JP5801410B2 - 検査用に生物試料を準備するための自動化されたシステムおよび方法 - Google Patents
検査用に生物試料を準備するための自動化されたシステムおよび方法 Download PDFInfo
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- JP5801410B2 JP5801410B2 JP2013538860A JP2013538860A JP5801410B2 JP 5801410 B2 JP5801410 B2 JP 5801410B2 JP 2013538860 A JP2013538860 A JP 2013538860A JP 2013538860 A JP2013538860 A JP 2013538860A JP 5801410 B2 JP5801410 B2 JP 5801410B2
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00079—Evaporation covers for slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00138—Slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00524—Mixing by agitating sample carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1037—Using surface tension, e.g. pins or wires
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Robotics (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46077510P | 2010-11-10 | 2010-11-10 | |
| US61/460,775 | 2010-11-10 | ||
| US201161510180P | 2011-07-21 | 2011-07-21 | |
| US61/510,180 | 2011-07-21 | ||
| PCT/US2011/060028 WO2012064873A1 (en) | 2010-11-10 | 2011-11-09 | Automated systems and methods for preparing biological specimens for examination |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015166725A Division JP6268444B2 (ja) | 2010-11-10 | 2015-08-26 | 検査用に生物試料を準備するための自動化されたシステムおよび方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545981A JP2013545981A (ja) | 2013-12-26 |
| JP2013545981A5 JP2013545981A5 (https=) | 2014-08-28 |
| JP5801410B2 true JP5801410B2 (ja) | 2015-10-28 |
Family
ID=45002154
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538860A Active JP5801410B2 (ja) | 2010-11-10 | 2011-11-09 | 検査用に生物試料を準備するための自動化されたシステムおよび方法 |
| JP2015166725A Active JP6268444B2 (ja) | 2010-11-10 | 2015-08-26 | 検査用に生物試料を準備するための自動化されたシステムおよび方法 |
| JP2017236872A Active JP6751382B2 (ja) | 2010-11-10 | 2017-12-11 | 検査用に生物試料を準備するための自動化されたシステムおよび方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015166725A Active JP6268444B2 (ja) | 2010-11-10 | 2015-08-26 | 検査用に生物試料を準備するための自動化されたシステムおよび方法 |
| JP2017236872A Active JP6751382B2 (ja) | 2010-11-10 | 2017-12-11 | 検査用に生物試料を準備するための自動化されたシステムおよび方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8454908B2 (https=) |
| EP (2) | EP3467469B1 (https=) |
| JP (3) | JP5801410B2 (https=) |
| CN (2) | CN103299173B (https=) |
| AU (2) | AU2011326511B2 (https=) |
| CA (1) | CA2817303C (https=) |
| ES (2) | ES2700297T3 (https=) |
| WO (1) | WO2012064873A1 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11249095B2 (en) * | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| US7468161B2 (en) | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| US20140152801A1 (en) | 2009-10-28 | 2014-06-05 | Alentic Microscience Inc. | Detecting and Using Light Representative of a Sample |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| AU2012287299C1 (en) | 2011-07-22 | 2016-02-18 | Roche Diagnostics Hematology, Inc. | Fluid sample preparation systems and methods |
| US9435818B2 (en) | 2011-07-22 | 2016-09-06 | Roche Diagnostics Hematology, Inc. | Sample transport systems and methods |
| AU2012287302B2 (en) | 2011-07-22 | 2015-02-19 | Roche Diagnostics Hematology, Inc. | Sample applicator sensing and positioning |
| JP5953141B2 (ja) * | 2012-06-27 | 2016-07-20 | 株式会社日立ハイテクノロジーズ | 発光計測装置 |
| US9817221B2 (en) | 2012-06-29 | 2017-11-14 | General Electric Company | Systems and methods for processing and imaging of biological samples |
| US9164015B2 (en) * | 2012-06-29 | 2015-10-20 | General Electric Company | Systems and methods for processing and imaging of biological samples |
| ES2808403T3 (es) | 2012-07-13 | 2021-02-26 | Roche Diagnostics Hematology Inc | Distribución controlada de muestras sobre sustratos |
| AU2013337611B2 (en) | 2012-11-01 | 2017-05-04 | Leica Biosystems Melbourne Pty Ltd | Slide staining assembly and cover member |
| JP6215336B2 (ja) * | 2012-11-01 | 2017-10-18 | ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッドＬｅｉｃａ Ｂｉｏｓｙｓｔｅｍｓ Ｍｅｌｂｏｕｒｎｅ Ｐｔｙ Ｌｔｄ | スライド輸送システム |
| SG11201505011YA (en) * | 2012-12-26 | 2015-07-30 | Ventana Med Syst Inc | Specimen processing systems and method for uniformly heating slides |
| US11274997B2 (en) | 2013-02-05 | 2022-03-15 | Tripath Imaging, Inc. | Cytological staining compositions and uses thereof |
| US10502666B2 (en) | 2013-02-06 | 2019-12-10 | Alentic Microscience Inc. | Sample processing improvements for quantitative microscopy |
| ES2939124T3 (es) * | 2013-04-05 | 2023-04-19 | Roche Diagnostics Hematology Inc | Sistemas y procedimientos automatizados para preparar muestras biológicas para su examen |
| JP2016531282A (ja) | 2013-06-26 | 2016-10-06 | アレンティック マイクロサイエンス インコーポレイテッド | 顕微鏡法に関するサンプル処理の改善 |
| DE102014001481A1 (de) * | 2013-10-28 | 2015-04-30 | Euroimmun Medizinische Labordiagnostika Ag | Verbesserte Vorrichtung und Verfahren für Reaktionen zwischen einer festen und einer flüssigen Phase |
| EP3080579B1 (en) | 2013-12-13 | 2022-07-27 | Ventana Medical Systems, Inc. | Automated slide processing apparatus |
| EP3080577B1 (en) | 2013-12-13 | 2021-07-28 | Ventana Medical Systems, Inc. | Thermal management in the context of automated histological processing of biological specimens and associated technology |
| AU2014363678B2 (en) | 2013-12-13 | 2016-12-08 | Ventana Medical Systems, Inc. | Staining reagents and other liquids for histological processing of biological specimens and associated technology |
| WO2015086531A1 (en) | 2013-12-13 | 2015-06-18 | Ventana Medical Systems, Inc. | Automated processing systems and methods of thermally processing microscope slides |
| GB2524227B (en) * | 2014-01-17 | 2017-07-26 | Ffe Ltd | Method of forming an imaging reference device |
| CN104849121A (zh) * | 2015-02-06 | 2015-08-19 | 上海乐辰生物科技有限公司 | 生物样品处理仪器 |
| JP6908624B2 (ja) | 2016-04-27 | 2021-07-28 | ベンタナ メディカル システムズ， インコーポレイテッド | リアルタイム体積制御するためのシステムおよび方法 |
| WO2017191118A1 (en) | 2016-05-03 | 2017-11-09 | Ventana Medical Systems, Inc. | System and method for monitoring reagent concentrations |
| CN106092892A (zh) * | 2016-08-12 | 2016-11-09 | 关慧娟 | 粉碎式自动玻片观察装置 |
| EP3995212B1 (en) | 2016-12-30 | 2025-03-12 | Roche Diagnostics Hematology, Inc. | Sample processing systems |
| US10704993B2 (en) | 2017-06-06 | 2020-07-07 | United States Of America As Represented By The Secretary Of The Department Of The Interior | Subsurface environment sampler with actuator movable collection chamber |
| EP3669178B1 (en) | 2017-08-17 | 2023-07-19 | Abbott Point Of Care Inc | Systems for performing optical and electrochemical assays |
| WO2019035082A1 (en) | 2017-08-17 | 2019-02-21 | Abbott Point Of Care Inc. | TECHNIQUES FOR PERFORMING OPTICAL AND ELECTROCHEMICAL ASSAYS WITH UNIVERSAL CIRCUITS |
| CN117664688A (zh) * | 2017-08-17 | 2024-03-08 | 莱卡生物系统墨尔本私人有限公司 | 样品处理组件 |
| US11067526B2 (en) | 2017-08-17 | 2021-07-20 | Abbott Point Of Care Inc. | Devices, systems, and methods for performing optical and electrochemical assays |
| FR3072171B1 (fr) * | 2017-10-06 | 2021-02-19 | Diagdev | Dispositif et procede de coloration d'un element organique sur une lame |
| CN108896363A (zh) * | 2018-05-28 | 2018-11-27 | 杭州智微信息科技有限公司 | 一种骨髓涂片数字化的流程方法 |
| CN109142008A (zh) * | 2018-08-31 | 2019-01-04 | 江苏世泰实验器材有限公司 | 一种使病理组织标本着色的固定液 |
| JP7548903B2 (ja) | 2018-11-20 | 2024-09-10 | ヴェンタナ メディカル システムズ， インク． | 形態学的特徴およびバイオマーカー発現のために細胞サンプルを調製および分析するための方法およびシステム |
| AU2019410098B2 (en) | 2018-12-20 | 2024-08-15 | Leica Biosystems Melbourne Pty Ltd | A slide tray assembly |
| EP3990901A4 (en) * | 2019-06-26 | 2023-10-04 | Pathcore Inc. | DEVICES FOR TESTING AN ADEQUATE EXPOSURE OF A TISSUE SAMPLE TO A TREATMENT MEDIUM AND METHODS AND USES THEREOF |
| CN115720625A (zh) | 2020-02-22 | 2023-02-28 | 克拉拉帕斯股份有限公司 | 组织切片术相关应用中的面向和质量控制 |
| CN115698710A (zh) * | 2020-05-20 | 2023-02-03 | 罗氏血液诊断股份有限公司 | 使用自动化平台制备打印在载玻片上的生物标志物和罗曼诺夫斯基型染色的样品 |
| US11959835B2 (en) | 2020-10-23 | 2024-04-16 | Clarapath, Inc. | Preliminary diagnoses of cut tissue sections |
| WO2022271732A1 (en) * | 2021-06-21 | 2022-12-29 | Clarapath, Inc. | Integrated system for preparation of pathology samples |
| JP2025501669A (ja) | 2021-12-20 | 2025-01-22 | クララパス， インコーポレイテッド | 切断品質予測を伴う自動化組織切片化システム |
| WO2025119902A1 (en) | 2023-12-04 | 2025-06-12 | F. Hoffmann-La Roche Ag | Hemoglobin determination methods and systems |
| WO2025131829A1 (en) | 2023-12-18 | 2025-06-26 | F. Hoffmann-La Roche Ag | Method and system for applying a liquid sample onto a substrate for image analysis |
| WO2025196261A1 (en) | 2024-03-22 | 2025-09-25 | Roche Diagnostics International Ag | Automated method for microscopic analysis of a biological sample |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2515869C3 (de) * | 1975-04-11 | 1979-11-08 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Vorrichtung zur Herstellung von vorbeschichteten Objektträgern |
| JPS5872049A (ja) * | 1981-10-27 | 1983-04-28 | Matsushita Electric Ind Co Ltd | 電気泳動パタ−ン選択染色装置 |
| JPH0320760Y2 (https=) * | 1984-12-18 | 1991-05-07 | ||
| JPH0545549U (ja) * | 1991-03-22 | 1993-06-18 | 澄晴 野地 | 生物組織の処理装置 |
| US5419279A (en) | 1992-09-29 | 1995-05-30 | Hoffmann-La Roche Inc. | Apparatus for depositing and staining cytological material on a microscope slide |
| US5458749A (en) * | 1994-05-02 | 1995-10-17 | Univeristy Of Iowa Research Foundation | Device and process for staining electrophoretic gels |
| US5948360A (en) | 1994-07-11 | 1999-09-07 | Tekmar Company | Autosampler with robot arm |
| GB9506312D0 (en) * | 1995-03-28 | 1995-05-17 | Medical Res Council | Improvements in or relating to sample processing |
| JP2883294B2 (ja) * | 1995-07-07 | 1999-04-19 | アロカ株式会社 | 生物組織処理装置及び試薬処理ユニット |
| JP2909412B2 (ja) * | 1995-07-31 | 1999-06-23 | アロカ株式会社 | 生物組織の処理装置 |
| AUPN762196A0 (en) * | 1996-01-17 | 1996-02-08 | Australian Biomedical Corporation Limited | Specimen preparation apparatus |
| AUPN923596A0 (en) | 1996-04-12 | 1996-05-09 | Australian Biomedical Corporation Limited | Method and apparatus for treatment of human or animal cell samples |
| JP3245813B2 (ja) * | 1996-11-27 | 2002-01-15 | 東京エレクトロン株式会社 | 塗布膜形成装置 |
| JPH11202215A (ja) * | 1998-01-09 | 1999-07-30 | Chiyoda Mfg Co Ltd | 顕微鏡標本のカバーガラス貼着方法と装置 |
| US6096271A (en) | 1998-02-27 | 2000-08-01 | Cytologix Corporation | Random access slide stainer with liquid waste segregation |
| EP1078240A1 (en) | 1998-05-15 | 2001-02-28 | Cellavision AB | A method and a device for preparing a biological specimen |
| JPH11337460A (ja) * | 1998-05-22 | 1999-12-10 | Sony Corp | 分析試料調製方法 |
| WO2000063670A1 (en) * | 1999-04-20 | 2000-10-26 | Cytologix Corporation | Fluid exchange in a chamber on a microscope slide |
| US6673620B1 (en) | 1999-04-20 | 2004-01-06 | Cytologix Corporation | Fluid exchange in a chamber on a microscope slide |
| EP1208378B9 (en) | 1999-07-08 | 2014-12-10 | Lee H. Angros | Antigen recovery and/or staining apparatus and method |
| JP3620013B2 (ja) | 1999-07-09 | 2005-02-16 | 日本光電工業株式会社 | 血液塗抹標本の染色方法および染色装置 |
| DE10002920A1 (de) * | 2000-01-19 | 2001-07-26 | Epigenomics Ag | Kontaktierungsvorrichtung |
| US20020114742A1 (en) | 2001-02-20 | 2002-08-22 | Hitachi, Ltd. | Test chamber |
| JP2002323416A (ja) | 2001-02-20 | 2002-11-08 | Hitachi Ltd | 検査容器 |
| US7247338B2 (en) * | 2001-05-16 | 2007-07-24 | Regents Of The University Of Minnesota | Coating medical devices |
| DE10218988C1 (de) * | 2002-04-24 | 2003-11-20 | Horst Dieter Becker | Vorrichtung und Verfahren zum Benetzen von Objekten |
| AU2003239283A1 (en) * | 2002-06-13 | 2003-12-31 | Millenium Biologix Ag | Reaction chamber |
| EP1596972B1 (de) | 2003-02-27 | 2008-01-09 | Advalytix AG | Verfahren und vorrichtung zur erzeugung von bewegung in einem dünnen flüssigkeitsfilm |
| US8038337B2 (en) | 2003-02-27 | 2011-10-18 | Beckman Coulter, Inc. | Method and device for blending small quantities of liquid in microcavities |
| US7186522B2 (en) | 2003-03-31 | 2007-03-06 | Cytyc Corporation | Papanicolau staining process |
| US20060073074A1 (en) | 2004-10-06 | 2006-04-06 | Lars Winther | Enhanced sample processing system and methods of biological slide processing |
| US7767152B2 (en) * | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
| US7744817B2 (en) | 2003-08-11 | 2010-06-29 | Sakura Finetek U.S.A., Inc. | Manifold assembly |
| US7501283B2 (en) | 2003-08-11 | 2009-03-10 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
| US9518899B2 (en) | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
| EP1697719B1 (en) | 2003-12-23 | 2018-09-19 | Ventana Medical Systems, Inc. | Method and apparatus for efficient thin film fluid processing of flat surfaces |
| AU2005267018B2 (en) | 2004-07-23 | 2008-10-23 | Ventana Medical Systems, Inc. | Method and apparatus for applying fluids to a biological sample |
| US7217006B2 (en) * | 2004-11-20 | 2007-05-15 | Automatic Power, Inc. | Variation of power levels within an LED array |
| CN101203597A (zh) * | 2005-04-21 | 2008-06-18 | 塞莱勒斯诊断公司 | 用于自动快速免疫组织化学的芯吸盒方法和设备 |
| US8263414B2 (en) * | 2005-05-23 | 2012-09-11 | Siemens Healthcare Diagnostics Inc. | Dispensing of a diagnostic liquid onto a diagnostic reagent |
| WO2008055096A2 (en) | 2006-10-30 | 2008-05-08 | Ventana Medical Systems, Inc. | Thin film apparatus and method |
| WO2008149797A1 (ja) | 2007-06-01 | 2008-12-11 | Takaharu Enjoji | 誘電体微粒子濃縮装置 |
| DE102008018982A1 (de) | 2008-04-14 | 2009-11-05 | Merz, Hartmut, Prof. Dr. med. | Automatische Vorrichtung zur Durchführung von Nachweisreaktionen und Verfahren zur Dosierung von Reagenzien auf Objektträgern |
| US9017610B2 (en) | 2008-04-25 | 2015-04-28 | Roche Diagnostics Hematology, Inc. | Method of determining a complete blood count and a white blood cell differential count |
| WO2010074915A2 (en) * | 2008-12-23 | 2010-07-01 | Ventana Medical Systems, Inc. | Evaporation mitigation for slide staining apparatus |
| JP4985667B2 (ja) * | 2009-01-30 | 2012-07-25 | パナソニック株式会社 | 基板保持装置 |
| BR112012011181A2 (pt) * | 2009-11-13 | 2020-10-13 | Ventana Medical Systems, Inc. | ''estação de processsamento de peças corrediça automatizada e método de processamento de uma amostra'' |
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| US20120149050A1 (en) | 2012-06-14 |
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