WO2009063962A1 - Fat emulsion containing medicinal agent, and process for production thereof - Google Patents

Fat emulsion containing medicinal agent, and process for production thereof Download PDF

Info

Publication number
WO2009063962A1
WO2009063962A1 PCT/JP2008/070736 JP2008070736W WO2009063962A1 WO 2009063962 A1 WO2009063962 A1 WO 2009063962A1 JP 2008070736 W JP2008070736 W JP 2008070736W WO 2009063962 A1 WO2009063962 A1 WO 2009063962A1
Authority
WO
WIPO (PCT)
Prior art keywords
fat
oil
medicinal agent
agent
emulsion containing
Prior art date
Application number
PCT/JP2008/070736
Other languages
French (fr)
Japanese (ja)
Inventor
Kiichiro Nabeta
Original Assignee
Techno Guard Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Techno Guard Co. Ltd. filed Critical Techno Guard Co. Ltd.
Priority to JP2009541177A priority Critical patent/JP5340954B2/en
Publication of WO2009063962A1 publication Critical patent/WO2009063962A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy

Abstract

The object is to provide: a fat emulsion containing a medicinal agent, which can be used as an injection preparation, an eye drop, a nose drop, an inhalation preparation or the like, and which has transparency and excellent stability; and a process for producing the fat emulsion. Specifically disclosed is a fat emulsion containing a medicinal agent, which comprises at least a poorly water-soluble medicinal agent, an oil-and-fat, an emulsifying agent and water, wherein the content of the oil-and-fat is 0.05 to 2 mg/mL, wherein the ratio of the medicinal agent to the oil-and-fat [(medicinal agent)/(oil-and-fat)] is 0.01 to 20 by weight (provided that the total amount of the medicinal agent and the oil-and-fat is up to 5 mg/mL), and wherein the ratio of the emulsifying agent to the oil-and-fat [(emulsifying agent)/(oil-and-fat)] is 1 to 300 by weight. Also specifically disclosed is a process for producing the fat emulsion, which comprises emulsifying the constituent components, wherein the content of the oil-and-fat is 0.05 to 2 mg/mL, wherein the ratio of the medicinal agent to the oil-and-fat [(medicinal agent)/(oil-and-fat)] is 0.01 to 20 by weight (provided that the total amount of the medicinal agent and the oil-and-fat is up to 5 mg/mL), and wherein the ratio of the emulsifying agent to the oil-and-fat [(emulsifying agent)/(oil-and-fat)] is 1 to 300 by weight.
PCT/JP2008/070736 2007-11-16 2008-11-14 Fat emulsion containing medicinal agent, and process for production thereof WO2009063962A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009541177A JP5340954B2 (en) 2007-11-16 2008-11-14 Drug-containing fat emulsion and method for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007297879 2007-11-16
JP2007-297879 2007-11-16

Publications (1)

Publication Number Publication Date
WO2009063962A1 true WO2009063962A1 (en) 2009-05-22

Family

ID=40638808

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/070736 WO2009063962A1 (en) 2007-11-16 2008-11-14 Fat emulsion containing medicinal agent, and process for production thereof

Country Status (2)

Country Link
JP (1) JP5340954B2 (en)
WO (1) WO2009063962A1 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010270023A (en) * 2009-05-20 2010-12-02 Techno Guard Kk Nonaqueous composition containing adipose particle holding medicament, and method for producing the same
FR2962044A1 (en) * 2010-04-21 2012-01-06 Horus Pharma LACRYMIMETIC EMULSION
JP2014001203A (en) * 2012-05-23 2014-01-09 Q P Corp Method for increasing content of nonsteroidal anti-inflammatory agent in fat emulsion and pharmaceutical composition
JP2014237722A (en) * 2014-09-19 2014-12-18 ロート製薬株式会社 Ophthalmic composition for contact lens
JP2017506671A (en) * 2014-02-14 2017-03-09 ホアン，ジンジュン Composition of nanoemulsion delivery system
CN106727308A (en) * 2016-12-14 2017-05-31 广东药科大学 A kind of dexamethasone lipid emulsion droplet ocular fluid and preparation method thereof
CN107441044A (en) * 2017-08-29 2017-12-08 辅必成（上海）医药科技有限公司 A kind of nanometer fat emulsion
US10413384B2 (en) 2015-06-29 2019-09-17 Kettenbach Gmbh & Co. Kg Container for storing and dispensing at least one component and method therefor
WO2020017571A1 (en) * 2018-07-18 2020-01-23 テイコク ファーマ ユーエスエー インコーポレーテッド Flurbiprofen-axetil-containing fat emulsion and method for manufacturing same
WO2020017578A1 (en) * 2018-07-18 2020-01-23 テクノガード株式会社 Oxycam-based drug-containing injection agent
CN112704674A (en) * 2019-10-25 2021-04-27 北京远大九和药业有限公司 Oral emulsion and its prepn and use
US11103490B2 (en) 2010-10-12 2021-08-31 Chiesi Farmaceutici S.P.A. Clevidipine emulsion formulations containing antimicrobial agents
JP7456599B2 (en) 2017-01-12 2024-03-27 テクノガード株式会社 Drug-containing fat emulsion and its manufacturing method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505368A (en) * 1992-03-26 1995-06-15 ファーモス　コーポレイション Local and transdermal administration system using ultra-fine oil spheres
JPH11332463A (en) * 1998-05-28 1999-12-07 Nof Corp Oil-soluble matter-solubilized composition, its production and food/drink containing the same
JP2000143542A (en) * 1998-11-10 2000-05-23 Wakamoto Pharmaceut Co Ltd Sparingly soluble immunosuppressant-containing o/w emulsion pharmaceutical preparation
JP2005225818A (en) * 2004-02-13 2005-08-25 Otsuka Pharmaceut Factory Inc Medicinal composition of paclitaxel or docetaxel
JP2007039430A (en) * 2005-06-29 2007-02-15 Mitsubishi Chemicals Corp Particulate dispersion composition, method for producing the same and particulate substance and medicine
JP2007525536A (en) * 2004-03-01 2007-09-06 エフゲニー パヴロヴィッチ ゲルマノフ Perfluoro organic compound medical emulsion and its production

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505368A (en) * 1992-03-26 1995-06-15 ファーモス　コーポレイション Local and transdermal administration system using ultra-fine oil spheres
JPH11332463A (en) * 1998-05-28 1999-12-07 Nof Corp Oil-soluble matter-solubilized composition, its production and food/drink containing the same
JP2000143542A (en) * 1998-11-10 2000-05-23 Wakamoto Pharmaceut Co Ltd Sparingly soluble immunosuppressant-containing o/w emulsion pharmaceutical preparation
JP2005225818A (en) * 2004-02-13 2005-08-25 Otsuka Pharmaceut Factory Inc Medicinal composition of paclitaxel or docetaxel
JP2007525536A (en) * 2004-03-01 2007-09-06 エフゲニー パヴロヴィッチ ゲルマノフ Perfluoro organic compound medical emulsion and its production
JP2007039430A (en) * 2005-06-29 2007-02-15 Mitsubishi Chemicals Corp Particulate dispersion composition, method for producing the same and particulate substance and medicine

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010270023A (en) * 2009-05-20 2010-12-02 Techno Guard Kk Nonaqueous composition containing adipose particle holding medicament, and method for producing the same
FR2962044A1 (en) * 2010-04-21 2012-01-06 Horus Pharma LACRYMIMETIC EMULSION
WO2011131765A3 (en) * 2010-04-21 2012-02-23 Horus Pharma Artificial tear emulsion
US11103490B2 (en) 2010-10-12 2021-08-31 Chiesi Farmaceutici S.P.A. Clevidipine emulsion formulations containing antimicrobial agents
JP2014001203A (en) * 2012-05-23 2014-01-09 Q P Corp Method for increasing content of nonsteroidal anti-inflammatory agent in fat emulsion and pharmaceutical composition
JP2017506671A (en) * 2014-02-14 2017-03-09 ホアン，ジンジュン Composition of nanoemulsion delivery system
JP2014237722A (en) * 2014-09-19 2014-12-18 ロート製薬株式会社 Ophthalmic composition for contact lens
US10413384B2 (en) 2015-06-29 2019-09-17 Kettenbach Gmbh & Co. Kg Container for storing and dispensing at least one component and method therefor
CN106727308A (en) * 2016-12-14 2017-05-31 广东药科大学 A kind of dexamethasone lipid emulsion droplet ocular fluid and preparation method thereof
JP7456599B2 (en) 2017-01-12 2024-03-27 テクノガード株式会社 Drug-containing fat emulsion and its manufacturing method
CN107441044A (en) * 2017-08-29 2017-12-08 辅必成（上海）医药科技有限公司 A kind of nanometer fat emulsion
WO2020017571A1 (en) * 2018-07-18 2020-01-23 テイコク ファーマ ユーエスエー インコーポレーテッド Flurbiprofen-axetil-containing fat emulsion and method for manufacturing same
WO2020017578A1 (en) * 2018-07-18 2020-01-23 テクノガード株式会社 Oxycam-based drug-containing injection agent
CN111032033A (en) * 2018-07-18 2020-04-17 帝国制药美国公司 Fat emulsion containing flurbiprofen axetil and method for producing same
CN112704674A (en) * 2019-10-25 2021-04-27 北京远大九和药业有限公司 Oral emulsion and its prepn and use
CN112704674B (en) * 2019-10-25 2024-03-12 北京远大九和药业有限公司 A pharmaceutical oral emulsion, and its preparation method and application

Also Published As

Publication number Publication date
JP5340954B2 (en) 2013-11-13
JPWO2009063962A1 (en) 2011-03-31

Similar Documents

Publication Publication Date Title
WO2009063962A1 (en) Fat emulsion containing medicinal agent, and process for production thereof
WO2008039737A3 (en) A method of administering a film product containing a drug
WO2009152189A8 (en) Low dose topiramate/phentermine compostion and methods of use thereof
WO2007043057A3 (en) Compositions for nasal delivery
WO2006114520A3 (en) Substituted pyrrolo-pyridines, composition containing them, method for their producing and use thereof
EP2123257A3 (en) Stable high Vitamin C content polyol-in-oil emulsified system and its preparation
WO2006113631A3 (en) Bioenhanced compositions
MY160074A (en) Protopanaxadiol-type ginsenoside compositions and uses thereof
DK1897558T3 (en) SOLID PREPARATION OF 2-HEXADECYLOXY-6-METHYL-4H-3,1-BENZOXAZIN-4-ON
EA033397B1 (en) Method of treating prediabetes, type 1 or type 2 diabetes mellitus or improving glycemic control in a patient with said disorders
MX2009003542A (en) Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates.
BRPI0922796A2 (en) PHARMACEUTICAL TABLET FOR ORAL ADMINISTRATION AND MANUFACTURING METHOD
WO2008133330A1 (en) Stable solid preparation comprising 4,5-epoxymorphinan derivative
MX2010003603A (en) Method of treating polycystic kidney diseases with ceramide derivatives.
MY160829A (en) Powdered oil composition and production method thereof, and method of improving the functionality of the oil-in-water emulsion
WO2009008656A3 (en) A soap composition for atopic dermatitis containing fermented extract of xanthium strumarium l. and preparation method thereof
IN2015DN02751A (en)
EP1527770A3 (en) A cosmetic mask composition
BR112014013097A2 (en) Polyolefin foaming method using acrylated epoxidized fatty acid and foam produced from this
WO2010095042A3 (en) Pyridocarbazole type compounds and applications thereof
WO2009051217A1 (en) Fentanyl-containing percutaneous absorption preparation
WO2008073764A3 (en) Substantially pure fluorescein
WO2007078848A3 (en) Preparation of pharmaceutical salts of 3-o-(3',3'-dimethlsuccinyl) betulinic acid
WO2011019735A3 (en) Nutritional supplements
CN102038029A (en) Hairtail preservative

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08850049

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2009541177

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08850049

Country of ref document: EP

Kind code of ref document: A1