JP5792748B2 - 結晶化法及びバイオアベイラビリティ - Google Patents
結晶化法及びバイオアベイラビリティ Download PDFInfo
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- JP5792748B2 JP5792748B2 JP2012552048A JP2012552048A JP5792748B2 JP 5792748 B2 JP5792748 B2 JP 5792748B2 JP 2012552048 A JP2012552048 A JP 2012552048A JP 2012552048 A JP2012552048 A JP 2012552048A JP 5792748 B2 JP5792748 B2 JP 5792748B2
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- lysine
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- 230000008018 melting Effects 0.000 description 1
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- 239000012046 mixed solvent Substances 0.000 description 1
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- 239000003921 oil Substances 0.000 description 1
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- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
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- 230000000144 pharmacologic effect Effects 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
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- 229940002612 prodrug Drugs 0.000 description 1
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- 229960005206 pyrazinamide Drugs 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
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- 229940089617 risedronate Drugs 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 229940112726 skelid Drugs 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
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- 239000008109 sodium starch glycolate Substances 0.000 description 1
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- 229940079832 sodium starch glycolate Drugs 0.000 description 1
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- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- 239000008117 stearic acid Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
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- 238000006277 sulfonation reaction Methods 0.000 description 1
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- 229920002994 synthetic fiber Polymers 0.000 description 1
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- 239000007916 tablet composition Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30211010P | 2010-02-06 | 2010-02-06 | |
| US61/302,110 | 2010-02-06 | ||
| US31287910P | 2010-03-11 | 2010-03-11 | |
| US61/312,879 | 2010-03-11 | ||
| US31850310P | 2010-03-29 | 2010-03-29 | |
| US61/318,503 | 2010-03-29 | ||
| US33302810P | 2010-05-10 | 2010-05-10 | |
| US33304110P | 2010-05-10 | 2010-05-10 | |
| US61/333,028 | 2010-05-10 | ||
| US61/333,041 | 2010-05-10 | ||
| US35954410P | 2010-06-29 | 2010-06-29 | |
| US61/359,544 | 2010-06-29 | ||
| USPCT/US2010/043892 | 2010-07-30 | ||
| PCT/US2010/043892 WO2011014766A2 (en) | 2009-07-31 | 2010-07-30 | Crystallization method and bioavailability |
| US12/847,568 US8399023B2 (en) | 2009-07-31 | 2010-07-30 | Crystallization method and bioavailability |
| PCT/US2010/043916 WO2011014781A1 (en) | 2009-07-31 | 2010-07-30 | Novel oral forms of a phosphonic acid derivative |
| US12/847,568 | 2010-07-30 | ||
| USPCT/US2010/043916 | 2010-07-30 | ||
| US37981410P | 2010-09-03 | 2010-09-03 | |
| US61/379,814 | 2010-09-03 | ||
| US45577810P | 2010-10-26 | 2010-10-26 | |
| US61/455,778 | 2010-10-26 | ||
| PCT/US2011/023427 WO2011097269A1 (en) | 2010-02-06 | 2011-02-02 | Crystallization method and bioavailability |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015156109A Division JP6190429B2 (ja) | 2010-02-06 | 2015-08-06 | 結晶化法及びバイオアベイラビリティ |
Publications (3)
| Publication Number | Publication Date |
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| JP2013519632A JP2013519632A (ja) | 2013-05-30 |
| JP2013519632A5 JP2013519632A5 (enExample) | 2014-03-27 |
| JP5792748B2 true JP5792748B2 (ja) | 2015-10-14 |
Family
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| JP2015156109A Expired - Fee Related JP6190429B2 (ja) | 2010-02-06 | 2015-08-06 | 結晶化法及びバイオアベイラビリティ |
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| JP2015156109A Expired - Fee Related JP6190429B2 (ja) | 2010-02-06 | 2015-08-06 | 結晶化法及びバイオアベイラビリティ |
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| EP (1) | EP2531200B1 (enExample) |
| JP (2) | JP5792748B2 (enExample) |
| AU (2) | AU2012216632B2 (enExample) |
| CA (1) | CA2826548A1 (enExample) |
| CY (1) | CY1119192T1 (enExample) |
| DK (1) | DK2531200T3 (enExample) |
| ES (1) | ES2638072T3 (enExample) |
| HR (1) | HRP20171201T1 (enExample) |
| HU (1) | HUE035744T2 (enExample) |
| IL (1) | IL221306A0 (enExample) |
| LT (1) | LT2531200T (enExample) |
| PL (1) | PL2531200T3 (enExample) |
| PT (1) | PT2531200T (enExample) |
| SI (1) | SI2531200T1 (enExample) |
| WO (1) | WO2011097269A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| WO2011014781A1 (en) * | 2009-07-31 | 2011-02-03 | Thar Pharmaceuticals, Inc. | Novel oral forms of a phosphonic acid derivative |
| KR101813728B1 (ko) | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| EP2531200B1 (en) * | 2010-02-06 | 2017-07-12 | Grünenthal GmbH | Crystallization method and bioavailability |
| WO2012071517A2 (en) * | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| CN102268023B (zh) * | 2011-08-15 | 2013-04-17 | 南京丰融化学技术有限公司 | 头孢类衍生物cxd的晶型 |
| US10413560B2 (en) | 2012-05-14 | 2019-09-17 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds for treating disease |
| US9956238B2 (en) | 2014-05-15 | 2018-05-01 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US20140349974A1 (en) * | 2014-08-12 | 2014-11-27 | Antecip Bioventures Ii Llc | Zoledronic acid dosage forms for the treatment of pain |
| US10413561B2 (en) | 2012-05-14 | 2019-09-17 | Antecip Bioventures Ii Llc | Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases |
| US9999629B2 (en) | 2012-05-14 | 2018-06-19 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10493085B2 (en) | 2012-05-14 | 2019-12-03 | Antecip Bioventures Ii Llc | Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases |
| US10350227B2 (en) | 2012-05-14 | 2019-07-16 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US10016445B2 (en) | 2012-05-14 | 2018-07-10 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| PL2849758T3 (pl) * | 2012-05-14 | 2018-08-31 | Antecip Bioventures Ii Llc | Kompozycje zawierające kwas zoledronowy lub pokrewne związki do uśmierzania bólu zapalnego i stanów powiązanych |
| US11654152B2 (en) | 2012-05-14 | 2023-05-23 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| US10463682B2 (en) | 2012-05-14 | 2019-11-05 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating low back pain |
| EP2968371A4 (en) * | 2013-03-12 | 2017-04-12 | The Board of Trustees of the Leland Stanford Junior University | Modulation of cellular dna repair activity to intercept malignancy |
| US11406713B2 (en) | 2013-03-15 | 2022-08-09 | Xortx Therapeutics, Inc. | Xanthine oxidase inhibitor formulations |
| KR101739244B1 (ko) * | 2013-10-25 | 2017-05-23 | 안테씨프 바이오벤쳐스 투 엘엘씨 | 질병의 치료를 위한, 졸레드론산 또는 관련 화합물의 경구 투여용 조성물 |
| MX2018002627A (es) * | 2015-09-18 | 2018-12-17 | Gruenenthal Chemie | Metodo de cristalizacion y biodisponibilidad. |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| KR102723076B1 (ko) * | 2016-12-15 | 2024-11-28 | 제이투에이치바이오텍 (주) | 3성분 코크리스탈 |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| KR20220008824A (ko) | 2019-04-17 | 2022-01-21 | 컴퍼스 패쓰파인더 리미티드 | 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법 |
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| US6677320B2 (en) * | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
| EP1416919A1 (en) | 2001-07-17 | 2004-05-12 | Teva Pharmaceutical Industries Ltd. | Dosage forms for immediate gastric release of a calcium transport stimulator coupled with delayed gastric release of a bis-phosphonate |
| US20040220264A1 (en) * | 2003-03-17 | 2004-11-04 | Yu Ruey J | Bioavailability and improved delivery of acidic pharmaceutical drugs |
| ES2322592T3 (es) * | 2003-07-03 | 2009-06-23 | Teva Pharmaceutical Industries Ltd. | Formas cristalinas de acido zoledronico, formas cristlinas de la sal sodica de zoledronato, sal sodica de zoledronato amorfa y procedimientos para su preparacion. |
| US20060068010A1 (en) * | 2004-09-30 | 2006-03-30 | Stephen Turner | Method for improving the bioavailability of orally delivered therapeutics |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| WO2011014781A1 (en) * | 2009-07-31 | 2011-02-03 | Thar Pharmaceuticals, Inc. | Novel oral forms of a phosphonic acid derivative |
| KR101813728B1 (ko) * | 2009-07-31 | 2017-12-29 | 그뤼넨탈 게엠베하 | 결정화 방법 및 생체이용률 |
| EP2531200B1 (en) * | 2010-02-06 | 2017-07-12 | Grünenthal GmbH | Crystallization method and bioavailability |
| WO2012071517A2 (en) * | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| CN102070668B (zh) * | 2010-12-23 | 2013-07-24 | 蚌埠丰原医药科技发展有限公司 | 一种利用相转移催化剂制备唑来膦酸及其钠盐的方法 |
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2011
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- 2011-02-02 PT PT117402842T patent/PT2531200T/pt unknown
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- 2011-02-02 CA CA2826548A patent/CA2826548A1/en not_active Abandoned
- 2011-02-02 HU HUE11740284A patent/HUE035744T2/en unknown
- 2011-02-02 SI SI201131269T patent/SI2531200T1/sl unknown
- 2011-02-02 WO PCT/US2011/023427 patent/WO2011097269A1/en not_active Ceased
- 2011-02-02 ES ES11740284.2T patent/ES2638072T3/es active Active
- 2011-02-02 HR HRP20171201TT patent/HRP20171201T1/hr unknown
- 2011-02-02 PL PL11740284T patent/PL2531200T3/pl unknown
- 2011-02-02 LT LTEP11740284.2T patent/LT2531200T/lt unknown
- 2011-02-02 DK DK11740284.2T patent/DK2531200T3/en active
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2012
- 2012-08-05 IL IL221306A patent/IL221306A0/en unknown
- 2012-09-04 AU AU2012216632A patent/AU2012216632B2/en not_active Ceased
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2015
- 2015-08-06 JP JP2015156109A patent/JP6190429B2/ja not_active Expired - Fee Related
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2016
- 2016-08-25 AU AU2016219653A patent/AU2016219653B2/en not_active Ceased
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2017
- 2017-08-07 CY CY20171100845T patent/CY1119192T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011097269A1 (en) | 2011-08-11 |
| CA2826548A1 (en) | 2011-08-11 |
| JP6190429B2 (ja) | 2017-08-30 |
| HUE035744T2 (en) | 2018-05-28 |
| IL221306A0 (en) | 2012-10-31 |
| AU2016219653A1 (en) | 2016-09-15 |
| WO2011097269A9 (en) | 2012-12-27 |
| JP2016006096A (ja) | 2016-01-14 |
| AU2016219653B2 (en) | 2018-05-31 |
| DK2531200T3 (en) | 2017-09-11 |
| ES2638072T3 (es) | 2017-10-18 |
| CY1119192T1 (el) | 2018-02-14 |
| AU2012216632B2 (en) | 2016-05-26 |
| JP2013519632A (ja) | 2013-05-30 |
| PT2531200T (pt) | 2017-08-24 |
| SI2531200T1 (sl) | 2017-12-29 |
| EP2531200A4 (en) | 2014-01-08 |
| HRP20171201T1 (hr) | 2017-10-06 |
| EP2531200B1 (en) | 2017-07-12 |
| PL2531200T3 (pl) | 2017-10-31 |
| LT2531200T (lt) | 2017-09-25 |
| EP2531200A1 (en) | 2012-12-12 |
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