JP5925770B2 - ナイアシン模倣体、およびその使用方法 - Google Patents

ナイアシン模倣体、およびその使用方法 Download PDF

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Publication number
JP5925770B2
JP5925770B2 JP2013516830A JP2013516830A JP5925770B2 JP 5925770 B2 JP5925770 B2 JP 5925770B2 JP 2013516830 A JP2013516830 A JP 2013516830A JP 2013516830 A JP2013516830 A JP 2013516830A JP 5925770 B2 JP5925770 B2 JP 5925770B2
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Prior art keywords
niacin
present
acid
group
certain embodiments
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Expired - Fee Related
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JP2013516830A
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Japanese (ja)
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JP2013529645A (ja
JP2013529645A5 (enExample
Inventor
ダブリュー バチョヴチン，ウィリアム
ダブリュー バチョヴチン，ウィリアム
ライ，フンセン
オコンネル，ダニエル
ウー，ウェンゲン
ピー キリツィー，クリストファー
ピー キリツィー，クリストファー
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Arisaph Pharmaceuticals Inc
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Arisaph Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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JP2013516830A 2010-06-24 2011-06-24 ナイアシン模倣体、およびその使用方法 Expired - Fee Related JP5925770B2 (ja)

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US35824510P 2010-06-24 2010-06-24
US61/358,245 2010-06-24
PCT/US2011/041869 WO2011163612A1 (en) 2010-06-24 2011-06-24 Niacin mimetics, and methods of use thereof

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JP2013529645A JP2013529645A (ja) 2013-07-22
JP2013529645A5 JP2013529645A5 (enExample) 2014-08-07
JP5925770B2 true JP5925770B2 (ja) 2016-05-25

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US (2) US8937063B2 (enExample)
EP (1) EP2584899B1 (enExample)
JP (1) JP5925770B2 (enExample)
AU (1) AU2011270719B2 (enExample)
CA (1) CA2802945A1 (enExample)
WO (1) WO2011163612A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016128452A (ja) * 2010-06-24 2016-07-14 トラスティーズ オブ タフツ カレッジ ナイアシン模倣体、およびその使用方法

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KR102194745B1 (ko) 2013-03-13 2020-12-24 포르마 세라퓨틱스 인크. Ｆａｓｎ 억제용 신규 화합물 및 조성물
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
WO2016077832A2 (en) 2014-11-14 2016-05-19 Gemphire Therapeutics Inc. PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS
KR20180073597A (ko) * 2015-11-06 2018-07-02 젬파이어 세러퓨틱스 인코포레이티드 혼합 이상지질혈증의 치료
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
EP3873214A4 (en) 2018-10-29 2022-07-13 Forma Therapeutics, Inc. Solid forms of (4-(2-fluoro-4-(1-methyl-1 h-benzo[d]imidazol-5-yl)benzoyl) piperazin-1-yl)(1-hydroxycyclopropyl)methanone
US11633554B1 (en) * 2019-06-11 2023-04-25 Luca Puviani Adaptive systems and methods for delivery of a medicament
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH445129A (fr) 1964-04-29 1967-10-15 Nestle Sa Procédé pour la préparation de composés d'inclusion à poids moléculaire élevé
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
US3426011A (en) 1967-02-13 1969-02-04 Corn Products Co Cyclodextrins with anionic properties
US3453257A (en) 1967-02-13 1969-07-01 Corn Products Co Cyclodextrin with cationic properties
US3453259A (en) 1967-03-22 1969-07-01 Corn Products Co Cyclodextrin polyol ethers and their oxidation products
US4021436A (en) 1974-03-15 1977-05-03 Claudio Cavazza Derivatives of nicotinic acid with amines variously substituted
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4503223A (en) 1983-08-11 1985-03-05 Usv Pharmaceutical Corporation Process for the purification of N-morpholinoalkyl dihydropyridines
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
EP2319513A1 (en) 1993-09-20 2011-05-11 Abbott Respiratory LLC Nicotinic acid compositons for treating hyperlipidemia and related methods therefor
IL115849A0 (en) 1994-11-03 1996-01-31 Merz & Co Gmbh & Co Tangential filtration preparation of liposomal drugs and liposome product thereof
US6603000B2 (en) 2001-07-11 2003-08-05 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis for heteroarylamine compounds
EP1636187A1 (en) * 2003-06-12 2006-03-22 Novo Nordisk A/S Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase
JP2008519080A (ja) * 2004-11-05 2008-06-05 アリーナ ファーマシューティカルズ， インコーポレイテッド ナイアシン受容体部分的アゴニストを含む、潮紅および脂質関連障害を処置するための組成物
US20070105793A1 (en) * 2005-11-04 2007-05-10 Curt Hendrix Compositions and methods using nicotinic acid for treatment of hypercholesterolemia, hyperlipidemia nd cardiovascular disease
CA2659747C (en) * 2006-08-03 2015-09-08 Trustees Of Tufts College Non-flushing niacin analogues, and methods of use thereof
AU2008219599A1 (en) 2007-03-01 2008-09-04 Concourse Health Sciences Llc Isomers of inositol niacinate and uses thereof
MX2011004553A (es) 2008-10-29 2011-07-20 Sirtris Pharmaceuticals Inc Piridina, piridina biciclica y analogos relacionados como moduladores de sirtuina.
WO2010065549A1 (en) * 2008-12-01 2010-06-10 Paul Slowey Multi compartment body part scraping fluid collection device
JP5925771B2 (ja) * 2010-06-24 2016-05-25 トラスティーズ オブ タフツ カレッジ ナイアシン模倣体、およびその使用方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016128452A (ja) * 2010-06-24 2016-07-14 トラスティーズ オブ タフツ カレッジ ナイアシン模倣体、およびその使用方法

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