JP5763067B2 - センサーデバイスに関連する改善 - Google Patents
センサーデバイスに関連する改善 Download PDFInfo
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- JP5763067B2 JP5763067B2 JP2012522240A JP2012522240A JP5763067B2 JP 5763067 B2 JP5763067 B2 JP 5763067B2 JP 2012522240 A JP2012522240 A JP 2012522240A JP 2012522240 A JP2012522240 A JP 2012522240A JP 5763067 B2 JP5763067 B2 JP 5763067B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Wood Science & Technology (AREA)
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- Molecular Biology (AREA)
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- Physics & Mathematics (AREA)
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- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
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- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
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- Food Science & Technology (AREA)
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- General Physics & Mathematics (AREA)
- Pathology (AREA)
Applications Claiming Priority (5)
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|---|---|---|---|
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Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201007711D0 (en) * | 2010-05-07 | 2010-06-23 | Pa Consulting Services | Devices and methods for testing analytes |
| US9970933B2 (en) * | 2011-10-06 | 2018-05-15 | Ingibio, Ltd. | Method for manufacturing multiple-diagnosis membrane sensor by using screen printing |
| WO2013134491A1 (en) * | 2012-03-09 | 2013-09-12 | Siemens Healthcare Diagnostics Inc. | Calibration method for reagent card analyzers |
| WO2014018069A1 (en) * | 2012-07-27 | 2014-01-30 | Bayer Healthcare Llc | System and method for detecting used and dried sensors |
| US20140186866A1 (en) * | 2012-12-27 | 2014-07-03 | General Electric Company | Glucose Control Test Strip |
| EP2972333B1 (en) * | 2013-03-11 | 2018-09-19 | The University of Toledo | A biosensor device to target analytes in situ, in vivo, and/or in real time, and methods of making and using the same |
| GB2514846B (en) * | 2013-06-07 | 2015-09-30 | Lifescan Scotland Ltd | Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode |
| US9464994B2 (en) | 2013-07-30 | 2016-10-11 | Clemson University | High sensitivity tunable radio frequency sensors |
| JP6700246B2 (ja) | 2014-07-09 | 2020-05-27 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | 少量試料検知装置 |
| CN104597100B (zh) * | 2014-07-24 | 2021-11-05 | 南京工业大学 | 一种检测血清中甘油三酯的方法 |
| KR20180098599A (ko) * | 2015-12-28 | 2018-09-04 | 라이프스캔 스코트랜드 리미티드 | 전극 전압 감지 접속부를 갖는 전기화학-기반 분석 검사 스트립 및 이와 함께 사용하기 위한 핸드헬드 검사 측정기 |
| GB2549281A (en) * | 2016-04-11 | 2017-10-18 | Palintest Ltd | Electrochemical sensor |
| TWI589870B (zh) * | 2016-05-05 | 2017-07-01 | Vida Biotechnology Co Ltd | Biological test strip with isolated structure and method of use |
| CN106353387B (zh) * | 2016-08-24 | 2019-11-29 | 三诺生物传感股份有限公司 | 一种电化学测试条及同时检测多种待测物的方法 |
| WO2018106129A1 (en) | 2016-12-09 | 2018-06-14 | Digital Sensing Limited | Electrochemical sensors and methods of use thereof |
| US10191044B2 (en) * | 2017-01-04 | 2019-01-29 | David R. Hall | Flushable test strip |
| JP7167824B2 (ja) * | 2019-04-08 | 2022-11-09 | 日本電信電話株式会社 | 発汗分析装置 |
| DE102019120897A1 (de) | 2019-08-02 | 2021-02-04 | Endress+Hauser Group Services Ag | Mobile Anlage für das Kalibrieren, Verifizieren und/oder Justieren eines Sensors und Verfahren zum Kalibrieren, Verifizieren und/oder Justieren eines Sensors |
| CN110716048B (zh) * | 2019-10-30 | 2021-08-13 | 烟台芥子生物技术有限公司 | 干性免疫比浊试剂及其制备方法和应用 |
| FR3111267B1 (fr) * | 2020-06-12 | 2024-05-10 | Univ Grenoble Alpes | Procede pour determiner une concentration reelle d’un substrat a l’aide d’un ensemble de biocapteurs auto-calibres et dispositif pour la mise en œuvre du procede |
| WO2023001292A1 (zh) * | 2021-07-22 | 2023-01-26 | 华广生技股份有限公司 | 微型生物传感器及其感测结构 |
| CN114923965B (zh) * | 2022-03-18 | 2023-05-23 | 杭州微策生物技术股份有限公司 | 一种一体式多指标传感器及其制作方法 |
| CN120820615A (zh) * | 2024-04-12 | 2025-10-21 | 南京晶捷生物科技有限公司 | 一种干膜自校准传感装置及其检测离子浓度的方法 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136145A (en) | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
| US4533629A (en) | 1981-04-17 | 1985-08-06 | Syva Company | Simultaneous calibration heterogeneous immunoassay |
| IL75464A (en) | 1984-06-12 | 1990-08-31 | Orgenics Ltd | Method and apparatus for multi-analyte assay |
| TW203120B (https=) | 1985-10-04 | 1993-04-01 | Abbott Lab | |
| JPS62231168A (ja) | 1986-03-21 | 1987-10-09 | ハイブリテツク・インコ−ポレイテツド | アナライト−レセプタ−分析用内部標準を設けるための改良法 |
| US4774192A (en) * | 1987-01-28 | 1988-09-27 | Technimed Corporation | A dry reagent delivery system with membrane having porosity gradient |
| AU634863B2 (en) | 1989-12-15 | 1993-03-04 | Roche Diagnostics Operations Inc. | Redox mediator reagent and biosensor |
| DK138090D0 (da) | 1990-06-06 | 1990-06-06 | Novo Nordisk As | Diagnostisk analysemetode |
| US5726064A (en) | 1990-11-22 | 1998-03-10 | Applied Research Systems Ars Holding Nv | Method of assay having calibration within the assay |
| US5272191A (en) | 1991-08-21 | 1993-12-21 | Fmc Corporation | Cold water soluble films and film forming compositions |
| US5284140A (en) | 1992-02-11 | 1994-02-08 | Eli Lilly And Company | Acrylic copolymer membranes for biosensors |
| US5393528A (en) | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
| US5582697A (en) | 1995-03-17 | 1996-12-10 | Matsushita Electric Industrial Co., Ltd. | Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same |
| AUPN363995A0 (en) | 1995-06-19 | 1995-07-13 | Memtec Limited | Electrochemical cell |
| US5628890A (en) | 1995-09-27 | 1997-05-13 | Medisense, Inc. | Electrochemical sensor |
| AUPN661995A0 (en) | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
| US6241862B1 (en) | 1996-02-14 | 2001-06-05 | Inverness Medical Technology, Inc. | Disposable test strips with integrated reagent/blood separation layer |
| DE19605583A1 (de) * | 1996-02-15 | 1997-08-21 | Bayer Ag | Elektrochemische Sensoren mit verbesserter Selektivität und erhöhter Empfindlichkeit |
| US5753517A (en) | 1996-03-29 | 1998-05-19 | University Of British Columbia | Quantitative immunochromatographic assays |
| US5962215A (en) | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
| DE19646392A1 (de) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| JP3460538B2 (ja) | 1997-10-08 | 2003-10-27 | 救急薬品工業株式会社 | 速溶性フィルム製剤 |
| US6153085A (en) | 1998-08-17 | 2000-11-28 | Stat-Chem, Inc. | Information storage and transmittal for medical diagnostic devices |
| US6193873B1 (en) | 1999-06-15 | 2001-02-27 | Lifescan, Inc. | Sample detection to initiate timing of an electrochemical assay |
| EP1269173B1 (en) | 2000-03-28 | 2005-08-17 | Diabetes Diagnostics, Inc. | Rapid response glucose sensor |
| CA2403646A1 (en) | 2000-03-28 | 2001-10-04 | Inverness Medical Technology, Inc. | Continuous process for manufacture of disposable electro-chemical sensor |
| DE10025580A1 (de) | 2000-05-24 | 2001-12-06 | Infineon Technologies Ag | Messverfahren mit Substanzsensoren und Messvorrichtung |
| JP4948737B2 (ja) | 2000-07-14 | 2012-06-06 | ライフスキャン・インコーポレイテッド | 化学反応速度を測定する電気化学的方法 |
| JP2004509739A (ja) | 2000-09-27 | 2004-04-02 | ベリオン インコーポレイテッド | 即時水溶解性カプセルおよびその製法 |
| US6555061B1 (en) | 2000-10-05 | 2003-04-29 | Lifescan, Inc. | Multi-layer reagent test strip |
| US6660292B2 (en) | 2001-06-19 | 2003-12-09 | Hf Flavoring Technology Llp | Rapidly disintegrating flavored film for precooked foods |
| US6419903B1 (en) | 2001-08-20 | 2002-07-16 | Colgate Palmolive Company | Breath freshening film |
| AU2002334550B2 (en) * | 2001-09-17 | 2008-01-10 | Phadia Ab | Multi-analyte assay device with multi-spot detection zone |
| US20030116447A1 (en) | 2001-11-16 | 2003-06-26 | Surridge Nigel A. | Electrodes, methods, apparatuses comprising micro-electrode arrays |
| CN1615434A (zh) | 2002-01-15 | 2005-05-11 | 埃葛梅崔克斯股份有限公司 | 适用于处理电化学信号的方法和装置 |
| US6946299B2 (en) | 2002-04-25 | 2005-09-20 | Home Diagnostics, Inc. | Systems and methods for blood glucose sensing |
| EP1515690A4 (en) | 2002-06-25 | 2006-05-24 | Wrigley W M Jun Co | ORAL REFRESHING AND CLEANING ORAL CAVITY PRODUCT CONTAINING A MAGNOLIA BARK EXTRACT |
| HK1080040B (en) | 2002-10-30 | 2010-08-06 | Lifescan Scotland Ltd | Enzyme print humidification in a continuous process for manufacture of electrochemical sensors |
| US20040115137A1 (en) | 2002-12-17 | 2004-06-17 | Verrall Andrew P. | Water-soluble film for oral administration |
| SI21400A (sl) | 2003-02-12 | 2004-08-31 | LEK farmacevtska družba d.d. | Stabilna farmacevtska oblika z inhibitorjem HMG-CoA reduktaze |
| US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
| EP1482056A3 (en) * | 2003-05-28 | 2006-01-04 | Matsushita Electric Industrial Co., Ltd. | Biosensor |
| JP4334969B2 (ja) | 2003-10-02 | 2009-09-30 | パナソニック株式会社 | 血液成分分析用センサ |
| DE10346863A1 (de) | 2003-10-09 | 2005-05-04 | Roche Diagnostics Gmbh | On-Board-Kontrolle für Analyseelemente |
| US7470397B2 (en) | 2003-10-24 | 2008-12-30 | Adhesives Research, Inc. | Disintegratable films for diagnostic devices |
| US9248146B2 (en) | 2003-10-24 | 2016-02-02 | Adhesives Research, Inc. | Dissolvable adhesive films for delivery of pharmaceutical or cosmetic agents |
| FR2862654B1 (fr) | 2003-11-20 | 2006-02-10 | Roquette Freres | Composition amylacee filmogene |
| ATE480761T1 (de) | 2003-12-05 | 2010-09-15 | Dexcom Inc | Kalibrationsmethoden für einen kontinuierlich arbeitenden analytsensor |
| BRPI0507376A (pt) | 2004-02-06 | 2007-07-10 | Bayer Healthcare Llc | espécie oxidável como uma referência interna para biossensores e método de uso |
| GB0403369D0 (en) * | 2004-02-16 | 2004-03-17 | Pa Consulting Services | Devices and methods for testing analytes |
| WO2005098431A1 (en) | 2004-03-05 | 2005-10-20 | Egomedical Swiss Ag | Analyte test system for determining the concentration of an analyte in a physiological fluid |
| WO2005114160A1 (en) | 2004-05-14 | 2005-12-01 | Bayer Healthcare Llc | Method for manufacturing a diagnostic test strip |
| US20080286359A1 (en) | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
| CA2475240A1 (en) | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to measure dynamic internal calibration true dose response curves |
| US20060024835A1 (en) | 2004-07-30 | 2006-02-02 | Matzinger David P | Analytical test strip with control zone |
| ES2334671T3 (es) * | 2004-08-13 | 2010-03-15 | Egomedical Technologies Ag | Sistema de ensayo de analitos para determinar la concentracion de un analito en un fluido fisiologico o acuoso. |
| GB0428130D0 (en) | 2004-12-22 | 2005-01-26 | Oxford Biosensors Ltd | Selective HDL cholesterol assay |
| US20080152761A1 (en) | 2006-12-20 | 2008-06-26 | Shiji Shen | Packaging of Food Products with Pullulan Films |
| GB0617276D0 (en) * | 2006-09-04 | 2006-10-11 | Suresensors | Device |
| ES2748685T3 (es) * | 2006-09-22 | 2020-03-17 | Ascensia Diabetes Care Holdings Ag | Sistema de biosensor que tiene estabilidad y rendimiento de hematocrito potenciados |
| US20090007947A1 (en) * | 2006-12-22 | 2009-01-08 | Angela Spangenberg | Portable weather shielding canopy |
| JP2010535038A (ja) | 2007-08-02 | 2010-11-18 | モノソル リミテッド ライアビリティ カンパニー | カルボキシメチルセルロースベースのフィルム、そのフィルムから製造される可食性食品キャスティング及びその使用方法 |
| MX2010006392A (es) | 2007-12-10 | 2010-07-02 | Bayer Healthcare Llc | Compensacion basada en la pendiente. |
| US8241697B2 (en) * | 2007-12-20 | 2012-08-14 | Abbott Point Of Care Inc. | Formation of immobilized biological layers for sensing |
| US8603768B2 (en) | 2008-01-17 | 2013-12-10 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
| GB201007711D0 (en) | 2010-05-07 | 2010-06-23 | Pa Consulting Services | Devices and methods for testing analytes |
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| WO2011012848A8 (en) | 2011-03-10 |
| CN102471796A (zh) | 2012-05-23 |
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| CA2767950C (en) | 2019-11-12 |
| US20120135509A1 (en) | 2012-05-31 |
| EP2459730A1 (en) | 2012-06-06 |
| JP2013500492A (ja) | 2013-01-07 |
| WO2011012848A1 (en) | 2011-02-03 |
| CA2767950A1 (en) | 2011-02-03 |
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