JP5836262B2 - サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法 - Google Patents

サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法 Download PDF

Info

Publication number
JP5836262B2
JP5836262B2 JP2012500968A JP2012500968A JP5836262B2 JP 5836262 B2 JP5836262 B2 JP 5836262B2 JP 2012500968 A JP2012500968 A JP 2012500968A JP 2012500968 A JP2012500968 A JP 2012500968A JP 5836262 B2 JP5836262 B2 JP 5836262B2
Authority
JP
Japan
Prior art keywords
composition
container
pge
vivo
item
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2012500968A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012521349A (ja
JP2012521349A5 (https=
Inventor
ジョン ディー. メンドライン,
ジョン ディー. メンドライン,
フランシーン エス. ファローズ,
フランシーン エス. ファローズ,
アール. スコット ティーズ,
アール. スコット ティーズ,
ダニエル シューメイカー,
ダニエル シューメイカー,
Original Assignee
フェイト セラピューティクス, インコーポレイテッド
フェイト セラピューティクス, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フェイト セラピューティクス, インコーポレイテッド, フェイト セラピューティクス, インコーポレイテッド filed Critical フェイト セラピューティクス, インコーポレイテッド
Publication of JP2012521349A publication Critical patent/JP2012521349A/ja
Publication of JP2012521349A5 publication Critical patent/JP2012521349A5/ja
Application granted granted Critical
Publication of JP5836262B2 publication Critical patent/JP5836262B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2271Neuropeptide Y
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
JP2012500968A 2009-03-19 2010-03-18 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法 Expired - Fee Related JP5836262B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16171709P 2009-03-19 2009-03-19
US61/161,717 2009-03-19
US24876509P 2009-10-05 2009-10-05
US61/248,765 2009-10-05
PCT/US2010/027852 WO2010108028A2 (en) 2009-03-19 2010-03-18 Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015094512A Division JP6177273B2 (ja) 2009-03-19 2015-05-05 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法

Publications (3)

Publication Number Publication Date
JP2012521349A JP2012521349A (ja) 2012-09-13
JP2012521349A5 JP2012521349A5 (https=) 2013-04-25
JP5836262B2 true JP5836262B2 (ja) 2015-12-24

Family

ID=42740238

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2012500968A Expired - Fee Related JP5836262B2 (ja) 2009-03-19 2010-03-18 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法
JP2015094512A Expired - Fee Related JP6177273B2 (ja) 2009-03-19 2015-05-05 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法
JP2017047351A Withdrawn JP2017105840A (ja) 2009-03-19 2017-03-13 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法
JP2018177292A Withdrawn JP2018199724A (ja) 2009-03-19 2018-09-21 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法
JP2020140050A Withdrawn JP2020186273A (ja) 2009-03-19 2020-08-21 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2015094512A Expired - Fee Related JP6177273B2 (ja) 2009-03-19 2015-05-05 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法
JP2017047351A Withdrawn JP2017105840A (ja) 2009-03-19 2017-03-13 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法
JP2018177292A Withdrawn JP2018199724A (ja) 2009-03-19 2018-09-21 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法
JP2020140050A Withdrawn JP2020186273A (ja) 2009-03-19 2020-08-21 サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法

Country Status (4)

Country Link
US (1) US20120202288A1 (https=)
EP (2) EP2408444A4 (https=)
JP (5) JP5836262B2 (https=)
WO (1) WO2010108028A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379292A (zh) 2008-11-06 2018-08-10 印第安纳大学研究与技术公司 增强造血干细胞植入过程的材料和方法
WO2010108028A2 (en) * 2009-03-19 2010-09-23 Fate Therapeutics, Inc. Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same
US11459545B2 (en) 2009-11-15 2022-10-04 Indiana University Research And Technology Corporation Methods to enhance delivery and engraftment of stem cells including the identification of specific prostaglandin E2 receptors
US10213464B2 (en) * 2011-01-13 2019-02-26 Scipharm Sarl Method for enhancing engraftment of haematopoetic stem cells
ES2769270T3 (es) 2011-09-30 2020-06-25 Bluebird Bio Inc Compuestos para transducción viral mejorada
JP6220791B2 (ja) 2011-12-02 2017-10-25 フェイト セラピューティクス,インコーポレイテッド 増強された幹細胞組成物
EP2785350B1 (en) 2011-12-02 2018-05-02 Fate Therapeutics, Inc. Improved methods of treating ischemia
WO2014150602A1 (en) 2013-03-15 2014-09-25 Fate Therapeutics, Inc. Cell potency assay for therapeutic potential
US9943545B2 (en) * 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
WO2014153363A1 (en) * 2013-03-18 2014-09-25 Northeastern University Method for generation of broadly neutralizing anti-pathogen antibodies
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN104614455B (zh) * 2014-12-25 2016-10-05 上海景峰制药有限公司 一种前列地尔注射液的含量检测方法
US20180112180A1 (en) 2015-01-26 2018-04-26 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
US20180214487A1 (en) 2015-07-21 2018-08-02 The Children's Medical Center Corporation Pd-l1 expressing hematopoietic stem cells and uses
IL261002B2 (en) 2016-02-12 2024-07-01 Bluebird Bio Inc Vcn enhancer compositions and methods of using the same
WO2017139561A1 (en) 2016-02-12 2017-08-17 Bluebird Bio, Inc. Vcn enhancer compositions and methods of using the same
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
EP4706758A3 (en) 2019-05-21 2026-05-06 Ardelyx, Inc. Methods for inhibiting phosphate transport
EP4146797A1 (en) 2020-05-06 2023-03-15 Orchard Therapeutics (Europe) Limited Treatment for neurodegenerative diseases
CN114854674B (zh) * 2022-06-20 2025-01-24 中国农业大学 dbcAMP在制备原始卵泡体外激活剂中的应用
CN115636776B (zh) * 2022-10-10 2024-05-07 厦门欧瑞捷生物科技有限公司 一种以PGF2α合成中的副产物为原料合成前列地尔的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790840A (fr) * 1971-11-01 1973-04-30 Upjohn Co Solutions de medicaments instables et leur preparation
US5004681B1 (en) * 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
US5753516A (en) * 1995-02-03 1998-05-19 Heagy; Wyrta E. Screening method for ligands of the EBI-1 receptor
US6440734B1 (en) * 1998-09-25 2002-08-27 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
AU2183900A (en) 1998-12-24 2000-07-31 Alcon Laboratories, Inc. Ep4 receptor agonists for treatment of dry eye
HK1048302A1 (zh) 1999-08-13 2003-03-28 大正制药株式会社 前列腺素衍生物
DE60120007T2 (de) 2000-01-31 2006-11-16 Pfizer Products Inc., Groton Verwendung von Aktivatoren des Prostaglandinrezeptores 4 zur Behandlung von akuter oder chronischer Niereninsuffizienz
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
FR2825261B1 (fr) 2001-06-01 2003-09-12 Maco Pharma Sa Ligne de prelevement du sang placentaire comprenant une poche de rincage
US7179643B2 (en) * 2001-06-14 2007-02-20 Reliance Life Sciences Pvt. Ltd. Device and a process for expansion of haemopoeitic stem cells for therapeutic use
JP2003093048A (ja) * 2001-09-26 2003-04-02 Asahi Kasei Corp 新規細胞製剤製造用培養媒体
US6747037B1 (en) 2003-06-06 2004-06-08 Allergan, Inc. Piperidinyl prostaglandin E analogs
US20050032122A1 (en) * 2003-08-06 2005-02-10 Shiaw-Min Hwang Optimizing culture medium for CD34<+> hematopoietic cell expansion
GB0329620D0 (en) 2003-12-22 2004-01-28 Pharmagene Lab Ltd EP2 receptor agonists
WO2005065396A2 (en) * 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
JP2008518013A (ja) 2004-10-26 2008-05-29 アラーガン、インコーポレイテッド プロスタグランジンep4アゴニストによる処置方法およびデリバリー方法
DE102005062741A1 (de) 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Fluorene und Carbazole als Liganden des EP2 Rezeptors
RU2425876C2 (ru) * 2006-03-24 2011-08-10 Чилдрен'З Медикал Сентер Корпорейшн Способ модулирования роста гематопоэтических стволовых клеток
EP2094839B1 (en) * 2006-12-08 2020-02-05 University of Rochester Expansion of hematopoietic stem cells
US8871752B2 (en) * 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
WO2010108028A2 (en) * 2009-03-19 2010-09-23 Fate Therapeutics, Inc. Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same

Also Published As

Publication number Publication date
WO2010108028A2 (en) 2010-09-23
US20120202288A1 (en) 2012-08-09
EP2408444A4 (en) 2012-09-26
JP2017105840A (ja) 2017-06-15
JP2012521349A (ja) 2012-09-13
JP2018199724A (ja) 2018-12-20
WO2010108028A3 (en) 2011-03-31
JP6177273B2 (ja) 2017-08-09
EP3533445A1 (en) 2019-09-04
JP2020186273A (ja) 2020-11-19
JP2015180645A (ja) 2015-10-15
EP2408444A2 (en) 2012-01-25

Similar Documents

Publication Publication Date Title
JP6177273B2 (ja) サイクリックampエンハンサーおよび/またはepリガンドを含む組成物、ならびにこれを調製および使用する方法
Bowie et al. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect
JP6530732B2 (ja) 造血性幹細胞の増殖を調節する方法
AU2016212090B2 (en) Composition for use in increasing engraftment efficacy of haematopoetic stem cells after transplantation
JP6110309B2 (ja) 造血幹細胞の生着を増進させるための方法
US10092599B2 (en) Methods for enhancing hematopoietic stem/progenitor cell engraftment
JP2021046432A (ja) 急性放射線症候群を治療するための組成物及び方法
AU2017374947A1 (en) New anti-angiogenic extracellular vesicles
Erkan et al. Brain thromboxane A2 via arachidonic acid cascade induces the hypothalamic–pituitary–gonadal axis activation in rats
AU2015315162A1 (en) Stimulation of ovarian follicle development and oocyte maturation
Chen et al. Platelet‐Derived Mitochondria Attenuate 5‐FU‐Induced Injury to Bone‐Associated Mesenchymal Stem Cells
KR20190039725A (ko) 배아 이식을 촉진하고 유산을 방지하지 위한 옥시토신 길항제 투여 방법
US20170333483A1 (en) Methods for enhancing hematopoietic stem/progenitor cell engraftment
McConico et al. In utero cell transfer between porcine littermates
WO2025019473A1 (en) Isoxazole-3-carboxyamide compounds for enhancing telomerase reverse transcriptase (tert) expression
US20250120956A1 (en) Azole Compounds for Enhancing Telomerase Reverse Transcriptase (TERT) Expression
HK1241742B (en) Composition for use in increasing engraftment efficacy of haematopoetic stem cells after transplantation

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130306

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130306

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140319

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140618

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140625

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140701

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150505

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20150610

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150701

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150904

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150908

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20151009

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20151102

R150 Certificate of patent or registration of utility model

Ref document number: 5836262

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees