JP5917789B2 - 脂質ベースの医薬化合物の製造のための水性系、その組成物、方法、および使用 - Google Patents
脂質ベースの医薬化合物の製造のための水性系、その組成物、方法、および使用 Download PDFInfo
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- JP5917789B2 JP5917789B2 JP2009532562A JP2009532562A JP5917789B2 JP 5917789 B2 JP5917789 B2 JP 5917789B2 JP 2009532562 A JP2009532562 A JP 2009532562A JP 2009532562 A JP2009532562 A JP 2009532562A JP 5917789 B2 JP5917789 B2 JP 5917789B2
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- lipid
- acid
- amphotericin
- active compound
- cholesterol
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Description
本明細書で使用される、「脂質組成物」という用語は、リポソーム形態、ベシクル形態、ミセル形態、乳剤形態が可能であって、投与される場合、実質的に非毒性である、両性化合物を指す。脂質組成物は、卵ホスファチジルコリン(EPC)、卵ホスファチジルグリセロール(EPG)、大豆ホスファチジルコリン(SPC)、水素添加大豆ホスファチジルコリン(HSPC)、ジミリストイルホスファチジルコリン(DMPC)、ジミリストイルホスファチジルグリセロール(DMPG)、ジパルミトイルホスファチジルコリン(DPPC)、ジステアロイルホスファチジルグリセロール(DSPG)、ジパルミトイルホスファチジルグリセロール(DMPG)、コレステロール(Chol)、コレステロール硫酸およびその塩(CS)、コレステロールヘミスクシナートおよびその塩(Chems)、コレステロールリン酸およびその塩(CP)、リン酸コレステリル、ならびに他のヒドロキシコレステロールまたはアミノコレステロール誘導体を含み得るが、それらに限定されない。
いくつかの実施形態では、本発明の製造方法は、活性化合物(例えば、パクリタキセル)と、コレステリル誘導体(例えば、硫酸コレステリル)と、ホスファチジルコリン、例えば、大豆ホスファチジルコリンまたは水素添加大豆ホスファチジルコリンとを、水または緩衝液中で混合するステップを含む。結果として生じる懸濁液は、任意の所望の温度20〜120℃の範囲で、均質化または超音波処理可能である。塩基または緩衝液の例は、二塩基性コハク酸ナトリウム、酢酸ナトリウム、一塩基性リン酸ナトリウム、二塩基性リン酸ナトリウム、三塩基性リン酸ナトリウム、水酸化ナトリウム等を含むが、それらに限定されない。組成物は、さらに糖類を含有し得る。糖類の例は、スクロース、乳糖、デキストロース、トレハロース、マルトース等を含むが、それらに限定されない。糖類の百分率は、5%から約25%の範囲であり得る。結果として生じる懸濁液は、均質化または超音波処理され、粒径を減少することができる。いくつかの実施形態では、水和化懸濁液は、好適なフィルタを通して濾過し、形成される複合体のサイズ分布を制御される。いくつかの組成物では、水和化懸濁液は、凍結乾燥され、粉末形態の組成物を得ることができる。いくつかの実施形態では、水和化組成物は、加圧滅菌可能である。
Claims (11)
- 活性化合物の脂質製剤を製造するための方法であって、
水性系を使用して脂質製剤の懸濁液を製造するプロセスの使用を含み、ここで前記水性系を使用して前記懸濁液を製造する前記プロセスが有機溶媒の使用を含まず、かつ前記方法は:
i)水、水に溶解された塩化ナトリウム、又は水に溶解された緩衝剤からなる水性媒体に対して、少なくとも一つの固体状の脂質、並びに部分的に水溶性であるか又は水に不溶性の薬剤である、少なくとも一つの固体状の活性化合物を添加すること;
ii)ステップi)の前記水性媒体、前記固体状の脂質、及び前記固体状の活性化合物からなる混合物を共に処理し、規定の粒径の脂質−化合物懸濁液を形成すること;
iii)ステップii)の前記規定の粒径の脂質−化合物懸濁液を凍結乾燥し、凍結乾燥された物質を形成すること;並びに
iv)ステップiii)の前記凍結乾燥された物質を水性媒体で再構成し、規定の粒径の脂質製剤の懸濁液を得ること
を含み、前記規定の粒径は5ミクロン未満の平均粒径を有し、
前記少なくとも1つの脂質が、コレステロール、又はコレステロール硫酸及びその塩、コレステロールヘミスクシナート及びその塩、コレステロールリン酸及びその塩から成る群から選択されるコレステロール誘導体と、少なくとも1つのリン脂質とを含む、前記方法。 - 前記少なくとも1つの脂質が、コレステロール硫酸と、水素添加ダイズホスファチジルコリン、大豆ホスファチジルコリン、及び大豆レシチンから選択されるリン脂質とを含む、請求項1に記載の方法。
- ステップi)の水性媒体が水である、請求項1又は2に記載の方法。
- 前記少なくとも1つの活性化合物が、ポリエン抗生物質、マクロライド、抗癌剤、治療タンパク質、リボザイム、及び免疫抑制剤から成る群から選択される、請求項1〜3のいずれか1項に記載の方法。
- 前記少なくとも1つの活性化合物が、ドセタキセル、パクリタキセル、ドキソルビシン、エピルビシン、タモキシフェン、エンドキシフェン、エトポシド、アントラサイクリン、アンホテリシンB、タクロリムス及びサクロリムス、シクロスポリン、並びにメトトレキサートから成る群から選択される、請求項1〜4のいずれか1項に記載の方法。
- 前記脂質製剤の懸濁液が、ポリエチレングリコールをさらに含む、請求項1〜5のいずれか1項に記載の方法。
- 前記活性化合物対前記コレステロール又はコレステロール誘導体のモル比が、10:1と1:10との間である、請求項1〜6のいずれか1項に記載の方法。
- 前記少なくとも1つの脂質が、水素添加大豆ホスファチジルコリン又は大豆ホスファチジルコリンを含み、活性化合物と水素添加大豆ホスファチジルコリン又は大豆ホスファチジルコリンのモル比が、1:1と1:100との間である、請求項1〜7のいずれか1項に記載の方法。
- 前記脂質−化合物懸濁液が、総脂質濃度2.5重量%から95重量%を含む、請求項1〜8のいずれか1項に記載の方法。
- 前記脂質−化合物懸濁液の活性化合物対脂質の重量対重量比が、1:10と1:100との間である、請求項1〜9のいずれか1項に記載の方法。
- 前記水性媒体、前記固体状の脂質、及び前記固体状の活性化合物からなる混合物を共に前記処理することが、選択されたサイズの開口部を通して前記水性媒体、前記固体状の脂質、及び前記固体状の活性化合物を押し出すこと、及び/又は高圧分離均質化によって処理することを含む、請求項1〜10のいずれか1項に記載の方法。
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2101731T3 (pl) | 2006-11-21 | 2018-07-31 | Jina Pharmaceuticals Inc. | Endoksyfen do zastosowania w leczeniu nowotworu |
US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
PL2344198T3 (pl) | 2008-09-27 | 2021-05-31 | Jina Pharmaceuticals Inc. | Preparaty farmaceutyczne na bazie lipidów do stosowania miejscowego |
JP5627039B2 (ja) | 2009-06-19 | 2014-11-19 | サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド | 薬物のナノ分散体およびその調製のための方法 |
US20170340563A1 (en) * | 2009-09-23 | 2017-11-30 | Curirx Inc. | Methods for the Preparation of Liposomes Comprising Drugs |
US8591942B2 (en) * | 2009-09-23 | 2013-11-26 | Indu JAVERI | Methods for the preparation of liposomes comprising docetaxel |
CA2823747C (en) | 2011-01-04 | 2019-07-23 | Archivel Farma, Sl | Liposome formulation suitable for treating or preventing tuberculosis |
WO2013104943A1 (en) | 2012-01-12 | 2013-07-18 | Archivel Farma, S.L. | Mtb-c vaccine against asthma |
US10220095B2 (en) | 2013-03-15 | 2019-03-05 | Taiwan Liposome Company, Ltd | Controlled drug release liposome compositions and methods thereof |
JP2016535734A (ja) * | 2013-10-21 | 2016-11-17 | エンザイモテック リミテッド | コリン及びその誘導体を含む組成物、その用途及び調製方法 |
AU2014345193C1 (en) * | 2013-11-08 | 2020-09-10 | Activus Pharma Co., Ltd. | Aqueous suspension preparation comprising nanoparticles of macrolide antibacterial agent |
EP3150196A1 (en) * | 2015-09-30 | 2017-04-05 | Sun Pharma Advanced Research Company Ltd | Process for the preparation of unilamellar liposomal composition |
MX2018008267A (es) * | 2016-01-07 | 2018-09-28 | Univ Western Health Sciences | Formulaciones para el tratamiento del cancer de vejiga. |
US20170290852A1 (en) * | 2016-04-08 | 2017-10-12 | Wisconsin Alumni Research Foundation | Micelle formulations of amphotericin b |
WO2017177228A1 (en) | 2016-04-08 | 2017-10-12 | The Board Of Trustees Of The University Of Illinois | Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia |
US20200155583A1 (en) * | 2017-02-21 | 2020-05-21 | Ico Therapeutics Inc. | Solid oral formulations of amphotericin b |
EP4324460A3 (en) | 2017-09-15 | 2024-04-24 | Dyve Biosciences, Inc. | Sodium bicarbonate for use in the treatment of gout and related disorders |
RU2752417C1 (ru) * | 2017-11-30 | 2021-07-28 | Схилпа Медикаре Лимитед | Композиция на основе липосомальной формы доцетаксела для инъекций с высоким содержанием лекарственного средства |
EP3603682A1 (en) * | 2018-08-03 | 2020-02-05 | Alchilife S.r.l. | Tablet with an antimycotic agent, medical device and method for preserving harvested corneas |
US11857680B2 (en) * | 2018-11-26 | 2024-01-02 | Shilpa Medicare Limited | Composition of docetaxel liposomal injection with high drug loading |
US20230226002A1 (en) * | 2020-06-15 | 2023-07-20 | University Of Utah Research Foundation | Retinal bioavailbility of synthetic very-long-chain polyunsaturated fatty acids |
WO2022081479A2 (en) * | 2020-10-12 | 2022-04-21 | Durect Corporation | Crystalline sodium cholesteryl sulfonate |
WO2022081481A2 (en) * | 2020-10-12 | 2022-04-21 | Durect Corporation | Crystalline sodium cholesteryl sulfate |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5782310A (en) * | 1980-11-11 | 1982-05-22 | Tanabe Seiyaku Co Ltd | Production of liposome preparation |
JPS5782311A (en) * | 1980-11-11 | 1982-05-22 | Tanabe Seiyaku Co Ltd | Production of liposome preparation |
JPS6058915A (ja) * | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | 薬物含有脂質小胞体製剤 |
US5084269A (en) * | 1986-11-06 | 1992-01-28 | Kullenberg Fred W | Adjuvant for dose treatment with antigens |
MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
EP0556394B1 (en) * | 1990-11-06 | 2002-06-19 | Nippon Shinyaku Company, Limited | Lyophilized preparation and production thereof |
DE4207481A1 (de) * | 1992-03-10 | 1993-09-16 | Bayer Ag | Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung |
ATE223205T1 (de) * | 1994-11-18 | 2002-09-15 | Aphios Corp | Verfahren zur herstellung von liposomen, die hydrophobische artzneistoffe enthalten |
EP1333811A4 (en) * | 2000-10-16 | 2004-03-03 | Neopharm Inc | LIPOSOMAL PREPARATION BASED ON MITOXANTRONE |
ATE413164T1 (de) * | 2000-11-09 | 2008-11-15 | Neopharm Inc | Sn-38-lipidkomplexe und verfahren zu ihrer verwendung |
CN1658845A (zh) * | 2002-06-11 | 2005-08-24 | 爱的发制药集团 | 隐形脂质纳米胶囊,其制备方法,及其作为活性成分载体的应用 |
WO2005044229A1 (en) * | 2003-11-05 | 2005-05-19 | The Australian National University | Dispersions and methods of preparing them |
US20060110441A1 (en) * | 2004-10-28 | 2006-05-25 | Harry Wong | Lyophilized liposome formulations and method |
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2016
- 2016-07-07 US US15/204,826 patent/US20160310600A1/en not_active Abandoned
-
2020
- 2020-07-09 US US16/924,529 patent/US20200345849A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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WO2008127358A3 (en) | 2008-12-24 |
US20160310600A1 (en) | 2016-10-27 |
JP2010505965A (ja) | 2010-02-25 |
JP2016041704A (ja) | 2016-03-31 |
PL2076244T3 (pl) | 2017-05-31 |
HUE031951T2 (en) | 2017-08-28 |
US20200345849A1 (en) | 2020-11-05 |
PT2076244T (pt) | 2017-03-09 |
EP2076244A2 (en) | 2009-07-08 |
WO2008127358A2 (en) | 2008-10-23 |
ES2617747T3 (es) | 2017-06-19 |
EP2076244A4 (en) | 2013-01-09 |
EP2076244B1 (en) | 2016-12-07 |
CA2666322A1 (en) | 2008-10-23 |
DK2076244T3 (en) | 2017-02-27 |
CA2666322C (en) | 2013-04-23 |
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