvent can be selected according to the usage method.

  The solution-form surfactant composition may be prepared when using the surfactant composition, or may be prepared in advance. In any case, the solution-form surfactant composition is prepared by first preparing a solution of the surfactant, adjusting the pH of the solution according to the use of the surfactant composition, and then adjusting the alkali metal salt and other components. It is preferable to prepare by adding and dissolving.

  Here, when the use of the surfactant composition is a cleaning agent, the pH of the surfactant solution is preferably set in a range in which the detergency of the anionic surfactant is increased, specifically, 4 to 11 It is preferable to set to. In particular, when the use as a body cleanser is planned, the pH of the surfactant solution is preferably set in the range of 5.5 to 10.5, which hardly causes irritation to the skin. On the other hand, when the use is an emulsifier or an antistatic agent, the pH of the surfactant solution can be arbitrarily set according to the purpose of use of the surfactant composition.

  As described above, the pH of the surfactant solution adjusted according to the use of the surfactant composition varies greatly when an alkali metal salt is added, and the significance of pH adjustment may be impaired. In particular, when the surfactant composition is used as a cleaning agent for body or body hair, if the pH of the surfactant solution varies greatly during the preparation, it becomes difficult to use the prepared surfactant composition solution as a cleaning agent. Sometimes. For this reason, when preparing a surfactant composition in a solution that can be used as a cleaning agent, depending on the type of alkali metal salt added to the surfactant solution (for example, carbonate, bicarbonate or hydroxide salt) When adding an alkali metal salt to the surfactant solution, it is preferable to suppress pH variation by adding a pH buffering agent together.

  Examples of the pH buffer used for this purpose include glycine, sodium borate, sodium carbonate, sodium hydrogen carbonate, acetic acid, sodium acetate, succinic acid, potassium dihydrogen phosphate, maleic acid, tris (hydroxymethyl) aminomethane. , Sodium cacodylate, 3,3-dimethylglutaric acid, CHES (N-cyclohexyl-2-aminoethanesulfonic acid), CAPSO (N-cyclohexyl-2-hydroxy-3-aminopropanesulfonic acid) and CAPS (N-cyclohexyl) -3-aminopropanesulfonic acid) and the like.

  The concentration of the anionic surfactant in the solution-like surfactant composition can be appropriately adjusted according to the use of the surfactant composition, and is not particularly limited, but is usually 0.01 W / It is preferable to set it to V% or more and 40 W / V% or less.

  When the surfactant composition of the present invention is used as a cleaning agent, for example, an appropriate amount of a surfactant composition in solution is applied to an object to be cleaned or a cleaning tool such as a cloth or sponge, and water is appropriately applied. Wash the object to be cleaned while bubbling. In this case, it is preferable to wash off the surfactant composition adhering to the object to be cleaned with clean water. When the surfactant composition of the present invention is used as an emulsifier, the method of use thereof is not particularly limited, and the surfactant composition of the present invention can be used in the same manner as a normal emulsifier. In this case, the surfactant composition of the present invention may be used as an aqueous solution or as a solution dissolved in an organic solvent. When the surfactant composition of the present invention is used as an antistatic agent, a solution-like surfactant composition is appropriately applied to the surface of an object to be treated such as a resin product that is easily charged, and then dried. For this reason, it is preferable to use what was prepared for the solution-form surfactant composition using the organic solvent which does not produce malfunctions, such as being highly volatile and melt | dissolving a process target object.

[Experimental example]
Experimental example A
(Experimental example A1)
A surfactant aqueous solution in which N-lauroyl sarcosine sodium was dissolved in distilled water to adjust the concentration of N-lauroyl sarcosine sodium to 0.1 w / v% was prepared. And 1 mL of prepared surfactant aqueous solution was fractionated as sample water, and this was preincubated in a 37 degreeC water bath.

  Next, Staphylococcus aureus NBRC13276 was added to the pre-incubated sample water so that the number of bacteria became 1.4E + 08 CFU / mL and contacted for 10 seconds, and then 100 μL of a part of the sample water was taken. Then, the collected sample water is added to the SCDLP medium manufactured by Nippon Pharmaceutical Co., Ltd. to inactivate the surfactant, and then appropriately diluted, and the diluted sample water is used with the SCDLP agar medium manufactured by Nippon Pharmaceutical Co., Ltd. The number of bacteria after 24 hours at 36 ° C. was measured by the smearing method used. The logarithmic decrease value of the number of bacteria is shown in Table 1 and FIG.

(Experimental examples A2 to A4)
A part of the surfactant aqueous solution prepared in Experimental Example A1 was collected as sample water, and an alkali metal salt shown in Table 1 was added to this sample water so as to have a concentration shown in the same table, thereby reducing the amount of sample water to 1 mL. Adjusted. The sample water was preincubated in a 37 ° C. water bath.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Example A1, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 1 and FIG.

(Experimental Examples A5 to A7)
The same distilled water as used in Experimental Example A1 was used as the sample water, and only the alkali metal salt shown in Table 1 was added to this sample water so as to have the concentration shown in the same table, thereby adjusting the amount of the sample water to 1 mL. . The sample water was preincubated in a 37 ° C. water bath.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Example A1, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 1 and FIG.

Experimental example B
(Experimental examples B1, B2)
A surfactant solution shown in Table 2 was dissolved in distilled water to prepare a surfactant aqueous solution having a surfactant concentration adjusted to 0.2 w / v%. And 1 mL of prepared surfactant aqueous solution was fractionated as sample water, and this was preincubated in a 37 degreeC water bath.

  Next, Staphylococcus aureus NBRC13276 was added to the pre-incubated sample water so that the number of bacteria reached 1.9E + 08 CFU / mL and contacted for 10 seconds, and then 100 μL of a part of the sample water was collected. Then, the collected sample water is added to the SCDLP medium manufactured by Nippon Pharmaceutical Co., Ltd. to inactivate the surfactant, and then appropriately diluted, and the diluted sample water is used with the SCDLP agar medium manufactured by Nippon Pharmaceutical Co., Ltd. The number of bacteria after 24 hours at 36 ° C. was measured by the smearing method used. The logarithmic decrease value of the number of bacteria is shown in Table 2 and FIG.

(Experimental examples B3 and B4)
A part of the surfactant aqueous solution prepared in Experimental Examples B1 and B2 was collected as sample water, and the alkali metal salt shown in Table 2 was added to the sample water so as to have the concentration shown in the same table, thereby the amount of sample water Was adjusted to 1 mL. The sample water was preincubated in a 37 ° C. water bath.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Examples B1 and B2, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 2 and FIG.

(Experiment B5)
The same distilled water as used in Experimental Example B1 was used as the sample water, and only the alkali metal salt shown in Table 2 was added to the sample water so as to have the concentration shown in the same table, thereby adjusting the amount of the sample water to 1 mL. . The sample water was preincubated in a 37 ° C. water bath.

  Next, the pre-incubated sample water was treated in the same manner as after the pre-incubation in Experimental Examples B1 and B2, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 2 and FIG.

Experimental example C
(Experimental example C1)
A surfactant aqueous solution in which sodium dodecylbenzenesulfonate was dissolved in distilled water to adjust the sodium dodecylbenzenesulfonate concentration to 0.1 w / v% was prepared. And 1 mL of prepared surfactant aqueous solution was fractionated as sample water, and this was preincubated in a 37 degreeC water bath.

  Next, Staphylococcus aureus NBRC13276 was added to the pre-incubated sample water so that the number of bacteria was 2.9E + 08 CFU / mL and contacted for 10 seconds, and then 100 μL of a part of the sample water was taken. Then, the collected sample water is added to the SCDLP medium manufactured by Nippon Pharmaceutical Co., Ltd. to inactivate the surfactant, and then appropriately diluted, and the diluted sample water is used with the SCDLP agar medium manufactured by Nippon Pharmaceutical Co., Ltd. The number of bacteria after 24 hours at 36 ° C. was measured by the smearing method used. The logarithmic decrease value of the number of bacteria is shown in Table 3 and FIG.

(Experimental examples C2 to C4)
A part of the surfactant aqueous solution prepared in Experimental Example C1 was collected as sample water, and an alkali metal salt shown in Table 3 was added to this sample water so as to have a concentration shown in the same table, thereby reducing the amount of sample water to 1 mL. Adjusted. The sample water was preincubated in a 37 ° C. water bath. For Experimental Example C4, the amount of sample water was adjusted to 1 mL by simultaneously adding an aqueous glycine solution at the time of addition of the alkali metal salt and the glycine concentration was adjusted to 30 mM. Reduced fluctuations.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Example C1, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 3 and FIG.

(Experimental examples C5 to C7)
The same distilled water as used in Experimental Example C1 was used as sample water, and the amount of sample water was adjusted to 1 mL by adding only the alkali metal salt shown in Table 3 to the concentration shown in Table 3 to this sample water. . The sample water was preincubated in a 37 ° C. water bath. For Experimental Example C7, the amount of sample water was adjusted to 1 mL by simultaneously adding a glycine aqueous solution at the time of addition of the alkali metal salt and the glycine concentration was adjusted to 30 mM. Suppressed.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Example C1, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 3 and FIG.

Experimental example D
(Experimental example D1)
A surfactant aqueous solution in which sodium dodecyl sulfate was dissolved in distilled water and the sodium dodecyl sulfate concentration was adjusted to 0.2 w / v% was prepared. And 1 mL of prepared surfactant aqueous solution was fractionated as sample water, and this was preincubated in a 37 degreeC water bath.

  Next, Staphylococcus aureus NBRC13276 was added to the pre-incubated sample water so that the number of bacteria was 2.9E + 08 CFU / mL and contacted for 10 seconds, and then 100 μL of a part of the sample water was taken. Then, the collected sample water is added to the SCDLP medium manufactured by Nippon Pharmaceutical Co., Ltd. to inactivate the surfactant, and then appropriately diluted, and the diluted sample water is used with the SCDLP agar medium manufactured by Nippon Pharmaceutical Co., Ltd. The number of bacteria after 24 hours at 36 ° C. was measured by the smearing method used. The logarithmic decrease value of the number of bacteria is shown in Table 4 and FIG.

(Experimental examples D2, D3)
A part of the surfactant aqueous solution prepared in Experimental Example D1 was collected as sample water, and an alkali metal salt shown in Table 4 was added to this sample water so as to have a concentration shown in the same table, thereby reducing the amount of sample water to 1 mL. Adjusted. The sample water was preincubated in a 37 ° C. water bath.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Example D1, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 4 and FIG.

(Experimental examples D4 and D5)
The same distilled water used in Experimental Example D1 was used as the sample water, and only the alkali metal salt shown in Table 4 was added to this sample water so as to have the concentration shown in the same table, thereby adjusting the amount of the sample water to 1 mL. . The sample water was preincubated in a 37 ° C. water bath.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Example D1, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 4 and FIG.

Experimental example E
(Experimental Example E1)
A surfactant aqueous solution in which monododecyl sodium phosphate was dissolved in distilled water to adjust the monododecyl sodium phosphate concentration to 0.3 w / v% was prepared. And 1 mL of prepared surfactant aqueous solution was fractionated as sample water, and this was preincubated in a 37 degreeC water bath.

  Next, Staphylococcus aureus NBRC13276 was added to the pre-incubated sample water so that the number of bacteria became 1.4E + 08 CFU / mL and contacted for 10 seconds, and then 100 μL of a part of the sample water was taken. Then, the collected sample water is added to the SCDLP medium manufactured by Nippon Pharmaceutical Co., Ltd. to inactivate the surfactant, and then appropriately diluted, and the diluted sample water is used with the SCDLP agar medium manufactured by Nippon Pharmaceutical Co., Ltd. The number of bacteria after 24 hours at 36 ° C. was measured by the smearing method used. The logarithmic decrease value of the number of bacteria is shown in Table 5 and FIG.

(Experimental Examples E2 to E5)
A part of the surfactant aqueous solution prepared in Experimental Example E1 was collected as sample water, and an alkali metal salt shown in Table 5 was added to the sample water so as to have a concentration shown in the same table, thereby reducing the amount of sample water to 1 mL. Adjusted. The sample water was preincubated in a 37 ° C. water bath.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Example E1, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 5 and FIG.

(Experimental examples E6 to E9)
The same distilled water as used in Experimental Example E1 was used as the sample water, and only the alkali metal salt shown in Table 5 was added to this sample water so as to have the concentration shown in the same table, thereby adjusting the amount of the sample water to 1 mL. . The sample water was preincubated in a 37 ° C. water bath.

  Next, the pre-incubated sample water was subjected to the same treatment as that after the pre-incubation in Experimental Example E1, and the number of bacteria was measured. The logarithmic decrease value of the number of bacteria is shown in Table 5 and FIG.

Claims (3)

Monododecyl sodium phosphate ,
An alkali metal salt different from the ionic surfactant,
The alkali metal salt is a formate;
Surfactant composition. The surfactant composition according to claim 1, which is a solution containing sodium monododecyl phosphate and the alkali metal salt. The surfactant composition according to claim 2, further comprising a pH buffer.

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