JP2017537973A5 - - Google Patents
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- JP2017537973A5 JP2017537973A5 JP2017540317A JP2017540317A JP2017537973A5 JP 2017537973 A5 JP2017537973 A5 JP 2017537973A5 JP 2017540317 A JP2017540317 A JP 2017540317A JP 2017540317 A JP2017540317 A JP 2017540317A JP 2017537973 A5 JP2017537973 A5 JP 2017537973A5
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- 238000000034 method Methods 0.000 claims description 198
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 119
- 108091034117 Oligonucleotide Proteins 0.000 claims description 87
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 84
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 84
- 102000004890 Interleukin-8 Human genes 0.000 claims description 76
- 108090001007 Interleukin-8 Proteins 0.000 claims description 76
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims description 76
- 229940096397 interleukin-8 Drugs 0.000 claims description 76
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 74
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 74
- 101700026522 SMAD7 Proteins 0.000 claims description 72
- 102000049873 Smad7 Human genes 0.000 claims description 72
- 125000003729 nucleotide group Chemical group 0.000 claims description 22
- 239000002773 nucleotide Substances 0.000 claims description 21
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 20
- 208000011231 Crohn disease Diseases 0.000 claims description 18
- LUCHPKXVUGJYGU-XLPZGREQSA-N 5-methyl-2'-deoxycytidine Chemical compound O=C1N=C(N)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 LUCHPKXVUGJYGU-XLPZGREQSA-N 0.000 claims description 9
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 8
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 8
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 230000009266 disease activity Effects 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 55
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 3
- 108010074051 C-Reactive Protein Proteins 0.000 description 9
- 102100032752 C-reactive protein Human genes 0.000 description 9
- 238000002965 ELISA Methods 0.000 description 6
- 101000652166 Homo sapiens Mothers against decapentaplegic homolog 7 Proteins 0.000 description 6
- 102000044356 human SMAD7 Human genes 0.000 description 6
- 238000007726 management method Methods 0.000 description 6
- 231100000682 maximum tolerated dose Toxicity 0.000 description 6
- 150000003431 steroids Chemical class 0.000 description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 235000006694 eating habits Nutrition 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000000391 smoking effect Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 2
- ABASMUXUCSQFKC-PKEKLUKKSA-N mongersen Chemical compound CC1=CN([C@H]2C[C@H](OP(=S)(O)OC[C@H]3O[C@H](C[C@@H]3OP(=S)(O)OC[C@H]4O[C@H](C[C@@H]4OP(=S)(O)OC[C@H]5O[C@H](C[C@@H]5OP(=S)(O)OC[C@H]6O[C@H](C[C@@H]6OP(=S)(O)OC[C@H]7O[C@H](C[C@@H]7O)N8C=CC(=NC8=O)N)n9cnc%10C(=O)NC(=Nc9%10)N)n%11cnc%12c(N)ncnc%11%12)N%13C=CC(=NC%13=O)N)n%14cnc%15C(=O)NC(=Nc%14%15)N)[C@@H](COP(=S)(O)O[C@H]%16C[C@@H](O[C@@H]%16COP(=S)(O)O[C@H]%17C[C@@H](O[C@@H]%17COP(=S)(O)O[C@H]%18C[C@@H](O[C@@H]%18COP(=S)(O)O[C@H]%19C[C@@H](O[C@@H]%19COP(=S)(O)O[C@H]%20C[C@@H](O[C@@H]%20COP(=S)(O)O[C@H]%21C[C@@H](O[C@@H]%21COP(=S)(O)O[C@H]%22C[C@@H](O[C@@H]%22COP(=S)(O)O[C@H]%23C[C@@H](O[C@@H]%23COP(=S)(O)O[C@H]%24C[C@@H](O[C@@H]%24COP(=S)(O)O[C@H]%25C[C@@H](O[C@@H]%25COP(=S)(O)O[C@H]%26C[C@@H](O[C@@H]%26COP(=S)(O)O[C@H]%27C[C@@H](O[C@@H]%27COP(=S)(O)O[C@H]%28C[C@@H](O[C@@H]%28COP(=S)(O)O[C@H]%29C[C@@H](O[C@@H]%29COP(=S)(O)O[C@H]%30C[C@@H](O[C@@H]%30CO)n%31cnc%32C(=O)NC(=Nc%31%32)N)N%33C=C(C)C(=O)NC%33=O)N%34C=C(C)C(=NC%34=O)N)n%35cnc%36C(=O)NC(=Nc%35%36)N)N%37C=CC(=NC%37=O)N)N%38C=CC(=NC%38=O)N)N%39C=CC(=NC%39=O)N)N%40C=CC(=NC%40=O)N)N%41C=C(C)C(=O)NC%41=O)N%42C=C(C)C(=O)NC%42=O)N%43C=CC(=NC%43=O)N)N%44C=C(C)C(=O)NC%44=O)N%45C=CC(=NC%45=O)N)N%46C=CC(=NC%46=O)N)N%47C=CC(=NC%47=O)N)O2)C(=O)N=C1N ABASMUXUCSQFKC-PKEKLUKKSA-N 0.000 description 1
- 229950002917 mongersen Drugs 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462065596P | 2014-10-17 | 2014-10-17 | |
| US201462065586P | 2014-10-17 | 2014-10-17 | |
| US62/065,586 | 2014-10-17 | ||
| US62/065,596 | 2014-10-17 | ||
| US201462085949P | 2014-12-01 | 2014-12-01 | |
| US62/085,949 | 2014-12-01 | ||
| PCT/EP2015/074070 WO2016059243A2 (en) | 2014-10-17 | 2015-10-16 | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537973A JP2017537973A (ja) | 2017-12-21 |
| JP2017537973A5 true JP2017537973A5 (enExample) | 2018-11-29 |
Family
ID=54356321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540317A Pending JP2017537973A (ja) | 2014-10-17 | 2015-10-16 | バイオマーカーレベルを使用してsmad7アンチセンスオリゴヌクレオチドを投与するおよびモニタリングするための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20170233736A1 (enExample) |
| EP (2) | EP3693736A3 (enExample) |
| JP (1) | JP2017537973A (enExample) |
| CA (1) | CA2964673A1 (enExample) |
| WO (1) | WO2016059243A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| RS56049B1 (sr) | 2008-11-13 | 2017-09-29 | Nogra Pharma Ltd | Antisens kompozicije i postupci za pripremu i upotrebu istih |
| KR102099990B1 (ko) | 2011-09-15 | 2020-04-13 | 노그라 파마 리미티드 | 항-smad7 요법의 반응성을 모니터링하는 방법 |
| RU2667960C2 (ru) | 2012-04-18 | 2018-09-25 | Ногра Фарма Лимитед | Способы лечения диабета и/или улучшения выживания панкреатических островков после трансплантации |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| CN106573065A (zh) * | 2014-05-09 | 2017-04-19 | 诺格尔制药有限公司 | 用于治疗炎症性肠病的方法 |
| EP3207136A1 (en) | 2014-10-17 | 2017-08-23 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| MA41271A (fr) * | 2014-12-26 | 2017-10-31 | Celgene Alpine Invest Company Ii Llc | Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7 |
| US11162097B2 (en) | 2016-02-23 | 2021-11-02 | Nogra Pharma Limited | Methods of treating intestinal fibrosis using SMAD7 inhibition |
| CA3030994C (en) | 2016-08-15 | 2020-12-22 | Intercontinental Great Brands Llc | Multi-layer film and reclosable film package |
| MX2019001249A (es) | 2016-08-15 | 2019-04-25 | Intercontinental Great Brands Llc | Pelicula de capas multiples y empaque de pelicula que puede volver a cerrarse. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159697A (en) | 2000-01-19 | 2000-12-12 | Isis Pharmaceuticals, Inc. | Antisense modulation of Smad7 expression |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| JP2012507723A (ja) * | 2008-11-03 | 2012-03-29 | シェーリング コーポレイション | 炎症性腸疾患生物マーカーおよび関連治療方法 |
| RS56049B1 (sr) * | 2008-11-13 | 2017-09-29 | Nogra Pharma Ltd | Antisens kompozicije i postupci za pripremu i upotrebu istih |
| KR102099990B1 (ko) * | 2011-09-15 | 2020-04-13 | 노그라 파마 리미티드 | 항-smad7 요법의 반응성을 모니터링하는 방법 |
| US20150125398A1 (en) * | 2012-05-11 | 2015-05-07 | University Of Iowa Research Foundation | Multimodal imaging methods using mesoporous silica nanoparticles |
| EP3207136A1 (en) * | 2014-10-17 | 2017-08-23 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
-
2015
- 2015-10-16 WO PCT/EP2015/074070 patent/WO2016059243A2/en not_active Ceased
- 2015-10-16 US US15/519,489 patent/US20170233736A1/en not_active Abandoned
- 2015-10-16 EP EP19211956.8A patent/EP3693736A3/en not_active Withdrawn
- 2015-10-16 CA CA2964673A patent/CA2964673A1/en not_active Abandoned
- 2015-10-16 EP EP15785081.9A patent/EP3213070A2/en not_active Withdrawn
- 2015-10-16 JP JP2017540317A patent/JP2017537973A/ja active Pending
-
2019
- 2019-10-15 US US16/601,905 patent/US20200032264A1/en not_active Abandoned
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