JP5903433B2 - 癌の治療に有用なｖｅｇｆｒ阻害剤およびｍｅｋ阻害剤の医薬的組み合わせ - Google Patents
癌の治療に有用なｖｅｇｆｒ阻害剤およびｍｅｋ阻害剤の医薬的組み合わせ Download PDFInfo
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US37719610P | 2010-08-26 | 2010-08-26 | |
| US61/377,196 | 2010-08-26 | ||
| PCT/US2011/048906 WO2012027438A1 (en) | 2010-08-26 | 2011-08-24 | Pharmaceutical combination of a vegfr inhibitor and a mek inhibitor useful for treating cancer |
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| JP2013536243A JP2013536243A (ja) | 2013-09-19 |
| JP2013536243A5 JP2013536243A5 (enExample) | 2014-10-09 |
| JP5903433B2 true JP5903433B2 (ja) | 2016-04-13 |
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| US (4) | US20130165456A1 (enExample) |
| EP (1) | EP2608790A4 (enExample) |
| JP (1) | JP5903433B2 (enExample) |
| WO (1) | WO2012027438A1 (enExample) |
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| TWI505828B (zh) | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產（第二）有限公司 | 新穎醫藥組成物 |
| US20150306099A1 (en) * | 2012-11-27 | 2015-10-29 | Glaxosmithkline Llc | Combination |
| TWI839690B (zh) * | 2013-07-12 | 2024-04-21 | 印度商皮拉馬爾企業有限公司 | 治療黑色素瘤的藥物組合的用途 |
| EP2913048A1 (en) * | 2014-02-27 | 2015-09-02 | ratiopharm GmbH | Pharmaceutical composition comprising trametinib |
| KR102341660B1 (ko) | 2016-09-19 | 2021-12-23 | 노파르티스 아게 | Raf 억제제 및 erk 억제제를 포함하는 치료적 조합 |
| ES2952265T3 (es) | 2017-05-02 | 2023-10-30 | Novartis Ag | Terapia combinada que comprende un inhibidor de Raf y trametinib |
| EP3969449B1 (en) | 2019-05-13 | 2025-02-12 | Novartis AG | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer |
| JP2023526223A (ja) * | 2020-05-11 | 2023-06-21 | クリーブ セラピューティクス，インク． | がん処置のためのＶＣＰ／ｐ９７阻害薬 |
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| KR100847169B1 (ko) | 2000-12-21 | 2008-07-17 | 글락소 그룹 리미티드 | 혈관형성 조절제로서의 피리미딘아민 |
| EP1755394A4 (en) | 2004-04-16 | 2009-08-05 | Smithkline Beecham Corp | METHOD OF TREATING CANCER |
| WO2005121142A1 (en) | 2004-06-11 | 2005-12-22 | Japan Tobacco Inc. | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido’2,3-d! pyrimidine derivatives and related compounds for the treatment of cancer |
| US7378423B2 (en) | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| WO2008125820A1 (en) * | 2007-04-13 | 2008-10-23 | Astrazeneca Ab | Combination therapy comprising azd2171 and azd6244 or mek-inhibitor ii |
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2011
- 2011-08-24 US US13/819,091 patent/US20130165456A1/en not_active Abandoned
- 2011-08-24 WO PCT/US2011/048906 patent/WO2012027438A1/en not_active Ceased
- 2011-08-24 JP JP2013526118A patent/JP5903433B2/ja not_active Expired - Fee Related
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2014
- 2014-07-10 US US14/327,660 patent/US20140323506A1/en not_active Abandoned
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2015
- 2015-08-19 US US14/829,689 patent/US20150352117A1/en not_active Abandoned
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2017
- 2017-05-08 US US15/588,787 patent/US20170239255A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20140323506A1 (en) | 2014-10-30 |
| WO2012027438A1 (en) | 2012-03-01 |
| EP2608790A4 (en) | 2014-04-02 |
| US20130165456A1 (en) | 2013-06-27 |
| EP2608790A1 (en) | 2013-07-03 |
| US20170239255A1 (en) | 2017-08-24 |
| US20150352117A1 (en) | 2015-12-10 |
| JP2013536243A (ja) | 2013-09-19 |
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