JP5829921B2 - 骨折リスク評価のためのコンピュータの作動方法 - Google Patents
骨折リスク評価のためのコンピュータの作動方法 Download PDFInfo
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- 206010017076 Fracture Diseases 0.000 title claims description 35
- 208000010392 Bone Fractures Diseases 0.000 title claims description 29
- 238000011017 operating method Methods 0.000 title claims description 15
- 238000012502 risk assessment Methods 0.000 title claims description 12
- 210000000988 bone and bone Anatomy 0.000 claims description 27
- 230000037182 bone density Effects 0.000 claims description 20
- 238000005259 measurement Methods 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 238000011156 evaluation Methods 0.000 claims description 12
- 239000013078 crystal Substances 0.000 claims description 10
- 230000008034 disappearance Effects 0.000 claims description 9
- 238000012545 processing Methods 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 3
- 238000004088 simulation Methods 0.000 claims description 3
- 208000001132 Osteoporosis Diseases 0.000 description 18
- 238000004458 analytical method Methods 0.000 description 11
- 230000001009 osteoporotic effect Effects 0.000 description 8
- 208000006386 Bone Resorption Diseases 0.000 description 7
- 230000024279 bone resorption Effects 0.000 description 7
- 230000011164 ossification Effects 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 229910052586 apatite Inorganic materials 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 239000012227 artificial bone substitute Substances 0.000 description 1
- 230000004097 bone metabolism Effects 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
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- Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Description
Claims (3)
- 人又は動物の骨梁の撮影により得られ、骨部分が一定の大きさのボクセルから構成される所定の三次元の範囲の骨梁デジタルイメージモデルをデータの形で記憶装置に保存し骨折のリスクを評価するためにシミュレーションによって処理する骨折リスク評価のためのコンピュータの作動方法であって、
前記骨梁デジタルイメージモデルにストレス負荷をかけながら、骨梁表面のボクセルにおける応力が、周囲の平均応力よりも生成閾値レベル以上に大きければ当該ボクセルに接する新たな1以上のボクセルを生成し、周囲の平均応力よりも消失閾値レベル以下に小さければ当該ボクセルを含む1以上のボクセルを消失させる過程を繰り返して前記骨梁デジタルイメージモデルを再構築する前記コンピュータによる処理工程と、
前記再構築後の骨梁デジタルイメージモデルに少なくとも前記ストレス負荷と直交方向に測定負荷をかけて応力分布測定を行う前記コンピュータによる処理工程と、を有することを特徴とする骨折リスク評価のためのコンピュータの作動方法。 - 請求項1に記載の骨折リスク評価のためのコンピュータの作動方法において、
患者の測定された骨密度に合わせて生成閾値レベルと消失閾値レベルを調整し、前記再構築により前記骨梁デジタルイメージモデルを作製し、当該骨密度に対応する応力分布を測定することを特徴とする骨折リスク評価のためのコンピュータの作動方法。 - 請求項1又は2に記載の骨折リスク評価のためのコンピュータの作動方法において、
前記骨梁デジタルイメージモデルのボクセルにおけるBAp結晶の配向方向のヤング率を他の方向よりも大きくして応力を算出することを特徴とする骨折リスク評価のためのコンピュータの作動方法。
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JP6457785B2 (ja) * | 2014-11-11 | 2019-01-23 | 株式会社ファソテック | 生体質感モデル作製方法および生体質感モデル作製プログラム |
US20180020999A1 (en) * | 2015-02-13 | 2018-01-25 | Shimadzu Corporation | Bone analyzing device |
KR102227938B1 (ko) * | 2018-06-20 | 2021-03-16 | 한국생산기술연구원 | 골다공증 예측 방법 |
JP7187421B2 (ja) * | 2019-10-31 | 2022-12-12 | 富士フイルム株式会社 | 画像処理装置、画像処理方法、及び画像処理プログラム |
CN110874838B (zh) * | 2019-11-12 | 2023-08-18 | 东南大学 | 一种断裂骨小梁的搜索方法 |
JP7462181B2 (ja) * | 2019-11-29 | 2024-04-05 | 国立研究開発法人理化学研究所 | 三次元微小硬さ分布測定方法及び三次元微小硬さ分布測定システム |
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JP3782295B2 (ja) * | 2000-08-28 | 2006-06-07 | 独立行政法人科学技術振興機構 | 骨組織再生のための代替物構造設計支援方法とその装置 |
EP1605824A2 (en) * | 2003-03-25 | 2005-12-21 | Imaging Therapeutics, Inc. | Methods for the compensation of imaging technique in the processing of radiographic images |
US8073521B2 (en) * | 2003-09-19 | 2011-12-06 | Imatx, Inc. | Method for bone structure prognosis and simulated bone remodeling |
EP1952303B8 (en) * | 2005-11-11 | 2016-08-17 | Hologic, Inc. | Estimating risk of future bone fracture utilizing three-dimensional bone density model |
JP4967121B2 (ja) * | 2006-05-10 | 2012-07-04 | 国立大学法人大阪大学 | 骨粗鬆症の評価方法 |
JP5156472B2 (ja) * | 2008-04-30 | 2013-03-06 | ラトックシステムエンジニアリング株式会社 | 椎体海綿骨の検査プログラムおよび検査装置 |
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