JP5746038B2 - Cnsの炎症性疾患の治療のための化合物および方法 - Google Patents

Cnsの炎症性疾患の治療のための化合物および方法 Download PDF

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JP5746038B2
JP5746038B2 JP2011535539A JP2011535539A JP5746038B2 JP 5746038 B2 JP5746038 B2 JP 5746038B2 JP 2011535539 A JP2011535539 A JP 2011535539A JP 2011535539 A JP2011535539 A JP 2011535539A JP 5746038 B2 JP5746038 B2 JP 5746038B2
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oligonucleotide
cells
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treatment
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JP2012507308A5 (enExample
JP2012507308A (ja
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バンドホルツ,リサ・シャーロッタ
ギーレン,アレクサンダー
ザルガリ,アレゾウ
ヴォン,ステイン・オリバー
アクセルッソン,ラース−ゴエラン
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インデックス・ファーマシューティカルズ・アクチエボラーグ
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/17Immunomodulatory nucleic acids
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/313Phosphorodithioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2011535539A 2008-11-04 2009-11-04 Cnsの炎症性疾患の治療のための化合物および方法 Expired - Fee Related JP5746038B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11128708P 2008-11-04 2008-11-04
US61/111,287 2008-11-04
SE0802339 2008-11-04
SE0802339-2 2008-11-04
PCT/SE2009/051247 WO2010053435A2 (en) 2008-11-04 2009-11-04 Compounds and methods for the treatment of inflammatory diseases of the cns

Publications (3)

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JP2012507308A JP2012507308A (ja) 2012-03-29
JP2012507308A5 JP2012507308A5 (enExample) 2012-12-06
JP5746038B2 true JP5746038B2 (ja) 2015-07-08

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JP2011535539A Expired - Fee Related JP5746038B2 (ja) 2008-11-04 2009-11-04 Cnsの炎症性疾患の治療のための化合物および方法

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US (3) US8637479B2 (enExample)
EP (1) EP2350283B1 (enExample)
JP (1) JP5746038B2 (enExample)
AU (1) AU2009311753B2 (enExample)
CA (1) CA2778961C (enExample)
DK (1) DK2350283T3 (enExample)
ES (1) ES2560782T3 (enExample)
WO (1) WO2010053435A2 (enExample)

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* Cited by examiner, † Cited by third party
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WO2010053430A1 (en) 2008-11-04 2010-05-14 Index Pharmaceuticals Ab Compounds and methods for reducing the recruitment and/or migration of polymorphonuclear cells
EP2468866A1 (en) * 2010-12-21 2012-06-27 Index Pharmaceuticals AB Biologically active oligonucleotides capable of modulating the immune system
WO2012084991A1 (en) * 2010-12-21 2012-06-28 Index Pharmaceuticals Ab Biologically active oligonucleotides capable of modulating the immune system ii
EP2596806A1 (en) 2011-11-25 2013-05-29 Index Pharmaceuticals AB Method for prevention of colectomy
WO2019006122A1 (en) * 2017-06-28 2019-01-03 University Of Pittsburgh-Of The Commonwealth System Of Higher Education HOT EXTRUSION FOR VAGINAL FILM PHARMACEUTICAL PRODUCTS

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040996A1 (es) * 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
AU2004255470B2 (en) * 2003-07-10 2010-08-19 Cytos Biotechnology Ag Packaged virus-like particles
US20110070575A1 (en) * 2004-12-08 2011-03-24 Coley Pharmaceutical Group, Inc. Immunomodulatory Compositions, Combinations and Methods
WO2006065751A2 (en) * 2004-12-13 2006-06-22 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
SI2179737T1 (sl) * 2005-07-01 2014-02-28 Index Pharmaceuticals Ab Modulacija reakcije na stereoide
ATE476193T1 (de) * 2005-07-01 2010-08-15 Index Pharmaceuticals Ab Immunstimulatorisches verfahren
EP1940419A2 (en) * 2005-09-09 2008-07-09 Oregon Health and Science University Neuroprotectants
EP1940472A1 (en) * 2005-10-28 2008-07-09 Index Pharmaceuticals AB Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
WO2007095316A2 (en) 2006-02-15 2007-08-23 Coley Pharmaceutical Gmbh Compositions and methods for oligonucleotide formulations
EP1894941A1 (en) * 2006-09-01 2008-03-05 Institut Pasteur Treatment of cervical carcinoma with a recombinant adenylate cyclase carrying HPV antigens
EP2573176B1 (en) * 2007-05-04 2016-04-06 InDex Pharmaceuticals AB Tumour growth inhibitory compounds and methods of their use
EP2155889A4 (en) * 2007-05-25 2010-06-16 Centocor Ortho Biotech Inc TOLL RECEPTOR 3 MODULATORS AND USES THEREOF
WO2009045145A1 (en) * 2007-10-05 2009-04-09 Index Pharmaceuticals Ab Novel compounds for the treatment or alleviation of edema, and methods for their use
AU2009260907A1 (en) * 2008-06-18 2009-12-23 Index Pharmaceuticals Ab Combination therapies against cancer
WO2010053430A1 (en) * 2008-11-04 2010-05-14 Index Pharmaceuticals Ab Compounds and methods for reducing the recruitment and/or migration of polymorphonuclear cells

Also Published As

Publication number Publication date
WO2010053435A3 (en) 2010-07-08
EP2350283A4 (en) 2013-02-13
CA2778961A1 (en) 2010-05-14
AU2009311753A1 (en) 2010-05-14
US20110293702A1 (en) 2011-12-01
AU2009311753B2 (en) 2015-01-15
EP2350283B1 (en) 2015-11-04
ES2560782T3 (es) 2016-02-22
CA2778961C (en) 2019-06-18
EP2350283A2 (en) 2011-08-03
DK2350283T3 (en) 2016-02-01
US20140128456A1 (en) 2014-05-08
JP2012507308A (ja) 2012-03-29
WO2010053435A2 (en) 2010-05-14
US20180230463A1 (en) 2018-08-16
US8637479B2 (en) 2014-01-28

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