JP5759894B2 - Medical or medical auxiliary composition comprising zeolite and sericite - Google Patents

Description

  The present invention relates to a medical or medical supplement composition comprising zeolite and sericite.

Zeolite adsorbs toxic chemicals, heavy metals, adsorbs moisture and adjusts humidity, suppresses bacterial growth, adjusts pH, has a virus-adsorbing effect, and has a far-red effect Are known. And in patent document 1, zeolite is mentioned as one component in a disposable foamable washing | cleaning article, and the zeolite is mentioned as patent document 2 as a support | carrier of an active ingredient.
It is known that sericite has a function of protecting the skin, has an appropriate moisturizing effect on the skin, and has a far-red effect. Patent Document 3 mentions sericite as one component of a cosmetic filler.

Special table 2007-510006 Special table 2004-538300 JP 2005-325121 A

  The problem to be solved by the present invention is to increase the usefulness of zeolite and sericite in various medical fields.

The main feature of the present invention is that it has been found that there is a synergistic effect by blending known zeolite and sericite. That means
1. A medical or medical supplement composition comprising zeolite and sericite.
2. 2. The composition according to item 1, which is an external composition or an oral composition.
3. 3. The composition according to item 1 or 2, wherein the sericite is a particle having a particle size of 50 μm or less.
4). 4. The composition according to any one of items 1 to 3, wherein the zeolite is a particle having a particle diameter of 300 μm or less.
5. 5. The composition according to any one of items 1 to 4, wherein the blending ratio of zeolite and sericite is about 10 to about 90% by weight: about 90 to about 10% by weight.
6). The external composition is a spray preparation, a kneaded preparation, a solution, a suspension, a powder, a cream, an aerosol, an ointment, a liniment, or a suppository, according to any one of items 2 to 5 above. Composition.
7). 6. The composition according to any one of items 2 to 5 above, wherein the composition for external use is a composition for preparation at the time of use.
8). 6. The composition according to any one of items 2 to 5 above, wherein the oral composition is a capsule preparation, powder, tablet, suspension, or granule.
9. 9. The composition according to any one of items 1 to 8, wherein the total amount of zeolite and sericite is about 50% by weight or more in the composition.
10. A pharmaceutical, quasi-drug, cosmetic or hygiene product prepared by applying, blending or absorbing the composition according to any one of the preceding items 1 to 9.
11. 11. The pharmaceutical product, quasi-drug, cosmetic product or hygiene product according to the item 10 prepared by coating or absorbing paper, fiber, fibrous material, non-woven fabric, absorbent cotton or film.

  The composition of the present invention has a clear synergistic effect in treatment and improvement effects compared to the use of zeolite or sericite alone.

A photograph of the result of treatment of the composition of the present invention to a volunteer with burn symptoms in hair removal treatment with an esthetic laser. The part of the knee. As of June 28, the knees were burned, but on July 4, they returned to almost normal skin. A photograph of the result of treatment of the composition of the present invention to a volunteer with burn symptoms in hair removal treatment with an esthetic laser. The part of the back. As of June 28th, his back was completely burned, but on July 4th he returned to almost normal skin. A photograph of the result of treatment of the composition of the present invention to a volunteer with burn symptoms in hair removal treatment with an esthetic laser. The area around the navel. As of June 28, the area around the navel was red, but on July 4, it returned to almost normal skin.

The present invention is a medical or medical supplement composition comprising zeolite and sericite.
Zeolite is a generic name for aluminosilicates with fine pores in the crystals. The Japanese name is also called fukuseki. It is a naturally occurring mineral that contains water in it and appears to boil when heated, so the Greek word zeo (boiling) and lithos (stone) are combined to name it zeolite. . Zeolite is used as a molecular sieve, ion-exchange material, catalyst, and adsorbent. At present, zeolites with various properties have been artificially synthesized and are industrially important materials. For example, the following zeolites are known.

amicite
K ₄ Na ₄ [Al ₈ Si ₈ O ₃₂ ] · 10H ₂ O, monoclinic system.
Ammonium leucite (ammonioleucite)
(NH ₄ ) [AlSi ₂ O ₆ ], tetragonal system.
Anorcime
Na [AlSi ₂ O ₆ ] / H ₂ O, equiaxed, tetragonal, orthorhombic, monoclinic, triclinic.
Barrerite
Na ₂ [Al ₂ Si ₇ O ₁₈ ] · 6H ₂ O, orthorhombic.
bellbergite
(K, Ba, Sr) ₂ Sr ₂ Ca ₂ (Ca, Na) ₄ [Al ₁₈ Si ₁₈ O ₇₂ ] .30H ₂ O, hexagonal system.
bikitaite
Li [AlSi ₂ O ₆ ] / H ₂ O, monoclinic and triclinic.
boggsite
Ca ₈ Na ₃ [Al ₁₉ Si ₇₇ O ₁₉₂ ] / 70H ₂ O, orthorhombic.

brewsterite (series name)
(Sr, Ba) ₂ [Al ₄ Si ₁₂ O ₃₂ ] · 10H ₂ O, monoclinic / triclinic.
brewsterite-Sr
brewsterite-Ba
Chabazite (series name)
(Ca _0.5 , Na, K) ₄ [Al ₄ Si ₈ O ₂₄ ] · 12H ₂ O, trigonal and triclinic.
Chabazite-Ca
Soda rhodolite (chabazite-Na)
Potassium chabazite-K
chiavennite
CaMn [Be ₂ Si ₅ O ₁₃ (OH) ₂ ] · 2H ₂ O, orthorhombic.

Clinoptilolite (series name)
(Na, K, Ca _0.5 , Sr _0.5 , Ba _0.5 , Mg _0.5 ) ₆ [Al ₆ Si ₃₀ O ₇₂ ] · ˜20H ₂ O, monoclinic system.
Potassium clinoptilolite (clinoptilolite-K)
Soda clinoptilolite (clinoptilolite-Na)
Clinoptilolite-Ca
Cowlesite
Ca [Al ₂ Si ₃ O ₁₀ ] · 5.3H ₂ O, orthorhombic system.
Dachiardite (series name)
(Ca _0.5 , Na, K) _4-5 [Al _4-5 Si _20-19 O ₄₈ ] · 13H ₂ O, monoclinic system.
Ash dachiardite (dachiardite-Ca)
Soda-Dakiardite (dachiardite-Na)
Edingtonite
Ba [Al ₂ Si ₃ O ₁₀ ] · 4H ₂ O, orthorhombic and tetragonal.
Epistilbite
(Ca, Na ₂ ) [Al ₂ Si ₄ O ₁₂ ] · 4H ₂ O, monoclinic and triclinic.

Erionite (series name)
K ₂ (Na, Ca _0.5 ) ₈ [Al ₁₀ Si ₂₆ O ₇₂ ] · 30H ₂ O, hexagonal system.
Soda erionite (erionite-Na)
Cary Elionite (erionite-K)
Erionite-Ca
faujasite (series name)
(Na, Ca _0.5 , Mg _0.5 , K) _x [Al _x Si _12-x O ₂₄ ] · 16H ₂ O, equiaxed system.
faujasite-Na
faujasite-Ca
faujasite-Mg

Ferrierite (series name)
(K, Na, Mg _0.5 , Ca _0.5 ) ₆ [Al ₆ Si ₃₀ O ₇₂ ] · 18H ₂ O, orthorhombic and monoclinic.
Ferrierite-Mg
Califerierite (ferrierite-K)
Soda ferrierite (ferrierite-Na)
Garronite
NaCa _2.5 [Al ₆ Si ₁₀ O ₃₂ ], 14H ₂ O, tetragonal and orthorhombic.
gaultite
Na ₄ [Zn ₂ Si ₇ O ₁₈ ] ・ 5H ₂ O, orthorhombic.
Gismondine
Ca [Al ₂ Si ₂ O ₈ ] · 4.5H ₂ O, monoclinic system.

Gmelinite (series name)
(Na ₂ , Ca, K ₂ ) ₄ [Al ₈ Si ₁₆ O ₄₈ ] · 22H ₂ O, hexagonal system.
Soda gmelinite (gmelinite-Na)
Ash gmelinite-Ca
Caligmelinite (gmelinite-K)
Gobbinsite
Na ₅ [Al ₅ Si ₁₁ O ₃₂ ] · 12H ₂ O, orthorhombic.
Gonnardite
(Na, Ca) _6-8 [(Al, Si) ₂₀ O ₄₀ ] .12H ₂ O, tetragonal system.
goosecreekite
Ca [Al ₂ Si ₆ O ₁₆ ] · 5H ₂ O, monoclinic system.
gottardiite
Na ₃ Mg ₃ Ca ₅ [Al ₁₉ Si ₁₁₇ O ₂₇₂ ] / 93H ₂ O, orthorhombic.
Heavy soil zeolitic (harmotome)
(Ba _0.5 , Ca _0.5 , K, Na) ₅ [Al ₅ Si ₁₁ O ₃₂ ] · 12H ₂ O, monoclinic system.

Heulandite (series name)
(Ca _0.5 , Sr _0.5 , Ba _0.5 , Mg _0.5 , Na, K) ₉ [Al ₉ Si ₂₇ O ₇₂ ] · -24H ₂ O, monoclinic system.
Heulandite-Ca
Strontium pyroxenite (heulandite-Sr)
Soda pyrolite (heulandite-Na)
Potassium pyroxenite (heulandite-K)
hsianghualite
Li ₂ Ca ₃ [Be ₃ Si ₃ O ₁₂ ] F ₂ , equiaxed system.
kalborsite
K ₆ [Al ₄ Si ₆ O ₂₀ ] B (OH) ₄ Cl, tetragonal system.

Laumontite
Ca ₄ [Al ₈ Si ₁₆ O ₄₈ ] • 18H ₂ O, monoclinic system.
Leucite
K [AlSi ₂ O ₆ ], tetragonal system.
Levyne (series name)
(Ca _0.5 , Na, K) ₆ [Al ₆ Si ₁₂ O ₃₆ ] · ˜17H ₂ O, trigonal system.
Asylite (levyne-Ca)
Sodalevite (levyne-Na)

lovdarite
K ₄ Na ₁₂ [Be ₈ Si ₂₈ O ₇₂ ] ・ 18H ₂ O, orthorhombic system.
maricopaite
(Pb ₇ Ca ₂ ) [Al ₁₂ Si ₃₆ (O, OH) ₁₀₀ ] · n (H ₂ O, OH), n to 32, orthorhombic system.
mazzite
(Mg _2.5 K ₂ Ca _1.5 ) [Al ₁₀ Si ₂₆ O ₇₂ ] · 30H ₂ O, hexagonal system.
merlinoite
K ₅ Ca ₂ [Al ₉ Si ₂₃ O ₆₄ ] · 22H ₂ O, orthorhombic.
Mesolite
Na ₁₆ Ca ₁₆ [Al ₄₈ Si ₇₂ O ₂₄₀ ] · 64H ₂ O, orthorhombic system.
montesommaite
K ₉ [Al ₉ Si ₂₃ O ₆₄ ] · 10H ₂ O, orthorhombic system.
mordenite
(Na ₂ , Ca, K ₂ ) ₄ [Al ₈ Si ₄₀ O ₉₆ ] · 28H ₂ O, orthorhombic system.

mutinaite
Na ₃ Ca ₄ [Al ₁₁ Si ₈₅ O ₁₉₂ ] / 60H ₂ O, orthorhombic.
Sodaite (natrolite)
Na ₂ [Al ₂ Si ₃ O ₁₀ ] · 2H ₂ O, orthorhombic.
offretite
CaKMg [Al ₅ Si ₁₃ O ₃₆ ] · 16H ₂ O, hexagonal system.
pahasapaite
(Ca _5.5 Li _3.6 K _1.2 Na _0.2 ) Li ₈ [Be ₂₄ P ₂₄ O ₉₆ ] · 38H ₂ O, equiaxed system.
partheite
Ca ₂ [Al ₄ Si ₄ O ₁₅ (OH) ₂ ] · 4H ₂ O, monoclinic system.
paulingite (series name)
(K, Ca _0.5 , Na, Ba _0.5 ) ₁₀ [Al ₁₀ Si ₃₂ O ₈₄ ] / 27-44H ₂ O, equiaxed system.
paulingite-K
paulingite-Ca

perlialite
K ₉ Na (Ca, Sr) [Al ₁₂ Si ₂₄ O ₇₂ ] .15H ₂ O, hexagonal system.
Phillipsite (series name)
(K, Na, Ca _0.5 , Ba _0.5 ) _x [Al _x Si _16-x O ₃₂ ] · 12H ₂ O, monoclinic system.
Soda zeolitic (phillipsite-Na)
Potash cross-stone (phillipsite-K)
Ashesite (phillipsite-Ca)
Pollucite
(Cs, Na) [AlSi ₂ O ₆ ] · nH ₂ O, where (Cs + n) = 1, equiaxed system.

roggianite
Ca ₂ [Be (OH) ₂ Al ₂ Si ₄ O ₁₃ ] ・ <2.5H ₂ O, tetragonal system.
Scolecite
Ca [Al ₂ Si ₃ O ₁₀ ] · 3H ₂ O, monoclinic system.
Stellarite
Ca [Al ₂ Si ₇ O ₁₈ ] · 7H ₂ O, orthorhombic.
Stilbite (series name)
(Ca _0.5 , Na, K) ₉ [Al ₉ Si ₂₇ O ₇₂ ] · 28H ₂ O, monoclinic system.
Stilbite-Ca
Soda bite (stilbite-Na)

terranovaite
NaCa [Al ₃ Si ₁₇ O ₄₀ ],> 7H ₂ O, orthorhombic.
Thomsonite
Ca ₂ Na [Al ₅ Si ₅ O ₂₀ ] · 6H ₂ O, orthorhombic system.
tschernichite
Ca [Al ₂ Si ₆ O ₁₆ ] · ~ 8H ₂ O, tetragonal system.
tschortnerite
_{Ca 4 (K 2, Ca,} Sr, Ba) 3 Cu 3 (OH) 8 [Al 12 Si 12 O 48] · nH 2 O, n~20, isometric system.
Wairakite
Ca [Al ₂ Si ₄ O ₁₂ ] · 2H ₂ O, monoclinic and tetragonal.
weinebeneite
Ca [Be ₃ (PO ₄ ) ₂ (OH) ₂ ] · 4H ₂ O, monoclinic system.
willhendersonite
K _x Ca _(1.5-0.5x) [Al ₃ Si ₃ O ₁₂ ] ・ 5H ₂ O, where 0 <x <1, triclinic system.
Yugawaraite
Ca [Al ₂ Si ₆ O ₁₆ ] ・ 4H ₂ O, monoclinic and triclinic.

Zeolite used in Examples of the present invention is Izukalite 63 (Table 3) manufactured by Izuka Co., Ltd. and Sun Zeolite SS manufactured by Sun Zeolite Industry, but is not particularly limited. Suitable zeolite crystals include clinoptilolite (Table 5) [clinoptilolite (series name) (Na, K, Ca _0.5 , Sr _0.5 , Ba _0.5 , Mg _0.5 ) ₆ [Al ₆ Si ₃₀ O ₇₂ ]-20H ₂ O, monoclinic, potash clinoptilolite (clinoptilolite-K), soda clinoptilolite (clinoptilolite-Na), clinoptilolite (clinoptilolite-Ca)] and mordenite [(Ca, Na ₂ , K ₂ ) Al ₂ Si ₁₀ O ₂₄ · 7H ₂ O]. The zeolite used is preferably natural. The purity of the zeolite is about 70% or more, more preferably about 80% or more, and more preferably about 90% or more. Zeolite is used after being pulverized and refined, and those having a particle size of 300 μm or less, preferably 200 μm or less, and more preferably 100 μm or less are used. The chlorine replacement capacity is 120 meq / 100 g or more, more preferably 130 meq / 100 g or more, and generally 120 to 180 meq / 100 g. The pH is more preferably 6.5-8, more preferably 6-9.

In the present invention, sericite is also called sericite and is a fine grain of muscovite, a layered silicate mineral, and is a kind of clay mineral.
The chemical composition is KAl ₂ AlSi ₃ O ₁₀ (OH) _2, which is the same as muscovite, and is monoclinic. Large-scale sericite deposits are often formed by hydrothermal alteration of acidic or neutral volcanic rocks, and are produced as silky or powdery masses. Mainly, feldspar is altered and iron, magnesium, calcium, etc. are leached. In Japan, various mines mined sericite during the post-war reconstruction period, but the mining is still ongoing in the Toshiro Mine in Kitasakura-gun, Aichi Prefecture and Kamijima Town, Izumo City, Shimane Prefecture. There is only one Nabeyama mine. In the Bandai Mine, Sanshin Mining Co., Ltd. sells purified sericite under the product name “Sanshin Mica”, which is mainly used as a raw material for cosmetics and chemicals due to its high purity and low impurities. . The Nabeyama Mine is sold under the trade name “Yodogawa Mica Z20” by Yodogawa Sangyo Co., Ltd. and is used in a wide range of applications from industrial raw materials to cosmetic raw materials. In general, it is used as a foundation for cosmetics or as a ceramic material. Also used as a heat-resistant lubricant. The finely pulverized product is also used as a reinforcing material such as plastic.

  The sericite used in the examples of the present invention is preferably exemplified by Yodogawa Mika Z20 (Table 4) from Yodogawa Industries, and other companies include Sanshin Mining Co., Ltd., Sanshin Mica FSE, and Sanshin Mica FSN. Sericite having a particle size of 50 μm or less, preferably 30 μm or less, and more preferably 10 μm or less is preferably used. Natural products are preferred. The pH is generally 4 to 9.5.

  The composition of zeolite and sericite of the present invention can be used as an external or oral preparation. The blending ratio is generally about 10 to about 90% by weight: about 90 to about 10% by weight. The term “substantially” means that even if it is slightly deviated from this range, the composition can be increased or decreased by several percent depending on the consideration of the counter effect, and means a uniform width. The same applies hereinafter. The total amount of zeolite and sericite is approximately 50% by weight or more in the composition. As other compounding agents, emulsifiers, excipients, stabilizers, water, oil components and the like can be selected from known components according to the purpose. In the case of the composition for external use, the blend of zeolite and sericite is about 10: about 90 to about 50: about 50, and sericite is an essential main component. In the case of an oral composition, the composition of zeolite and sericite is approximately 90: approximately 10 to approximately 50: approximately 50, and zeolite is an essential main component.

The composition for external use includes external medicines, quasi-drugs for external use, cosmetics and the like. The dosage form is not limited, and examples thereof include spray preparations, kneaded preparations, solutions, suspensions, creams, aerosols, ointments, liniments, and suppositories.

  One embodiment of the composition for external use of the present invention is prepared by mixing a mixture of zeolite and sericite with water. The mixing ratio with water is related to the hardness and use of the preparation, but is generally mixed powder: water = 100: 30 to 100: 300. From the viewpoint of ease of use and effect as an external preparation, particularly in the case of a kneaded preparation, the mixing ratio with water is preferably a mixed powder: water = 100: 40 to 100: 80, preferably 100: 50 to 100: 75, more preferably 100: 60 to 100: 75, and even more preferably 100: 65 to 100: 70. The water is preferably neutral. For emulsification, water may contain an oil and fat component, a surfactant and the like, and the other components in water are preferably about 30% by weight or less. If it is contained more than this, the effect on the skin will be reduced, for example, the affinity with the skin and the functions inherent to zeolite and sericite are inhibited by oil components and organic chemicals.

  The composition for external use of the present invention can be used, for example, by applying a kneaded preparation or a paste preparation which is a mixed preparation with water or the like as it is. Moreover, what coated the composition for external use on the surface, such as paper, a fibrous material, a nonwoven fabric, absorbent cotton, or a film, can also be used. When a kneaded preparation is applied, it is preferable to take measures to prevent moisture from evaporating in order to prevent the preparation from drying. However, this does not mean that the dried composition is ineffective. Of course, the kneaded preparation may be filled in a closed container such as a tube, taken out from the container at the time of use, and applied to the surface of paper, fiber, fibrous substance, nonwoven fabric, absorbent cotton or film. In the composition for external use of the present invention, a mixed preparation with water or the like may be used as a liquid preparation with a relatively high proportion of water, or as a spray. Further, the composition for external use of the present invention may be in a dosage form in which the mixed powder is sprayed as it is. When spraying, the object needs to be previously moistened with water or the like, or the powder can be spray-applied to the object as it is in a state where body fluid is sufficiently leaked, such as a wound. Furthermore, the composition for external use of the present invention may be formulated into a liquid / kneaded preparation used for various skins, hairs, etc., or a preparation that can be mixed at the time of use.

Examples of the oral composition of the present invention include capsule preparations, powders, tablets, suspensions, granules and the like. Capsules can be formulated by including mixed powders in capsules, and of course, excipients may be used. As a powder, a mixed powder of zeolite and sericite can be formulated as it is, and as a suspension, a suspension preparation that can be orally prepared can be prepared by a preparation with a relatively large proportion of water. In the case of oral ingestion, the powder may be ingested with water, ingested with other foods, or the powder of the preparation of the present invention can be added to a known sprinkling ingredient. .
The oral composition of the present invention can be used as a food additive or a feed additive. For example, powder additives and kneaded additives that can be easily added to foods and feeds are included.

  The composition of zeolite and sericite of the present invention was confirmed to have a synergistic effect effective for the following uses. For external application, burn skin disease, itching / sagging / pain of skin due to eczema, atopic dermatitis, cuts, scratches, nail baldness, inflammatory disease, sunburn inflammation measures, flesh, muscle pain, bruise, bruise, sprain Suitable examples include icing substitute, athlete's foot, urticaria, bronchitis, asthma, stomatitis, periodontal disease, and cancer pain. These are used by applying a powder or a kneaded product as it is or by applying it to a sheet or a table and applying it to an affected area. The effect is demonstrated in 30 minutes to 1 hour, but the burns and soreness that heals are cured in a few minutes, and the itchiness of the skin disappears in a few minutes. It will disappear. In this way, pain, itching, heat, etc. due to direct perception have immediate effects. For mild cases, there are cases where itching and pain disappeared after tens of seconds to one minute after application. It may be changed once to several times a day depending on the thirst of the preparation. However, the effect is not lost because it dries. Complete cure in a few days.

  Preferred examples of oral application include bronchitis, asthma, gastric ulcer, duodenal ulcer, gastritis, stomatitis, chronic gastritis, periodontal disease, chronic liver disease, elimination of fatigue fatigue, hay fever, halitosis, cancer and the like. These are taken with the powder as it is or in combination with other foods. However, for stomatitis, periodontal disease, gum bleeding, etc., the paste-like preparation is applied directly to the affected area. Or include the suspension in the mouth. The effect is exhibited in 30 minutes to 1 hour, but it may be taken once to several times a day. Many cure completely in a few days to around 10 days.

The present invention also relates to a pharmaceutical, a quasi-drug, a cosmetic or a hygiene product prepared by applying, blending or absorbing the above-described zeolite and sericite composition.
Quasi-drugs include mouth fresheners, hair restorers, hair removers, hair dyes, sanitary treatments, cleansing cotton, stomachic medicines, oral and throat medicines, bactericides / disinfectants, skin reptiles and soups, etc. .
Cosmetics include shampoos, rinses, lotions, creams, shaving agents, sunscreens, medicated soaps, and the like.
Hygiene products include diapers, toilet paper, tissues, pads, athlete's foot pads, wound pads, earpick swabs, beauty supplies, sheets, pillowcases, and the like.
If a product is prepared by previously applying, blending or absorbing the composition of the present invention, a product suitable for skin-friendly skin diseases can be provided. Of course, it is also possible to provide a product suitable for skin that is effective for rough skin, skin troubles, etc. as beauty products such as cosmetics and packs.

  The composition of zeolite and sericite of the present invention may be blended in advance with other various drugs to form an external composition, or a composition for preparation at the time of use. For example, it can be a compounding agent with a liquid preparation for skin / hair treatment or a kneaded preparation, or a compounding agent at the time of use. For example, blending with a hair dye, a perm solution, and a shaving agent is included, and a composition of about 2 to 10% by weight of zeolite and sericite is blended with respect to the hair dye, the perm solution, or the shaving agent. The For the blending, a pre-blended preparation may be prepared, but it may be used as a combination preparation (kit preparation). After blending into hair dye, perm solution, shaving agent, etc., after hair dyeing, perm, shaving, etc. is completed, it is safe to dye hair without itching, rough skin, soreness, pain, and allergic symptoms.・ Perm and shave.

  The present invention will be described below with reference to examples and experimental examples. The examples of the present invention are illustrated below, and the essence of the present invention is that the combined use of zeolite and sericite exerts a synergistic effect on various diseases. As long as it is this essence, everything is within the scope of the present invention.

Formulation Example 1-1
Same-weight mixture of zeolite (Izuka Co., Ltd., Izukalite 63) with a particle size of 63 μm or less and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mica Z20) with an average particle size of 2 μm and water. (10 g of water is added per 5 g of the mixture to obtain a suspension) to obtain a suspension, and 15 g of Japanese paper (1 mm thick, 80 mm long, 100 mm wide) is immersed in the suspension to fully The mixture was soaked. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-2
75 parts by weight of zeolite (Izuka Co., Ltd., Izucalite 63) with a particle size of 63 μm or less and sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle size of 20 μm and an average particle size of 2 μm Part of the mixture and water were mixed (10 g of water was added per 5 g of the mixture to obtain a suspension) to obtain a suspension, and 15 g of Japanese paper (thickness 1 mm, length 80 mm, width 100 mm) was immersed in the suspension. Let the Japanese paper soak into the mixture. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-3
75 parts by weight of zeolite having a particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) and sericite having a maximum particle size of 20 μm and an average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica Z20) 25 parts by weight Mix the mixture and water (add 10 g of water per 5 g of the mixture to obtain a suspension) to obtain a suspension, and immerse 15 g of Japanese paper (thickness 1 mm, length 80 mm, width 100 mm) in the suspension. Thoroughly soak the mixture into Japanese paper. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-4
Same-weight mixture of zeolite (Izuka Co., Ltd., Izukalite 250) with a particle size of 250 μm or less and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mica Z20) with an average particle size of 20 μm and an average particle size of 2 μm and water (10 g of water is added per 5 g of the mixture to obtain a suspension) to obtain a suspension, and 15 g of Japanese paper (1 mm thick, 80 mm long, 100 mm wide) is immersed in the suspension to fully The mixture was soaked. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-5
Same weight of zeolite (Sun Zeolite Industry Co., Ltd., Sun Zeolite SS) with particle size of 75μm to 250μm and sericite with maximum particle size of 20μm and average particle size of 2μm (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) Mix the mixture and water (add 10 g of water per 5 g of mixture to obtain a suspension) to obtain a suspension, and immerse 15 g of Japanese paper (thickness 1 mm, length 80 mm, width 100 mm) into the suspension. The mixture was soaked in Japanese paper. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-6
Mixing a mixture of the same weight of zeolite (Izuka Co., Ltd., Izukalite 63) with a particle size of 63 μm or less and sericite (Sanshin Mining Co., Ltd., Sanshin Mika FSE) with an average particle size of 10 μm and water (mixture) Add 10 g of water per 5 g to obtain a suspension) to obtain a suspension, and immerse 15 g of Japanese paper (thickness 1 mm, length 80 mm, width 100 mm) into the suspension, and thoroughly soak the mixture into the Japanese paper I didn't. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-7
Mixing the same weight mixture of high-purity zeolite (Table 5) with an average particle size of 20 μm and sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle size of 20 μm and an average particle size of 2 μm and water (mixture) Add 10 g of water per 5 g to obtain a suspension) to obtain a suspension, and immerse 15 g of Japanese paper (thickness 1 mm, length 80 mm, width 100 mm) into the suspension, and thoroughly soak the mixture into the Japanese paper I didn't. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-8
A mixture of 25 parts by weight of high-purity zeolite (Table 5) with an average particle size of 20 μm and 75 parts by weight of sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle size of 20 μm and an average particle size of 2 μm; Mix water (add 10 g of water per 5 g of mixture to obtain a suspension) to obtain a suspension, and immerse 15 g of Japanese paper (thickness 1 mm, length 80 mm, width 100 mm) into the suspension. Soaked the mixture. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-9
A mixture of 75 parts by weight of high-purity zeolite (Table 5) with an average particle size of 20 μm and 25 parts by weight of sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with an average particle size of 20 μm and an average particle size of 2 μm and water (10 g of water is added per 5 g of the mixture to obtain a suspension) to obtain a suspension, and 15 g of Japanese paper (1 mm thick, 80 mm long, 100 mm wide) is immersed in the suspension to fully The mixture was soaked. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-10
A mixture of 40 parts by weight of high-purity zeolite (Table 5) with an average particle size of 20 μm and 60 parts by weight of sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with an average particle size of 20 μm and an average particle size of 2 μm and water (10 g of water is added per 5 g of the mixture to obtain a suspension) to obtain a suspension, and 15 g of Japanese paper (1 mm thick, 80 mm long, 100 mm wide) is immersed in the suspension to fully The mixture was soaked. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-11
Mix the same-weight mixture of high-purity zeolite (Table 5) with an average particle size of 20μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mica FSE) with an average particle size of 10μm (water per 5g of the mixture) 10 g was added to obtain a suspension, and a suspension was obtained. 15 g of Japanese paper (thickness 1 mm, length 80 mm, width 100 mm) was immersed in the suspension, and the mixture was sufficiently impregnated into the Japanese paper. Thereafter, the Japanese paper was dried to prepare an external preparation. As a control, an external preparation was prepared using the same amount of each single item instead of the mixture.

Formulation Example 1-12
Mix the same-weight mixture of high-purity zeolite (Table 5) with an average particle size of 20μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mica FSE) with an average particle size of 10μm (water per 5g of the mixture) 10 g was added to obtain a suspension) to obtain a suspension, and 4 g of the suspension and the following Brone (registered trademark) products (one agent and two agents) were prepared as a hair dye for mixing at the time of use. :
1 agent 40g Ingredients: Paraaminophenol, metaaminophenol, toluene-2,5-diamine, resorcin, paraaminoorcresol, purified water, stearyl alcohol, PG, monoethanolamine, polyoxyethylene cetyl ether, dimethyldiallylammonium chloride / acrylamide Copolymer liquid, strong ammonia water, methylpolysiloxane, liquid paraffin, dimethyldiallylammonium chloride / acrylic acid copolymer liquid, behenyl alcohol, oleyl alcohol, polydimethylmethylenepiperidinium chloride liquid, highly polymerized methylpolysiloxane (1 ) Stearyltrimethylammonium chloride, aminoethylaminopropyl / methylpolysiloxane copolymer, fragrance, anhydrous sodium sulfite, ascorbic acid, ammonium bicarbonate, dialkyl chloride 12-18) Dimethylammonium solution, edetate, isopropanol, long-chain dibasic acid bis-3-methoxypropylamide, chamomile extract (1), seaweed extract (1), royal jelly extract, 1,3-butylene glycol, ethanol , Phosphoric acid 2 parts 40g Ingredients: Hydrogen peroxide water, ice making water, liquid paraffin, behenyl alcohol, concentrated glycerin, concentrated glycerin, polyoxyethylene cetyl ether, stearyl alcohol, alkyltrimethylammonium chloride, trimethylglycine, ethanol, hydroxyethane dibos Phosphonic acid solution, oxyquinoline sulfate (2) sodium hydroxide solution, phosphoric acid Using this mixed preparation, the result of hair dyeing treatment was good with no itching or skin eczema.

Formulation Example 1-13
It was prepared as a mixed preparation at the time of use in the same manner except that Preparation Example 1-12 and 8 g of the suspension were used. As a result of using this mixed preparation and performing a hair dyeing treatment, neither itching nor skin eczema occurred, and the result was good.

Formulation Example 1-14
30 parts by weight of high-purity zeolite (Table 5) with an average particle size of 20 μm and 70 parts by weight of sericite (Sanshin Mining Co., Ltd., Sanshin Mica FSE) with an average particle size of 10 μm are mixed with water ( 10 g of water is added per 5 g of the mixture to obtain a suspension. A suspension is obtained, and 6 g of the suspension and the following Shero (registered trademark) products (one agent and two agents) are mixed at the time of use. Prepared as an agent:
1 agent 60g Ingredients: 5 monoaminoorthocresol, paraaminophenol, paraphenylenediamine, metaaminophenol, resorcin Other components: HEDTA 3Na solution, PEG-8, PEG (20), POE cetyl ether, aminoethylamino Propylmethyl, siloxane / dimethylsiloxane copolymer, araalkyl alcohol, edetate, olive oil, xylitol, diethylenetriamine pentaacetic acid 5Na solution, water-soluble collagen solution 1, stearyl alcohol, cetearyl alcohol, taurine, Evening primrose oil, theanine, phytosterol, grape seed oil, behenyl alcohol, polydimethylmethylenepiperidinium solution, beeswax, anhydrous zinc acid, monoethanolamine, petrolatum, Ph regulator, yellow 203
2 agents 60g Active ingredient: Hydrogen peroxide water Other ingredients: PG, POE (20) POP (4) Cetyl ether, POE cetyl ether, isostearyl alcohol, citric acid, steartrimonium chloride, cetanol, phenoxyethanol The result of the hair dyeing treatment using the mixed preparation was good with no itching or eczema on the skin.

Formulation Example 1-15
It was prepared as a mixed preparation at the same time except that Preparation Example 1-14 and 12 g of the suspension were used. As a result of using this mixed preparation and performing a hair dyeing treatment, neither itching nor skin eczema occurred, and the result was good.

Formulation Example 2-1
Same-weight mixture of zeolite (Izuka Co., Ltd., Izukalite 63) with a particle size of 63 μm or less and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mica Z20) with an average particle size of 2 μm and water. (5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-2
75 parts by weight of zeolite (Izuka Co., Ltd., Izukalite 63) having a particle size of 63 μm or less and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mika Z20) having a maximum particle size of 20 μm and an average particle size of 2 μm. A mixture of parts by weight and water were mixed (5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded formulation.

Formulation Example 2-3
25 parts by weight of zeolite (Izuka Co., Ltd., Izucalite 63) with a particle size of 63 μm or less and sericite with a maximum particle size of 20 μm and an average particle size of 2 μm (Yodogawa Industries Co., Ltd., Yodogawa Mica Z20) A mixture of parts by weight and water were mixed (5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded formulation.

Formulation Example 2-4
A mixture of the same weight of zeolite (San Zeolite Industry Co., Ltd., Sun Zeolite SS) with a particle size of 75 μm to 250 μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mika FSE) with an average particle size of 10 μm and water. Mixing (adding 5 g of water per 5 g of the mixture to obtain a kneaded product) gave a kneaded preparation.

Formulation Example 2-5
Mixing the same weight mixture of high-purity zeolite (Table 5) with an average particle size of 20 μm and sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle size of 20 μm and an average particle size of 2 μm and water (mixture) 5 g of water was added per 5 g to obtain a kneaded product, and a kneaded preparation was obtained.

Formulation Example 2-6
A mixture of 25 parts by weight of high-purity zeolite having an average particle size of 20 μm (Table 5) and 75 parts by weight of sericite having a maximum particle size of 20 μm and an average particle size of 2 μm (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20). And water were mixed (5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-7
A mixture of 75 parts by weight of high-purity zeolite (Table 5) with an average particle diameter of 20 μm and 25 parts by weight of sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle diameter of 20 μm and an average particle diameter of 2 μm. And water were mixed (5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-8
Mix the same-weight mixture of high-purity zeolite (Table 5) with an average particle size of 20μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mica FSE) with an average particle size of 10μm (water per 5g of the mixture) 5 g was added to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-9
Same-weight mixture of zeolite (Izuka Co., Ltd., Izukalite 63) with a particle size of 63 μm or less and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mica Z20) with an average particle size of 2 μm and water. Were mixed (1.5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-10
75 parts by weight of zeolite (Izuka Co., Ltd., Izukalite 63) having a particle size of 63 μm or less and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mika Z20) having a maximum particle size of 20 μm and an average particle size of 2 μm. A mixture of parts by weight and water were mixed (2.5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded formulation.

Formulation Example 2-11
25 parts by weight of zeolite (Izuka Co., Ltd., Izucalite 63) with a particle size of 63 μm or less and sericite with a maximum particle size of 20 μm and an average particle size of 2 μm (Yodogawa Industries Co., Ltd., Yodogawa Mica Z20) A mixture of a part by weight and water were mixed (1.5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded formulation.

Formulation Example 2-12
A mixture of the same weight of zeolite (San Zeolite Industry Co., Ltd., Sun Zeolite SS) with a particle size of 75 μm to 250 μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mika FSE) with an average particle size of 10 μm and water. Mixing (adding 2 g of water per 5 g of the mixture to obtain a kneaded product) gave a kneaded preparation.

Formulation Example 2-13
Mixing the same weight mixture of high-purity zeolite (Table 5) with an average particle size of 20 μm and sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle size of 20 μm and an average particle size of 2 μm and water (mixture) 2 g of water was added per 5 g to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-14
A mixture of 25 parts by weight of high-purity zeolite having an average particle size of 20 μm (Table 5) and 75 parts by weight of sericite having a maximum particle size of 20 μm and an average particle size of 2 μm (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20). And water were mixed (3 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-15
A mixture of 75 parts by weight of high-purity zeolite (Table 5) with an average particle diameter of 20 μm and 25 parts by weight of sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle diameter of 20 μm and an average particle diameter of 2 μm. And water were mixed (2.5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-16
Mix the same-weight mixture of high-purity zeolite (Table 5) with an average particle size of 20μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mica FSE) with an average particle size of 10μm (water per 5g of the mixture) 2.5 g was added to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-17
Same-weight mixture of zeolite (Izuka Co., Ltd., Izukalite 63) with a particle size of 63 μm or less and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mica Z20) with an average particle size of 2 μm and water. (3 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-18
75 parts by weight of zeolite (Izuka Co., Ltd., Izukalite 63) having a particle size of 63 μm or less and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mika Z20) having a maximum particle size of 20 μm and an average particle size of 2 μm. A mixture of parts by weight and water were mixed (3.5 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-19
25 parts by weight of zeolite (Izuka Co., Ltd., Izucalite 63) with a particle size of 63 μm or less and sericite with a maximum particle size of 20 μm and an average particle size of 2 μm (Yodogawa Industries Co., Ltd., Yodogawa Mica Z20) A mixture of a part by weight and water were mixed (3 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded formulation.

Formulation Example 2-20
A mixture of the same weight of zeolite (San Zeolite Industry Co., Ltd., Sun Zeolite SS) with a particle size of 75 μm to 250 μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mika FSE) with an average particle size of 10 μm and water. Mixing (adding 3.5 g of water per 5 g of the mixture to obtain a kneaded product) gave a kneaded preparation.

Formulation Example 2-21
Mixing the same weight mixture of high-purity zeolite (Table 5) with an average particle size of 20 μm and sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle size of 20 μm and an average particle size of 2 μm and water (mixture) 3 g of water was added per 5 g to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-22
A mixture of 25 parts by weight of high-purity zeolite having an average particle size of 20 μm (Table 5) and 75 parts by weight of sericite having a maximum particle size of 20 μm and an average particle size of 2 μm (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20). And water were mixed (3.1 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-23
A mixture of 75 parts by weight of high-purity zeolite (Table 5) with an average particle diameter of 20 μm and 25 parts by weight of sericite (Yodogawa Mika Co., Ltd., Yodogawa Mica Z20) with a maximum particle diameter of 20 μm and an average particle diameter of 2 μm. And water were mixed (3.3 g of water was added per 5 g of the mixture to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-24
Mix the same-weight mixture of high-purity zeolite (Table 5) with an average particle size of 20μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mica FSE) with an average particle size of 10μm (water per 5g of the mixture) 3.4 g was added to obtain a kneaded product) to obtain a kneaded preparation.

Formulation Example 2-25
30 parts by weight of high-purity zeolite (Table 5) with an average particle size of 20 μm and 70 parts by weight of sericite (Sanshin Mining Co., Ltd., Sanshin Mica FSE) with an average particle size of 10 μm are mixed with water ( 7 g of water is added per 10 g of the mixture to obtain a kneaded product) to obtain a kneaded product, and 4 g of the kneaded product and the following Brone (registered trademark) products (one agent and two agents) are mixed at the time of use Prepared as an agent:
1 agent 40g Ingredients: Paraaminophenol, metaaminophenol, toluene-2,5-diamine, resorcin, paraaminoorcresol, purified water, stearyl alcohol, PG, monoethanolamine, polyoxyethylene cetyl ether, dimethyldiallylammonium chloride / acrylamide Copolymer liquid, strong ammonia water, methylpolysiloxane, liquid paraffin, dimethyldiallylammonium chloride / acrylic acid copolymer liquid, behenyl alcohol, oleyl alcohol, polydimethylmethylenepiperidinium chloride liquid, highly polymerized methylpolysiloxane (1 ) Stearyltrimethylammonium chloride, aminoethylaminopropyl / methylpolysiloxane copolymer, fragrance, anhydrous sodium sulfite, ascorbic acid, ammonium bicarbonate, dialkyl chloride 12-18) Dimethylammonium solution, edetate, isopropanol, long-chain dibasic acid bis-3-methoxypropylamide, chamomile extract (1), seaweed extract (1), royal jelly extract, 1,3-butylene glycol, ethanol , Phosphoric acid 2 parts 40g Ingredients: Hydrogen peroxide water, ice making water, liquid paraffin, behenyl alcohol, concentrated glycerin, concentrated glycerin, polyoxyethylene cetyl ether, stearyl alcohol, alkyltrimethylammonium chloride, trimethylglycine, ethanol, hydroxyethane dibos Phosphonic acid solution, oxyquinoline sulfate (2) sodium hydroxide solution, phosphoric acid Using this mixed preparation, the result of hair dyeing treatment by a usual method was good with no itching or skin eczema.

Formulation Example 2-26
Formulation Example 2-25 was prepared in the same manner except that 8 g of the kneaded product was used, and prepared as a mixed preparation at the time of use. Using this mixed preparation, the result of hair dyeing treatment by a usual method was also good with no itching or eczema on the skin.

Formulation Example 2-27
Mix the same-weight mixture of high-purity zeolite (Table 5) with an average particle size of 20 μm and sericite (Sanshin Mining Co., Ltd., Sanshin Mica FSE) with an average particle size of 10 μm (water per 10 g of the mixture) 7 g was added to obtain a kneaded product, and a kneaded product was obtained, and 6 g of the kneaded product and the following Cello (registered trademark) products (one agent and two agents) were prepared as a mixed hair dye at the time of use:
1 agent 60g Active ingredient: 5 mono-aminoorthocresol, paraaminophenol, paraphenylenediamine, metaaminophenol, resorcin Other ingredients: HEDTA 3Na solution, PEG-8, PEG (20), POE cetyl ether, aminoethyla Minopropylmethyl, siloxane-dimethylsiloxane copolymer, araalkyl alcohol, edetate, olive oil, xylitol, diethylenetriamine pentaacetic acid 5Na solution, aqueous collagen solution 1, stearyl alcohol, cetearyl alcohol, taurine , Evening primrose oil, theanine, phytosterol, grape seed oil, behenyl alcohol, polydimethylmethylenepiperidinium solution, beeswax, sodium zinc anhydride, monoethanolamine, petrolatum, Ph adjuster, yellow 203
2 agents 60g Active ingredient: Hydrogen peroxide water Other ingredients: PG, POE (20) POP (4) Cetyl ether, POE cetyl ether, isostearyl alcohol, citric acid, steartrimonium chloride, cetanol, phenoxyethanol The results of using a mixed preparation and dyeing the hair by the usual method were good with no itching or eczema on the skin.

Formulation Example 2-28
Formulation Example 2-27 was prepared in the same manner as in Example 12 except that 12 g of the suspension was used. Using this mixed preparation, the result of hair dyeing treatment by a usual method was also good with no itching or eczema on the skin.

Formulation Example 3
Each kneaded product obtained in Formulation Examples 2-1 to 2-24 was applied to a non-woven fabric of 80 mm × 100 mm to a thickness of 0.5 mm, and cellophane was stacked from above to prepare each external preparation to prevent drying. did.

Formulation Example 4
Zeolite with particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high purity zeolite (Table 5) and sericite with maximum particle size of 20 μm and average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica) The same weight mixture of Z20) was sufficiently stirred to prepare a powder formulation. Moreover, zeolite: sericite = 25: 75 weight mixture and 75:25 weight mixture were obtained, and each powder formulation was prepared.

Formulation Example 5
Zeolite with particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high purity zeolite (Table 5) and sericite with maximum particle size of 20 μm and average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica) A mixture of the same weight of Z20) and water were mixed (30 g of water was added per 20 g of the mixture to obtain a suspension) to obtain a suspension. The suspension was mixed during the paper manufacturing process, after which the paper was dried and prepared to prepare toilet paper. Similarly, tissues, paper sanitary products, and paper diapers were prepared. Each product was prepared in the same manner using zeolite: sericite = 25: 75 weight mixture and 75:25 weight mixture.

Formulation Example 6
Zeolite with particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high purity zeolite (Table 5) and sericite with maximum particle size of 20 μm and average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica) Mix the same weight mixture of Z20) and water (add 30 g of water per 20 g of mixture to obtain a suspension) to obtain a suspension, and 1 cm square of fabric product (sanitary products, absorbent cotton, gauze, non-woven fabric, diaper) A 0.5 cc suspension per spray was prepared by spraying. Each product was prepared in the same manner using zeolite: sericite = 25: 75 weight mixture and 75:25 weight mixture.

Formulation Example 7
Zeolite with particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high purity zeolite (Table 5) and sericite with maximum particle size of 20 μm and average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica) A No. 3 capsule was filled with 50 mg of the same weight mixture of Z20) to obtain a capsule preparation. Further, each capsule preparation was prepared using zeolite: sericite = 25: 75 weight mixture and 75:25 weight mixture in the same manner.

Formulation Example 8
Zeolite with particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high purity zeolite (Table 5) and sericite with maximum particle size of 20 μm and average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica) A mixture of the same weight of Z20) and water were mixed (100 g of water was added per 50 mg of mixture to obtain a mixed solution) to obtain a mixed solution to prepare an aqueous solution preparation for oral consumption. In addition, zeolite: sericite = 25: 75 weight mixture and 75:25 weight mixture were used in the same manner to prepare aqueous solutions for oral intake.

Formulation Example 9
Zeolite with particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high purity zeolite (Table 5) and sericite with maximum particle size of 20 μm and average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica) A mixture of Z20) having the same weight and the sprinkling component were mixed (50 g of sprinkling component was added per 50 mg of the mixture to obtain a mixture) to obtain a mixture, and a preparation for oral consumption was prepared.

Formulation Example 10
Zeolite with particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high purity zeolite (Table 5) and sericite with maximum particle size of 20 μm and average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica) A mixture of the same weight of Z20) and agar powder were mixed (50 g of agar powder was added per 50 mg of mixture to obtain a mixture) to obtain a mixture, which was dissolved in water and then jellied to prepare a preparation for oral consumption.

Formulation Example 11
Zeolite with particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high purity zeolite (Table 5) and sericite with maximum particle size of 20 μm and average particle size of 2 μm (manufactured by Yodogawa Industries Co., Ltd., Yodogawa Mica) A mixture of the same weight of Z20) and a soap component was mixed (50 g of soap component was added per 10 g of the mixture to obtain a mixture) to obtain a mixture, which was solidified to prepare a soap formulation. In the case of shampoo, 3% by weight was prepared in the shampoo solution. In the case of a bath agent, the mixture and the bath component were mixed at 80:20. As the esthetic preparation, the kneaded preparation of Preparation Example 2 can be used.

Formulation Example 12
For the preparation of food for dogs and cats, zeolite with a particle size of 63 μm or less (Izuka Co., Ltd., Izukalite 63) or high-purity zeolite (Table 5) and sericite with a maximum particle size of 20 μm and an average particle size of 2 μm ( Mix the same weight mixture of Yodogawa Sakai Co., Ltd., Yodogawa Mica Z20) and dog and cat food ingredients (add 200 mg of dog and cat food ingredients per 5 mg of mixture to obtain a mixture) to obtain a mixture, and add water to this Mixing (adding 205 mg of water per 205 mg of mixture to obtain a kneaded product) was semi-dried to obtain a semi-dried product for dogs and cats.

Experimental Example Test Method Test Method A:
Zeolite simple substance, sericite simple substance, and a mixture of the same weight of sericite and zeolite were each dissolved in water, soaked in Japanese paper, dried, and applied to the affected area. Alternatively, a mixture of sericite and zeolite was mixed with an appropriate amount of water, made into a paste, and applied to the affected area. The thickness may be about whether the skin is visible or not visible. Controls were similarly tested using zeolite alone or sericite alone. The test subject is an approved volunteer.
Test method B:
0.5 g of zeolite and 0.5 g of sericite were mixed and filled into 2 capsules of No. 3, and 2 capsules were taken orally once a day. As a control, 3 capsules containing 0.5 g of sericite were orally ingested 2 capsules once a day, and 3 capsules containing 0.5 g of zeolite were orally ingested 2 capsules once a day. The zeolite used was Izukalite 63 (manufactured by Izuka Co., Ltd.) or high-purity zeolite (Table 5), but the effect was substantially the same. High-purity zeolite has less impurities and is more preferable for use in vivo and in vitro. As the sericite, Yodogawa Mica Z20 (manufactured by Yodogawa Industries) was used. The test subject is an approved volunteer.
result:
The results are shown in Tables 1 and 2. The results of combined use, zeolite alone, and sericite alone are shown in order. The symptom section in the table schematically shows the state of the subject before treatment, and the degree of symptom means the severity before treatment of each symptom, and is roughly divided into low, medium and heavy. ◎ in the column of improvement effect after treatment is completely cured from the start of treatment, ○ is slow but it is gradually improved (almost cured but a little symptom or pain remains), x is slightly improved but not cured Showed the case. The numbers mean the number of days from the start of treatment to complete cure. A and B in the column of the test method mean the above test method A and test method B.

  Test Examples 1 to 3 are female volunteers with itching, soreness, and pain in the genital area. The kneaded preparation of Preparation Example 2-1 was applied to the affected area in three places. The effects of zeolite (manufactured by Izuka Co., Ltd., Izukalite 63) or high-purity zeolite (Table 5) were substantially the same. As a result, the mixed preparation part was completely cured in 3 days, while the zeolite single preparation part was slightly improved in 10 days, and the sericite single preparation part was substantially improved in 5 days. Similarly, Test Examples 4 to 6 are female volunteers with itching, soreness, and pain in the genital area. The kneaded preparation of Preparation Example 2-1 was applied to the affected part in three places. As a result, the mixed preparation part was completely cured in 4 days, while the zeolite single preparation part was slightly improved in 9 days, and the sericite single preparation part was substantially improved in 6 days. In Test Examples 7 to 9, the kneaded preparation of Preparation Example 2-1 was applied to the affected area in three places with a male volunteer with a pubic crotch and itching. As a result, the mixed preparation portion was completely cured in 5 days, whereas the zeolite single preparation portion was slightly improved in 14 days, and the sericite single preparation portion was almost improved in 8 days.

Test Example 10 was a male volunteer diagnosed with atopic dermatitis aged 0 to 15 years. The kneaded preparation of Preparation Example 2-1 was applied to the inflamed site. As a result, the mixed preparation was completely cured in 3 to 5 days, whereas the zeolite single preparation was ineffective and the sericite single preparation was ineffective.
Test Examples 11, 12, and 13 were also applied to volunteers diagnosed with atopic dermatitis in the same manner as Test Example 10, and the results were equivalent.
Test Examples 14 to 16 were male volunteers diagnosed with atopic dermatitis and applied the kneaded preparation of Preparation Example 2-1 to the affected area in three places. As a result, the mixed preparation part was completely cured in 7 days, whereas the zeolite single preparation part was ineffective and the sericite single preparation part was ineffective.

Test Examples 17 to 19 are volunteer women with bronchitis, and the paste preparation of Preparation Example 2-1 was applied to the throat and chest. As a result, the mixed preparation was completely cured in one day, while the zeolite single preparation was treated for 10 days from 15 days before the mixed preparation was applied. Although it was treated for a day, the effect was slightly improved.
Test Examples 20 to 22 are asthmatic volunteers who applied the kneaded preparation of Preparation Example 2-1 to the throat and chest. As a result, the mixed preparation was completely cured in one day, whereas the zeolite single preparation was treated for 14 days from 24 days before the mixed preparation was applied. Although it was treated, the effect was a little improved.

  Test Examples 23 and 24 were volunteers diagnosed with meat separation, and the kneaded preparation of Formulation Example 2-1 was applied to the meat separation site. As a result, the mixed preparations were completely cured in an average of 60 minutes, whereas the zeolite single preparation was slightly improved in 2 days, and the sericite single preparation was almost improved in 1 to 2 days.

Skin symptoms become severe when moisture (humidity) and temperature are suitable for bacterial growth. If itching is scratched, the bacteria will propagate further in the wound. Symptoms are not improved if the bacteria grow more strongly than immunity. Zeolite adsorbs toxic chemicals and heavy metals, absorbs moisture and adjusts humidity, suppresses the growth of bacteria, adjusts pH, has the effect of adsorbing viruses, and has a far-red effect. Sericite has a function of protecting the skin, has an appropriate moisturizing effect on the skin, and has a far-red effect. Each single is effective, but zeolite alone cannot be cured completely. However, when the affected area has a lot of moisture, the effect of zeolite is great. Compared to zeolite alone, sericite alone is more effective, but the synergistic effect of the blend of zeolite and sericite is great, and it exhibits a particularly high symptom-improving effect.
The formulation is less practical because it thickens and dries out powder. In addition to formulation example 2-1, the blending ratio of zeolite and sericite was in the range of 10:90 to 50:50, and 10:90 and 25:75 were examined for the effect as an external preparation, but the tendency was almost the same. It was confirmed that sericite is an essential component.

  In addition, the special effect of the composition of the present invention was confirmed for meat separation. In dealing with meat loss, it is said that "RICE", which is the basis for dealing with sports disorders, is the basis for treatment of meat loss. RICE is an acronym for Rest, Cooling, Compression, and Elevation. “Lie down, rest,” “Cooling the affected area,” “Pressing the affected area,” “ This is a first-aid rule that raises the affected area above the heart. Continue to follow RICE treatment for 48 hours after a flesh is released, and if the pain has subsided, use heat therapy to promote recovery. In some cases, anti-inflammatory drugs are used to reduce pain, treat the patient with electrical therapy, or ultrasonic therapy. In any case, however, it takes a considerable amount of time and days to eliminate the fever and pain, and it takes weeks to months to return to the original state. There are also many recurrences of the same part. Here, when the composition comprising the mixture of zeolite and sericite of the present invention is applied to the affected area, the pain and fever depend on the degree, but it can be cured in several minutes to several tens of minutes. Significantly shortened. For athletes, the length of time they can't move is also the time for muscle weakness, and complete cure in a short time is a great merit. In general, there are many injuries such as flesh in the whole body, and in elderly people, there are cases in which the muscles of the back are damaged and pneumonia is caused. The treatment with the composition according to the present invention, not the treatment of RICE, can be easily treated and healed quickly. There is no other means to exert such an effect.

  Test Examples 25 to 27 are volunteers diagnosed with gastric ulcer, and the capsule preparation was taken orally. As a result, the mixed preparation was completely cured in 10 days, whereas the zeolite single preparation was treated for 30 days from 60 days before the mixed preparation treatment, but the degree of improvement was slightly improved, and the sericite single preparation was treated for 30 days from 30 days before the mixed preparation treatment. However, there was a slight improvement. Test Examples 28 to 30 were volunteers diagnosed with duodenal ulcer, and the capsule preparation was taken orally. As a result, the mixed preparation was completely cured in 8 days, whereas the zeolite single preparation was treated for 30 days from 60 days before the mixed preparation treatment, but the degree of improvement was slightly, and the sericite single preparation was treated for 30 days from 30 days before the mixed preparation treatment. However, there was a slight improvement. Test Examples 31 to 33 are volunteers diagnosed with reflux gastritis, and the capsule preparation was taken orally. As a result, the mixed preparation was completely cured in 7 days, while the zeolite single preparation was treated for 35 days from 65 days before the mixed preparation treatment, but the sericite single preparation was treated for 30 days from 30 days before the mixed preparation treatment. It was the effect of improvement.

  Test Examples 35 to 37 are volunteers diagnosed with stomatitis, and the paste preparation of Preparation Example 2-1 was applied to the inflamed area of the mouth. As a result, while the mixed preparation part was completely cured in one day, the zeolite single preparation was treated for 4 days from 7 days before the mixed preparation treatment, but the degree of improvement was slightly improved, and the sericite single preparation was treated for 3 days from 3 days before the mixed preparation treatment. However, the effect was somewhat improved.

Test Examples 38 to 40 are volunteers diagnosed with chronic gastritis, and the capsule preparation was taken orally. As a result, the mixed preparation was completely cured in 2 days, whereas the zeolite single preparation was treated for 7 days from 11 days before the mixed preparation treatment, but the sericite single preparation was treated for 4 days from 4 days before the mixed preparation treatment. It was the effect of improvement.

  Test Examples 41 to 43 are volunteers diagnosed with periodontal disease, and the paste preparation of Preparation Example 2-1 was applied to the periodontitis part and simultaneously the capsule preparation was taken orally. As a result, the mixed preparation was completely cured in one day, whereas the zeolite single preparation was treated for 5 days from 8 days before the mixed preparation treatment, but the degree of improvement was slightly, and the sericite single preparation was treated for 3 days from 3 days before the mixed preparation treatment. However, there was a slight improvement.

  Test Examples 44 to 46 are volunteers diagnosed with chronic liver disease, and the capsule preparation was taken orally. As a result, the mixed preparation was completely cured in 10 days, whereas the zeolite single preparation was treated for 30 days from 60 days before the mixed preparation treatment, but the degree of improvement was slightly improved, and the sericite single preparation was treated for 30 days from 30 days before the mixed preparation treatment. However, there was a slight improvement. Test Example 47 was a male volunteer with fatigue fatigue from 45 to 70 years old, and the capsule preparation was taken orally. As a result, the mixed preparation was completely cured in 1 to 3 days, whereas the zeolite single preparation was treated for 5 to 7 days from 10 to 14 days before the mixed preparation treatment, but the degree of improvement was slightly, and the sericite single preparation was treated with the mixed preparation 5 Although the treatment was carried out for 5 to 7 days from 7 days before, the effect was slightly improved. Test Examples 48 to 50 were volunteers diagnosed with hay fever, and the capsule preparation was taken orally. As a result, the mixed preparation was completely cured in 10 days, whereas the zeolite single preparation was treated for 30 days from 60 days before the mixed preparation treatment, but the degree of improvement was slightly improved, and the sericite single preparation was treated for 30 days from 30 days before the mixed preparation treatment. Was an invalid effect.

  Regarding the oral capsule preparation, the mixing ratio of zeolite and sericite was changed from 90:10 to 50:50, for example 90:10, 75:25, and the effect was examined, but the results were almost the same. It was confirmed that zeolite was an essential main component.

Experimental example 2
From the next day, the kneaded preparation of Formulation Example 2-1 was applied to the volunteers who had become burned by esthetic laser hair removal treatment. The formulation was replaced once a day. A photograph after one week and a photograph before treatment were obtained (FIGS. 1, 2, and 3). The treatment improved the burn clearly.

Experimental example 3
When Oronaine (registered trademark) ointment was applied to the affected area on a volunteer with mild burns and tingling, the tingling pain took on the third day and took 10 days to complete. When the kneaded preparation of Example 2-6 was applied to the affected area to the same level of burn volunteers, the pain of irritation was removed in 1 hour and was completely cured in 3 days.

Experimental Example 4
When a commercially available poultice was applied to the affected part of the volunteer who had left the flesh, the pain did not go away a little, and it took 10 days to recover completely. When the kneaded preparation of Example 2-6 was applied to the affected area at the same level of meat removal volunteers, the pain took within 1 hour and was completely cured in 3 days.

Experimental Example 5
When the paste-like preparation of Example 2-6 was applied from the chest to the side of the abdomen, the pain was removed within 1 hour.

Experimental Example 6
Mix the same weight mixture of high purity zeolite (Table 5) and sericite (Yodogawa Mine Co., Ltd., Yodogawa Mica Z20) with a maximum particle size of 20μm and an average particle size of 2μm (add 100g of water per 50mg of the mixture). Then, a liquid mixture was obtained, and an aqueous solution preparation for oral ingestion was prepared. When this was taken by a volunteer at the end of lung cancer for about 2 months, the lungs became clean and completely cured.

  The medical composition or medical auxiliary composition of the present invention exhibits an unprecedented effect on various skin diseases and the like, and provides a novel composition that is extremely useful as medical, medical auxiliary, and healthy food.

Claims (4)

A composition for the treatment of atopic dermatitis or external treatment aid, comprising zeolite and sericite. A composition for the treatment of burns or external treatment aids, comprising zeolite and sericite. A composition for the treatment of skin itch / eczema by hair dyeing comprising zeolitic and sericite, or an external treatment aid. Treatment or therapeutic auxiliary external composition of itching, sores, pain in the genital-genital crotch formed by blending the zeolite and sericite.