JP5792724B2 - 癒着防止バリアとしての噴霧可能なポリマー - Google Patents

癒着防止バリアとしての噴霧可能なポリマー Download PDF

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Publication number
JP5792724B2
JP5792724B2 JP2012526927A JP2012526927A JP5792724B2 JP 5792724 B2 JP5792724 B2 JP 5792724B2 JP 2012526927 A JP2012526927 A JP 2012526927A JP 2012526927 A JP2012526927 A JP 2012526927A JP 5792724 B2 JP5792724 B2 JP 5792724B2
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JP
Japan
Prior art keywords
particles
plga
polymer
film
water
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Expired - Fee Related
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JP2012526927A
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English (en)
Japanese (ja)
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JP2013502993A5 (enExample
JP2013502993A (ja
Inventor
ジェイ． イートン，ドナルド
ジェイ． イートン，ドナルド
フアン，ビン
エー． サヴィット，マイケル
エー． サヴィット，マイケル
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Ara Medical LLC
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Ara Medical LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0076—Sprayable compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/08—Copolymers of ethene
    • C08L23/0846—Copolymers of ethene with unsaturated hydrocarbons containing atoms other than carbon or hydrogen
    • C08L23/0869—Copolymers of ethene with unsaturated hydrocarbons containing atoms other than carbon or hydrogen with unsaturated acids, e.g. [meth]acrylic acid; with unsaturated esters, e.g. [meth]acrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012526927A 2009-08-27 2010-08-24 癒着防止バリアとしての噴霧可能なポリマー Expired - Fee Related JP5792724B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23766909P 2009-08-27 2009-08-27
US61/237,669 2009-08-27
US12/705,436 US9649331B2 (en) 2009-08-27 2010-02-12 Sprayable polymers as adhesion barriers
US12/705,436 2010-02-12
PCT/US2010/046529 WO2011031457A2 (en) 2009-08-27 2010-08-24 Sprayable polymers as adhesion barriers

Publications (3)

Publication Number Publication Date
JP2013502993A JP2013502993A (ja) 2013-01-31
JP2013502993A5 JP2013502993A5 (enExample) 2013-10-03
JP5792724B2 true JP5792724B2 (ja) 2015-10-14

Family

ID=43625293

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012526927A Expired - Fee Related JP5792724B2 (ja) 2009-08-27 2010-08-24 癒着防止バリアとしての噴霧可能なポリマー

Country Status (5)

Country Link
US (4) US9649331B2 (enExample)
EP (1) EP2470223B1 (enExample)
JP (1) JP5792724B2 (enExample)
CA (1) CA2772343A1 (enExample)
WO (1) WO2011031457A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
DE102011114986A1 (de) 2011-09-28 2013-03-28 Ethris Gmbh Sprühsystem
CN102433684B (zh) * 2011-11-04 2015-06-10 无锡中科光远生物材料有限公司 一种超细复合纤维膜、其制备方法及其用途
EP2783704A4 (en) * 2011-11-25 2015-04-15 Otsuka Pharma Co Ltd PHARMACEUTICAL COMPOSITION FOR PREVENTION OF LAMINATION OR HEMOSTASIS
DE102013211316A1 (de) 2013-06-17 2014-12-18 Aesculap Ag Hämostyptikum
WO2015089317A1 (en) * 2013-12-11 2015-06-18 Case Western Reserve University Spray on hemostatic system
US9962462B2 (en) * 2015-06-11 2018-05-08 Case Western Reserve University Dry spray on hemostatic system
SG11202001547RA (en) * 2017-09-12 2020-03-30 Shilpa Medicare Ltd Tranexamic acid spray for knee arthroplasty
US10624729B2 (en) 2017-10-12 2020-04-21 C.R. Bard, Inc. Repair prosthetic curl mitigation
US11013501B2 (en) 2017-12-08 2021-05-25 Davol, Inc. Method of protecting the peritoneum against tearing and other injury before an active surgical intervention at or near the peritoneum
US12263185B2 (en) * 2018-02-05 2025-04-01 Bc3 Technologies, Inc. Hemostatic material and spray

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GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4895724A (en) * 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
US5725491A (en) * 1988-10-03 1998-03-10 Atrix Laboratories, Inc. Method of forming a biodegradable film dressing on tissue
DE3916020C2 (de) 1989-05-17 1994-06-01 Burkhard Dr Wichert Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE69329594T2 (de) * 1992-02-28 2001-05-31 Board Of Regents, The University Of Texas System Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5836970A (en) * 1996-08-02 1998-11-17 The Kendall Company Hemostatic wound dressing
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
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US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
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DE60026357T2 (de) 1999-11-12 2006-10-19 MacroMed, Inc., Sandy An- und abschwellende polymermischungen
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US20020010150A1 (en) 2000-04-28 2002-01-24 Cortese Stephanie M. Homostatic compositions of polyacids and polyalkylene oxides and methods for their use
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KR100523953B1 (ko) 2002-08-27 2005-10-25 주식회사 엘지생명과학 천연다당류와 히알루론산의 마이크로비드 및 이의 제조 방법
US20050048115A1 (en) 2003-08-27 2005-03-03 Murty Mangena Buprenorphine microspheres
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Also Published As

Publication number Publication date
US20170304191A1 (en) 2017-10-26
US20110052712A1 (en) 2011-03-03
US20190060219A9 (en) 2019-02-28
WO2011031457A2 (en) 2011-03-17
WO2011031457A3 (en) 2011-07-21
EP2470223B1 (en) 2017-01-04
US9649331B2 (en) 2017-05-16
US20190070102A1 (en) 2019-03-07
CA2772343A1 (en) 2011-03-17
EP2470223A2 (en) 2012-07-04
US10543168B2 (en) 2020-01-28
EP2470223A4 (en) 2013-04-03
US20220054403A1 (en) 2022-02-24
JP2013502993A (ja) 2013-01-31

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