JP5774718B2 - メラニン促進局所用組成物 - Google Patents
メラニン促進局所用組成物 Download PDFInfo
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- JP5774718B2 JP5774718B2 JP2013542007A JP2013542007A JP5774718B2 JP 5774718 B2 JP5774718 B2 JP 5774718B2 JP 2013542007 A JP2013542007 A JP 2013542007A JP 2013542007 A JP2013542007 A JP 2013542007A JP 5774718 B2 JP5774718 B2 JP 5774718B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Description
本発明は、皮膚を黒くする(サンレスタンニング)組成物および方法、すなわちドーパミン前駆体およびクルクミンに基づいて皮膚を黒くする組成物および方法に関する。これらの組成物を製造する方法が提供される。
日焼けした皮膚は、一般に個人の外見の望ましい美的要素である。日焼けした外見は、健康で、若々しく、かつ一般的により魅力的に見えることと関連する。
本発明は、ドーパミン前駆体とクルクミンの相乗的組み合わせで構成されるサンレスタンニング組成物を提供する。
チロシン(Tyr)は非必須アミノ酸であり、アミノ酸、フェニルアラニン(Phe)から合成される。それは、多くの高タンパク質食品、例えば大豆製品、ニワトリ、シチメンチョウ、魚、ピーナッツ、アーモンド、アボカド、ミルク、チーズ、ヨーグルト、カッテージチーズ、ライマメ、カボチャ種子、およびゴマ種子に見られる。PheのTyrへの変換は、酵素フェニルアラニンヒドロキシラーゼ、モノオキシゲナーゼによって触媒される。この酵素は、フェニルアラニンの6炭素芳香族環の末端にヒドロキシル基の付加をもたらす反応を触媒し、それによってそれはチロシンになる。チロシンは疎水性である一方、フェニルアラニンよりも有意に可溶性である。
Claims (21)
- 皮膚に適用するためのサンレスタンニング組成物であって、
チロシン、N−アセチルチロシンおよびフェニルアラニンからなる群から選択される少なくとも1つのドーパミン前駆体の有効量、ならびにクルクミンの有効量からなるメラニン上方制御のための相乗的組み合わせ;ならびに
皮膚科学的に許容される担体
を含む組成物。 - ドーパミン前駆体がタンニング組成物の1〜30重量パーセント存在する、請求項1に記載の組成物。
- ドーパミン前駆体がタンニング組成物の5〜20重量パーセント存在する、請求項2に記載の組成物。
- ドーパミン前駆体がタンニング組成物の10〜15重量パーセント存在する、請求項3に記載の組成物。
- ドーパミン前駆体がN−アセチルチロシンである、請求項1に記載の組成物。
- ドーパミン前駆体がN−アセチルチロシンとフェニルアラニンの組み合わせである、請求項1に記載の組成物。
- クルクミンがタンニング組成物の0.05〜10重量パーセント存在する、請求項1に記載の組成物。
- クルクミンがタンニング組成物の1.0〜5重量パーセント存在する、請求項7に記載の組成物。
- クルクミンがタンニング組成物の2.0重量パーセント存在する、請求項8に記載の組成物。
- フェニルイソチオシアネートをさらに含む、請求項1に記載の組成物。
- フェニルイソチオシアネートがタンニング組成物の0.5〜10.0重量パーセント存在する、請求項10に記載の組成物。
- フェニルイソチオシアネートがタンニング組成物の1.0〜8.0重量パーセント存在する、請求項11に記載の組成物。
- フェニルイソチオシアネートがタンニング組成物の2.0〜5.0重量パーセント存在する、請求項12に記載の組成物。
- 皮膚科学的に許容される担体がヒアルロン酸ナトリウム、フォスファチジルコリン、パルミチン酸イソプロピル、セテアリルアルコール、モノステアリン酸グリセロール、シアバター、スクアラン、シリコーンおよびジメチルエタノールアミンからなる群から選択される1つ以上の薬剤を含む、請求項1に記載の組成物。
- α−ヒドロキシ酸、カフェイン、ビタミンD3、ケルセチン、スルフォラファン、ならびにアスパラギン酸マグネシウム、グルコン酸亜鉛およびグルコン酸銅の混合物からなる群から選択される1つ以上の薬剤をさらに含む、請求項1に記載の組成物。
- 組成物のpHが2.5〜6.0の範囲である、請求項1に記載の組成物。
- 組成物のpHが3.0〜5.5の範囲である、請求項16に記載の組成物。
- 組成物のpHが3.8〜5.0の範囲である、請求項17に記載の組成物。
- 組成物がローション剤である、請求項1に記載の組成物。
- 10〜15重量パーセントのドーパミン前駆体;
1〜3重量パーセントのクルクミン;および
2〜5重量パーセントのフェニルイソチオシアネート
を含むサンレスタンニング組成物であって、バランスが水であり、該ドーパミン前駆体がチロシン、N−アセチルチロシン、フェニルアラニン、およびその混合物からなる群から選択される、組成物。 - 水相、油相、水性ジメチルエタノールアミン混合物、チロシン、N−アセチルチロシンおよびフェニルアラニンから選択されるドーパミン前駆体、クルクミン、ならびに防腐剤を含むサンレスタンニング組成物を製造する方法であって、
水相を油相に添加すること;
水相を油相と混合すること;
38〜40℃まで冷却すること;
38℃の温度でジメチルエタノールアミン混合物を添加すること;
生じた混合物に35℃の温度でドーパミン前駆体およびクルクミンを添加すること;
ホモジナイズすること;
防腐剤を添加すること;ならびに
適量の水を添加して全体を100.00にすること
である工程を含む方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/957,016 US8414869B2 (en) | 2010-11-30 | 2010-11-30 | Melanin promoting topical composition |
US12/957,016 | 2010-11-30 | ||
PCT/US2011/059323 WO2012074672A1 (en) | 2010-11-30 | 2011-11-04 | Melanin promoting topical composition |
Publications (2)
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JP2013544283A JP2013544283A (ja) | 2013-12-12 |
JP5774718B2 true JP5774718B2 (ja) | 2015-09-09 |
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JP2013542007A Expired - Fee Related JP5774718B2 (ja) | 2010-11-30 | 2011-11-04 | メラニン促進局所用組成物 |
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Country | Link |
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US (1) | US8414869B2 (ja) |
EP (1) | EP2645983B1 (ja) |
JP (1) | JP5774718B2 (ja) |
CN (1) | CN103338741B (ja) |
AU (1) | AU2011337131B2 (ja) |
BR (1) | BR112013013445A2 (ja) |
CL (1) | CL2013001511A1 (ja) |
MX (1) | MX2013005995A (ja) |
WO (1) | WO2012074672A1 (ja) |
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US9962361B2 (en) | 2011-01-03 | 2018-05-08 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
US9532969B2 (en) | 2011-02-08 | 2017-01-03 | The William M. Yarbrough Foundation | Method for treating psoriasis |
US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
US10434081B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Inhibitors of macrophage migration inhibitory factor |
US10335387B2 (en) | 2012-07-26 | 2019-07-02 | The William M. Yarbrough Foundation | Method for treating infectious diseases with isothiocyanate functional compounds |
US20140234433A1 (en) * | 2013-02-15 | 2014-08-21 | Nicholas V. Perricone | Topical Composition for Stimulating Epidermis and Dermis Layers of the Skin |
US9289374B2 (en) * | 2014-04-23 | 2016-03-22 | Lifevantage Corporation | Topical compositions and methods for reducing oxidative stress |
AU2014399900B2 (en) * | 2014-07-02 | 2017-08-03 | Halliburton Energy Services, Inc. | Surfactant formulations for reduced and delayed adsorption |
FR3032351B1 (fr) * | 2015-02-05 | 2018-03-23 | Gelyma | Utilisation d'au moins un extrait de macralgue pour augmenter la synthese de melanine dans les melanocytes |
CN111732951B (zh) * | 2020-07-06 | 2022-05-20 | 山西大学 | 一种氮掺杂绿色荧光碳量子点及其制备方法和应用 |
US20230248849A1 (en) * | 2020-07-27 | 2023-08-10 | Board Of Regents, The University Of Texas System | Contrast agents for detection of enzyme activities based on melanin synthesis |
CN112472818B (zh) * | 2020-11-16 | 2022-05-03 | 安徽农业大学 | 一种通过修饰天然黑色素作为载体的纳米材料及其制备方法和应用 |
CN114159351B (zh) * | 2021-12-16 | 2023-08-04 | 四川大学 | 一种具有紫外防护功能的人造黑色素染发剂及其制备方法 |
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EP2014276A1 (en) * | 2007-06-20 | 2009-01-14 | Cognis IP Management GmbH | Cosmetic compositions comprising sclareolide and hesperidin methyl chalcone |
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-
2010
- 2010-11-30 US US12/957,016 patent/US8414869B2/en active Active
-
2011
- 2011-11-04 AU AU2011337131A patent/AU2011337131B2/en not_active Ceased
- 2011-11-04 MX MX2013005995A patent/MX2013005995A/es active IP Right Grant
- 2011-11-04 CN CN201180066218.1A patent/CN103338741B/zh not_active Expired - Fee Related
- 2011-11-04 WO PCT/US2011/059323 patent/WO2012074672A1/en active Application Filing
- 2011-11-04 JP JP2013542007A patent/JP5774718B2/ja not_active Expired - Fee Related
- 2011-11-04 BR BR112013013445A patent/BR112013013445A2/pt not_active Application Discontinuation
- 2011-11-04 EP EP11844389.4A patent/EP2645983B1/en not_active Not-in-force
-
2013
- 2013-05-28 CL CL2013001511A patent/CL2013001511A1/es unknown
Also Published As
Publication number | Publication date |
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US20120134938A1 (en) | 2012-05-31 |
EP2645983A1 (en) | 2013-10-09 |
AU2011337131B2 (en) | 2015-11-19 |
AU2011337131A1 (en) | 2013-06-13 |
WO2012074672A1 (en) | 2012-06-07 |
JP2013544283A (ja) | 2013-12-12 |
BR112013013445A2 (pt) | 2016-07-12 |
CL2013001511A1 (es) | 2014-02-07 |
US8414869B2 (en) | 2013-04-09 |
EP2645983B1 (en) | 2016-05-25 |
CN103338741B (zh) | 2016-09-07 |
CN103338741A (zh) | 2013-10-02 |
EP2645983A4 (en) | 2014-04-23 |
MX2013005995A (es) | 2013-07-22 |
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