JP5757864B2 - 水溶性アセトアミノフェン類似体 - Google Patents
水溶性アセトアミノフェン類似体 Download PDFInfo
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- JP5757864B2 JP5757864B2 JP2011510691A JP2011510691A JP5757864B2 JP 5757864 B2 JP5757864 B2 JP 5757864B2 JP 2011510691 A JP2011510691 A JP 2011510691A JP 2011510691 A JP2011510691 A JP 2011510691A JP 5757864 B2 JP5757864 B2 JP 5757864B2
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- JP
- Japan
- Prior art keywords
- acetaminophen
- compound
- pharmaceutically acceptable
- composition
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000002360 preparation method Methods 0.000 claims description 14
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 12
- 239000003937 drug carrier Substances 0.000 claims description 11
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 10
- 239000012535 impurity Substances 0.000 claims description 9
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- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims description 8
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- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 5
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- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 4
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- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 4
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- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 claims description 4
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- A61K31/66—Phosphorus compounds
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
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Landscapes
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| BRPI0912326A2 (pt) | 2008-05-20 | 2015-10-06 | Neurogesx Inc | análogos de acetaminofeno hidrossolúveis |
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| WO2012137225A1 (en) * | 2011-04-08 | 2012-10-11 | Sphaera Pharma Pvt. Ltd | Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds |
| CA2849731C (en) | 2011-09-22 | 2020-01-14 | Acorda Therapeutics, Inc. | Acetaminophen conjugates, compositions and methods of use thereof |
| WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| AU2015290098B2 (en) | 2014-07-17 | 2018-11-01 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| CN106715456B (zh) | 2014-08-12 | 2023-08-29 | 莫纳什大学 | 定向淋巴的前药 |
| AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| TWI755257B (zh) | 2014-10-21 | 2022-02-11 | 美商艾伯維有限公司 | 卡比多巴及左旋多巴之前藥及使用方法 |
| CA3013751C (en) * | 2015-03-03 | 2023-08-08 | Kindred Biosciences, Inc. | Compositions and methods for treatment and prevention of pyrexia in horses |
| EP3347340A4 (en) | 2015-09-08 | 2019-01-23 | Monash University | LYMPHENLEITUNGSPRODRUGS |
| US20190224220A1 (en) * | 2016-04-20 | 2019-07-25 | Abbvie Inc. | Carbidopa and L-Dopa Prodrugs and Methods of Use |
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| CA2849731C (en) | 2011-09-22 | 2020-01-14 | Acorda Therapeutics, Inc. | Acetaminophen conjugates, compositions and methods of use thereof |
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- 2009-05-20 CN CN201510381430.7A patent/CN105254662A/zh active Pending
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- 2009-05-20 JP JP2011510691A patent/JP5757864B2/ja not_active Expired - Fee Related
- 2009-05-20 CN CN2009801282182A patent/CN102149672A/zh active Pending
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| Publication number | Publication date |
|---|---|
| US10442826B2 (en) | 2019-10-15 |
| MX2010012648A (es) | 2010-12-14 |
| US20200002364A1 (en) | 2020-01-02 |
| BRPI0912326A2 (pt) | 2015-10-06 |
| CA2724877A1 (en) | 2009-11-26 |
| CN102149672A (zh) | 2011-08-10 |
| JP2018135392A (ja) | 2018-08-30 |
| WO2009143295A1 (en) | 2009-11-26 |
| US9981998B2 (en) | 2018-05-29 |
| CA2724877C (en) | 2016-09-13 |
| US20160264605A1 (en) | 2016-09-15 |
| EP2291348A4 (en) | 2013-05-15 |
| US20190092795A1 (en) | 2019-03-28 |
| US11021498B2 (en) | 2021-06-01 |
| JP2017057217A (ja) | 2017-03-23 |
| JP6063072B2 (ja) | 2017-01-18 |
| JP2014111658A (ja) | 2014-06-19 |
| KR101698028B1 (ko) | 2017-01-26 |
| RU2010151952A (ru) | 2012-06-27 |
| CN105254662A (zh) | 2016-01-20 |
| IL209382A0 (en) | 2011-01-31 |
| EP2291348A1 (en) | 2011-03-09 |
| JP2020114876A (ja) | 2020-07-30 |
| AU2009249067A1 (en) | 2009-11-26 |
| US20110212926A1 (en) | 2011-09-01 |
| KR20110018897A (ko) | 2011-02-24 |
| JP2016084359A (ja) | 2016-05-19 |
| JP2011520977A (ja) | 2011-07-21 |
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