JP5859981B2 - 担体組成物 - Google Patents
担体組成物 Download PDFInfo
- Publication number
- JP5859981B2 JP5859981B2 JP2012551448A JP2012551448A JP5859981B2 JP 5859981 B2 JP5859981 B2 JP 5859981B2 JP 2012551448 A JP2012551448 A JP 2012551448A JP 2012551448 A JP2012551448 A JP 2012551448A JP 5859981 B2 JP5859981 B2 JP 5859981B2
- Authority
- JP
- Japan
- Prior art keywords
- phosphate
- carrier composition
- tocopheryl
- compound
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- -1 phosphate compound Chemical class 0.000 claims description 90
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- 230000000975 bioactive effect Effects 0.000 claims description 58
- 238000009472 formulation Methods 0.000 claims description 58
- 239000010452 phosphate Substances 0.000 claims description 58
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- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 claims description 41
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 25
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- 230000009677 vaginal delivery Effects 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
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Description
本発明は、電子移動剤および極性非プロトン溶媒のリン酸塩化合物を含む担体組成物に関する。担体化合物で処方された生理活性化合物は、特性を改善するために示されてきた。
用語「電子移動剤」は、リン酸化されてもよい、および非リン酸化形態で、比較的安定なラジカル分子を生じるために電子を受容でき、または可逆的なレドックスシステムに関与するために化合物を許容するための2つの電子を受容できる化合物を指す。電子移動剤の例は、抗酸化剤およびそれらの誘導体を含む。
化学では、溶媒は、極性の増加により、非極性非プロトン、極性非プロトン、および極性プロトン溶媒にグループ化されてもよい。溶媒の極性は、どのような種類の化合物を溶解できるかおよびどのような他の溶媒または液体化合物を混和するかを決定する。一般的に、極性溶媒は、極性化合物をもっとも溶解し、および非極性溶媒は、非極性溶媒をもっとも溶解する、すなわち「似ているもの同士は溶け合う」。
用語「生理活性化合物」は、医療、治療、美容および獣医学目的のためのヒトまたは動物で生物学的な効果を有する任意の化学物質を指し、および薬物、薬用化粧品、栄養補助食品、および栄養剤を含む医薬品を包含する。いくつかの生理活性化合物が、これらの分類の一超について分類され得ることが理解されるであろう。
ベンゾカイン、クロロプロカイン、コカイン、レセルピン、グアネチジン、シクロメチルカイン、ジメトカイン/ラロカイン、プロポキシカイン、プロカイン/ノボカイン、プロパラカイン、テトラカイン/アメトカイン;アルチカイン、ブピバカイン、カルチカイン、シンコカイン/ジブカイン、エチドカイン、レボブピバカイン、リドカイン/リグノカイン、メピバカイン、ピペロカイン、プリロカイン、ロピバカイン、トリメカイン、プロポフォール、ハロタン、エンフルラン、バルビツレート、ベンゾジアゼピン、ネオスチグミンおよびケタミンなどのアミノ‐エステルおよびアミノ‐アミド麻酔薬を含む。
カルムスチン、シクロフォスファミド、イホスファミド、ストレプトゾトシンおよびメクロレタミンを含む。
アムロジピン、アラニジピン、アゼルニジピン、バルニジピン、ベニジピン、シルニジピン、クレビジピン、クロニジピン、ダロジピン、デキシニグルジピン、エホニジピン、エルナジピン、エルゴジピン、フェロジピン、フロルジピン、フルニジピン、イガニジピン、イスラジピン、ラシジピン、レミジピン、レルカニジピン、マニジピン、メスルジピン(mesuldipine)、ニカルジピン、ニフェジピン、ニルジピン、ニルバジピン、ニモジピン、ニソルジピン、ニトレンジピン、オルラジピン、オキソジピン、パロニジピン、プラニジピン、サガニジピン、ソルニジピン、テルジピン、チアムジピン、トロンボジピン、ワタニジピン、ベラパミル、ガロパミル、ベンゾチアゼピン、ジルチアゼム、ミベフラジル、ベプリジル、フルスピリレンおよびフェンジリンを含む。
アミオダロン、ジソピラミド、フレカイニドアセテート、キニジンサルフェート、ニトログリセリン、ラノラジン、アミオダロン、イソソルビドおよびアルテプラーゼを含む。
アモキシシリン、アンピシリン、アジスロマイシン、ベネタミンペニシリン、ブレオマイシン、ベンゾイルペルオキシド、シノキサシン、クロラムフェニコール、ダウノルビシン、プリカマイシン、フルオロキノロン、シプロフロキサシン、クラリスロマイシン、クリンダマイシン、クリンダマイシンフォスフェート(clindesse)、クロファジミン、クロロヘキシジングルコネート、クロキサシリン、デメクロサイクリン、ドキシサイクリン、エリスロマイシン、エチオナミド、イミペネム、インドメタシン、リモサイクリン、ミノサイクリン、ナリジクス酸、ニトロフラントイン、ペニシリン、リファンピシン、スピラマイシンナトリウム、スルファセタミド、スルファベンザミド、スルファドキシン、スルファメラジン、スルファアセタミド、スルファジアジン、スルファフラゾール、スルファメトキサゾール、スルファピリジン、テトラサイクリン、セファレキシン、セフジニル、トリクロサン、オフロキサシン、バンコシン、グリブリド、ムピロシン、セフプロジル、セフロキシムアキセチル、ノルフロキサシン、イソニアジド、ルプロン、D‐ペニシラミン、レボフロキサシン、ガチフォキサシン(gatifoxacine)、およびトリメトプリムを含む。
ドキソルビシン、6‐チオグアニン、パクリタキセル、ドセタキセル、カンプトテシン、メゲストロールアセテート、ナベルビン、シタラビン、フルダラビン、6‐メルカプトプリン、5‐フルオロウラシル、テニポシド、ビンブラスチン、ビンクリスチン、シスプラチン、コルヒチン、カルボプラチン、プロカルバジンおよびエトプシドを含む。
アルプラゾラム、アモキサピン、ベンタゼパム、ブロマゼパム、クロラジピン(clorazipine)、クロバザム、クロチアゼパム、ジアゼパム、ロラゼパム、フルニトラゼパム、フルラゼパム、ロルメタゼパム、メダゼパム、ニトラゼパム、オキサゼパム、テマゼパム、マプロチリン、ミアンセリン、ノルトリプチリン、リスペリドン、セルトラリン、トラゾドン、バロペリドール(baloperidol)、トリミプラミンマレート、フルオキセチン、オンダンセトロン、ミダゾラム、クロルプロマジン、ハロペリドール、トリアゾラム、クロザピン、フルオプロマジン、フルフェナジンデカノエート、フルアニソン、ペルフェナジン、ピモジド、プロクロルペラジン、スルピリド、チオリダジン、パロキセチン、シタロプラム、ブプロピオン、フェネルジン、オランザピン、ジバルプロエクスナトリウムおよびベンラファクシンを含む。
オピオイド受容体アゴニストおよびアンタゴニストを含み、混合されたアゴニスト/アンタゴニスト活性を示す化合物および部分的アゴニスト活性を示す化合物、モルヒネ、デポモルヒネ(depomorphine)、エトルフィン、ジアセチルモルヒネ、ヒドロモルフォン、オキシモルフォン、レボルファノール、メタドン、レボメタジル、メペリジン、フェンタニル、スルフェンタニル、アルフェンタニル、コデイン、ヒドロコドン、オキシコドン、テバイン、デソモルヒネ、ニコモルヒネ、ジプロパノイルモルヒネ、ベンジルモルヒネ、エチルモルヒネ、ペチジン、メタドン、トラマドール、デキストロプロポキシフェン;ナロキソンおよびナルトレキソン;ブプレノルフィン、ナルブフィン、ブトルファノール、ペンタゾシンおよびエチルケトシクラゾシンを含む。
アゾチオピン(azothiopine)、アミトリプチリン、ファモチジン、プロメタジン、パロキセチン、オキスカルバゼピンおよびメルタザピン(mertazapine)を含む。
アセトヘキサミド、クロルプロパミド、グリベンクライド(glibenclaraide)、グリクラジド、グリピジド、メトホルミン、トラザミド、グリブリド、グリメピリドおよびトルブタミドを含む。
ベクラミド、カルバマゼピン、ガパペンチン、チアガビン、ビガバトリン、トピラマート、クロナゼパム、エトトイン、メトイン、メトスクシミド、メチルフェノバルビトン、オキシカルバゼピン、パラメタジオン、フェナセミド、フェノバルビトン、フェニトイン、フェンスクシミド、プリミドン、スルチアム、フェニトインナトリウム、ニロフラントインモノハイドレート、ガバペンチン、ラモトリジン、ゾニサミド、エトスクシミドおよびバルプロ酸を含む。
ゾルピデムタータレート、アミロバルビトン、バルビトン、ブトバルビトン、ペントバルビトン、ブロチゾラム、カルブロマール、クロルジアゼポキシド、クロルメチアゾール、エチナメート、メプロバメート、メタカロン、シクロベンザプレン、シクロベンザプリン、チザニジン、バクロフェン、ブタルビタール、ゾピクロン、アトラクリウム、ツボクラリンおよびフェノバルビタールを含む。
アムホテリシン、ブトコナゾールニトレート、クロトリマゾール、エコナゾールニトレート、フルコナゾール、フルシトシン、グリセオフルビン、イトラコナゾール、ケトコナゾール、ミコナゾール、ナタマイシン、ナイスタチン、スルコナゾールニトレート、テルコナゾール、チオコナゾールおよびウンデセン酸;ベンズニダゾール、クリオキノール、デコキネート、ジヨードヒドロキシキノリン、ジロキサニドフロアート、ジニトルミド、フラゾリドン、メトロニダゾール、ニモラゾール、ニトロフラゾン、オルニダゾール、テルビナフィン、クロトリマゾール、クロロキン、メフロキン、イトラコナゾール、ピリメタミン、プラジカンテル、キナクリン、メベンダゾールおよびチニダゾールを含む。
カンデサルタン、ヒドララジン、クロニジン、トリアムテレン、フェロジピン、ゲムフィブロジル、フェノフィブラート、ニフェディカル、プラゾシン、メカミラミン、ドキサゾシン、ドブタミンおよびレキセチルを含む。
ジヒドロエルゴタミンメシレート、エルゴタミンタータレート、メチセルギドマレート、ピゾチフェンマレートおよびスマトリプタンスクシネートを含む。
アトロピン、ベンズヘキソール、ビペリデン、エトプロパジン、ヒヨスチアミン、メペンゾラートブロミド、オキシブチニン、オキシフェンサイクリミンおよびトロピカミドを含む。
アミノグルテチミド、アムサクリン、アザチオプリン、ブスルファン、クロラムブシル、シクロスポリン、ダカルバジン、エストラムスチン、エトポシド、ロムスチン、メルファラン、メルカプトプリン、メトトレキサート、マイトマイシン、ミトタン、ミトザントロン、プロカルバジン、タモキシフェンシトレート、テストラクトン、タクロリムス、メルカプトプリンおよびシロリムスを含む。
ブロモクリプチンメシレート、レボドパ、トルカポン、ロピニロール、ブロモクリプチン、スルホニルウレアなどの血糖降下剤、ビグアナイド剤、α‐グルコシダーゼ阻害剤、チアゾリジンジオン、カベルゴリン、カルビドパおよびリスリドマレートを含む。
カルビマゾールおよびプロピルチオウラシルを含む。
アマンタジン、レチノビル(retinovir)、シドフォビル、アシクロビル、ファムシクロビル、リバビリン、アンプレナビル、インディナビル、リマンタジンおよびエファビレンツ、ペンシクロビル、ガンシクロビル、ビダラビン、アバカビル、アデフォビル、アンプレナビル、デラビルジン、ジダノシン、スタブジン、ザルシタビン、ジドブジン、エンフュービルタイドおよびインターフェロンを含む。
アムリノン、ミルリノン、ジギトキシン、ジゴキシン、エノキシモン、ラナトシドCおよびメジゴキシンを含む。
フェノフィブラート、クロフィブラート、プロブコール、エゼチミブおよびトルセトラピブを含む。
メオキシカム(meoxicam)、トリアムシノロン、クロモリン、ネドクロミル、ヒドロキシクロロキン、モンテルカスト、ジレウトン、ザフィルルカストおよびメロキシカムを含む。
フェキソフェナジン、クロラールハイドレート、ヒドロキシジン、プロメタジン、セチラジン(cetirazine)、シメチジン、シクリジン、メクリジン、ジメンヒドリナート、ロラタジン、ニザチジンおよびプロメタジンを含む。
オメプラゾール、ランソプラゾール、パントプラゾールおよびラニチジンを含む。
ヒドロクロロチアジド、アミロリド、アセタゾラミド、フロセミドおよびトルセミドを含む。
ジクロフェナク、アセクロフェナク、アセメタシン、アルクロフェナク、ブロムフェナク、エトドラク、インドメタシン、インドメタシンファルネシル、ナブメトン、オキサメタシン、プログルメタシン、スリンダクおよびトルメチンを含むクラスのアリールアルカン酸サブ‐グループ;アルミノプロフェン、ベノキサプロフェン、カルプロフェン、デクスイブプロフェン、デクスケトプロフェン、フェンブフェン、フェノプロフェン、フルノキサプロフェン、フルルビプロフェン、イブプロフェン、イブプロキサム、インドプロフェン、ケトプロフェン、ケトロラク、ロキソプロフェン、ミロプロフェン、ナプロキセン、オキサプロジン、ピルプロフェン、スプロフェン、タレンフルルビルおよびチアプロフェン酸を含むクラスの2‐アリールプロピオン酸(プロフェン)サブ‐グループ;およびフルフェナム酸、メクロフェナム酸、メフェナム酸およびトルフェナム酸を含むクラスのN‐アリールアントラニル酸(フェナム酸)サブ‐グループ;トロメタミン、セレコキシブ、ネパフェナク、アスピリン、ロフェコキシブ、ナプロキセン、スリンダク、ピロキシカム、フェイルブタゾン、トルメチン、インドメタシン、アセトアミノフェン(パラセタモール)、トラマドールおよびプロポキシフェンを含む。
レチノール、レチナール、トレチノイン(レチノイン酸、レチン‐A)、イソトレチノインおよびアリトレチノインなどの第一世代レチノイド;エトレチナートとその代謝物アシトレチンなどの第二世代レチノイド;タザロテン、ベキサロテンおよびアダパレンなどの第三世代レチノイドを含む
副腎皮質刺激ホルモン(ACTH)、抗利尿ホルモン(バソプレシン)、心房性ナトリウム利尿因子(ANF)、心房性ナトリウム利尿ペプチド(ANP)、ベクロメタゾン、コルチゾン、スコポラミン、ドーパミン、エピネフリン、カテコールアミン、コレシストキニン、クロミフェン、シトレート、ダナゾール、デキサメサゾン、ジエチルスチルベストロール(DES)、エチニルエストラジオール、フルドロコルチゾン、フィナステライド、卵胞刺激ホルモン、ガストリン、ヒドロキシプロゲステロン、成長ホルモン、インスリン、レプチン、黄体形成ホルモン、メドロキシプロゲステロンアセテート、メストラノール、キネストロール、メチルテストステロン、ナンドロロン、ノルエチンドロン、ノルエチステロン、ノルゲストレル、エストラジオール、共役エストロゲン、オキサンドロロン、オキシトシン、プレドニゾン、プロゲステロン、プロラクチン、プロスタグランジン、ソマトスタチン、スタノゾロール、スチベステロール(stibestrol)、チロキシン、プレドニゾロンフォスフェート、トリアムシノロン、ミフェプリストンアセトニド、ブデソニド、レボチロキシン、テストステロン、テストステロシピオネート、フルオキシメステロン、フルタミド、モメタゾンフロエート、シプロテロン、フルオロメトロン、ゴセレリン、ロイプロリド、カルシトニン、ハロベタゾール、ヒドロコルチゾールおよびチボロンを含む。
アトルバスタチン、フルバスタチン、ロバスタチン、ナイスタチン、ロスバスタチン、プラバスタチン、オルリスタットおよびシンバスタチンを含む。
アンフェタミン、フェンテルミン、チラミン、エフェドリン、メタラミノール、フェニレフリン、デクスアンフェタミン、デキスフェンフルラミン、フェンフルラミン、ニコチン、カフェインおよびマジンドールを含む。
デスモプレシンを含む。
カルベジロール、テラゾシン、フェントラミンとメントールを含む。
レベチラセタム、レビチラセタムおよびドネペジルを含む。
ベンザプリル(benzapril)、エナラプリル、ラミプリル、フォシノプリルナトリウム、リシノプリル、ミノキシジル、イソソルビド、ラムプリル(rampril)およびキナプリルを含む。
アテノロール、チモロール、ピンドロール、プロパノロールヒドロクロリド、ビソプロロール、エスモロール、メトプロロールスクシネート、メトプロロールおよびメトプロロールタータレートを含む。
ロサルタンを含む。
アブシキシマブ、クロピドロゲル(clopidrogel)、チロフィバンおよびアスピリンを含む。
トラマドール、トラマドールヒドロクロリド、アロプリノール、カルシトリオール、シロスタゾール、ソルタロール(soltalol)、ウルソジオール(urasodiol)、ブロムペリドール、ドロペリドール、フルペンチキソールデカノエート、アルブテロール、アルブテロールサルフェート、カリソプロドール、クロベタゾール、ロピニロール、ラベタロール、およびメトカルバモールを含む。
アミオデロン(amioderine)、フルチカゾン、スピロノラクトン、プレドニゾン、トリアゾドン(triazodone)、デスオキシメタゾン、メチルプレドニスドン(methyl prednisdone)、ベンゾナテートナブメトンおよびブスピロンを含む。
メトクロプラミドを含む。
ドルゾラミド、ブリモニジン、オロパタジン、シクロペントレート、ピロカルピンおよびエコチオフェートを含む。
ワルファリン、エノキサパリンおよびレピルジンを含む。
プロベネシドとスルフィンピラゾンを含む。
イプラトロピウムを含む。
ラロキシフェン、パミドロネートおよびリセドロネートを含む。
アセチルヘキサペプチド‐3、アセチルヘキサペプチド‐8、アセチルオクタペプチドおよび1‐カルノシンを含む。
トキソイド(不活性トキソイド化合物);タンパク質、タンパク質サブユニットおよびポリペプチド; DNAおよびRNAなどのポリヌクレオチド;コンジュゲート;サポニン、ビロソーム、無機および有機アジュバント、例えば、ゾスタバックスなどのアジュバントを含むワクチンを含む。
コエンザイムQ10(またはユビキノン)、ユビキノールまたはレスベラトロール;α、β、またはγ‐カロテン、リコピン、ルテイン、ゼアキサンチンおよびアスタキサンチンなどのカロテノイド;リコピン、ルテインおよびゼアキサンチンなどの植物栄養素;リノール酸、共役リノール酸、リノレン酸、ドコサヘキサエン酸(DHA)およびエイコサペンタエン酸(EPA)を含むが、限定されないオメガ‐3脂肪酸およびそれらのグリセロール‐などの不飽和脂肪酸;ビタミンD(D2、D3およびそれらの誘導体)、ビタミンE(α、β、γ、δ‐トコフェロール、または、α、β、γ、δ‐トコトリエノール)、ビタミンA(レチノール、レチナール、レチノイン酸および誘導体)、ビタミンK(K1、K2、K3およびそれらの誘導体)を含む脂溶性ビタミン、カプリル酸/カプリン酸トリグリセリド、葉酸、鉄、ナイアシン、グリセリルリノレート、オメガ6脂肪酸、ビタミンF、セレン、シアノコバラミン、アロエベラ、ベータグルカン、ビサボロール、茶(緑茶)抽出物、カプリル酸/カプリン酸トリグリセリド、ツボクサ(ゴーツコーラ)抽出物、セテアリルオリベート、クロロフィル、シトラスシネンシス(オレンジ)オイル、ココイルプロリン、ジカプリルエーテル、ラウリミノジプロピオネートトコフェリルフォスフェート2ナトリウム(ビタミンEフォスフェート)、グリセリン、グリセリルオレアート、グリチルリーザグラブラ(Glycyrrhiza glabra)(リコリス)根抽出物、ハマメリスバージニア(ウィッチヘーゼル)抽出物、乳酸、レシチン、ルテイン、マカダミアインテグリフォリア(マカダミア)シードオイル、マトリカリアカモミラ(カモミール)抽出物、オエノセラビエニス(oenothera biennis)(月見草)オイル、オレアエウロパエア(olea europaea)(オリーブ)葉抽出物、米ぬかオイル、パーシアグラティッシマ(アボカド)オイル、ポリゴナムマルチフロラム(polygonum multiflorum)抽出物、ポメグラネートステロール、レスベラトロール、ロサエグランテリア(ローズヒップ)オイル、サンタルムスピカタム(santalum spicatum)(サンダルウッド)オイル、チタニウムジオキシド、葉酸、グリセリン、グリセリルリノレート(オメガ6脂肪酸、ビタミンF)、ビタミンAパルミテート、ヴィティスヴィニフェラ(グレープシード)オイル、ハロベタゾール、アデノシン、アデノシントリフォスフェート、アルファヒドロキシ酸、アラントイン、ヒアルロン酸および誘導体、イソルトロール(isolutrol)、トラネキサム酸、グリコール酸、アルギニン、アスコルビルグルコサミン、アスコルビルパルミテート、サリチル酸、カルノシン酸、アルファリポ酸、ガンマリノレン酸(GLA)、パンテノール、レチニルプロピオネート、レチニルパルミテート、フルフリルアデニン、レチナールデヒド、銅ペプチド、イデベノン、ジメチルアミノエタノール(DMAE)、ナイアシンアミド、β-グルカン、パルミトイルペンタペプチド‐4、パルミトイルオリゴペプチド/テトラペプチド(tetrapetide)‐7、エトシン、セラミド、フェニルアラニン、グルクロノラクトン、L‐カルニチン、ヒドロキシルアパタイト(hydroxylapetite)、パルミトイルトリペプチド(tripetide)‐3、フォルスコリン、酸化亜鉛、α‐ビサボロール、オイゲノール、シリビン、大豆イソフラボン、アウクビン、カタルポール、アルニカカミソニス(arnica chamissonis)由来のプソイドグアイアノリド(pseudoguaianolide)、ロスマリン酸、ロスマノール、サリシン、サリゲニンおよびサリチル酸などのサリチレート、タキサステロール(taxasterol)α‐ラクツセロール、イソラクツセロール、タラキサコシド、セレミド(ceremide)、アルブチン、ジンゲロール、シャガオール(shagaol)、ハイパーシン(hypercin)、エラスチン、コラーゲンおよびそれらのペプチドを含む。
N,N‐ジメチル‐ホルムアミド(DMF)、N‐メチル‐2‐ピロリドン(NMP)、ジメチルスルホキシド(DMSO)、N,N‐ジメチルアセトアミド(DMAC)、ジメチルスルホキシド、ジオキサンヘキサメチルフォスフォロトリアミド(dioxane hexamethylphosphorotriamide)、プロピレンカーボネート、ガンマ‐ブチロールアセトン、モノメチルエチルアセテート、エチルラクテート、1,3ジメチル‐2‐イミダゾリジノン(ジメチルイソソルビド、またはDMI)、イソプロピルミリステート、プロピレングリコールリシノレート、イソノニルイソノナノエートおよび脂肪酸のスクロースエステル、イソプロピルミリステート、イソプロピルパルミテート、イソプロピルイソステアレート、ジイソプロピルアジペート、ジイソプロピルジメレート、マレイン酸ダイズ油(maleated soybean oil)、オクチルパルミテート、セチルラクテート、グリセリン、カプリリルグリセロール、スクアレン、ビサボロール、ベンジルアルコール、セチルリシノレート、セチルアセテート、麦芽グリセライド、ミリスチルラクテート、デシルオレアート、イソプロピルラノレート、ペンタエリスリチルテトラステアレート、ネオペンチルグリコールジカプリレート/ジカプレート、イソノニルイソノナノエート、イソトリデシルイソノナノエート、ミリスチルミリステート、オクチルドデカノール、およびオクチルヒドロキシステアレートからなる群から選択される極性非プロトン溶媒の存在が、他の種類の溶媒、例えばエタノール、または十分に定義された極性および非極性領域を有する界面活性剤と電子移動剤のリン酸化合物を含む担体組成物と比較して、電子移動剤のリン酸化合物の溶解性を増加できることを驚くべきことに見出した。
生理活性化合物は、任意の投与経路により送達されてもよい。投与経路は、効果により3つのカテゴリーに広く分けられ、すなわち、所望される効果が局所的であり、よって物質が、その反応が所望される場所に直接的に適用される「局所的(topical)」、所望される効果が全身的(非局所的)であり、よって物質が、消化管を介して与えられる「経腸的(enteral)」、および所望される効果が全身的であり、物質が、消化管以外のルートにより与えられる「非経口的(parenteral)」である。米国食品医薬品局は、111の異なる経路を認識する。以下は、投与経路の例の非限定的なリストである。
担体組成物および生理活性化合物を含む調合物は、経腸または非経口投与のための任意の適当な剤形に調製されてもよい。当業者は、経腸および非経口投与のための適当な剤形であろうものを容易に認識するであろう。経腸投与のための適当な剤形は、カプセル、錠剤、ピル、または頬側、舌下などの特殊錠剤、チュアブル錠剤または口腔内崩壊錠を含むが、限定されない。適当な剤形の他の例は、食用の薄膜があるであろう。
本発明の担体組成物は、さまざまな技術により調製されてもよい。担体組成物を調製するための一つの方法は、電子移動剤のリン酸塩化合物と極性非プロトン溶媒を結合すること、およびその後、水を加えることを含む。生理活性化合物の溶解性および安定性に依拠して、水性または溶媒相のいずれかに溶解されてもよい。一般的に、極性非プロトン溶媒は、30℃またはそれ以上の温度に加熱され、および電子移動剤のリン酸塩化合物は、極性非プロトンで溶解される。もし生理活性化合物が、極性非プロトン溶媒で可溶なら、その後、電子移動剤のリン酸塩化合物および極性非プロトン溶媒が、結合しおよび調合物のバランスが、水で調製される。
トコフェリルフォスフェート(TPM)およびさまざまな溶媒を含む担体組成物で処方されたコエンザイムQ10(CoQ10)の経皮吸収についての研究
方法
0.05w/w%のCoQ10を含むニベアヴィサージュ(Nivea Visage)(登録商標)(コントロール)を決定した。これを基準にして、上記方法に従って調製した以下の3つの調合物を試験した。
比較上のエタノール性の調合物(pH4.5)
成分 含有量(w/w%)
CoQ10 0.05
TPM 1
エタノール 10
水中のカルボポール 0.5
調合物(A)(pH4.5)
成分 含有量(w/w%)
CoQ10 0.05
TPM 1
N‐メチル‐2‐ピロリドン(NMP) 10
水中のカルボポール 0.5
調合物(B)(pH4.5)
成分 含有量(w/w%)
CoQ10 0.05
TPM 1
ジメチルイソソルビド(DMI) 10
水中のカルボポール 0.5
全層ヒト皮膚を、12ml垂直フランツ型拡散セル(Permegear,PA)で使用のために腹壁形成術手順により得た。すべての皮下脂肪および結合組織を除去した。皮膚をアルミホイルのシートの間で平らに凍結し、および実験の朝まで、−20℃で保存した。
比較上のエタノール性調合物および本発明の調合物(A)および(B)は、非処理皮膚サンプル内の内在性のレベルと比較して、皮膚で検出されるCoQ10の量が増加した(図1参照)。これらの増加は、106‐238%の範囲であり(表1下部参照)、およびすべて統計的に有意であった(p<0.005)。比較では、ニベアヴィサージュ(登録商標)で処理後の平均CoQ10レベルは、〜10%の増加し、そしてそれは、有意とみなされなかった。比較上のエタノール性調合物および本発明の調合物(A)および(B)は、ニベアヴィサージュ(登録商標)を超えて、皮膚に送達されたCoQ10の量について有意な増加を生み出した(p<0.002)(表1参照)。これらの増加は、190%‐310%までの範囲であった。
この実施例は、TPMおよび極性非プロトン溶媒を含む担体が、TPMおよびエタノールを含む担体に対して、有用およびより安定な代替品を提供することを示した。
TPMおよびエチルラクテートで処方されたインスリンの薬物動態についての研究
方法
ネガティブコントロール‐KYゼリー
ラットに局所的な調合物をすり込む物理的プロセスにより生じる血中グルコースについての低下を監視するために使用する。ストレスは、血中グルコースについて広範な変動を引き起こし得る。
ポジティブコントロール‐溶媒としてエタノールを使用するTPM/インスリン
Phosphagenicsにより生産された標準TPM/インスリン調合物を、有効性のために第1相および第2相臨床試験で使用した。この調合物は、STZラットモデルで、血中グルコースを再現性よく低下した。この調合物は、水中に、2.26mg/mlインスリン、溶媒として30%エタノール、2%TPM(2:1)および1%ヒドロキシプロピルセルロースHを含む。
TPM/インスリンEL1‐3
エタノールの代替品としてエチルラクテートを含む、3つの異なるTPM/インスリン調合物を試験した。調合物(すべてpH7)は以下:
IN#1:水中に、12mg/mlインスリン、4%エチルラクテート、4%TPM(2:1)および1%ヒドロキシプロピルセルロースH
IN#2:水中に、12mg/mlインスリン、15%エチルラクテート、2%TPM(2:1)および1%ヒドロキシプロピルセルロースH
IN#3:水中に、2.26mg/mlインスリン、4%エチルラクテート、4%TPM(2:1)および1%ヒドロキシプロピルセルロースH
を含む。
本研究は、最適な投与量を決定するために、ストレプトゾトシン処理糖尿病ラット中のグルコースホメオスタシスでエチルラクテートを含む新規のTPM/インスリン調合物の効果を試験するために設計した。動物(n=15)は、オスおよび10‐12週齢である。すべての動物は、体重>300gであり、および絶食状態で循環グルコース濃度>10mmol/L(平均絶食グルコース濃度が、22.20±2.96mmol/Lであった)を有した。研究の重要なエンドポイントは、5時間インスリン負荷試験の間の血中グルコースレベルであり、下記のように実施した。
糖尿病を、用時調製でクエン酸ナトリウム緩衝液(0.1mol/L、pH4.5)中に溶解したストレプトゾトシン(STZ)50mg/kg(Sigma Chemicals)の単回腹腔内注射の投与により、引き起こした。ラットは、仮に、それらの血中グルコースが、STZ注射後、24時間で16mmol/L超であれば、糖尿病とみなし、および研究において包含した。すべてのグループで、血中グルコース測定を、尾の先(tali tipping)からスポットサンプルを得ることにより行った。動物を、試験前にSTZ投与後、5日間置いた。
調合物の適用前24時間、動物を麻酔し、および毛皮〜30cm2を調合物の吸収を促進できる皮膚のなんらかの損傷を避けるために背中から剃った。TPM/インスリンを剃った領域に渡って、12mg/cm2の投与量で塗った。インスリン負荷試験は、毛皮を除去した後、24時間行った。それぞれの処理の後、動物を、次の処理の前、3日間回復させた。
動物を、インスリンまたはコントロール調合物の適用の前に、2時間絶食した。スポット血液サンプルを、調合物の適用後、0、30、60、90、120、180、240および300分で、尾から採取した。血中グルコースレベルを、グルコーススティック(AccuChek,Roche Diagnostics)を使用して、同様のタイムポイントで決定した。
すべてのTPM/インスリン調合物は、糖尿病ラットで、血中グルコース濃度の有意な低下を引き起こした(図2参照)。血中グルコースは、適用後30分で、開始値から有意に低下し(p<0.05)、および実験の期間の間、より低く維持した。曲線下面積により示すように、明細書中で試験した調合物の間で、血中グルコースの低下について差はなかった(図3参照)。4%程度の低いエチルラクテート濃度は、従って、30%のエタノール性濃度と同じくらい効果的であるように見える。この特定の調合物において、増加したインスリン含有量は、増加した有効性に変換されていないが、エチルラクテート調合物の増加した親水性相は、また増加したタンパク質濃度を許容する。
エチルラクテートは、経皮性の送達において機能障害を伴わずにTPM/インスリン調合物についてエタノールを置換することができる。2%または4%程度の低いエチルラクテート濃度を、30%エタノールと置換するために使用してもよく、そしてそれは、タンパク質などの不安定な分子のフェディリティを保証するために、親水性薬物のより高い濃度およびより水性環境を潜在的に許容する。
TPMおよびエチルラクテートを伴うジクロフェナク調合物の経皮性の送達についての研究
方法
TPMおよびエチルラクテートを含む、4つの異なるジクロフェナク調合物を試験した。ジクロフェナクジエチルアミン(D)およびナトリウム塩(DNa)形態を使用した。調合物は以下:
DICLO#1:水中に、5%ジクロフェナクジエチルアミン、1%TPM(6:4)、2%エチルラクテート、1%ヒドロキシプロピルセルロースH
DICLO#2:水中に、5%ジクロフェナクナトリウム塩、1%TPM(6:4)、12%エチルラクテート、1%ヒドロキシプロピルセルロースH
DICLO#3:水中に、5%ジクロフェナクナトリウム塩、1%TPM(6:4)、22%エチルラクテート、1%ヒドロキシプロピルセルロースH
DICLO#4:水中に、5%ジクロフェナクジエチルアミン、1%TPM(6:4)、12%エチルラクテート、1%ヒドロキシプロピルセルロースH
である。
動物実験のための承認は、モナッシュ大学生物科学学部の動物倫理委員会(プロトコル BAM/B/2006/31)により承認された。全層ラット腹部皮膚を、12ml垂直フランツ型拡散セル(Permegear,PA)で使用した。ラットを、CO2ガスを使用して窒息により屠殺し、および腹部領域を注意深く剃り、および切除した。すべての皮下脂肪および結合組織を除去した。皮膚を、アルミホイルのシートの間で平らに凍結し、および実験の朝まで、−20℃で保存した。
エチルラクテートを含む調合物は、経皮的なジクロフェナク送達を導入することができた。ジエチルアミンおよび分子のナトリウム形態は、皮膚を透過できた。興味深いことに、最も低いエチルラクテート濃度(2%)を伴う調合物が、もっとも経皮的な送達を産生することができた。
以下は3つの調合物例である。
1.デイクリーム
水溶液(精製水)
アセチルオクタペプチド‐3
エチルヘキシルメトキシシンナマート
グリセリン
C12‐15アルキルベンゾエート
セテアリルアルコール(および)セテアレス‐20
ベンゾフェノン‐3
オクチルサリチレート
プロピレングリコール
d‐アルファ‐トコフェリルフォスフェート(モノおよびジフォスフェートの混合物)
グリセリルステアレート(および)PEG‐100ステアレート
ジメチコン
カプリリルグリコール
フェノキシエタノール
トコフェロール
キサンタンガム
ヒドロキシエチルセルロース
シトラスオーランティアムダルシス(Citrus Aurantium Dulcis)(オレンジ)オイル
カルノシン
レチノール
ポリソルベート20
カメリアシネンシス(緑茶)抽出物
サンタルムアルバム(Santalum Album)(サンダルウッド)オイル
EDTA二ナトリウム
ユビキノン
d‐リモネン
ファルネソール
リナロール
水溶液(精製水)
グリセリン
C12‐15アルキルベンゾエート
セテアリルアルコール(および)セテアレス‐20
カプリル酸/カプリン酸トリグリセリド
アセチルオクタペプチド‐3
ジメチコン
d‐アルファ‐トコフェリルフォスフェート(モノおよびジフォスフェートの混合物)
セチルアルコール
カプリリルグリコール
トコフェロール
レチノール
ポリソルベート20
カルノシン
ヒドロキシエチルセルロース
トリエタノールアミン
キサンタンガム
マグネシウムアルミニウムシリケート
ユビキノン
フェノキシエタノール
EDTA二ナトリウム
水(水溶液)
アロエバルバデンシス(Aloe barbardensis)(アロエベラ)
セテアリルオリベート
グリセロールオレアート
デシルキュベート
d‐アルファ‐トコフェリルフォスフェート(モノまたはジフォスフェートの混合物)
スクアレン(オリーブ)
ラウリミノジプロピオネートトコフェリルフォスフェート2ナトリウム
トコフェロール(アルファ、デルタ、ガンマ、ベータ天然ビタミンE)
プルラン
オリザサティバ(米)ぬかオイル(および)トコトリエノール
ベータカロテン(ビタミンA)
グリセリルリノレート(オメガ6脂肪酸ビタミンF)
アミノ酪酸
グリセリルモノステレート
ビサボロール
レスベラトロール
ビタミンAパルミテート
コレカルシフェロール(ビタミンD3)
カラギナン
メナキノン(ビタミンK)
アスコルビルパルミテート(ビタミンC)
乳酸
フェノキシエタノール
ベンジルアルコール
デヒドロ酢酸
Claims (37)
- 生理活性化合物の送達のための担体組成物であって、ここで前記送達が、非経口投与経路であり、以下:
(i)モノ‐(トコフェリル)フォスフェート、モノ‐(トコフェリル)フォスフェート一ナトリウム塩、モノ‐(トコフェリル)フォスフェート二ナトリウム塩、ジ‐(トコフェリル)フォスフェート、ジ‐(トコフェリル)フォスフェート一ナトリウム塩、またはそれらの混合物からなる群から選択される電子移動剤のリン酸塩化合物;および
(ii)濃度が担体組成物の全濃度の0.05%w/w〜30%w/wである、N‐メチル‐2‐ピロリドン(NMP)、エチルラクテート、または1,3ジメチル‐2‐イミダゾリジノン
を含む、前記担体組成物。 - 前記トコフェリルフォスフェートが、非中和形態である、請求項1に記載の担体組成物。
- 前記非中和トコフェリルフォスフェートが、2〜4の範囲のpHを有する、請求項2に記載の担体組成物。
- 前記非中和トコフェリルフォスフェートが、2〜3の範囲のpHを有する、請求項2に記載の担体組成物。
- 前記非中和トコフェリルフォスフェートが、2または3のpHを有する、請求項2に記載の担体組成物。
- 前記担体が、少なくとも2:1の比率で、モノ‐(トコフェリル)フォスフェートとジ‐(トコフェリル)フォスフェートの混合物を含む、請求項1に記載の担体組成物。
- 前記担体が、4:1〜1:4の範囲内で、モノ‐(トコフェリル)フォスフェートとジ‐(トコフェリル)フォスフェートの混合物を含む、請求項1に記載の担体組成物。
- 前記担体が、6:4〜8:2の範囲内で、モノ‐(トコフェリル)フォスフェートとジ‐(トコフェリル)フォスフェートの混合物を含む、請求項1に記載の担体組成物。
- 前記担体が、6:4または8:2の比率で、モノ‐(トコフェリル)フォスフェートとジ‐(トコフェリル)フォスフェートの混合物を含む、請求項1に記載の担体組成物。
- 前記電子移動剤のリン酸塩化合物が、前記担体組成物の全濃度の0.01%w/w〜20%w/wの範囲内の量である、請求項1に記載の担体組成物。
- 前記電子移動剤のリン酸塩化合物が、前記担体組成物の全濃度の0.01%w/w〜10%w/wの範囲内の量である、請求項1に記載の担体組成物。
- 前記電子移動剤のリン酸塩化合物が、前記担体組成物の全濃度の0.01%w/w〜5%w/wの範囲内の量である、請求項1に記載の担体組成物。
- 前記電子移動剤のリン酸塩化合物が、前記担体組成物の全濃度の0.05%w/w〜2%w/wの範囲内の量である、請求項1に記載の担体組成物。
- 前記電子移動剤のリン酸塩化合物が、前記担体組成物の全濃度の0.1%w/w、1%w/w、または5%w/wの量である、請求項1に記載の担体組成物。
- 前記濃度が、前記担体組成物の全濃度の0.05%w/w〜20%w/wである、請求項1に記載の担体組成物。
- 前記濃度が、0.05%w/w〜10%w/wである、請求項1に記載の担体組成物。
- 前記濃度が、0.05%w/w〜5%w/wである、請求項1に記載の担体組成物。
- 前記濃度が、0.05%w/w〜3%w/wである、請求項1に記載の担体組成物。
- 前記濃度が、0.05%w/w〜2%w/wである、請求項1に記載の担体組成物。
- 前記濃度が、0.05%w/w〜1%w/wである、請求項1に記載の担体組成物。
- 生理活性化合物の送達のための担体組成物の調製における、
(i)モノ‐(トコフェリル)フォスフェート、モノ‐(トコフェリル)フォスフェート一ナトリウム塩、モノ‐(トコフェリル)フォスフェート二ナトリウム塩、ジ‐(トコフェリル)フォスフェート、ジ‐(トコフェリル)フォスフェート一ナトリウム塩、またはそれらの混合物からなる群から選択される電子移動剤のリン酸塩化合物;および
(ii)濃度が前記担体組成物の全濃度の0.05%w/w〜30%w/wである、N‐メチル‐2‐ピロリドン(NMP)、エチルラクテート、または1,3ジメチル‐2‐イミダゾリジノン
の使用であって、ここで前記送達が、非経口投与経路である、前記使用。 - 生理活性化合物の送達のための担体組成物の調製方法であって、ここで前記送達が、非経口投与経路であり、以下:
(i)モノ‐(トコフェリル)フォスフェート、モノ‐(トコフェリル)フォスフェート一ナトリウム塩、モノ‐(トコフェリル)フォスフェート二ナトリウム塩、ジ‐(トコフェリル)フォスフェート、ジ‐(トコフェリル)フォスフェート一ナトリウム塩、またはそれらの混合物からなる群から選択される電子移動剤のリン酸塩化合物;および
(ii)濃度が担体組成物の全濃度の0.05%w/w‐30%w/wである、N‐メチル‐2‐ピロリドン(NMP)、エチルラクテート、または1,3ジメチル‐2‐イミダゾリジノン
を組み合わせる工程を含む、前記調製方法。 - 請求項1の担体組成物および生理活性化合物を含む調合物。
- 前記生理活性化合物が、医薬品もしくはそれらの医薬的に許容される誘導体、栄養補助食品もしくはそれらの栄養補助食品的に許容される誘導体、または薬用化粧品もしくはそれらの薬用化粧品的に許容される誘導体である、請求項23に記載の調合物。
- 前記生理活性化合物が、ラドカイン、ジクロフェナク、ケトララック(ketoralac)、プリロカイン、ハロベタゾール、ヒドロコルチゾールまたはそれらの組み合わせである、請求項23に記載の調合物。
- 前記生理活性化合物が、前記担体組成物の全濃度の0.001%w/w〜15%w/wの量で存在する、請求項23に記載の調合物。
- 前記生理活性化合物が、前記担体組成物の全濃度の0.001%w/w〜10%w/wの量で存在する、請求項23に記載の調合物。
- 前記生理活性化合物が、前記担体組成物の全濃度の0.001%w/w〜5%w/wの量で存在する、請求項23に記載の調合物。
- 前記生理活性化合物が、前記担体組成物の全濃度の0.001%w/w〜2%w/wの量で存在する、請求項23に記載の調合物。
- 前記生理活性化合物が、前記担体組成物の全濃度の0.001%w/w〜1%w/wの量で存在する、請求項23に記載の調合物。
- 前記生理活性化合物が、前記担体組成物の全濃度の0.001%w/w〜0.1%w/wの範囲内の量で存在する、請求項23に記載の調合物。
- 前記生理活性化合物が、前記担体組成物の全濃度の0.001%w/w〜0.05%w/wの範囲内の量で存在する、請求項23に記載の調合物。
- 前記生理活性化合物が、前記担体組成物の全濃度の1%w/w、2%w/w、または5%w/wの量で存在する、請求項23に記載の調合物。
- 請求項1に記載の担体組成物に生理活性化合物を添加するためのステップを含む、請求項23に記載の調合物の調製方法。
- 請求項1の担体組成物中の生理活性化合物の有効量が投与される、病的状態の対象のための請求項23に記載の調合物。
- 生理活性化合物の送達および/または生物学的利用能を改善するための請求項23に記載の調合物。
- モノ‐(トコフェリル)フォスフェート、モノ‐(トコフェリル)フォスフェート一ナトリウム塩、モノ‐(トコフェリル)フォスフェート二ナトリウム塩、ジ‐(トコフェリル)フォスフェート、ジ‐(トコフェリル)フォスフェート一ナトリウム塩からなる群から選択される電子移動剤のリン酸塩化合物の溶解性および安定性を増加するための、0.05%w/w〜30%w/wの量でのN‐メチル‐2‐ピロリドン(NMP)、エチルラクテート、または1,3ジメチル‐2‐イミダゾリジノンの使用。
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AU (1) | AU2011213484B2 (ja) |
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Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2531047A4 (en) | 2010-02-05 | 2014-03-19 | Phosphagenics Ltd | CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE |
MX2012011355A (es) | 2010-03-30 | 2012-11-30 | Phosphagenics Ltd | Parche de suministro transdermico. |
US9561243B2 (en) * | 2011-03-15 | 2017-02-07 | Phosphagenics Limited | Composition comprising non-neutralised tocol phosphate and a vitamin A compound |
CN104042502B (zh) * | 2014-06-10 | 2016-04-27 | 刘佰岭 | 一种深层渗透吸收并促进新陈代谢延缓衰老的护肤组合物 |
MA41688A (fr) * | 2014-10-16 | 2017-08-22 | Honeywell Int Inc | Procédé de séparation de fluorure d'hydrogène de mélanges fluorure d'hydrogène/hydrocarbures halogénés au moyen de liquides ioniques |
CA3007587C (en) | 2015-12-09 | 2023-12-05 | Phosphagenics Limited | Pharmaceutical formulation |
WO2017214497A1 (en) | 2016-06-10 | 2017-12-14 | Clarity Cosmetics Inc. | Non-comedogenic hair and scalp care formulations and method for use |
JP7198754B2 (ja) | 2016-12-21 | 2023-01-04 | アベーチョ バイオテクノロジー リミテッド | 方法 |
WO2019148087A1 (en) * | 2018-01-29 | 2019-08-01 | Duke University | Compositions and methods of enhancing 5-hydroxytryptophan bioavailability |
CN115916183A (zh) * | 2020-01-10 | 2023-04-04 | 布里奥里生物技术公司 | 含有罗非昔布的局部用组合物及其制备和使用方法 |
US12059486B2 (en) | 2021-01-13 | 2024-08-13 | Rodan &Fields, LLC | Cosmetic compositions |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2457932A (en) * | 1949-01-04 | Salts of tocopheryl phosphoric | ||
US4977282A (en) * | 1984-04-17 | 1990-12-11 | Henkel Corporation | Production of d-alpha-tocopherol from natural plant sources |
CN1077800C (zh) * | 1993-07-01 | 2002-01-16 | 韩美药品工业株式会社 | 环孢菌素软胶囊组合物 |
FR2714595B1 (fr) * | 1993-12-30 | 1996-02-02 | Oreal | Emulsion eau dans huile contenant du rétinol, son utilisation et son conditionnement. |
AU2113199A (en) * | 1998-01-12 | 1999-07-26 | Betagene, Inc. | Media for neuroendocrine cells |
FR2777179A1 (fr) * | 1998-04-09 | 1999-10-15 | Lvmh Rech | Compositions cosmetiques ou dermatologiques comprenant un vehicule a base d'un liquide hydrophobe |
AUPR549901A0 (en) * | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
CA2426852C (en) * | 2000-11-14 | 2010-01-26 | Vital Health Sciences Pty Ltd | Formulation containing phosphate derivatives of electron transfer agents |
KR100612398B1 (ko) * | 2000-11-14 | 2006-08-16 | 바이탈 헬스 사이언시즈 피티와이 리미티드 | 포스페이트 유도체의 착체 |
TW576859B (en) * | 2001-05-11 | 2004-02-21 | Shipley Co Llc | Antireflective coating compositions |
WO2002102385A1 (en) * | 2001-06-14 | 2002-12-27 | Sampad Bhattacharya | Compositions comprising cgmppde5 inhibitor for transdermal delivery to the erectile tissue of the penis |
US8008345B2 (en) * | 2001-07-27 | 2011-08-30 | Vital Health Sciences Pty. Ltd. | Dermal therapy using phosphate derivatives of electron transfer agents |
AUPR684801A0 (en) * | 2001-08-06 | 2001-08-30 | Vital Health Sciences Pty Ltd | Supplement therapy |
MXPA04001779A (es) * | 2001-09-26 | 2004-05-31 | Vital Health Sciences Pty Ltd | Modulacion de almacenamiento de vitamina. |
AU2002950713A0 (en) * | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
US20050152858A1 (en) * | 2003-07-11 | 2005-07-14 | Isp Investments Inc. | Solubilizing agents for active or functional organic compounds |
US7207669B2 (en) * | 2003-12-19 | 2007-04-24 | Arizona Chemical Company | Jet printing inks containing polymerized fatty acid-based polyamides |
JP4758347B2 (ja) * | 2004-06-29 | 2011-08-24 | 独立行政法人科学技術振興機構 | ヒアルロン酸を用いた小型肝細胞の選択的培養法および分離法 |
BRPI0513673B8 (pt) * | 2004-08-03 | 2021-07-27 | Vital Health Sciences Pty Ltd | método para produzir um medicamento para aumentar a eficácia e o transporte dos compostos biologicamente ativos enteralmente administrados, e composição farmacêutica |
JP4523388B2 (ja) * | 2004-11-19 | 2010-08-11 | 日本メナード化粧品株式会社 | コラーゲン合成促進剤及び皮膚外用剤 |
US20060120979A1 (en) * | 2004-12-02 | 2006-06-08 | Joel Rubin | Skin care composition comprising hydroquinone and a substantially anhydrous base |
US20060228395A1 (en) * | 2005-04-11 | 2006-10-12 | Robert Lamb | Vitamin E phosphate/phosphatidylcholine liposomes to protect from or ameliorate cell damage |
CA2611831C (en) * | 2005-06-17 | 2014-09-16 | Vital Health Sciences Pty Ltd. | A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
US20080029910A1 (en) * | 2006-08-02 | 2008-02-07 | Edwards David L | Layout of array of electrical interconnect to increase i/o density packaging |
WO2008034178A1 (en) * | 2006-09-21 | 2008-03-27 | Salvatore Iemma | Topical depilating composition |
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2011
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US20190298834A1 (en) | 2019-10-03 |
AU2011213484A1 (en) | 2012-08-23 |
EP2531219A1 (en) | 2012-12-12 |
WO2011094822A1 (en) | 2011-08-11 |
ZA201205832B (en) | 2013-05-29 |
EP2531219A4 (en) | 2015-01-14 |
CA2788675C (en) | 2018-01-16 |
CN102740891A (zh) | 2012-10-17 |
JP2017141294A (ja) | 2017-08-17 |
AU2011213484B2 (en) | 2015-07-09 |
CA2788675A1 (en) | 2011-08-11 |
IL221185A (en) | 2017-12-31 |
KR20120115991A (ko) | 2012-10-19 |
NZ601528A (en) | 2015-04-24 |
RU2012133467A (ru) | 2014-02-10 |
US20120283233A1 (en) | 2012-11-08 |
JP2015193640A (ja) | 2015-11-05 |
SG182836A1 (en) | 2012-09-27 |
US20160375136A1 (en) | 2016-12-29 |
JP2013518822A (ja) | 2013-05-23 |
CN102740891B (zh) | 2016-08-10 |
MX2012009068A (es) | 2012-09-07 |
BR112012019508A2 (pt) | 2018-03-13 |
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