JP5762414B2 - 急性音響外傷の治療方法 - Google Patents

急性音響外傷の治療方法 Download PDF

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Publication number
JP5762414B2
JP5762414B2 JP2012526892A JP2012526892A JP5762414B2 JP 5762414 B2 JP5762414 B2 JP 5762414B2 JP 2012526892 A JP2012526892 A JP 2012526892A JP 2012526892 A JP2012526892 A JP 2012526892A JP 5762414 B2 JP5762414 B2 JP 5762414B2
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composition
disulfonyl
hearing loss
aat
nac
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Japanese (ja)
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JP2013502461A (ja
JP2013502461A5 (https=
Inventor
リチャード ダーナ コプケ、
リチャード ダーナ コプケ、
ロバート エイ． フロイド、
ロバート エイ． フロイド、
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Oklahoma Medical Research Foundation
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Oklahoma Medical Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Endoscopes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012526892A 2009-08-24 2010-08-24 急性音響外傷の治療方法 Active JP5762414B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27411809P 2009-08-24 2009-08-24
US61/274,118 2009-08-24
PCT/US2010/046420 WO2011028503A1 (en) 2009-08-24 2010-08-24 Methods for treating acute acoustic trauma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015116630A Division JP6038233B2 (ja) 2009-08-24 2015-06-09 急性音響外傷の治療方法

Publications (3)

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JP2013502461A JP2013502461A (ja) 2013-01-24
JP2013502461A5 JP2013502461A5 (https=) 2013-10-03
JP5762414B2 true JP5762414B2 (ja) 2015-08-12

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ID=43649578

Family Applications (2)

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JP2012526892A Active JP5762414B2 (ja) 2009-08-24 2010-08-24 急性音響外傷の治療方法
JP2015116630A Active JP6038233B2 (ja) 2009-08-24 2015-06-09 急性音響外傷の治療方法

Family Applications After (1)

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JP2015116630A Active JP6038233B2 (ja) 2009-08-24 2015-06-09 急性音響外傷の治療方法

Country Status (8)

Country Link
US (2) US10555915B2 (https=)
EP (1) EP2470015B1 (https=)
JP (2) JP5762414B2 (https=)
AU (1) AU2010289838C1 (https=)
CA (1) CA2772097C (https=)
ES (1) ES2563777T3 (https=)
IL (1) IL218302A (https=)
WO (1) WO2011028503A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10751385B2 (en) 2015-02-20 2020-08-25 Institut Pasteur Prevention and/or treatment of hearing loss or impairment
US20180256756A1 (en) * 2015-09-18 2018-09-13 Oklahoma Medical Research Foundation Method of transporting an agent across blood-brain, blood-cochlear or blood-cerebrospinal fluid barrier
TWI642431B (zh) * 2016-10-28 2018-12-01 西德有機化學藥品股份有限公司 Ｎ－乙醯半胱胺酸用於治療突發性感覺神經性聽力損失的方法
CN110248650A (zh) * 2016-10-31 2019-09-17 霍夫耳科研究所 用于增强突触发生和神经突发生的方法
KR20190119046A (ko) * 2017-01-19 2019-10-21 오톨로직 파마슈틱스, 인크. N-아세틸시스테인의 제제 및 이의 용도
JP6999896B2 (ja) 2017-09-21 2022-01-19 学校法人慶應義塾 音響外傷難聴モデル動物の作製方法及びそれにより作製される音響外傷難聴モデル動物
US20210137861A1 (en) * 2018-05-03 2021-05-13 Hough Ear Institute Methods for reducing accumulated pathologic tau protein
AU2019339352B2 (en) * 2018-09-12 2025-05-22 Hough Ear Institute Methods for treating hearing loss incident to cochlear implant surgery
US11857551B1 (en) 2020-07-10 2024-01-02 Ting Therapeutics Llc Methods for the prevention and treatment of hearing loss
EP4309655A1 (en) * 2022-07-22 2024-01-24 Consejo Superior de Investigaciones Científicas (CSIC) Quinolylnitrone derivatives for use in the prevention and/or treatment of hearing loss

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
US6177434B1 (en) * 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms
US6649621B2 (en) * 1997-12-16 2003-11-18 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms
US6469049B1 (en) 2000-04-21 2002-10-22 The United States Of America As Represented By The Secretary Of The Army Method of treating, preventing or inhibiting central nervous system injuries and diseases
SE0001916D0 (sv) 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
WO2004096256A1 (en) 2001-01-23 2004-11-11 The United States Of America, As Represented By The Secretary Of The Navy Methods for preventing and treating loss of balance function due to oxidative stress
US7700111B2 (en) * 2002-01-17 2010-04-20 The Regents Of The University Of Michigan Auditory nerve protection and re-growth
WO2005016243A2 (en) 2003-06-09 2005-02-24 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and an antioxidant agent for the treatment of central nervous system disorders
US20050182060A1 (en) 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
WO2007119578A1 (ja) 2006-03-29 2007-10-25 Kaneka Corporation 神経系細胞機能改善剤
AU2007277193B2 (en) * 2006-07-25 2013-06-13 Hough Ear Institute Methods for treating acute acoustic trauma
UA97486C2 (ru) 2006-08-29 2012-02-27 Дженентек, Инк. Применение тенектеплазы для лечения острого ишемического инсульта
US20100234402A1 (en) * 2007-05-31 2010-09-16 Gideon Dreyfuss Methods and compositions for treating spinal muscular atrophy
KR20130097813A (ko) * 2008-04-21 2013-09-03 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US20140302322A1 (en) 2011-09-06 2014-10-09 Ricardo Prada Silvy Single wall carbon nanotube purification process and improved single wall carbon nanotubes

Also Published As

Publication number Publication date
AU2010289838A1 (en) 2012-04-19
AU2010289838B2 (en) 2013-11-07
WO2011028503A1 (en) 2011-03-10
US10555915B2 (en) 2020-02-11
JP2013502461A (ja) 2013-01-24
IL218302A (en) 2017-02-28
EP2470015B1 (en) 2016-01-13
CA2772097C (en) 2019-04-30
CA2772097A1 (en) 2011-03-10
US20120172435A1 (en) 2012-07-05
EP2470015A4 (en) 2013-01-09
IL218302A0 (en) 2012-04-30
AU2010289838C1 (en) 2014-03-06
US20170224635A1 (en) 2017-08-10
ES2563777T3 (es) 2016-03-16
JP6038233B2 (ja) 2016-12-07
JP2015172071A (ja) 2015-10-01
EP2470015A1 (en) 2012-07-04

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