JP5903433B2 - 癌の治療に有用なｖｅｇｆｒ阻害剤およびｍｅｋ阻害剤の医薬的組み合わせ - Google Patents
癌の治療に有用なｖｅｇｆｒ阻害剤およびｍｅｋ阻害剤の医薬的組み合わせ Download PDFInfo
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Landscapes
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| US37719610P | 2010-08-26 | 2010-08-26 | |
| US61/377,196 | 2010-08-26 | ||
| PCT/US2011/048906 WO2012027438A1 (en) | 2010-08-26 | 2011-08-24 | Pharmaceutical combination of a vegfr inhibitor and a mek inhibitor useful for treating cancer |
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| JP2013536243A JP2013536243A (ja) | 2013-09-19 |
| JP2013536243A5 JP2013536243A5 (enExample) | 2014-10-09 |
| JP5903433B2 true JP5903433B2 (ja) | 2016-04-13 |
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| US (4) | US20130165456A1 (enExample) |
| EP (1) | EP2608790A4 (enExample) |
| JP (1) | JP5903433B2 (enExample) |
| WO (1) | WO2012027438A1 (enExample) |
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| TWI505828B (zh) | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產（第二）有限公司 | 新穎醫藥組成物 |
| US20150306099A1 (en) * | 2012-11-27 | 2015-10-29 | Glaxosmithkline Llc | Combination |
| TWI839690B (zh) | 2013-07-12 | 2024-04-21 | 印度商皮拉馬爾企業有限公司 | 治療黑色素瘤的藥物組合的用途 |
| EP2913048A1 (en) * | 2014-02-27 | 2015-09-02 | ratiopharm GmbH | Pharmaceutical composition comprising trametinib |
| CN109715163B (zh) | 2016-09-19 | 2022-11-22 | 诺华股份有限公司 | 包含raf抑制剂和erk抑制剂的治疗组合 |
| WO2018203219A1 (en) | 2017-05-02 | 2018-11-08 | Novartis Ag | Combination therapy |
| EP4563150A3 (en) | 2019-05-13 | 2025-07-23 | Novartis AG | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl) isonicotinamide as raf inhibitors for the treatment of cancer |
| CN115916779B (zh) * | 2020-05-11 | 2025-09-16 | 克立弗治疗学股份有限公司 | 用于治疗癌症的VCP/p97抑制剂 |
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| MXPA03005696A (es) | 2000-12-21 | 2003-10-06 | Glaxo Group Ltd | Pirimidinaminas como moduladores de angiogenesis. |
| JP2007532658A (ja) * | 2004-04-16 | 2007-11-15 | スミスクライン ビーチャム コーポレーション | がんの治療方法 |
| US7378423B2 (en) | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| KR100883289B1 (ko) * | 2004-06-11 | 2009-02-11 | 니뽄 다바코 산교 가부시키가이샤 | 암 치료용5-아미노-2,4,7-트리옥소-3,4,7,8-테트라히드로-2ｈ-피리도[2,3-ｄ]피리미딘 유도체 및 관련 화합물 |
| US20100130519A1 (en) * | 2007-04-13 | 2010-05-27 | Stephen Robert Wedge | Combination therapy comprising azd2171 and azd6244 or mek-inhibitor ii |
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2011
- 2011-08-24 JP JP2013526118A patent/JP5903433B2/ja not_active Expired - Fee Related
- 2011-08-24 EP EP11820572.3A patent/EP2608790A4/en not_active Withdrawn
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2014
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2015
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2017
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| JP2013536243A (ja) | 2013-09-19 |
| EP2608790A4 (en) | 2014-04-02 |
| WO2012027438A1 (en) | 2012-03-01 |
| US20170239255A1 (en) | 2017-08-24 |
| US20150352117A1 (en) | 2015-12-10 |
| EP2608790A1 (en) | 2013-07-03 |
| US20130165456A1 (en) | 2013-06-27 |
| US20140323506A1 (en) | 2014-10-30 |
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