JP5827123B2 - 乱用の可能性が低いｐｅｇ化オピオイド - Google Patents

乱用の可能性が低いｐｅｇ化オピオイド Download PDF

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Publication number
JP5827123B2
JP5827123B2 JP2011526872A JP2011526872A JP5827123B2 JP 5827123 B2 JP5827123 B2 JP 5827123B2 JP 2011526872 A JP2011526872 A JP 2011526872A JP 2011526872 A JP2011526872 A JP 2011526872A JP 5827123 B2 JP5827123 B2 JP 5827123B2
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Japan
Prior art keywords
compound
opioid
less
mpeg
oligomer
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Expired - Fee Related
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JP2011526872A
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Japanese (ja)
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JP2012502904A5 (cg-RX-API-DMAC7.html
JP2012502904A (ja
Inventor
シー． シモン ジュード−フィッシュバーン，
シー． シモン ジュード−フィッシュバーン，
ティモシー エー． リエリー，
ティモシー エー． リエリー，
アルバート ザカリアス，
アルバート ザカリアス，
イーマ ガーサハニ，
イーマ ガーサハニ，
Original Assignee
ウェルズ ファーゴ バンク ナショナル アソシエイション
ウェルズ ファーゴ バンク ナショナル アソシエイション
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Priority claimed from US12/558,395 external-priority patent/US8173666B2/en
Application filed by ウェルズ ファーゴ バンク ナショナル アソシエイション, ウェルズ ファーゴ バンク ナショナル アソシエイション filed Critical ウェルズ ファーゴ バンク ナショナル アソシエイション
Publication of JP2012502904A publication Critical patent/JP2012502904A/ja
Publication of JP2012502904A5 publication Critical patent/JP2012502904A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011526872A 2008-09-16 2009-09-16 乱用の可能性が低いｐｅｇ化オピオイド Expired - Fee Related JP5827123B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19224708P 2008-09-16 2008-09-16
US61/192,247 2008-09-16
US12/558,395 2009-09-11
US12/558,395 US8173666B2 (en) 2007-03-12 2009-09-11 Oligomer-opioid agonist conjugates
PCT/US2009/005174 WO2010033195A1 (en) 2008-09-16 2009-09-16 Pegylated opioids with low potential for abuse

Publications (3)

Publication Number Publication Date
JP2012502904A JP2012502904A (ja) 2012-02-02
JP2012502904A5 JP2012502904A5 (cg-RX-API-DMAC7.html) 2012-11-08
JP5827123B2 true JP5827123B2 (ja) 2015-12-02

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JP2011526872A Expired - Fee Related JP5827123B2 (ja) 2008-09-16 2009-09-16 乱用の可能性が低いｐｅｇ化オピオイド

Country Status (10)

Country Link
US (2) US20110237614A1 (cg-RX-API-DMAC7.html)
EP (2) EP2340044A1 (cg-RX-API-DMAC7.html)
JP (1) JP5827123B2 (cg-RX-API-DMAC7.html)
KR (1) KR101660996B1 (cg-RX-API-DMAC7.html)
CN (1) CN102159249A (cg-RX-API-DMAC7.html)
AU (1) AU2009292631A1 (cg-RX-API-DMAC7.html)
CA (1) CA2734333A1 (cg-RX-API-DMAC7.html)
IL (1) IL211762A (cg-RX-API-DMAC7.html)
MX (1) MX347741B (cg-RX-API-DMAC7.html)
WO (1) WO2010033195A1 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
EP3342427A1 (en) 2018-07-04
MX347741B (es) 2017-05-10
AU2009292631A1 (en) 2010-03-25
US20110237614A1 (en) 2011-09-29
US20160243111A1 (en) 2016-08-25
MX2011002748A (es) 2011-04-21
WO2010033195A1 (en) 2010-03-25
EP2340044A1 (en) 2011-07-06
IL211762A (en) 2016-06-30
CN102159249A (zh) 2011-08-17
IL211762A0 (en) 2011-06-30
JP2012502904A (ja) 2012-02-02
KR20110058783A (ko) 2011-06-01
CA2734333A1 (en) 2010-03-25
KR101660996B1 (ko) 2016-09-28

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