JP5773868B2 - アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用 - Google Patents

アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用 Download PDF

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JP5773868B2
JP5773868B2 JP2011516323A JP2011516323A JP5773868B2 JP 5773868 B2 JP5773868 B2 JP 5773868B2 JP 2011516323 A JP2011516323 A JP 2011516323A JP 2011516323 A JP2011516323 A JP 2011516323A JP 5773868 B2 JP5773868 B2 JP 5773868B2
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actriia
activin
polypeptide
actriia polypeptide
composition
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JP2011526626A (ja
JP2011526626A5 (https=
Inventor
マシュー エル． シャーマン，
マシュー エル． シャーマン，
ジャスビアー シーラ，
ジャスビアー シーラ，
ニールズ ボルグステイン，
ニールズ ボルグステイン，
Original Assignee
アクセルロン ファーマ， インコーポレイテッド
アクセルロン ファーマ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011516323A 2008-06-26 2009-06-26 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用 Active JP5773868B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13336808P 2008-06-26 2008-06-26
US61/133,368 2008-06-26
PCT/US2009/003838 WO2009158033A2 (en) 2008-06-26 2009-06-26 Antagonists of activin-actriia and uses for increasing red blood cell levels

Related Child Applications (1)

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JP2014022289A Division JP2014088438A (ja) 2008-06-26 2014-02-07 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用

Publications (3)

Publication Number Publication Date
JP2011526626A JP2011526626A (ja) 2011-10-13
JP2011526626A5 JP2011526626A5 (https=) 2012-08-09
JP5773868B2 true JP5773868B2 (ja) 2015-09-02

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JP2011516323A Active JP5773868B2 (ja) 2008-06-26 2009-06-26 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2014022289A Withdrawn JP2014088438A (ja) 2008-06-26 2014-02-07 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2015145499A Withdrawn JP2015187180A (ja) 2008-06-26 2015-07-23 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2016220297A Withdrawn JP2017036331A (ja) 2008-06-26 2016-11-11 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2018164195A Active JP6643432B2 (ja) 2008-06-26 2018-09-03 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2018164196A Withdrawn JP2018184484A (ja) 2008-06-26 2018-09-03 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2019231523A Withdrawn JP2020041002A (ja) 2008-06-26 2019-12-23 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2021176418A Withdrawn JP2022023184A (ja) 2008-06-26 2021-10-28 アクチビン－ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用

Family Applications After (7)

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JP2014022289A Withdrawn JP2014088438A (ja) 2008-06-26 2014-02-07 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2015145499A Withdrawn JP2015187180A (ja) 2008-06-26 2015-07-23 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2016220297A Withdrawn JP2017036331A (ja) 2008-06-26 2016-11-11 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2018164195A Active JP6643432B2 (ja) 2008-06-26 2018-09-03 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2018164196A Withdrawn JP2018184484A (ja) 2008-06-26 2018-09-03 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2019231523A Withdrawn JP2020041002A (ja) 2008-06-26 2019-12-23 アクチビン−ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用
JP2021176418A Withdrawn JP2022023184A (ja) 2008-06-26 2021-10-28 アクチビン－ＡｃｔＲＩＩａのアンタゴニストおよび赤血球レベルを高めるためのその使用

Country Status (10)

Country Link
EP (4) EP2318028B1 (https=)
JP (8) JP5773868B2 (https=)
KR (4) KR20210047374A (https=)
CN (2) CN102131515B (https=)
AU (4) AU2009262968A1 (https=)
CA (3) CA2729054C (https=)
DK (1) DK2318028T3 (https=)
ES (2) ES2791699T3 (https=)
NZ (2) NZ590326A (https=)
WO (2) WO2009158015A2 (https=)

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