JP5856739B2 - 血行促進用身体化粧料 - Google Patents
血行促進用身体化粧料 Download PDFInfo
- Publication number
- JP5856739B2 JP5856739B2 JP2011029772A JP2011029772A JP5856739B2 JP 5856739 B2 JP5856739 B2 JP 5856739B2 JP 2011029772 A JP2011029772 A JP 2011029772A JP 2011029772 A JP2011029772 A JP 2011029772A JP 5856739 B2 JP5856739 B2 JP 5856739B2
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- JP
- Japan
- Prior art keywords
- blood circulation
- carbon dioxide
- poe
- skin
- sheet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Landscapes
- Cosmetics (AREA)
Description
すなわち、本発明は、次の成分(A)〜(D):
(A)炭酸ガス100〜20000ppm
(B)TRPV3アゴニスト0.01〜5質量%
(C)多価アルコール及び/又はノニオン界面活性剤
(D)エタノール0〜5質量%
を含有する血行促進用身体化粧料を提供するものである。
本発明の血行促進用身体化粧料は、血行促進作用を増強及び持続させる身体化粧料であり、かかる血行促進用身体化粧料全量中に炭酸ガス(A)を100〜20000ppm含有する。好ましくは血行促進用身体化粧料は、血行促進用身体化粧料全量中に炭酸ガス(A)を300〜15000ppm、より好ましくは400〜10000ppm含有し、さらに好ましくは500〜3000ppm含有する。炭酸ガスの濃度が100ppm以上であれば充分な血行促進作用を得ることができるとともに、TRPV3アゴニストと併用することで血行促進作用の持続性の向上を図ることができる。一方、3000ppm以下であれば、炭酸ガスの溶解性の点から製造上好ましい。
表1に示す処方に従って未架橋状態の含水ゲル原液を調製した後、各成分を含有するゲルシートを作製した。具体的には、グリセリンとプロピレングリコールの混合液を混練機に投入し、コハク酸水溶液に分散させたカルボキシメチルセルロース、乾燥水酸化アルミニウムゲル、パラオキシ安息香酸メチルを配合して未架橋ゲルを調製した。次いで、得られた未架橋ゲルに、TRPV3アゴニストを加温溶解させた多価アルコール及び/又はノニオン界面活性剤をTRPV3アゴニストが適濃度になるように混合し、この未架橋状態のゲルを、PE(ポリエチレン)フィルムと不織布を積層したEVOH(エチレン・ビニルアルコール共重合体)フィルムとの間に挟み込み、ベーカー式アプリケーターにより、含水ゲルの厚さが1.5mmとなるように展延した。さらに、50℃で5日間熟成させて含水ゲルのイオン架橋反応を促進させて、架橋したゲルシートを得た。
5: 感覚なし
4: わずかに刺激感を感じる
3: 弱い刺激感を感じる
2: 強い刺激感を感じる
1: 非常に強い刺激感を感じる
表2に示す処方に従ってゲルシートを作製し、TRPV3アゴニストの溶解剤として多価アルコール又はノニオン界面活性剤の配合を検討した。カルバクロール及びリモネンは、多価アルコール又はノニオン界面活性剤に溶解させて、ゲル原液と混合し、熟成しゲルシートを調製した。裁断したゲルシートをアルミピロー中に炭酸ガスとともに封入し、5日間保持した後に皮膚に貼付して前腕における血流増加作用を評価した。結果を図3に示す。
炭酸ガス濃度と血行促進作用の関連を明らかにするために、アルミピローにゲルシートと共に封入する炭酸ガスの濃度を変動させた場合における、血行促進作用を評価した。本実験では、実施例1で得られたリモネン含有のシートを用い、炭酸ガス濃度を変動させたシートを作製し(表3)、得られたシートを前腕内側部に7分間貼付した後に剥離して、剥離した直後における皮膚紅潮レベルを目視により評価するとともに、0.5分後及び5分後における血流増加作用を評価した。結果を図4に示す。
質量%
エタノール 3.0
1,3−ブチレングリコール 6.0
グリセリン 5.0
プロピレングリコール 5.0
POE(15)ラウリルエーテル 0.5
リモネン 0.4
防腐剤 適量
精製水 残余
炭酸ガス 0.15
炭酸ガス以外の成分を混合、攪拌して均一とし、所定の量をアルミピローに入れた後に炭酸ガスを封入して血行促進用化粧水を得た。
質量%
ステアリン酸 2.5
セチルアルコール 1.5
エタノール 0.5
ワセリン 5.0
1,8−シネオール 0.4
炭酸ガス 0.15
プロピレングリコール 3.0
流動パラフィン 10.0
POE(10)モノオレイン酸エステル 2.0
PEG1500 3.0
トリエタノールアミン 1.0
亜硫酸水素ナトリウム 0.01
カルボキシビニルポリマー 0.05
防腐剤 適量
香料 適量
精製水 残余
炭酸ガス以外の成分を混合、攪拌して均一とし、所定の量をアルミピローに入れた後に炭酸ガスを注入して血行促進用乳液を得た。
質量%
エタノール 3.0
乳酸 0.1
プロピレングリコール 2.0
乳酸ナトリウム 0.3
POE(20)硬化ヒマシ油 0.5
リモネン 0.1
炭酸ガス 0.15
防腐剤 適量
香料 適量
精製水 残余
炭酸ガス以外の成分を混合、攪拌して均一とし、所定の量をアルミピローに入れた後に炭酸ガスを注入して血行促進用スキンローションを得た。
質量%
炭酸水素ナトリウム 30.0
炭酸ナトリウム 15.0
フマル酸 49.5
ポリエチレングリコール6000 5.0
ポリオキシエチレンステアリルエーテル 0.5
テトラオレイン酸ポリオキシエチレンソルビット 0.5
リモネン 0.5
香料 適量
質量%
炭酸ガス 1.5
液化石油ガス 0.5
イソペンタン 1.0
ラウリルリン酸 3.9
モノラウリン酸ポリグリセリル 1.0
カルボキシビミニルポリマー 0.1
アクリル酸・メタクリル酸アルキル共重合体 0.1
キサンタンガム 0.1
トリメチルグリシン 4.9
プロピレングリコール 1.6
L-アルギニン 3.0
ニコチン酸dl−α―トコフェロール 1.0
ヒドロキシエタンジホスホン酸 0.1
パラオキシ安息香酸メチル 0.2
リモネン 0.1
香料 適量
精製水 残量
二酸化炭素及び液化石油ガス以外を混合して原液を調製し、その後原液と二酸化炭素と液化石油ガス及びイソペンタンの混合ガスを耐圧容器に密封して血行促進用エアゾール組成物を得た。
Claims (3)
- 次の成分(A)〜(D):
(A)炭酸ガス100〜20000ppm
(B)TRPV3アゴニスト0.01〜5質量%
(C)多価アルコール及びノニオン界面活性剤
(D)エタノール0〜5質量%
を含有し、かつ
前記成分(B)と成分(C)との含有量比(質量比)が(B):(C)=1:50〜2:1である血行促進用身体化粧料。 - 前記成分(B)が、1,8-シネオール、リモネン、α-ピネン、フローラマット、メチルシクロオクチルカルボネート及びポイレナートからなる群より選ばれる1種又は2種以上である請求項1に記載の身体化粧料。
- 前記(C)成分の含有量が、0.1〜20質量%である請求項1又は2に記載の身体化粧料。
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