JP5792724B2 - 癒着防止バリアとしての噴霧可能なポリマー - Google Patents

癒着防止バリアとしての噴霧可能なポリマー Download PDF

Info

Publication number
JP5792724B2
JP5792724B2 JP2012526927A JP2012526927A JP5792724B2 JP 5792724 B2 JP5792724 B2 JP 5792724B2 JP 2012526927 A JP2012526927 A JP 2012526927A JP 2012526927 A JP2012526927 A JP 2012526927A JP 5792724 B2 JP5792724 B2 JP 5792724B2
Authority
JP
Japan
Prior art keywords
particles
plga
polymer
film
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012526927A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013502993A (ja
JP2013502993A5 (enExample
Inventor
ジェイ. イートン,ドナルド
ジェイ. イートン,ドナルド
フアン,ビン
エー. サヴィット,マイケル
エー. サヴィット,マイケル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ara Medical LLC
Original Assignee
Ara Medical LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ara Medical LLC filed Critical Ara Medical LLC
Publication of JP2013502993A publication Critical patent/JP2013502993A/ja
Publication of JP2013502993A5 publication Critical patent/JP2013502993A5/ja
Application granted granted Critical
Publication of JP5792724B2 publication Critical patent/JP5792724B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0076Sprayable compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04Homopolymers or copolymers of ethene
    • C08L23/08Copolymers of ethene
    • C08L23/0846Copolymers of ethene with unsaturated hydrocarbons containing atoms other than carbon or hydrogen
    • C08L23/0869Copolymers of ethene with unsaturated hydrocarbons containing atoms other than carbon or hydrogen with unsaturated acids, e.g. [meth]acrylic acid; with unsaturated esters, e.g. [meth]acrylic acid esters
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00Properties
    • C08L2201/06Biodegradable

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012526927A 2009-08-27 2010-08-24 癒着防止バリアとしての噴霧可能なポリマー Active JP5792724B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23766909P 2009-08-27 2009-08-27
US61/237,669 2009-08-27
US12/705,436 2010-02-12
US12/705,436 US9649331B2 (en) 2009-08-27 2010-02-12 Sprayable polymers as adhesion barriers
PCT/US2010/046529 WO2011031457A2 (en) 2009-08-27 2010-08-24 Sprayable polymers as adhesion barriers

Publications (3)

Publication Number Publication Date
JP2013502993A JP2013502993A (ja) 2013-01-31
JP2013502993A5 JP2013502993A5 (enExample) 2013-10-03
JP5792724B2 true JP5792724B2 (ja) 2015-10-14

Family

ID=43625293

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012526927A Active JP5792724B2 (ja) 2009-08-27 2010-08-24 癒着防止バリアとしての噴霧可能なポリマー

Country Status (5)

Country Link
US (4) US9649331B2 (enExample)
EP (1) EP2470223B1 (enExample)
JP (1) JP5792724B2 (enExample)
CA (1) CA2772343A1 (enExample)
WO (1) WO2011031457A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
DE102011114986A1 (de) 2011-09-28 2013-03-28 Ethris Gmbh Sprühsystem
CN102433684B (zh) * 2011-11-04 2015-06-10 无锡中科光远生物材料有限公司 一种超细复合纤维膜、其制备方法及其用途
AU2012341502B2 (en) * 2011-11-25 2016-05-26 Otsuka Pharmaceutical Factory, Inc. Pharmaceutical composition useful for adhesion prevention or hemostasis
DE102013211316A1 (de) 2013-06-17 2014-12-18 Aesculap Ag Hämostyptikum
WO2015089317A1 (en) * 2013-12-11 2015-06-18 Case Western Reserve University Spray on hemostatic system
US9962462B2 (en) * 2015-06-11 2018-05-08 Case Western Reserve University Dry spray on hemostatic system
AU2018332189B2 (en) * 2017-09-12 2021-08-19 Shilpa Medicare Limited Tranexamic acid spray for knee arthroplasty
US10624729B2 (en) 2017-10-12 2020-04-21 C.R. Bard, Inc. Repair prosthetic curl mitigation
US11013501B2 (en) 2017-12-08 2021-05-25 Davol, Inc. Method of protecting the peritoneum against tearing and other injury before an active surgical intervention at or near the peritoneum
US12263185B2 (en) * 2018-02-05 2025-04-01 Bc3 Technologies, Inc. Hemostatic material and spray

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4895724A (en) * 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
US5725491A (en) * 1988-10-03 1998-03-10 Atrix Laboratories, Inc. Method of forming a biodegradable film dressing on tissue
DE3916020C2 (de) 1989-05-17 1994-06-01 Burkhard Dr Wichert Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
BR9306038A (pt) * 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5836970A (en) * 1996-08-02 1998-11-17 The Kendall Company Hemostatic wound dressing
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US5906997A (en) 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
GB9800957D0 (en) 1998-01-17 1998-03-11 Process Intelligence Limited Test probe interface unit and method for manufacturing the same
AU5560899A (en) * 1998-08-14 2000-03-06 Incept Llc Methods and apparatus for in situ formation of hydrogels
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6153212A (en) 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
ATE318846T1 (de) 1999-11-12 2006-03-15 Macromed Inc An- und abschwellende polymermischungen
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
EP1292316B1 (en) 2000-04-28 2009-03-18 Fziomed Inc. Hemostatic compositions of polyacids and polyalkylene oxides and methods for their use
US20040018238A1 (en) 2001-02-26 2004-01-29 Shukla Atul J Biodegradable vehicles and delivery systems of biolgically active substances
KR100523953B1 (ko) 2002-08-27 2005-10-25 주식회사 엘지생명과학 천연다당류와 히알루론산의 마이크로비드 및 이의 제조 방법
US20050048115A1 (en) 2003-08-27 2005-03-03 Murty Mangena Buprenorphine microspheres
TW200524959A (en) 2003-09-08 2005-08-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modification product and drug carrier therefrom
DE602005026015D1 (de) 2004-08-17 2011-03-03 Tyco Healthcare Antiadhäsionssperrschicht
JP5226513B2 (ja) * 2005-08-26 2013-07-03 メルク セローノ ソシエテ アノニム ピラジン誘導体及びその使用
KR100785378B1 (ko) 2005-09-05 2007-12-14 주식회사 바이오레인 다층구조의 유착방지제
US20070248642A1 (en) * 2006-04-19 2007-10-25 Michael Dornish Foam and use thereof
US20070299155A1 (en) 2006-06-09 2007-12-27 Medivas, Llc Biodegradable polymer adhesion barriers
US8153695B2 (en) * 2007-06-04 2012-04-10 Boston Scientific Scimed, Inc. Methods for inhibiting post-surgical adhesions
EP3574909A1 (en) * 2008-01-30 2019-12-04 Imbed Biosciences, Inc. Methods and compositions for wound healing
US9649331B2 (en) 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers

Also Published As

Publication number Publication date
US20190070102A1 (en) 2019-03-07
JP2013502993A (ja) 2013-01-31
EP2470223A2 (en) 2012-07-04
EP2470223A4 (en) 2013-04-03
US9649331B2 (en) 2017-05-16
WO2011031457A3 (en) 2011-07-21
US10543168B2 (en) 2020-01-28
CA2772343A1 (en) 2011-03-17
US20220054403A1 (en) 2022-02-24
US20110052712A1 (en) 2011-03-03
EP2470223B1 (en) 2017-01-04
WO2011031457A2 (en) 2011-03-17
US20190060219A9 (en) 2019-02-28
US20170304191A1 (en) 2017-10-26

Similar Documents

Publication Publication Date Title
JP5792724B2 (ja) 癒着防止バリアとしての噴霧可能なポリマー
US12427105B2 (en) Hydrogel-based biological delivery vehicle
JP5757861B2 (ja) キトサン−含有保護用組成物
AU2004247006B2 (en) Compositions and methods for reducing scar tissue formation
ES2833001T3 (es) Micropartículas administrables in vivo a través de un conducto médico
JP2011245293A (ja) 生分解性ポリマーに封入された微小球粒子のフィルムおよびその作製方法
JP2010104791A (ja) 遅延ゲル化組成物およびその使用法
US20240285834A1 (en) Compositions Comprising Oxidized Cellulose
JP2012506903A (ja) スプレー可能なカプセル化された機能性微粒子組成物及びその製造方法
CN111954545A (zh) 制备止血组合物的方法
KR20170012867A (ko) 입자형 무세포 진피 기반의 온도감응성 유착방지 조성물의 제조방법
JP2011025013A (ja) 癒着防止材及びその製造方法
JP2024001354A (ja) 生体吸収性医療材料
JP2010518172A (ja) 腹腔内グルタミンによる術後癒着形成の減少
CN120981258A (zh) 用于密封组织中的渗漏的止血密封剂粉末

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130819

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130819

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140902

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141126

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141203

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141226

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150202

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150225

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150707

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150806

R150 Certificate of patent or registration of utility model

Ref document number: 5792724

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250