JP5746038B2 - Cnsの炎症性疾患の治療のための化合物および方法 - Google Patents

Cnsの炎症性疾患の治療のための化合物および方法 Download PDF

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JP5746038B2
JP5746038B2 JP2011535539A JP2011535539A JP5746038B2 JP 5746038 B2 JP5746038 B2 JP 5746038B2 JP 2011535539 A JP2011535539 A JP 2011535539A JP 2011535539 A JP2011535539 A JP 2011535539A JP 5746038 B2 JP5746038 B2 JP 5746038B2
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oligonucleotide
cells
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JP2012507308A5 (enExample
JP2012507308A (ja
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バンドホルツ,リサ・シャーロッタ
ギーレン,アレクサンダー
ザルガリ,アレゾウ
ヴォン,ステイン・オリバー
アクセルッソン,ラース−ゴエラン
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インデックス・ファーマシューティカルズ・アクチエボラーグ
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/313—Phosphorodithioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2011535539A 2008-11-04 2009-11-04 Cnsの炎症性疾患の治療のための化合物および方法 Expired - Fee Related JP5746038B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11128708P 2008-11-04 2008-11-04
US61/111,287 2008-11-04
SE0802339 2008-11-04
SE0802339-2 2008-11-04
PCT/SE2009/051247 WO2010053435A2 (en) 2008-11-04 2009-11-04 Compounds and methods for the treatment of inflammatory diseases of the cns

Publications (3)

Publication Number Publication Date
JP2012507308A JP2012507308A (ja) 2012-03-29
JP2012507308A5 JP2012507308A5 (enExample) 2012-12-06
JP5746038B2 true JP5746038B2 (ja) 2015-07-08

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JP2011535539A Expired - Fee Related JP5746038B2 (ja) 2008-11-04 2009-11-04 Cnsの炎症性疾患の治療のための化合物および方法

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US (3) US8637479B2 (enExample)
EP (1) EP2350283B1 (enExample)
JP (1) JP5746038B2 (enExample)
AU (1) AU2009311753B2 (enExample)
CA (1) CA2778961C (enExample)
DK (1) DK2350283T3 (enExample)
ES (1) ES2560782T3 (enExample)
WO (1) WO2010053435A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2464731T3 (es) 2008-11-04 2014-06-03 Index Pharmaceuticals Ab Compuestos y procedimientos para reducir el reclutamiento y/o migración de células polimorfonucleares
EP2468866A1 (en) * 2010-12-21 2012-06-27 Index Pharmaceuticals AB Biologically active oligonucleotides capable of modulating the immune system
WO2012084991A1 (en) * 2010-12-21 2012-06-28 Index Pharmaceuticals Ab Biologically active oligonucleotides capable of modulating the immune system ii
EP2596806A1 (en) 2011-11-25 2013-05-29 Index Pharmaceuticals AB Method for prevention of colectomy
US11672757B2 (en) * 2017-06-28 2023-06-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Hot melt extrusion for pharmaceutical vaginal film products

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040996A1 (es) * 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
AU2004255470B2 (en) * 2003-07-10 2010-08-19 Cytos Biotechnology Ag Packaged virus-like particles
EP1819364A4 (en) * 2004-12-08 2010-12-29 3M Innovative Properties Co COMPOSITIONS, IMMUNOMODULATORY COMBINATIONS AND ASSOCIATED METHODS
WO2006065751A2 (en) 2004-12-13 2006-06-22 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
SI2380584T1 (sl) * 2005-07-01 2014-04-30 Index Pharmaceuticals Ab Imunostimulatorni postopek
PT2179737E (pt) * 2005-07-01 2013-12-05 Index Pharmaceuticals Ab Método para modular a capacidade de resposta aos esteróides
WO2007030581A2 (en) * 2005-09-09 2007-03-15 Oregon Health & Science University Neuroprotectants
AU2006306805A1 (en) 2005-10-28 2007-05-03 Index Pharmaceuticals Ab Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
WO2007095316A2 (en) 2006-02-15 2007-08-23 Coley Pharmaceutical Gmbh Compositions and methods for oligonucleotide formulations
EP1894941A1 (en) * 2006-09-01 2008-03-05 Institut Pasteur Treatment of cervical carcinoma with a recombinant adenylate cyclase carrying HPV antigens
US8309529B2 (en) * 2007-05-04 2012-11-13 Index Pharmaceuticals Ab Tumour growth inhibitory compounds and methods of their use
EP2155889A4 (en) * 2007-05-25 2010-06-16 Centocor Ortho Biotech Inc TOLL RECEPTOR 3 MODULATORS AND USES THEREOF
EP2207555B1 (en) 2007-10-05 2013-07-24 InDex Pharmaceuticals AB Oligonucleotides for the treatment or alleviation of edema
US20110182880A1 (en) 2008-06-18 2011-07-28 Oliver Von Stein Combination Therapies Against Cancer
ES2464731T3 (es) * 2008-11-04 2014-06-03 Index Pharmaceuticals Ab Compuestos y procedimientos para reducir el reclutamiento y/o migración de células polimorfonucleares

Also Published As

Publication number Publication date
AU2009311753B2 (en) 2015-01-15
EP2350283A2 (en) 2011-08-03
AU2009311753A1 (en) 2010-05-14
CA2778961C (en) 2019-06-18
WO2010053435A3 (en) 2010-07-08
EP2350283B1 (en) 2015-11-04
WO2010053435A2 (en) 2010-05-14
CA2778961A1 (en) 2010-05-14
US20180230463A1 (en) 2018-08-16
US8637479B2 (en) 2014-01-28
US20110293702A1 (en) 2011-12-01
US20140128456A1 (en) 2014-05-08
DK2350283T3 (en) 2016-02-01
JP2012507308A (ja) 2012-03-29
ES2560782T3 (es) 2016-02-22
EP2350283A4 (en) 2013-02-13

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