JP5879410B2 - Contact lens ophthalmic composition - Google Patents

Description

The present invention relates to an ophthalmic composition for contact lenses. Specifically, the present invention relates to an ophthalmic composition that can be suitably used as an eye drop, an eye wash, a contact lens mounting solution, a contact lens care agent, and the like that can be used while wearing a contact lens.

The lacrimal fluid covering the surface of the eyeball has a three-layer structure of a mucus layer made of mucin, an aqueous layer, and an oil layer from the eyeball side. In addition, it is known that an amphiphilic phospholipid layer exists between the water layer and the oil layer, and the tear fluid is stabilized by bridging the water layer and the oil layer (non-patent document). Reference 1).
Since phospholipid is a tear component, various ophthalmic compositions for preventing or treating dry eye containing lecithin containing phospholipid as a main component have been proposed in recent years. Further, it is known that when a contact lens is used, it tends to cause dry eyes.
For example, Patent Document 1 describes that a composition containing castor oil and lecithin is useful for the prevention or treatment of dry eye, and is effective for the prevention and treatment of discomfort when wearing contact lenses. Yes. Patent Document 2 describes an ophthalmic composition for contact lenses containing a cooling agent and / or chlorobutanol and forming an oil-in-water emulsion with lecithin.
On the other hand, azulene sulfonic acid, glycyrrhizic acid, chlorpheniramine, neostigmine, cobalamin, retinol, tocopherol, and salts thereof are known as physiologically active ingredients and are also incorporated in ophthalmic compositions.
However, the actual situation is that the influence of lecithin and the above physiologically active components on the properties of contact lenses including wettability has not been sufficiently studied.

WO2006 / 009112 WO2005 / 025539

"Japanese ophthalmology" 74, No.6, 2003, 569-572

The present inventors have unexpectedly found that when lecithin is added to an ophthalmic composition, wettability to contact lenses is lowered.
An object of the present invention is to provide an ophthalmic composition for contact lenses that contains lecithin and has good wettability with respect to contact lenses.

The present inventors have repeated researches to solve the above problems, and have obtained the following knowledge.
Although the ophthalmic composition for contact lenses containing lecithin tends to decrease wettability to contact lenses, surprisingly, azulene sulfonic acid, glycyrrhizic acid, chlorpheniramine, neostigmine, cobalamin, retinol, tocopherol, and their By further including one or more components selected from the group consisting of salts, the decrease in wettability with respect to the contact lens by lecithin is suppressed.
Furthermore, the present inventors in the ophthalmic composition for contact lenses, lecithin, azulenesulfonic acid, glycyrrhizic acid, chlorpheniramine, neostigmine, cobalamin,
By using in combination with one or more physiologically active ingredients selected from the group consisting of retinol, tocopherol, and salts thereof, the stickiness of the ophthalmic composition for contact lenses, the feeling of sticking of the contact lenses to the eyes, and the contact lenses It was found that the increase in the adhesion of microorganisms to the plant was suppressed.
In addition, in the ophthalmic composition for contact lenses, the present inventors can further improve the wettability of the contact lens by further including menthol in addition to the above components, and the ophthalmic composition for contact lens is sticky and has an eye resistance. It was found that the feeling of sticking of the contact lens and the adhesion of microorganisms to the contact lens were further suppressed.

The present invention has been completed based on the above findings, and provides the following ophthalmic compositions for contact lenses.
Item 1. (A) lecithin, and
(B) Azulene sulfonic acid, glycyrrhizic acid, chlorpheniramine, neostigmine,
An ophthalmic composition for contact lenses comprising at least one compound selected from the group consisting of cobalamin, retinol, tocopherol, and pharmacologically acceptable salts thereof.
Item 2. Item 2. The composition according to Item 1, wherein the content of the component (A) is 0.001 to 5 w / v% with respect to the total amount of the composition.
Item 3. Item 3. The composition according to Item 1 or 2, wherein the content of the component (B) is 0.0001 to 0.5 w / v% with respect to the total amount of the composition.
Item 4. The content ratio of the component (A) and the component (B) is 0.00006-1 for the component (B) with respect to 1 part by weight of the component (A).
Item 4. The composition according to any one of Items 1 to 3, which is 000 parts by weight.
Item 5. Item 5. The composition according to any one of Items 1 to 4, further comprising menthol.
Item 6. Item 5 wherein the menthol content is 0.0005 to 0.1 w / v% based on the total amount of the composition.
A composition according to 1.
Item 7. (A) an ophthalmic composition for contact lenses containing lecithin, (B) azulenesulfonic acid,
A method for improving wettability to contact lenses, comprising adding one or more compounds selected from the group consisting of glycyrrhizic acid, chlorpheniramine, neostigmine, cobalamin, retinol, tocopherol, and pharmacologically acceptable salts thereof.
Item 8. (A) an ophthalmic composition for contact lenses containing lecithin, (B) azulenesulfonic acid,
Addition of one or more compounds selected from the group consisting of glycyrrhizic acid, chlorpheniramine, neostigmine, cobalamin, retinol, tocopherol, and pharmacologically acceptable salts thereof, the ability of inhibiting the adhesion of microorganisms to contact lenses Grant method.
Item 9. Item 7. A method for suppressing the adhesion of microorganisms to a contact lens, wherein the composition according to any one of Items 1 to 6 is contacted with the contact lens.
Item 10. (A) contact lens ophthalmic composition containing lecithin, (B) azulene sulfonic acid, glycyrrhizic acid, chlorpheniramine, neostigmine, cobalamin, retinol,
A method for imparting an ability to improve the sticky feeling or stickiness to eyes of a contact lens, comprising adding one or more compounds selected from the group consisting of tocopherol and pharmacologically acceptable salts thereof.

According to the knowledge of the present inventors, a conventional ophthalmic composition for contact lenses containing lecithin is
The wettability to the contact lens is poor, the contact lens is sticky or has a feeling of sticking to the eyes, and microorganisms tend to adhere to the contact lens.
On the other hand, the ophthalmic composition for contact lenses of the present invention has good wettability to contact lenses by containing a specific physiologically active component in addition to lecithin. for that reason,
Not only when used while wearing contact lenses, but also when used for contact lenses that have been removed from the eye, such as contact lens care agents, etc. Is effectively played.
In addition to lecithin, the ophthalmic composition for contact lenses of the present invention can contain a specific physiologically active ingredient, and can reduce stickiness and stickiness of the contact lens to the eyes.
Moreover, the ophthalmic composition for contact lenses of this invention has suppressed adhesion of the microorganisms to a contact lens. This not only suppresses the growth of microorganisms on the contact lens in contact with the eyeball surface, but also cleans the contact lens when used for contact lenses that are removed from the eye, such as contact lens care agents. Therefore, it is possible to suppress the migration of microorganisms to the cornea and conjunctiva through the contact lens.

It is a figure which shows the result of the wettability improvement test with respect to the contact lens performed in the Example. It is a figure which shows the result of the wettability improvement test with respect to the contact lens performed in the Example. It is a figure which shows the result of the wettability improvement test with respect to the contact lens performed in the Example. It is a figure which shows the result of the stickiness test (SCL wearer) performed in the Example. It is a figure which shows the result of the stickiness test (SCL wearer) performed in the Example. It is a figure which shows the result of the sticky feeling test (HCL wearer) performed in the Example. It is a figure which shows the result of the sticky feeling test (HCL wearer) performed in the Example. It is a figure which shows the result of the sticking feeling test (SCL wearer) of the contact lens performed in the Example. It is a figure which shows the result of the sticking feeling test (SCL wearer) of the contact lens performed in the Example. It is a figure which shows the result of the sticking feeling test (HCL wearer) of the contact lens performed in the Example. It is a figure which shows the result of the sticking feeling test (HCL wearer) of the contact lens performed in the Example. It is a figure which shows the result of the microbe adhesion suppression test done in the Example. It is a figure which shows the result of the microbe adhesion suppression test done in the Example. It is a figure which shows the result of the microbe adhesion suppression test done in the Example.

(I) Ophthalmic composition for contact lens The ophthalmic composition for contact lens of the present invention comprises:
(A) lecithin, and
(B) Azulene sulfonic acid, glycyrrhizic acid, chlorpheniramine, neostigmine,
A composition containing one or more components selected from the group consisting of cobalamin, retinol, tocopherol, and pharmacologically acceptable salts thereof.

Use of composition The ophthalmic composition for contact lenses of the present invention is preferably in a liquid state. Such ophthalmic compositions for contact lenses include, for example, eye drops and eyewashes used when wearing contact lenses (during wearing), contact lens wearing solutions, contact lens care agents (cleaning solutions, storage solutions, disinfecting solutions, rinsing solutions). Liquid, multipurpose solution) and the like. Since the composition of the present invention has good wettability with respect to contact lenses, it is particularly suitable for eye drops and eye wash, and is particularly suitable for eye drops.

In the present invention, the term “contact lens” (hereinafter sometimes simply referred to as “lens” or “CL”) includes all types of contact lenses such as hard, oxygen-permeable hard, and soft unless otherwise specified. Is done. For the classification of contact lenses, etc., the ISO standard “INTERNATIONAL STANDARD ISO11539 Ophthalmic optics? Contact lenses? Cla
In accordance with “ssification of contact lenses and contact lens materials”, other necessary conditions are also in accordance with ISO standards.

Further, in this specification, “soft contact lens” (hereinafter, sometimes simply referred to as “SCL”) means that specified as 4.5.1 hydrogel (filcon) materials in the above ISO11539. To do. In ISO11539, soft contact lenses are classified on the basis of moisture content, mol% of ionic monomer, and the like. For example, belonging to group IV
SCL has a common property that the moisture content is 50% or more, and the mol% of the ionic monomer among the constituent monomers of the raw material polymer is 1% or more. Soft contact lens materials include hydroxyethyl methacrylate (HEMA), 2,3-dihydroxypropyl methacrylate (GMA), N-vinylpyrrolidone (NVP), methacrylic acid or its salt (MA), silicone elastomer polydimethylsiloxane ( PDMSi), n-butyl methacrylate (BMA), n-butyl acrylate (BA), and copolymers thereof. Examples of material names based on USAN (United State Adopted Name) include Etafilco
nA etc. are mentioned. A special soft contact lens is a silicone hydrogel material contact lens. A silicone hydrogel contact lens is a silicone-containing material (for example, a polymer of silicone and acrylate).
A contact lens using a material obtained by copolymerizing a hydrophilic monomer (for example, hydroxyethyl methacrylate, dimethylacrylamide, etc.) with a TRIS or TRIS derivative.

In this specification, “hard contact lens” (hereinafter sometimes simply referred to as “HCL”) is defined as 4.5.2 non-hydrogel (focon) materials in the above ISO11539. Means. In ISO11539, hard contact lenses are classified based on the moisture content of silicon or fluorine in the material. For example, HCL belonging to Group I does not contain both silicon and fluorine in the polymer material, while HCL belonging to Group III
Contains both silicon and fluorine in the polymer material. Hard contact lens materials include methyl methacrylate (MMA), cellulose acetate butyrate (CAB), siloxanyl styrene, fluoro methacrylate, siloxanyl methacrylate, fluorine-containing methacrylate (FMA), silicone-containing methacrylate (SiMA), methacryl Examples include acids, dimethacrylic acid esters, dextran esters, fluorosilicones, and co-polymers thereof.
In general, hard contact lenses are less hydrophilic and softer than soft contact lenses, but the ophthalmic composition for contact lenses of the present invention also has better wettability for hard contact lenses. Therefore, the composition of the present invention is particularly suitable as an ophthalmic composition for hard contact lenses.

(A) component
<Lecithin>
The origin of lecithin is not particularly limited. Examples of lecithin include egg yolk lecithin, soybean lecithin, corn lecithin, peanut lecithin, rapeseed lecithin and the like. These lecithins may be unhydrogenated or hydrogenated (including completely hydrogenated and slightly hydrogenated).
The iodine value of lecithin is not particularly limited, and may be, for example, 10 or less. The range of iodine value is preferably about 20-100, more preferably about 30-90, even more preferably about 3
5 to 85. The acid value of lecithin is preferably 50 or less, more preferably 40 or less, and even more preferably 30 or less.

In addition, lecithin is phosphatidylcholine (PC), phosphatidylethanolamine (
PE), phosphatidyl inositol (PI), lysophosphatidylcholine (LPC) and other phospholipids are included, and phosphatidylcholine content is preferably 30% by weight or more of lecithin, more preferably 50% by weight or more. Preferably, lecithin that is 70% by weight or more is even more preferred. The phosphatidylethanolamine content is 50% of the total.
The lecithin is preferably not more than 30% by weight, more preferably not more than 30% by weight,
Even more preferred is lecithin that is no more than wt%. Further, lecithin having a phosphatidylinositol content of 50% by weight or less is preferable, lecithin having a content of 30% by weight or less is more preferable, and lecithin having a content of 15% by weight or less is even more preferable. Further, lecithin having a lysophosphatidylcholine content of 20% by weight or less is preferable, and lecithin having a content of 10% by weight or less is more preferable. Such lecithins include (Resinol S-10, Resinol S-10
M, Resinol S-10E, Resinol S-10EX, Resinol S-H50, Resinol WS-50, Resinol LL-20; Nikko Chemicals Corporation, (PL-30S, PL-100M, PC-98N, PL-100P ; Kewpie Co., Ltd.), (SLP-PC90, SLP-PC92H, SLP-White, SLP-White SP, SLP-White H, SL
P-PC70, SLP-PC70H, SLP-LPC70; Sakai Oil Co., Ltd.) (NC-21, NC-21E, NC-61;
Ltd.), (LipidE-80; Lipid), (Epikuron 120, Ovoyhion 160; Lucus Meyer).
Lecithin may be used alone or in combination of two or more.

The lecithin content in the composition of the present invention is about the total amount of lecithin relative to the total amount of the composition.
0.001-5 w / v% is preferred, about 0.005-2 w / v% is more preferred, and about 0.01-1.5 w / v% is even more preferred. If the lecithin content is in the above range, the effect of improving the wettability to the contact lens, the effect of improving the stickiness, the effect of improving the feeling of sticking the contact lens to the eyes, and the effect of suppressing the adhesion of microorganisms to the contact lens are stable for a long time. Can be obtained sufficiently.

(B) Component The “salt” in the present invention is a pharmacologically or physiologically acceptable salt.
<Azulenesulfonic acid and its salt>
Azulene sulfonic acid is a known compound also called water-soluble azulene, guaiazulene sulfonic acid, or 1,4-dimethyl-7-isopropylazulene-3-sulfonic acid. Azulene sulfonic acid and its salt have anti-inflammatory action and are widely used as active ingredients in ophthalmic compositions.
As salts of azulenesulfonic acid, salts with organic bases (organic amines such as methylamine, triethylamine, triethanolamine, morpholine, piperazine, pyrrolidine, amino acids, tripyridine, picoline, etc.), inorganic bases (ammonium; sodium, potassium, etc.) And alkaline earth metals such as calcium and magnesium; aluminum and the like) and the like.
Among the azulene sulfonic acids and salts thereof, the effects of the present invention are further improved, such as improved wettability to contact lenses, improved stickiness, improved adhesion of contact lenses to eyes, and suppression of microbial adhesion to contact lenses. Therefore, an alkali metal salt of azulene sulfonic acid is preferable, and sodium azulene sulfonate is more preferable.
Azulenesulfonic acid and its salt can be purchased commercially, can be synthesized according to well-known methods, and can also be extracted from Asteraceae plants.

<Glycyrrhizic acid and its salt>
Glycyrrhizic acid is 20β-carboxy-11-oxo-30-noroleana-12-en-3β-yl
= (β-D-glucopyranosyluronic acid)-(1 → 2) -α-D-glucopyranoside uronic acid is a known compound. Glycyrrhizic acid and its salt have anti-inflammatory action and are widely used as active ingredients in ophthalmic compositions.
Examples of the salt of glycyrrhizic acid include alkali metal salts such as sodium salt and potassium salt; ammonium salt and the like. Specific examples include alkali metal salts such as disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, and tripotassium glycyrrhizinate; and ammonium salts such as monoammonium glycyrrhizinate.
Among the glycyrrhizic acid and its salts, the effects of the present invention, such as improved wettability to contact lenses, improved stickiness, improved adhesion of contact lenses to the eyes, and suppression of microbial adhesion to contact lenses, are further improved. A salt of glycyrrhizic acid is preferred, an alkali metal salt of glycyrrhizic acid is more preferred, and dipotassium glycyrrhizinate is even more preferred.
Glycyrrhizic acid and its salt can be purchased commercially, can be synthesized according to well-known methods, and can also be extracted from licorice roots.

<Chlorpheniramine and its salt>
Chlorpheniramine is a known compound also called 3- (4-chlorophenyl) -N, N-dimethyl-3-pyridin-2-yl-propan-1-amine. Chlorpheniramine and its salt have an antihistaminic action and are widely used as active ingredients in ophthalmic compositions.
Examples of chlorpheniramine salts include organic acid salts such as maleate and fumarate; hydrochloride,
Examples thereof include inorganic acid salts such as sulfates.
Chlorpheniramine and a salt thereof may be any of d-form, l-form, and dl-form. Moreover, the form of a hydrate may be sufficient.
Among the chlorpheniramines and salts thereof, the effects of the present invention are further improved, such as improved wettability to contact lenses, improved stickiness, improved adhesion of contact lenses to eyes, and suppression of microorganism adhesion to contact lenses. A salt of chlorpheniramine is preferred, a chlorpheniramine organic acid salt is more preferred, chlorpheniramine maleate is even more preferred, and chlorpheniramine maleate is particularly preferred.
Chlorpheniramine and its salt can be purchased commercially or synthesized according to well-known methods.

<Neostigmine and its salt>
Neostigmine is a known compound also referred to as N-(-3-dimethylcarbamoyloxyphenyl) -N, N, N-trimethylammonium.
Neostigmine and its salt have an action of improving the focus control function of the eye, and are widely used as an active ingredient in ophthalmic compositions.
Examples of the salt of neostigmine include methyl sulfate (methyl sulfate neostigmine), bromide salt (neostigmine bromide) and the like.
Among neostigmine and its salts, the wettability improvement for contact lenses, the improvement of stickiness, the improvement of the contact feeling of the contact lenses to the eyes, and the effect of the present invention to suppress the adhesion of microorganisms to the contact lenses are further improved, Neostigmine salt is preferred, and neostigmine methylsulfate is more preferred.
Neostigmine and its salt can be purchased commercially or synthesized according to well-known methods.

<Cobalamin and its salt>
Cobalamin is a kind of water-soluble vitamin classified as vitamin B12. Cobalamin and a salt thereof have an effect of improving eye strain and are widely used as an active ingredient of an ophthalmic composition.
Cobalamin salts include cyanocobalamin, mecobalamin, hydroxocobalamin,
Examples thereof include hydroxocobalamin hydrochloride and hydroxocobalamin acetate.
Among the cobalamins and salts thereof, the wettability improvement for contact lenses, the improvement of stickiness, the improvement of the contact feeling of the contact lenses to the eyes, and the effect of the present invention of suppressing the adhesion of microorganisms to the contact lenses are further improved, A salt of cobalamin is preferred, and cyanocobalamin is more preferred.
Cobalamin and its salt can be purchased commercially or can be synthesized according to well-known methods.

<Retinol and its salt>
Retinol is a kind of fat-soluble vitamin classified as vitamin A. Retinol and salts thereof have a visual acuity-improving action and are widely used as active ingredients in ophthalmic compositions because they become the chromophore of the retinal photoreceptor cell rhodopsin.
Examples of the salt of retinol include organic acid salts such as palmitate and acetate, and inorganic acid salts such as ammonium salt.
Among the retinol and its salts, in the point that the effect of the present invention is improved, such as improvement of wettability to contact lenses, improvement of stickiness, improvement of sticking feeling of contact lenses to eyes, and suppression of microbial adhesion to contact lenses, Retinol salts are preferred, and retinol palmitate is more preferred.
Retinol and its salt can be purchased commercially or synthesized according to well-known methods.

<Tocopherol and its salt>
Tocopherol is a kind of fat-soluble vitamin classified as vitamin E, and is known to have an antioxidant action, and is widely used as an active ingredient in ophthalmic compositions.
Tocopherol and a salt thereof may be any of α-form, β-form, γ-form, and delta-form, and α-form is preferable, and d-form or l-form may be used. preferable. In particular, the d-α-isomer is preferable.
Examples of the salt of tocopherol include organic acid salts such as acetate, nicotinate and succinate, and inorganic acid salts such as ammonium salt.
Among the tocopherols and salts thereof, the wettability improvement for contact lenses, the improvement of stickiness, the improvement of the contact feeling of the contact lenses to the eyes, and the effect of the present invention of suppressing the adhesion of microorganisms to the contact lenses are further improved. Tocopherol salts are preferred, and tocopherol acetate is more preferred.
Tocopherol and its salt can be purchased commercially, or can be synthesized according to well-known methods.

  As the component (B), one type can be used alone, or two or more types can be used in combination.

<Content of component (B)>
The content of the component (B) in the composition of the present invention is appropriately set according to the type of the component (B), the type of the component (A) to be used together, etc. B) The total amount of ingredients is usually about 0.0001 to 0.5
It may be w / v%, and is preferably about 0.0002 to 0.3 w / v%.
Speaking of the content of each component,
When component (B) is azulene and / or a salt thereof: these are total amounts, usually about 0.0004 to 0.05 w / v%, preferably about 0.001 to 0.03 w / v%, more preferably based on the total amount of the composition Is about 0.004 ~
It may be 0.02w / v%.
When component (B) is glycyrrhizic acid and / or a salt thereof: These are total amounts, usually about 0.001 to 0.5 w / v%, preferably about 0.005 to 0.3 w / v%, and more preferably to the total amount of the composition Preferably about 0.
It should just be 05-0.25w / v%.
When component (B) is chlorpheniramine and / or a salt thereof: these are total amounts, usually about 0.001 to 0.1 w / v%, preferably about 0.006 to 0.03 w / v%, based on the total amount of the composition, More preferably, it may be about 0.01 to 0.03 w / v%.
When component (B) is neostigmine and / or a salt thereof: these are total amounts, usually about 0.0005 to 0.01 w / v%, preferably about 0.0007 to 0.007 w / v%, more preferably based on the total amount of the composition May be about 0.001 to 0.005 w / v%.
When component (B) is cobalamin and / or a salt thereof: these are total amounts, usually about 0.0001 to 0.02 w / v%, preferably about 0.0002 to 0.02 w / v%, more preferably based on the total amount of the composition Is about 0.00
It may be 4 to 0.02 w / v%.
When component (B) is retinol and / or a salt thereof: these are total amounts, usually about 1,000 to 100,000 IU (international units) / 100 mL, preferably about 5,000 to 75,000 IU based on the total amount of the composition (International unit) / 100 mL, more preferably about 10,000 to 50,000 IU (international unit) / 100 mL.
When component (B) is tocopherol and / or a salt thereof: these are total amounts, usually about 0.001 to 0.5 w / v%, preferably about 0.005 to 0.1 w / v%, more preferably based on the total amount of the composition Is about 0.01
It may be ˜0.05 w / v%.
If the content of the component (B) is in the above range, the medicinal effect is appropriately exerted, the wettability to the contact lens is improved, the stickiness is improved, the feeling of sticking of the contact lens to the eyes, and the contact lens. The effect of the present invention, ie, the suppression of microbial adhesion, can be sufficiently obtained.

Further, in the ophthalmic composition for contact lenses of the present invention, the ratio of the component (B) to the component (A) is not particularly limited, but from the viewpoint of further enhancing the effect of the present invention, (A) Examples include a range in which the total amount of the component (B) is about 0.00006 to 1000 parts by weight, preferably about 0.0001 to 750 parts by weight per 1 part by weight of the component.
More specifically, the following ranges are exemplified as the ratio of the component (B) per 1 part by weight of the total amount of the component (A). In addition, about retinol and / or its salt among (B) component, lecithin 1g
The amount of retinol and / or its salt relative to is shown in International Units (IU). Retinol and / or its salt 10000 I.U. (international units) is calculated assuming 1 g of retinol and / or its salt.
When component (B) is azulene sulfonic acid and / or a salt thereof: these are the total amount, usually about 0.000
06 to 5 parts by weight, preferably about 0.0002 to 3 parts by weight, more preferably about 0.002 to 2 parts by weight;
When component (B) is glycyrrhizic acid and / or a salt thereof: these are total amounts, usually about 0.0006
To 50 parts by weight, preferably about 0.003 to 30 parts by weight, more preferably about 0.03 to 25 parts by weight;
When component (B) is chlorpheniramine and / or a salt thereof: these are total amounts, usually about 0.000
6-10 parts by weight, preferably about 0.004-6 parts by weight, more preferably about 0.006-3 parts by weight;
When component (B) is neostigmine and / or a salt thereof: these are the total amount, usually about 0.00006 to
50 parts by weight, preferably about 0.0003 to 10 parts by weight, more preferably about 0.003 to 5 parts by weight;
When component (B) is cobalamin and / or a salt thereof: these are generally in a total amount of about 0.00006 to 4 parts by weight, preferably about 0.0001 to 3 parts by weight, more preferably about 0.002 to 2 parts by weight;
When component (B) is retinol and / or a salt thereof, the total amount of lecithin per 1 g (parts by weight) is usually 0.3 to 1000 I.U. (parts by weight), preferably about 0.5 to 750 I.U. Parts by weight), more preferably about 0.7 to 500 I.U. (parts by weight);
When component (B) is tocopherol and / or a salt thereof: these are total amounts, usually about 0.00006 to
50 parts by weight, preferably about 0.0003 to 10 parts by weight, more preferably about 0.003 to 5 parts by weight;
If the ratio of the component (B) to the component (A) is in the above range, the medicinal effect is appropriately exerted, and the wettability to the contact lens is improved, the feeling of stickiness is improved, the feeling of sticking of the contact lens to the eyes is improved, In addition, the effect of the present invention of suppressing the adhesion of microorganisms to contact lenses can be sufficiently obtained.

Menthol The ophthalmic composition of the present invention preferably further contains menthol, which improves the wettability of the contact lens, improves the feeling of stickiness, and improves the feeling of sticking of the contact lens to the eye. This is a composition in which the adhesion of microorganisms is further suppressed.
The menthol may be any of d-form, l-form, and dl-form, but the l-form is preferred because the effects of the present invention are further improved. Moreover, menthol may be contained as a component in essential oil.
Examples of essential oils containing such menthol include mint water, mint oil, peppermint oil and the like.
The content of menthol in the composition of the present invention is about 0.0005 to 0.1 w / v with respect to the total amount of the composition.
% Is preferred, about 0.001 to 0.08 w / v% is more preferred, and about 0.003 to 0.05 w / v% is even more preferred. If it is the said range, the effect of this invention can be improved further.

Known Active Ingredients In addition to the above ingredients, the ophthalmic composition for contact lenses of the present invention contains known active ingredients (
Pharmacologically active ingredients, physiologically active ingredients, etc.) can be blended. The type of such component is not particularly limited, and examples thereof include a decongestant component, an eye muscle modulator component, an anti-inflammatory component or an astringent component, an antihistamine component or an antiallergic component, vitamins, amino acids, antibacterial agents. Examples thereof include a drug component or a bactericidal component, a saccharide, a polymer compound or a derivative thereof, cellulose or a derivative thereof, a local anesthetic component, a glaucoma treatment component, a cataract treatment component, and the like. Examples of the pharmacologically active component and physiologically active component suitable in the present invention include the following components.

Decongestant: For example, α-adrenergic agonist, specifically epinephrine, epinephrine hydrochloride, ephedrine hydrochloride, oxymetazoline hydrochloride, tetrahydrozoline hydrochloride, naphazoline hydrochloride, phenylephrine hydrochloride, methylephedrine hydrochloride, epinephrine hydrogen tartrate,
Such as naphazoline nitrate. These may be d-form, l-form or dl-form.

Eye muscle modulator component: For example, cholinesterase inhibitor having an active center similar to acetylcholine, specifically, tropicamide, helenien, atropine sulfate and the like.

Anti-inflammatory component or astringent component: for example, zinc sulfate, zinc lactate, allantoin, epsilon-aminocaproic acid, indomethacin, lysozyme chloride, silver nitrate, pranoprofen,
Diclofenac sodium, bromfenac sodium, berberine chloride, berberine sulfate, etc.

Antihistamine component or antiallergic agent component: for example, agitazanolast, diphenhydramine or its hydrochloride, ketotifen fumarate, levocabastine or its hydrochloride, etc., amlexanox, ibudilast, tazanolast, tranilast, oxatomide, suplatast or tosylate thereof Such as sodium cromoglycate and potassium pemirolast.

Vitamins: For example, pyridoxine hydrochloride, flavin adenine dinucleotide sodium, pyridoxal phosphate, cyanocobalamin, panthenol, calcium pantothenate,
Sodium pantothenate, ascorbic acid, ubiquinone derivatives, etc.

Amino acids: for example, aminoethyl sulfonic acid (taurine), glutamic acid, creatinine, sodium aspartate, potassium aspartate, magnesium aspartate, magnesium aspartate mixture, glutamic acid, sodium glutamate, magnesium glutamate, epsilon-aminocaproic acid, glycine , Alanine, arginine, lysine, γ-aminobutyric acid, γ-aminovaleric acid, sodium chondroitin sulfate and the like. These may be d-form, l-form or dl-form.

Antibacterial component or bactericidal component: for example, alkylpolyaminoethylglycine, chloramphenicol, sulfamethoxazole, sulfisoxazole, sulfamethoxazole sodium, sulfisoxazole diethanolamine, sulfisoxa Zole monoethanolamine, sodium sulfisomezole, sodium sulfisomidine, ofloxacin, norfloxacin, levofloxacin, lomefloxacin hydrochloride, acyclovir and the like.

Sugars: For example, monosaccharides, disaccharides, specifically glucose, maltose, trehalose, sucrose, cyclodextrin, xylitol, sorbitol, mannitol and the like.

Polymer compound or derivative thereof: for example, alginic acid, sodium alginate, dextrin, dextran, pectin, hyaluronic acid, chondroitin sulfate, polyvinyl alcohol (completely or partially saponified product), polyvinylpyrrolidone, carboxyvinyl polymer,
Macrogol and its pharmaceutically acceptable salts.

Cellulose or derivatives thereof: for example, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose sodium, carboxyethyl cellulose, nitrocellulose and the like.

  Local anesthetic components: for example, chlorobutanol, procaine hydrochloride, lidocaine hydrochloride, etc.

In the field of ophthalmic compositions, the blending ratio of various active ingredients is known, and the blending ratio of the above-mentioned components in the composition of the present invention depends on the dosage form of the composition, the type of the pharmacologically active ingredient or the physiologically active ingredient, etc. It is set accordingly. For example, the blending ratio of the pharmacologically active ingredient or the physiologically active ingredient can be selected from the range of usually about 0.0001 to 30 w / v%, preferably about 0.001 to 10 w / v% with respect to the total amount of the ophthalmic composition.
A known active ingredient can be used individually by 1 type or in combination of 2 or more types.

Carriers, additives, and the composition of the present invention are appropriately selected from various carriers and additives according to conventional methods, depending on the use and form, as long as the effects of the present invention are not impaired. Can be made. As those carriers or additives, carriers commonly used in the preparation of solutions (aqueous solvents, aqueous or oily bases, etc.), surfactants, preservatives, bactericides or antibacterial agents, pH adjusters, isotonic agents Agent,
Various additives, such as a chelating agent, a buffering agent, and a stabilizer, can be mentioned.

Although the typical component used for the composition of this invention is illustrated below, it is not limited to these.

Carriers: aqueous solvents (water, hydrous ethanol, etc.), oils (vegetable oils such as sesame oil, castor oil, soybean oil, olive oil, etc .; animal oils such as squalane, mineral oils such as liquid paraffin and petrolatum), alcohols (polyethylene glycol, mannitol, etc.) Polyhydric alcohols; monohydric alcohols such as ethanol and propanol)

Surfactant: For example, polyoxyethylene (hereinafter abbreviated as POE) -polyoxypropylene (hereinafter abbreviated as POP) block copolymer (specifically, poloxamer 407, etc.), ethylenediamine POE-POP block copolymer adduct ( Specifically, poloxamine, etc.), P
Nonionic surfactants such as OE sorbitan fatty acid esters (specifically, polysorbate 80), POE hydrogenated castor oil (specifically, POE (60) hydrogenated castor oil), polyoxyl stearate; alkyldiaminoethyl Glycine-type amphoteric surfactants such as glycine; cationic surfactants of alkyl quaternary ammonium salts (specifically, benzalkonium chloride, benzethonium chloride, etc.). The numbers in parentheses indicate the number of added moles.

Perfume or refreshing agent: for example, terpenes (specifically, anethole, eugenol, geraniol, limonene, camphor, borneol, eucalyptus oil, bergamot oil, etc. These may be either d-form, l-form or dl-form. ), Essential oils (rose oil, etc.).

Preservatives, bactericides or antibacterials: for example, polydronium chloride, alkyldiaminoethylglycine hydrochloride, sodium benzoate, ethanol, benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, chlorobutanol, sorbic acid, potassium sorbate, dehydroacetic acid Sodium, methyl paraoxybenzoate, ethyl paraoxybenzoate,
Propyl paraoxybenzoate, butyl paraoxybenzoate, oxyquinoline sulfate, phenethyl alcohol, benzyl alcohol, biguanide compounds (specifically, polyhexamethylene biguanide or its hydrochloride), glowkill (trade name, manufactured by Rhodia), and the like.

pH regulator: for example, hydrochloric acid, sodium hydroxide, potassium hydroxide, calcium hydroxide,
Magnesium hydroxide, triethanolamine, monoethanolamine, diisopropanolamine, sulfuric acid, phosphoric acid, etc.

Isotonizing agents: for example, sodium bisulfite, sodium sulfite, potassium chloride, calcium chloride, sodium chloride, magnesium chloride, potassium acetate, sodium acetate, sodium bicarbonate, sodium carbonate, sodium thiosulfate, magnesium sulfate, dihydrogen phosphate Sodium, sodium dihydrogen phosphate, potassium dihydrogen phosphate, glycerin, propylene glycol and the like.

Chelating agents: for example, ascorbic acid, edetate tetrasodium, edetate sodium,
Citric acid and so on.

Buffer: citrate buffer, acetate buffer, carbonate buffer, borate buffer, phosphate buffer, etc. Specifically, citric acid, sodium citrate, acetic acid, potassium acetate, sodium acetate,
Sodium bicarbonate, sodium carbonate, boric acid, borax, sodium borate phosphoric acid, disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate and the like.

Stabilizers: dibutylhydroxytoluene, trometamol, sodium formaldehyde sulfoxylate (Longalite), tocopherol, sodium pyrosulfite, monoethanolamine, aluminum monostearate, glyceryl monostearate, etc.
A carrier and an additive can be used individually by 1 type or in combination of 2 or more types.

Property, pH
The ophthalmic composition of the present invention is usually an aqueous composition. In that case, the content of water is usually 70 w / v% or more, preferably 90 w / v% or more, more preferably 95 w / v% or more.
The pH of the ophthalmic composition of the present invention may be about 3 to 9, preferably about 5 to 8, and preferably about 5.5 to 7
.5 is more preferable.

Container The container filled with the ophthalmic composition of the present invention is not particularly limited, and examples thereof include containers containing materials such as polyethylene terephthalate, polyarylate, polycarbonate, polyethylene, and polypropylene. A container made of polyethylene terephthalate is particularly preferable. Preferably, the light-shielded container is filled. By putting it in a light shielding container, the ophthalmic composition of the present invention can be kept stable for a long period of time. The container may be shielded from light by, for example, mixing a colorant or the like with the above materials, or may be shielded from light by covering with a shrink film or an outer box.

Production Method The ophthalmic composition of the present invention can be prepared by a conventional method. For example, after each component is dispersed in a carrier such as water, it is homogenized, dissolved or emulsified using a homogenizer, etc.
What is necessary is just to prepare by adjusting.

Method of Use The usage and dosage of the ophthalmic composition of the present invention varies depending on the symptoms, age, etc. of the user, but according to the usual usage of eye drops, eye wash, contact lens mounting solution, contact lens care agent Good. For example, in the case of eye drops, it is usually sufficient to apply about 1 to 2 drops once a day about 1 to 6 times a day.
The ophthalmic composition of the present invention may be used for contact lens users, but among contact lens users, symptoms that are more preferably used due to the effects of the present invention include dry eye, eye fatigue, allergies. Those who show symptoms such as itchy eyes and redness are preferred. Therefore, the ophthalmic composition for contact lenses of the present invention is suitable for uses such as for dry eye, for eye fatigue, for allergies, for eye itchiness, and for hyperemia.

(II) Others The present invention provides (A) an ophthalmic composition containing lecithin, (B) azulenesulfonic acid, glycyrrhizic acid, chlorpheniramine, neostigmine, cobalamin, retinol, tocopherol, and pharmacologically acceptable thereof. Adding one or more compounds selected from the group consisting of salts, improving wettability to contact lenses, imparting ability to suppress adhesion of microorganisms to contact lenses, and feeling of stickiness or stickiness to eyes of contact lenses Includes methods for imparting improvement ability.
Further, the present invention includes a method for improving the feeling of stickiness of the contact lens or the feeling of sticking to the eye, in which the ophthalmic composition for contact lens of the present invention described above is brought into contact with the contact lens.
The types, concentrations, ratios, usage amounts and the like of each component in these methods are as described for the ophthalmic composition of the present invention.

EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these.
Moreover, the lecithin used for the test is as follows.
Soy lecithin (SLP-PC92H) Sakai Oil Co., Ltd. (Iodine value = 41, PC content = 95%)
Egg yolk lecithin (PL-100M) manufactured by Kewpie Co., Ltd. (Iodine value = 73, PC content = 80%)

1. Contact lens wettability test A new hard contact lens (Clear Blue (Group I, PMMA material), manufactured by Alpha Corporation) was rinsed thoroughly with purified water and immersed in purified water for 24 hours.
The lens water was wiped off, and using a syringe attached to a contact angle meter, the test solution was deposited on the surface of 1 μL lens, and the contact angle of the contact lens was measured. Each test solution was measured 6 times using 6 lenses.
The contact angle measurement conditions are as follows.
Equipment used: Contact angle meter Drop Master 500 (Kyowa Interface Science)
Drop volume: 1μl / lens Measurement time: 2 seconds after landing Contact angle calculation method: θ / 2 method

From the measured contact angle, the contact angle improvement rate for the borate buffer solution of Comparative Example 2 was calculated by the following formula (1).
<Formula (1)>
Contact angle improvement rate (%) = {1- (contact angle of each test solution / contact angle of Comparative Example 2)} × 100

The compositions of Comparative Examples 1-9 are shown in Table 1 below. The results are shown in FIG.

The contact angles of purified water (Comparative Example 1) and borate buffer (Comparative Example 2) were the same.
As is apparent from FIG. 1, when soy lecithin or egg yolk lecithin was added to the borate buffer (Comparative Examples 3 and 4), the contact angle was greatly increased, that is, the wettability was greatly deteriorated.
Next, in borate buffer solution, neostigmine methyl sulfate, sodium azulene sulfonate,
When chlorpheniramine maleate, dipotassium glycyrrhizinate, or cyanocobalamin is added (Comparative Examples 5 to 9), the contact angle is almost equal or increased compared to borate buffer,
That is, the wettability was equal or deteriorated.

  Next, the compositions of Examples 1 to 12 are shown in Tables 2 and 3 below. The results are shown in FIG.

As is clear from FIG. 2, lecithin, neostigmine methyl sulfate,
The test solutions of Examples 1 to 12 to which sodium azulene sulfonate, chlorpheniramine maleate, dipotassium glycyrrhizinate, or cyanocobalamin were added had a smaller contact angle than the borate buffer solution (Comparative Example 2). It was.
On the other hand, when (A) component lecithin alone (Comparative Example 3), and (B) component neostigmine methyl sulfate, sodium azulenesulfonate, chlorpheniramine maleate, dipotassium glycyrrhizinate, or cyanocobalamin alone Compared to (Comparative Examples 5 to 9), (A)
It can be seen that by combining both the component and the component (B), the contact angle is significantly reduced, that is, the wettability to the contact lens is greatly improved. Thus, a synergistic effect was recognized about the wettability improvement to a contact lens by combining both.

  Next, the compositions of Examples 13 to 20 are shown in Table 4 below. The results are shown in FIG.

* Combination ratio of retinol palmitate is international unit / 100mL
The unit of other ingredients is w / v%.

As is clear from FIG. 3, the test solutions of Examples 13 to 16 containing lecithin and chlorpheniramine maleate in the ophthalmic composition for contact lenses and further added with 1-menthol, sesame oil or castor oil were compared. Compared with Example 3 and Example 3, the wettability to the contact lens was greatly improved. Thus, in addition to (A) component and (B) component, the synergistic effect was recognized about the wettability improvement to a contact lens by combining 1-menthol, sesame oil, or castor oil.
Examples 17- using lecithin in combination with tocopherol acetate or retinol palmitate
The 20 test solutions had smaller contact angles than the borate buffer (Comparative Example 2). It can also be seen that the contact angle is significantly smaller than that of lecithin alone (Comparative Example 3), that is, the wettability to the contact lens is greatly improved.

Further, as a reference example, a nonionic surfactant known to have an emulsifying action was added to a borate buffer solution in the same manner as lecithin, and a wettability test was performed in the same manner as described above. Table 5 below shows the composition of the test solutions of Reference Examples 1 and 2 and the contact angle improvement rate with respect to the borate buffer solution (Comparative Example 2).

As is clear from Table 5, the aqueous test liquids (Reference Examples 1 and 2) to which polyoxyethylene hydrogenated castor oil 60 liquid or polysorbate 80 liquid, which is a nonionic surfactant, were added purified water (Comparative Example 1). ) And borate buffer (Comparative Example 2). That is, it showed a tendency different from lecithin.

2. Contact lens stickiness and stickiness test According to the prescriptions in Tables 6 to 8, the eye drops of Examples 2-1 to 2-11 and Comparative Examples 2-1 to 2-8 were prepared as normal eye drops. It was prepared according to the method (ordinary method), filled into a polyethylene terephthalate container (capacity 10 mL), and plugged.

* The mixing ratio of retinol palmitate is international units / 100mL.
The unit of other ingredients is w / v%.

For 6 subjects wearing 3 contact lenses (3 SCLs and 3 HCLs), one drop of the formulation of Comparative Example 2-1 (borate buffer) was instilled into one eye, and instillation of each of the other examples into the opposite eye One drop of the solution was instilled to evaluate the stickiness and stickiness of the contact lens.
The evaluation method was as follows. When the test subject applied the Comparative Example 2-1, the contact lens was sticky or sticky, and the strength of the stickiness was 0. Plus point if you do not feel more sticky or sticky (limit is +3 points)
In the case of feeling more, the negative point (the limit is -3 points), and the strength of the subjective feeling was expressed by an arbitrary score.

The results of averaging the scores for the “stickiness” of each of three subjects wearing SCL are shown in FIGS.
As apparent from FIGS. 4 to 5, when the subject is an SCL wearer, the test solution (Comparative Examples 2-2 to 2-4) in which lecithin is added to the borate buffer solution, and azulene sulfonic acid to the borate buffer solution The test liquids (Comparative Examples 2-5 to 2-8) to which sodium, chlorpheniramine maleate, dipotassium glycyrrhizinate, and neostigmine methylsulfate were added had a sticky feeling and borate buffer (Comparative Example 2-1). Or no difference from borate buffer (Comparative Example 2-1).
On the other hand, the test liquid (Example 2) which used together the lecithin which is (A) component, and the neostigmine methyl sulfate, sodium azulenesulfonate, chlorpheniramine maleate, or dipotassium glycyrrhizinate which are (B) components. -1 to 2-11) were less sticky than the borate buffer (Comparative Example 2-1).
That is, by combining the components (A) and (B), a synergistic effect was observed with respect to the improvement of stickiness.

Moreover, the result of having averaged the score about the "stickiness" of every three test subjects equipped with HCL is shown in FIGS. As is clear from FIGS. 6 to 7, the same tendency was observed even when the test subject was an HCL wearer.

8 to 9 show the results of averaging the scores for “contact lens sticking feeling” for each of three subjects wearing SCL. As is clear from FIGS. 8 to 9, when the subject is an SCL wearer, the test solution (Comparative Examples 2-2 to 2-4) in which lecithin is added to the borate buffer, maleic acid is added to the borate buffer. Test liquid to which chlorpheniramine, neostigmine methylsulfate, sodium azulenesulfonate, or dipotassium glycyrrhizinate was added (Comparative Example 2-5
In 2-8), the feeling of sticking of the contact lens was larger than that of the borate buffer solution (Comparative Example 2-1), or there was no difference from the borate buffer solution (Comparative Example 2-1).
In contrast, (A) component lecithin and (B) component neostigmine methyl sulfate,
Test liquids (Examples 2-1 to 2-11) used in combination with sodium azulene sulfonate, chlorpheniramine maleate, or dipotassium glycyrrhizinate were prepared with borate buffer (Comparative Example 2).
The feeling of sticking of the contact lens was small compared to -1).
That is, by combining the component (A) and the component (B), a synergistic effect was recognized with respect to the adhesion improving effect of the contact lens.

Moreover, the result of averaging the score about "the feeling of sticking of a contact lens" of every 3 test subjects wearing HCL is shown in FIGS. As is clear from FIGS. 10 to 11, the same tendency was observed even when the test subject was an HCL wearer.

3. Bacterial adhesion test for contact lenses Soft contact lenses (1d) are used as a pretreatment to remove contact lens preservation solution.
ay Accuview, group IV (material etafilcon A), Johnson & Johnson) was immersed in 5 mL of sterile physiological saline for 4 hours or more. Put 1mL of each test solution in a 24-well multiplate,
One pretreated lens was placed in each.
After 24 hours, use tweezers to gently cut the lens water off the edge of the well plate.
⁸ CFU / mL Pseudomonas aeruginosa ATCC9027 bacterial solution (suspended in physiological saline) 5 mL was placed in a 6-well multiplate and stored at room temperature for 30 minutes.
Next, in order to remove bacteria that did not adhere to the lens but only contacted, the lens was placed in a 12-well plate containing 5 mL of physiological saline using tweezers and shaken for 1 minute.
Next, using tweezers, move the lens to a Spitz tube containing 5 mL of new physiological saline, apply ultrasonic waves (38 kHz) for 3 minutes, and then stir with a test tube mixer for 1 minute to make each soft contact lens. Bacteria attached to were peeled off and used as an adherent bacterial solution.
Dilute the resulting adherent bacterial solution to an appropriate concentration for measurement, soy bean, casein,
Seed on digest-agar medium (SCDLP agar medium), cultured overnight at 33 ° C, counted the number of colonies observed, and corrected by the dilution factor, so that the number of bacteria attached to each lens (viable cell count) )
For each test solution, five experiments were performed using five lenses.

Each test solution (Comparative Examples 3-2 to 3-5, Examples 3-1 to 3-3, and Example 3) with respect to the number of adherent bacteria when a borate buffer solution (Comparative Example 3-1) is used as the test solution. Based on the number of adherent bacteria of -8 to 3-12), the bacterial adhesion inhibition rate (%) of these test solutions was calculated according to the following formula (2).
Similarly, the adherent bacteria of each test solution (Comparative Examples 3-7 to 3-9, Examples 3-4 to 3-7) when borate buffer (Comparative Example 3-6) is used as the test solution. Based on the number, the bacterial adhesion inhibition rate (%) of these test solutions was calculated according to the following formula (2).

<Formula (2)>
Bacterial adhesion inhibition rate (%)
= {1- (number of adherent bacteria in each test solution / number of adherent bacteria in the test solution of Comparative Example 3-1 or Comparative Example 3-6)} × 100

  The composition of each test solution is shown in Tables 9 to 11 below. The results are shown in FIGS.

As is clear from FIGS. 12 and 13, by adding lecithin to the borate buffer (
Comparative Example 3-2) and the amount of attached bacteria increased significantly. Further, by adding cyanocobalamin, neostigmine methyl sulfate, sodium azulene sulfonate, chlorpheniramine maleate or dipotassium glycyrrhizinate to borate buffer (Comparative Examples 3-3 to 3-
9) The amount of bacterial adhesion tended to increase.
In contrast, lecithin (component (A)) and cyanocobalamin, neostigmine methylsulfate, sodium azulenesulfonate, chlorpheniramine maleate or dipotassium glycyrrhizinate (component (B)) (Example 3) -1 to 3-7), the amount of bacteria attached was reduced. As described above, a synergistic effect was observed in the action of inhibiting the adhesion of bacteria to the contact lens by combining the components (A) and (B).
Further, as apparent from FIG. 14, the amount of bacterial adhesion was further reduced in the prescription in which menthol was added in addition to the A component and the B component.
Formulation Examples Tables 12 to 19 below show formulation examples of the ophthalmic composition for contact lenses of the present invention. The unit of the content ratio of each component in the table is “w / v%” in principle. However, the content ratio of retinol palmitate is “international unit / 100 mL”.

Since the ophthalmic composition for contact lenses of the present invention has good wettability to contact lenses and hardly adheres to the contact lenses, eye drops for contact lenses, mounting solutions, eye wash agents, and contact lens care agents As such, it is highly practical.

Claims (7)

(A) lecithin, and
(B) containing one or more compounds selected from the group consisting of azulenesulfonic acid, glycyrrhizic acid, chlorpheniramine, neostigmine, cobalamin, retinol, tocopherol, and pharmaceutically acceptable salts thereof,
The content of the component (B) is, based on the total amount of the composition, 0.0001~0.5w / v%, for contact lenses ophthalmology set Narubutsu.   The composition according to claim 1, wherein the content of the component (A) is 0.001 to 5 w / v% with respect to the total amount of the composition. Furthermore, the composition of Claim 1 or 2 containing a menthol. Furthermore, the composition in any one of Claims 1-3 containing oil. The composition according to any one of claims 1 to 4, which is an eye drop. The composition according to any one of claims 1 to 5, wherein the pH is 3 to 9. The composition according to any one of claims 1 to 6, which is filled in a container.