JP5840623B2 - 気道のウイルス感染症の治療に用いるｅｖ５７６ - Google Patents
気道のウイルス感染症の治療に用いるｅｖ５７６ Download PDFInfo
- Publication number
- JP5840623B2 JP5840623B2 JP2012547546A JP2012547546A JP5840623B2 JP 5840623 B2 JP5840623 B2 JP 5840623B2 JP 2012547546 A JP2012547546 A JP 2012547546A JP 2012547546 A JP2012547546 A JP 2012547546A JP 5840623 B2 JP5840623 B2 JP 5840623B2
- Authority
- JP
- Japan
- Prior art keywords
- agent
- protein
- respiratory tract
- complement
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000011282 treatment Methods 0.000 title description 18
- 206010062106 Respiratory tract infection viral Diseases 0.000 title description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 86
- 102000004169 proteins and genes Human genes 0.000 claims description 84
- 239000003795 chemical substances by application Substances 0.000 claims description 60
- 230000009385 viral infection Effects 0.000 claims description 36
- 210000002345 respiratory system Anatomy 0.000 claims description 35
- 208000036142 Viral infection Diseases 0.000 claims description 34
- 230000004054 inflammatory process Effects 0.000 claims description 34
- 201000010740 swine influenza Diseases 0.000 claims description 33
- 206010061218 Inflammation Diseases 0.000 claims description 32
- 102100031506 Complement C5 Human genes 0.000 claims description 31
- 208000015181 infectious disease Diseases 0.000 claims description 27
- 230000024203 complement activation Effects 0.000 claims description 21
- 230000000694 effects Effects 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 17
- 150000001413 amino acids Chemical class 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 15
- 108010034753 Complement Membrane Attack Complex Proteins 0.000 claims description 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 14
- 102000004856 Lectins Human genes 0.000 claims description 12
- 108090001090 Lectins Proteins 0.000 claims description 12
- 239000002523 lectin Substances 0.000 claims description 12
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims description 11
- 230000000295 complement effect Effects 0.000 claims description 11
- 201000004193 respiratory failure Diseases 0.000 claims description 11
- 206010022000 influenza Diseases 0.000 claims description 10
- 102000016574 Complement C3-C5 Convertases Human genes 0.000 claims description 9
- 108010067641 Complement C3-C5 Convertases Proteins 0.000 claims description 9
- 108010028773 Complement C5 Proteins 0.000 claims description 8
- 150000002066 eicosanoids Chemical class 0.000 claims description 8
- 241000315672 SARS coronavirus Species 0.000 claims description 7
- 206010064097 avian influenza Diseases 0.000 claims description 7
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 239000002773 nucleotide Substances 0.000 claims description 7
- 125000003729 nucleotide group Chemical group 0.000 claims description 7
- 108010078546 Complement C5a Proteins 0.000 claims description 6
- 230000002757 inflammatory effect Effects 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 4
- 241000238421 Arthropoda Species 0.000 claims description 4
- 208000034486 Multi-organ failure Diseases 0.000 claims description 4
- 208000010718 Multiple Organ Failure Diseases 0.000 claims description 4
- 206010069351 acute lung injury Diseases 0.000 claims description 4
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims description 4
- 241000712461 unidentified influenza virus Species 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 3
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 3
- 238000003776 cleavage reaction Methods 0.000 claims description 3
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 claims description 3
- 230000007017 scission Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 description 80
- 241000699670 Mus sp. Species 0.000 description 32
- 206010069767 H1N1 influenza Diseases 0.000 description 31
- 239000003981 vehicle Substances 0.000 description 27
- VNYSSYRCGWBHLG-AMOLWHMGSA-M leukotriene B4(1-) Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC([O-])=O VNYSSYRCGWBHLG-AMOLWHMGSA-M 0.000 description 26
- 238000010172 mouse model Methods 0.000 description 24
- 101000941598 Homo sapiens Complement C5 Proteins 0.000 description 23
- 208000009620 Orthomyxoviridae Infections Diseases 0.000 description 22
- 210000000440 neutrophil Anatomy 0.000 description 20
- 238000000034 method Methods 0.000 description 19
- 235000001014 amino acid Nutrition 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 15
- 230000009467 reduction Effects 0.000 description 13
- 230000027455 binding Effects 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 10
- 241000700605 Viruses Species 0.000 description 9
- 230000004154 complement system Effects 0.000 description 9
- 238000011081 inoculation Methods 0.000 description 9
- 108090000695 Cytokines Proteins 0.000 description 7
- 102000004127 Cytokines Human genes 0.000 description 7
- 108090001005 Interleukin-6 Proteins 0.000 description 7
- 108010076504 Protein Sorting Signals Proteins 0.000 description 7
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 239000012530 fluid Substances 0.000 description 7
- 230000037361 pathway Effects 0.000 description 7
- 239000002953 phosphate buffered saline Substances 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 241000238890 Ornithodoros moubata Species 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000003937 drug carrier Substances 0.000 description 5
- 229960003752 oseltamivir Drugs 0.000 description 5
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 description 4
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 102000037865 fusion proteins Human genes 0.000 description 4
- 108020001507 fusion proteins Proteins 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 241000238876 Acari Species 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 208000002979 Influenza in Birds Diseases 0.000 description 3
- 108050006654 Lipocalin Proteins 0.000 description 3
- 102000019298 Lipocalin Human genes 0.000 description 3
- 239000003443 antiviral agent Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 208000023504 respiratory system disease Diseases 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 108700006906 tick rEV131 Proteins 0.000 description 3
- 241000238682 Amblyomma americanum Species 0.000 description 2
- 108010089414 Anaphylatoxins Proteins 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- 241000258924 Ctenocephalides felis Species 0.000 description 2
- 241000227772 Dermacentor marginatus Species 0.000 description 2
- 241000255925 Diptera Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 241001480847 Ixodes persulcatus Species 0.000 description 2
- 208000037273 Pathologic Processes Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 241000219061 Rheum Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000002730 additional effect Effects 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 206010052015 cytokine release syndrome Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000000099 in vitro assay Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000015788 innate immune response Effects 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 231100000636 lethal dose Toxicity 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- PGZUMBJQJWIWGJ-ONAKXNSWSA-N oseltamivir phosphate Chemical compound OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 PGZUMBJQJWIWGJ-ONAKXNSWSA-N 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000009054 pathological process Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 229940061367 tamiflu Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 241000256111 Aedes <genus> Species 0.000 description 1
- 241000256118 Aedes aegypti Species 0.000 description 1
- 206010001889 Alveolitis Diseases 0.000 description 1
- 241001480735 Amblyomma cajennense Species 0.000 description 1
- 241001480736 Amblyomma hebraeum Species 0.000 description 1
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 description 1
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 description 1
- 241000256186 Anopheles <genus> Species 0.000 description 1
- 241000256182 Anopheles gambiae Species 0.000 description 1
- 241001480752 Argas persicus Species 0.000 description 1
- 241001480754 Argas reflexus Species 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 108700012434 CCL3 Proteins 0.000 description 1
- 102000000013 Chemokine CCL3 Human genes 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108010078596 Complement C5b Proteins 0.000 description 1
- 229940124073 Complement inhibitor Drugs 0.000 description 1
- 241000256054 Culex <genus> Species 0.000 description 1
- 241000256057 Culex quinquefasciatus Species 0.000 description 1
- 206010050685 Cytokine storm Diseases 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 208000016192 Demyelinating disease Diseases 0.000 description 1
- 206010012305 Demyelination Diseases 0.000 description 1
- 241001480819 Dermacentor andersoni Species 0.000 description 1
- 241000577477 Dermacentor reticulatus Species 0.000 description 1
- 241001480793 Dermacentor variabilis Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 244000182067 Fraxinus ornus Species 0.000 description 1
- 235000002917 Fraxinus ornus Nutrition 0.000 description 1
- 241000233007 Haemaphysalis inermis Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000750137 Hyalomma anatolicum anatolicum Species 0.000 description 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
- 241001480840 Ixodes hexagonus Species 0.000 description 1
- 241001480843 Ixodes ricinus Species 0.000 description 1
- 241000238703 Ixodes scapularis Species 0.000 description 1
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 1
- 101710091439 Major capsid protein 1 Proteins 0.000 description 1
- 101710151803 Mitochondrial intermediate peptidase 2 Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 102000003896 Myeloperoxidases Human genes 0.000 description 1
- 108090000235 Myeloperoxidases Proteins 0.000 description 1
- 108091061960 Naked DNA Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000092202 Ornithodoros erraticus Species 0.000 description 1
- 241000985247 Ornithodoros savignyi Species 0.000 description 1
- 241000255129 Phlebotominae Species 0.000 description 1
- 241001674048 Phthiraptera Species 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 241001480837 Rhipicephalus annulatus Species 0.000 description 1
- 241001481704 Rhipicephalus appendiculatus Species 0.000 description 1
- 241000949016 Rhipicephalus bursa Species 0.000 description 1
- 241000864246 Rhipicephalus decoloratus Species 0.000 description 1
- 241000238680 Rhipicephalus microplus Species 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 241000258242 Siphonaptera Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000624491 Strongylura scapularis Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 101100357018 Trypanosoma brucei brucei RNR2 gene Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 208000035868 Vascular inflammations Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 210000002821 alveolar epithelial cell Anatomy 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003376 axonal effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008236 biological pathway Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000004074 complement inhibitor Substances 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000001461 cytolytic effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000013764 eosinophil chemotaxis Effects 0.000 description 1
- 230000008378 epithelial damage Effects 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
- 238000002618 extracorporeal membrane oxygenation Methods 0.000 description 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000003960 inflammatory cascade Effects 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000005007 innate immune system Anatomy 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000008350 membranous glomerulonephritis Diseases 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 230000037125 natural defense Effects 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000002956 necrotizing effect Effects 0.000 description 1
- 230000032027 negative regulation of neutrophil apoptotic process Effects 0.000 description 1
- 230000011242 neutrophil chemotaxis Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 201000008171 proliferative glomerulonephritis Diseases 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000012384 transportation and delivery Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000002689 xenotransplantation Methods 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
- 244000089265 zong er cha Species 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1000318.4 | 2010-01-08 | ||
| GBGB1000318.4A GB201000318D0 (en) | 2010-01-08 | 2010-01-08 | Method of treatment |
| GB1005071.4 | 2010-03-25 | ||
| GBGB1005071.4A GB201005071D0 (en) | 2010-03-25 | 2010-03-25 | Method of treatment |
| PCT/GB2011/000022 WO2011083317A1 (en) | 2010-01-08 | 2011-01-10 | Ev576 for use in the treatment of viral infections of the respiratory tract |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516450A JP2013516450A (ja) | 2013-05-13 |
| JP2013516450A5 JP2013516450A5 (enExample) | 2014-02-13 |
| JP5840623B2 true JP5840623B2 (ja) | 2016-01-06 |
Family
ID=44305222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547546A Active JP5840623B2 (ja) | 2010-01-08 | 2011-01-10 | 気道のウイルス感染症の治療に用いるｅｖ５７６ |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20120283167A1 (enExample) |
| EP (1) | EP2521562B1 (enExample) |
| JP (1) | JP5840623B2 (enExample) |
| CN (1) | CN102762223B (enExample) |
| AU (2) | AU2011204483B2 (enExample) |
| CA (1) | CA2785612C (enExample) |
| NZ (1) | NZ601018A (enExample) |
| PL (1) | PL2521562T3 (enExample) |
| WO (1) | WO2011083317A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116785426A (zh) * | 2014-03-20 | 2023-09-22 | 因弗拉克斯有限责任公司 | 用于治疗病毒性肺炎的C5a抑制剂 |
| GB201410116D0 (en) * | 2014-06-06 | 2014-07-23 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| GB201602802D0 (en) | 2016-02-17 | 2016-03-30 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| EP4374922A3 (en) | 2016-06-14 | 2024-08-28 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antibodies and uses thereof |
| DK3612208T5 (da) | 2017-04-21 | 2024-09-02 | Volution Immuno Pharmaceuticals Sa | Coversin til behandlingen af autoimmune sygdomme med blisterdannelse |
| SG11202004662RA (en) | 2017-12-13 | 2020-06-29 | Regeneron Pharma | Anti-c5 antibody combinations and uses thereof |
| CN112203679A (zh) | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | Il-6抗体及其融合构建体和缀合物 |
| US20220047673A1 (en) * | 2018-09-10 | 2022-02-17 | Volution Immuno Pharmaceuticals Sa | Coversin for Use in the Treatment of Rheumatic Diseases |
| GB201905810D0 (en) * | 2019-04-25 | 2019-06-05 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
| US12097222B2 (en) | 2019-06-06 | 2024-09-24 | Spiritus Therapeutics, Inc. | Methods for attenuating viral infection and for treating lung injury |
| WO2020247675A1 (en) * | 2019-06-06 | 2020-12-10 | Spiritus Therapeutics, Inc. | Methods for attenuating viral infection and for treating lung injury |
| WO2020247610A1 (en) | 2019-06-06 | 2020-12-10 | Spiritus Therapeutics, Inc. | Mesenchymal stem cell-derived extracellular vesicles and uses thereof for treating and diagnosing fibrotic diseases |
| AU2019468121A1 (en) | 2019-09-27 | 2022-05-12 | Volution Immuno Pharmaceuticals Sa | Method of treatment of hematopoietic stem cell transplant associated thrombotic microangiopathy (HSCT-TMA) |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| CN115884764A (zh) * | 2020-04-01 | 2023-03-31 | 硫创治疗公司 | 用于治疗乙型冠状病毒感染的半胱胺前体化合物 |
| WO2021226404A1 (en) * | 2020-05-08 | 2021-11-11 | Kodiak Sciences Inc. | Use of il-6 antibodies and vegf traps, and fusion constructs and conjugates thereof |
| GB202218084D0 (en) | 2022-12-01 | 2023-01-18 | Volution Immuno Pharmaceuticals Sa | Fusion proteins |
| GB202408081D0 (en) | 2024-06-06 | 2024-07-24 | Volution Immuno Pharmaceuticals Sa | Methods of removing impurities |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3734093A (en) | 1992-02-27 | 1993-09-13 | Merck & Co., Inc. | Protein for inhibiting collagen-stimulated platelet aggregation |
| US7884066B2 (en) | 1999-10-05 | 2011-02-08 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
| US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| MXPA05012880A (es) * | 2003-06-02 | 2006-02-22 | Evolutec Ltd | Inhibidores de complemento. |
| GB0518443D0 (en) | 2005-09-09 | 2005-10-19 | Evolutec Ltd | Method of treating myasthenia gravis |
| US7274999B1 (en) * | 2006-03-10 | 2007-09-25 | Atmel Corporation | Brownout detector system and method |
| CA2649090A1 (en) * | 2006-04-12 | 2007-10-18 | Biocryst Pharmaceuticals, Inc. | Intramuscular antiviral treatments |
| JP2010502687A (ja) * | 2006-09-08 | 2010-01-28 | ヴァーレイ・リミテッド | 呼吸器疾患の治療方法 |
| GB0617734D0 (en) * | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
| GB0802116D0 (en) * | 2008-02-05 | 2008-03-12 | Natural Enviromental Res Counc | Treatment |
-
2011
- 2011-01-10 CN CN201180005464.6A patent/CN102762223B/zh active Active
- 2011-01-10 JP JP2012547546A patent/JP5840623B2/ja active Active
- 2011-01-10 WO PCT/GB2011/000022 patent/WO2011083317A1/en not_active Ceased
- 2011-01-10 PL PL11700973T patent/PL2521562T3/pl unknown
- 2011-01-10 US US13/521,011 patent/US20120283167A1/en not_active Abandoned
- 2011-01-10 CA CA2785612A patent/CA2785612C/en active Active
- 2011-01-10 NZ NZ601018A patent/NZ601018A/xx not_active IP Right Cessation
- 2011-01-10 EP EP11700973.8A patent/EP2521562B1/en active Active
- 2011-01-10 AU AU2011204483A patent/AU2011204483B2/en active Active
-
2015
- 2015-01-02 US US14/588,616 patent/US9522171B2/en active Active
-
2016
- 2016-05-11 AU AU2016203058A patent/AU2016203058B2/en active Active
- 2016-07-22 US US15/217,601 patent/US20170065677A1/en not_active Abandoned
-
2019
- 2019-06-07 US US16/434,737 patent/US20200155646A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20200155646A1 (en) | 2020-05-21 |
| US20120283167A1 (en) | 2012-11-08 |
| JP2013516450A (ja) | 2013-05-13 |
| AU2016203058B2 (en) | 2018-01-18 |
| EP2521562B1 (en) | 2019-09-18 |
| PL2521562T3 (pl) | 2020-04-30 |
| US20150196619A1 (en) | 2015-07-16 |
| AU2011204483A1 (en) | 2012-07-12 |
| US9522171B2 (en) | 2016-12-20 |
| US20170065677A1 (en) | 2017-03-09 |
| CA2785612A1 (en) | 2011-07-14 |
| AU2016203058A1 (en) | 2016-06-02 |
| CN102762223B (zh) | 2014-09-03 |
| CN102762223A (zh) | 2012-10-31 |
| NZ601018A (en) | 2013-09-27 |
| WO2011083317A1 (en) | 2011-07-14 |
| AU2011204483B2 (en) | 2016-02-11 |
| EP2521562A1 (en) | 2012-11-14 |
| CA2785612C (en) | 2019-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5840623B2 (ja) | 気道のウイルス感染症の治療に用いるｅｖ５７６ | |
| JP5784078B2 (ja) | 呼吸器疾患の治療方法 | |
| US20220249608A1 (en) | Method of Treating Peripheral Nerve Disorders | |
| RU2596785C2 (ru) | Композиция, содержащая пептид и ингибитор вирусной нейраминидазы | |
| DK2061501T3 (en) | METHOD OF TREATING RESPIRATORY DISORDERS | |
| JP2009533478A (ja) | 黄色ブドウ球菌感染症の治療用薬剤の製造のための活性成分としてｔｒａｐタンパク質自体の使用 | |
| AU2022410688A1 (en) | Recombinant protein for treating sars-cov2 disease | |
| HK40043003A (en) | Composition comprising a peptide and an inhibitor of viral neuraminidase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20130731 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20130731 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131220 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20131220 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20140307 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150106 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150406 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20150507 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150904 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20150918 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20151013 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20151111 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5840623 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |