DK2350283T3 - RELATIONS AND PROCEDURES FOR THE TREATMENT OF INFLAMMATORY DISEASES IN THE CENTRAL NERVOUS SYSTEM - Google Patents

RELATIONS AND PROCEDURES FOR THE TREATMENT OF INFLAMMATORY DISEASES IN THE CENTRAL NERVOUS SYSTEM Download PDF

Info

Publication number
DK2350283T3
DK2350283T3 DK09825063.2T DK09825063T DK2350283T3 DK 2350283 T3 DK2350283 T3 DK 2350283T3 DK 09825063 T DK09825063 T DK 09825063T DK 2350283 T3 DK2350283 T3 DK 2350283T3
Authority
DK
Denmark
Prior art keywords
seq
oligonucleotide
cells
treatment
idx9054
Prior art date
Application number
DK09825063.2T
Other languages
Danish (da)
English (en)
Inventor
Lisa Charlotta Bandholtz
Alexander Gielen
Arezou Zargari
Stein Oliver Von
Lars-Göran Axelsson
Original Assignee
Index Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Index Pharmaceuticals Ab filed Critical Index Pharmaceuticals Ab
Application granted granted Critical
Publication of DK2350283T3 publication Critical patent/DK2350283T3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/17Immunomodulatory nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/313Phosphorodithioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK09825063.2T 2008-11-04 2009-11-04 RELATIONS AND PROCEDURES FOR THE TREATMENT OF INFLAMMATORY DISEASES IN THE CENTRAL NERVOUS SYSTEM DK2350283T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11128708P 2008-11-04 2008-11-04
SE0802339 2008-11-04
PCT/SE2009/051247 WO2010053435A2 (en) 2008-11-04 2009-11-04 Compounds and methods for the treatment of inflammatory diseases of the cns

Publications (1)

Publication Number Publication Date
DK2350283T3 true DK2350283T3 (en) 2016-02-01

Family

ID=42153438

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09825063.2T DK2350283T3 (en) 2008-11-04 2009-11-04 RELATIONS AND PROCEDURES FOR THE TREATMENT OF INFLAMMATORY DISEASES IN THE CENTRAL NERVOUS SYSTEM

Country Status (8)

Country Link
US (3) US8637479B2 (enExample)
EP (1) EP2350283B1 (enExample)
JP (1) JP5746038B2 (enExample)
AU (1) AU2009311753B2 (enExample)
CA (1) CA2778961C (enExample)
DK (1) DK2350283T3 (enExample)
ES (1) ES2560782T3 (enExample)
WO (1) WO2010053435A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010053430A1 (en) 2008-11-04 2010-05-14 Index Pharmaceuticals Ab Compounds and methods for reducing the recruitment and/or migration of polymorphonuclear cells
EP2468866A1 (en) * 2010-12-21 2012-06-27 Index Pharmaceuticals AB Biologically active oligonucleotides capable of modulating the immune system
WO2012084991A1 (en) * 2010-12-21 2012-06-28 Index Pharmaceuticals Ab Biologically active oligonucleotides capable of modulating the immune system ii
EP2596806A1 (en) 2011-11-25 2013-05-29 Index Pharmaceuticals AB Method for prevention of colectomy
WO2019006122A1 (en) * 2017-06-28 2019-01-03 University Of Pittsburgh-Of The Commonwealth System Of Higher Education HOT EXTRUSION FOR VAGINAL FILM PHARMACEUTICAL PRODUCTS

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040996A1 (es) * 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
AU2004255470B2 (en) * 2003-07-10 2010-08-19 Cytos Biotechnology Ag Packaged virus-like particles
US20110070575A1 (en) * 2004-12-08 2011-03-24 Coley Pharmaceutical Group, Inc. Immunomodulatory Compositions, Combinations and Methods
WO2006065751A2 (en) * 2004-12-13 2006-06-22 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
SI2179737T1 (sl) * 2005-07-01 2014-02-28 Index Pharmaceuticals Ab Modulacija reakcije na stereoide
ATE476193T1 (de) * 2005-07-01 2010-08-15 Index Pharmaceuticals Ab Immunstimulatorisches verfahren
EP1940419A2 (en) * 2005-09-09 2008-07-09 Oregon Health and Science University Neuroprotectants
EP1940472A1 (en) * 2005-10-28 2008-07-09 Index Pharmaceuticals AB Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
WO2007095316A2 (en) 2006-02-15 2007-08-23 Coley Pharmaceutical Gmbh Compositions and methods for oligonucleotide formulations
EP1894941A1 (en) * 2006-09-01 2008-03-05 Institut Pasteur Treatment of cervical carcinoma with a recombinant adenylate cyclase carrying HPV antigens
EP2573176B1 (en) * 2007-05-04 2016-04-06 InDex Pharmaceuticals AB Tumour growth inhibitory compounds and methods of their use
EP2155889A4 (en) * 2007-05-25 2010-06-16 Centocor Ortho Biotech Inc TOLL RECEPTOR 3 MODULATORS AND USES THEREOF
WO2009045145A1 (en) * 2007-10-05 2009-04-09 Index Pharmaceuticals Ab Novel compounds for the treatment or alleviation of edema, and methods for their use
AU2009260907A1 (en) * 2008-06-18 2009-12-23 Index Pharmaceuticals Ab Combination therapies against cancer
WO2010053430A1 (en) * 2008-11-04 2010-05-14 Index Pharmaceuticals Ab Compounds and methods for reducing the recruitment and/or migration of polymorphonuclear cells

Also Published As

Publication number Publication date
WO2010053435A3 (en) 2010-07-08
EP2350283A4 (en) 2013-02-13
CA2778961A1 (en) 2010-05-14
AU2009311753A1 (en) 2010-05-14
US20110293702A1 (en) 2011-12-01
AU2009311753B2 (en) 2015-01-15
EP2350283B1 (en) 2015-11-04
ES2560782T3 (es) 2016-02-22
CA2778961C (en) 2019-06-18
EP2350283A2 (en) 2011-08-03
JP5746038B2 (ja) 2015-07-08
US20140128456A1 (en) 2014-05-08
JP2012507308A (ja) 2012-03-29
WO2010053435A2 (en) 2010-05-14
US20180230463A1 (en) 2018-08-16
US8637479B2 (en) 2014-01-28

Similar Documents

Publication Publication Date Title
CA2483012C (en) Oligonucleotide compositions and their use for the modulation of immune responses
US20180230463A1 (en) Compounds and Methods for the Treatment of Inflammatory Diseases of the CNS
AU2003243189B2 (en) Methods of using cytokine antagonists to treat HIV infection and AIDS
US9534219B2 (en) Methods of treating vascular inflammatory disorders
CA3024917A1 (en) Combinations of mrnas encoding immune modulating polypeptides and uses thereof
Jiang et al. A study on regulatory mechanism of miR-223 in ulcerative colitis through PI3K/Akt-mTOR signaling pathway.
JP2017537973A5 (enExample)
CN107362365A (zh) Gpr31抑制剂在制药中的应用
EP1776124A1 (en) Immune modulating oligonucleotides in connection with chemotherapeutic measures
CN115551520A (zh) 败血症和高细胞因子血症的治疗
US20180289692A1 (en) Tlr modulators and methods of use
WO2009033091A1 (en) Treatment of th17-mediated autoimmune disease via inhibition of stat3
CN101701218B (zh) 一种抑制Th1和Th17分化的免疫调节性寡聚脱氧核苷酸及应用
Wang et al. Suppressive effect of β, β-dimethylacryloyl alkannin on activated dendritic cells in psoriasis by the TLR7/8 pathway
CN105126119B (zh) 长非编码核糖核酸mrak009713小干扰rna在制备神经病理痛药物中的应用
CN108096579A (zh) 以c-Rel基因为靶点在制备治疗类风湿性关节炎的药物中的应用
JP2023093639A (ja) 新規製剤
Marsh Preconditioning reprograms TLR signaling following cerebral ischemia the emergence of a neuroprotective program
CN121154826A (zh) Apoe作为靶点在制备用于预防和/或治疗葡萄膜炎的药物中的应用
CN111939246A (zh) E3泛素连接酶Nedd4l在制备抗感染药物中的应用
CN102266317A (zh) 丙戊酸及其衍生物的应用
CN102078621A (zh) 调控浆细胞样树突状细胞i型干扰素表达的方法和组合物